Antibiotiki i Khimioterapiya最新文献_第4页

[Screening of Organisms Producing Inhibitors of 15-Lipoxygenase Among Micromycetes.] [微生物中15-脂氧合酶抑制剂的筛选]

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

M V Bibikova, I A Spiridonova, A N Danilenko, Yu A Kim, A F Korystova, V V Shaposhnikova, Yu N Korystov

引用次数: 0

[Antibiotic Resistance and Its Molecular Mechanisms in Carbapenem-Nonsusceptible Klebsiellapneumoniae Isolated in Pediatric ICUs in Moscow.] 莫斯科儿科icu中碳青霉烯不敏感克雷伯肺炎菌的耐药性及其分子机制[j]。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

O A Kryzhanovskaya, A V Lazareva, N M Alyabieva, R F Tepaev, O V Karaseva, I V Chebotar, N A Mayanskiy

{"title":"[Antibiotic Resistance and Its Molecular Mechanisms in Carbapenem-Nonsusceptible Klebsiellapneumoniae Isolated in Pediatric ICUs in Moscow.]","authors":"O A Kryzhanovskaya, A V Lazareva, N M Alyabieva, R F Tepaev, O V Karaseva, I V Chebotar, N A Mayanskiy","doi":"","DOIUrl":"","url":null,"abstract":"Klebsiellapneumoniae is a significant pathogen associated with hospital infections. Its was isolated in intensive care units (ICU) at two pediatric hospitals in Moscow in 2012-2014 from 41% (387/935) of the patients. The rate of carbapenem-nonsusceptibility (Carba-NS) amounted to 25% for imipenem and 27% for meropenem. For further analyses, 67 isolates were selected, including 57 Carba-NS and 10 Carba-susceptible (Carba-S). Among the isolates, 100% was nonsusceptible to the III-IV generation cephalosporins, 50-84% was resistant to aminoglycosides. The rate of nonsusceptibility to ciprofloxacin and phosphomycin exceeded 90%. All the tested Carba-S Kpneumoniae isolates were susceptible to tigecycline, whereas 25% of the Carba-NS isolates was tigecycline-NS. The prevalence of the colistin-NS isolates was the same in Carba-S (20%) and Carba-NS (26%) bacteria. The blamrx_ gene was carried by 100% of the Carba-S isolates, combining with the blaTEM gene in 60% of the isolates. In 89% of the Carba-NS isolates the OXA-48 carbapenemase was detected, which was combined with CTX-M and/or TEM in all but 1 isolate. Thus, over the last decade, the rate of Carba-NS among nosocomial Kpneuynoniae increased and the OXA-48 carbapenemase was shown to be dominating in the mechanism of Carba-NS in the pediatric ICUs in Moscow.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35908310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concentration-Dependent Enrichment of Linezolid-Resistant Staphylococcus aureus in an in vitro Dynamic Model. 体外动态模型中耐利奈唑胺金黄色葡萄球菌浓度依赖性富集。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

K N Alieva, E N Strukova, M V Golikova, Yu A Portnoy, A A Firsov

引用次数: 0

Molecular Mechanisms of Ceftaroline Susceptibility Reduction in Methicillin-Resistant Staphylococcus aureus. 耐甲氧西林金黄色葡萄球菌头孢他林敏感性降低的分子机制。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

V V Gostev, O S Kalinogorskaya, O A Dmitrenko, I A Tsvetkova, S V Sidorenko

{"title":"Molecular Mechanisms of Ceftaroline Susceptibility Reduction in Methicillin-Resistant Staphylococcus aureus.","authors":"V V Gostev, O S Kalinogorskaya, O A Dmitrenko, I A Tsvetkova, S V Sidorenko","doi":"","DOIUrl":"","url":null,"abstract":"Ceftaroline is a unique cephalosporin with activity against methicillin resistant Staphylococcus aureus (MRSA). It was approved for clinical use in the USA, Europe and Russian Federation since 2010 for the treatment of the skin and soft tissue infection and community-acquired pneumoniae. In the present study there was used molecular typing of 24 isolates of MRSA with reduced susceptibility to ceftaroline. For 8 isolates belonging to different genetic lines (ST8, ST239 and ST228) and requiring MICs there were determined antibiotic concentrations preventing formation of resistant mutants (mutant prevention concentration) and the ranges of the mutant selection window (MSW). The last majority of the isolates with reduced susceptibility to ceftaroline (MIC of 2 mcg/ml) belonged to the clonal line ST228. The whole genome sequencing of two isolates of ST228 showed that they belonged to the epidemic South Germany genetic line and were characterized by the presence of mutations in PBP2a (N146K) and PBP2 (C197Y) responsible for reduced susceptibility. The highest rates of MPC (32 mcg/ml) and MSW (2-16 mcg/ml) were observed in the clinical isolates belonging to the genetic line ST8. The isolates of ST239 and ST228 had the selection window within 2-4 mcg/ml. No dependence of the MIC and MPC/MSW levels was detected.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35913198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cephalopods as a Source of New Antimicrobial Substances]. [头足类动物作为新型抗菌物质的来源]。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

N N Besednova, N N Kovalev, T S Zaporozhets, T A Kuznetsova, A K Gazha

引用次数: 0

[Prophylaxis of Community-Acquired Pneumonia Outbreaks with Pneumococcal Polysaccharide Vaccine. Prospects Analysis for Russian Military Community]. 肺炎球菌多糖疫苗预防社区获得性肺炎暴发俄罗斯军事共同体前景分析[j]。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

I A Guchev, O I Klochkov, A I Sinopalnikov

{"title":"[Prophylaxis of Community-Acquired Pneumonia Outbreaks with Pneumococcal Polysaccharide Vaccine. Prospects Analysis for Russian Military Community].","authors":"I A Guchev, O I Klochkov, A I Sinopalnikov","doi":"","DOIUrl":"","url":null,"abstract":"Pneumococcal pneumonia and other diseases caused by pneumococci still remain the main factors of high morbidity and mortality rates throughout the world. Pneumococci as the leading pathogens of community-acquired pneumonia (CAP), acute otitis media and sinusitis also cause a number of other serious systemic disorders including invasive infections with high mortality in spite of the antimicrobial resistance status and adequate antimicrobials choice. Pneumococcal infections are responsible for 5-35% or more of community-acquired pneumonias. The burden of pneumonia (up to 100-200 per thousand) is recorded among military recruits in training centers. Since the specific environment of the soldiers could be carrected, their health protection requires medical surveillance. For these reasons, polysaccharide and more immunogenic conjugated pneumococcal vaccines were developed. There is now an urgent need to understand whether such vaccines are effective in military conscripts. Controversy about the effectiveness and value of the polysaccharide (PPV-23) vaccine as a CAP morbidity restriction measure still persists. There were implemented plenty of metaanalyses of pneumococcal vaccines in adults. Some of them showed that the vaccine was effective against bacteremic pneumococcal pneumonia in 'low risk' healthy adults and elders. There have been a number of poor quality observational studies in Russia where 'all pneumonia cases' were considered as an endpoint. It remains controversial whether these observational studies provide adequate evidence to justify the use of the polysaccharide vaccine in the groups of healthy young men for whom it is being advocated. In our analysis we found weak evidence supporting pneumococcal vaccination with PPV-23 for this group. Nevertheless, favorable tendency was found to immunize. It is the reason for a trail to find pharmacoepidemiological support for vaccination by novel conjugated vaccines with better immunogenicity.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34604317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plague Antibacterial Therapy. Historical Aspects and Future Prospects. 鼠疫抗菌治疗。历史方面和未来展望。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

I A Schipeleva, E I Markovskaya

引用次数: 0

Investigation of Thionins from Black Cumin (Nigella sativa L.) Seeds Showing Cytotoxic, Regulatory and Antifungal Activity. 黑孜然(Nigella sativa L.)中硫甙的研究显示细胞毒性、调节和抗真菌活性的种子。

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

A B Kul'ko, O V Kisl, V S Sadykova, V F Mikhailov, I M Vasilieva, L V Shulenina, G D Zasukhina, E A Rogozhin

引用次数: 0

Successful Tigecycline Use in Combined Therapy of Ventilator-Associated Hospital-Acquired Pneumonia: a Clinical Case. 替加环素成功联合治疗呼吸机相关医院获得性肺炎1例

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

G V Rodoman, I R Sumedi, S K Zyryanov, M A Ivzhits, O M Romashov, M I Aleksandrov, O Yu Markina, M A Lukin, I A Zaigraev, M R Smirnova

{"title":"Successful Tigecycline Use in Combined Therapy of Ventilator-Associated Hospital-Acquired Pneumonia: a Clinical Case.","authors":"G V Rodoman, I R Sumedi, S K Zyryanov, M A Ivzhits, O M Romashov, M I Aleksandrov, O Yu Markina, M A Lukin, I A Zaigraev, M R Smirnova","doi":"","DOIUrl":"","url":null,"abstract":"In patients under artificial lung ventilation (ALV) there is often observed development of severe ventilator-associated pneumonia (VAP) due to polyresistant hospital pathogens. It should be noted that in the patient described here with the initial diagnosis of community-acquired pneumonia rapidly subjected to prolonged ALV the previous antibacterial therapy by broad spectrum drugs significantly increased the risk of contamination just by multiresistant nosocomial strains, which hampered the starting therapy of nosocomial pneumonia either when there were not available or sometimes there were available microbial cultures. When the treatment of severe pneumonias caused by multiresistant hospital flora resistant to carbapenems is actual, in the alternative therapy it could be used tigecycline, a tetracycline from the group of glycylcyclines. A case of successful treatment of nosocomial VAP by tigecycline based on the results of the bronchoalveolar lavage (BAL) culture is described. The case is of interest because tigecycline was used as off label.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35929362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of Microbial Landscape of Wound Surface in Patients with Diabetic Foot Syndrome. 糖尿病足综合征患者创面微生物景观特征

Antibiotiki i Khimioterapiya Pub Date : 2016-01-01

A V Fedoseev, R V Siforov, A S Inytin, A A Chekushin, D V Krolivec

引用次数: 0