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Antibiotiki i Khimioterapiya最新文献

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[Contribution of microbiologists of Kirov City to development of penicillin and streptomycin production processes (70 years since development of technology for submerged production of first domestic antibiotics)]. 【基洛夫市微生物学家对盘尼西林和链霉素生产工艺发展的贡献(国产首个抗生素水下生产技术开发70年)】。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
M K Bakulin, A S Tumanov, V M Bakulin, V B Kalininskiĭ
{"title":"[Contribution of microbiologists of Kirov City to development of penicillin and streptomycin production processes (70 years since development of technology for submerged production of first domestic antibiotics)].","authors":"M K Bakulin,&nbsp;A S Tumanov,&nbsp;V M Bakulin,&nbsp;V B Kalininskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The publication is concerned with development of the technological processes for submered production of the first domestic antibiotics 70 years age. The literature data on the contribution of the microbiologists of the Kirov City and mainly the workers of the Red Army Research Institute of Epidemiology and Hygiene (nowadays Central Research Institute No. 48 of the Ministry of Defense of the Russian Federation, Kirov), to development of the manufacture processes for production of penicillin and streptomycin are reviewed.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32945586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of Hypecoum erectum extract on morphofunctional state of the liver in rats with tetracycline-associated hepatitis]. [海地瓜提取物对四环素相关性肝炎大鼠肝脏形态功能状态的影响]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
A A Toropova, S M Nikolaev, Ya G Razuvaeva, A V Fedorov, Z G Sambueva, I P Ubeeva
{"title":"[Effect of Hypecoum erectum extract on morphofunctional state of the liver in rats with tetracycline-associated hepatitis].","authors":"A A Toropova,&nbsp;S M Nikolaev,&nbsp;Ya G Razuvaeva,&nbsp;A V Fedorov,&nbsp;Z G Sambueva,&nbsp;I P Ubeeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of Hypecoum erectum L. extract on the morphofunctional condition of the liver in rats with experimental tetracycline-associated hepatitis was studied. The experiment included 40 albino rats Wistar. The animals treated with tetracycline hydrochloride (1.0 g/kg body weight) were exposed to the extract in a dose of 50 mg/kg for 5 days. On the 7th day of the experiment the following indices were determined: malonic dialdehyde concentration, catalase activity, the levels of ATP, pyruvate and lactate in the liver homogenate, as well as the blood levels of reduced glutathione. The liver pathomorphological investigation was applied. The H. erectum extract was shown to inhibit lipid peroxidation, to increase the activity of the host endogenous antioxidant system, to normalize the hepatocyte energy provision and to limit the liver degeneration.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33304782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Value of probiotic in reducing frequency of infectious complications in premature infants]. [益生菌对降低早产儿感染并发症发生率的价值]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
L A Lo Skiavo, N V Gonchar, A N Suvorov, N P Shabalov, S G Grigor'ev
{"title":"[Value of probiotic in reducing frequency of infectious complications in premature infants].","authors":"L A Lo Skiavo,&nbsp;N V Gonchar,&nbsp;A N Suvorov,&nbsp;N P Shabalov,&nbsp;S G Grigor'ev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty five premature infants with very low body weight were observed as inpatients to assess effectiveness of the nursing. The standard program of the care included: adequate primary resuscitation, respiratory support (use of surfactant), thermal mode, early provision of nutrients with full or partial parenteral nutrition, antimicrobial therapy and if possible early enteral nutrition. The patients of the main group (n = 29) along with the standard therapy (the volume of the enteral nutrition of 5 ml or more) were treated orally with liquid probiotic based on E. faecium L3 in a dose of 0.5 ml (5 x 10(8) CFU) 3 times a day for 14 days. The control group (n = 26) was under the standard therapy. The effectiveness of the infants management was estimated by the frequency of disruption of the nutrition, the frequency of infectious complications, the changes in the hematologic indices, the dynamics of the composition of the intestinal microflora. The infectious complications were evident from perinatal viral infection, intraamniotic infection, necrotizing enterocolitis. In the main group patients there was recorded a significant decrease of the frequency of infectious complications: 20.7% against 53.9% in the control group patients. The use of probiotic strain E. faecium L3 in the preterm infants promoted conservation of the immunomodulatory function of the intestinal indigenic microflora and restricted the growth of the nosocomial flora.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32527038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modern Russian Etiotropic Antiinfluenza Drugs]. [现代俄罗斯致病因性抗流感药物]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
F I Ershov, V V Poloskov
{"title":"[Modern Russian Etiotropic Antiinfluenza Drugs].","authors":"F I Ershov,&nbsp;V V Poloskov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two main groups of the Russian etiotropic drugs recommended by the Ministry of Health of the Russian Federation for prophylaxis or treatment of influenza are described in the review, i.e. chemotherapeutics whose targets are various stages of the influenza virus reproduction and interferons and their inductors engaging innate immunity patterns.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34072434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanisms of nephrotoxic action of immunodepressants, calcineurine inhibitors]. [免疫抑制剂、钙碱抑制剂肾毒性作用的机制]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
A V Nikitin
{"title":"[Mechanisms of nephrotoxic action of immunodepressants, calcineurine inhibitors].","authors":"A V Nikitin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of immunodepressants in the medical practice provided tens of thousands of favourable outcomes of the liver, kidney or heart transplantation and significant success in the treatment of a number of autoimmune diseases. Calcineurine inhibitors (cyclosporine A and tacrolimus) provoke a number of adverse reactions. Among them nephrotoxicity is clinically most dangerous. Complex estimation of the immunological and biochemical indices in the treatment with calcineurine inhibitors is an important precondition for increasing the efficacy of immunodepressive therapy and decreasing the frequency and level of the adverse reactions.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32527040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Umifenovir (Arbidol) efficacy in experimental mixed viral and bacterial pneumonia of mice]. [乌米诺韦(阿比多尔)治疗实验性小鼠病毒性和细菌性混合肺炎的疗效]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
I A Leneva, I N Falynskova, E I Leonova, I T Fedyakina, N R Makhmudova, E A Osipova, L N Lepekha, N A Mikhailova, V V Zverev
{"title":"[Umifenovir (Arbidol) efficacy in experimental mixed viral and bacterial pneumonia of mice].","authors":"I A Leneva,&nbsp;I N Falynskova,&nbsp;E I Leonova,&nbsp;I T Fedyakina,&nbsp;N R Makhmudova,&nbsp;E A Osipova,&nbsp;L N Lepekha,&nbsp;N A Mikhailova,&nbsp;V V Zverev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pneumonia often occurs as a secondary infection after influenza and accounts for a large proportion of the morbidity and mortality associated with seasonal and pandemic influenza outbreaks. The efficacy of umifenovir (Arbidol) was investigated on a murine model of S. aureus pneumonia following A/California/04/2009 (H1N1) influenza virusinfection. Oral treatment with umifenovir (40 and 60 mg/kg/day) in all the contamination schemes increased the survival rate in the mice from 0% to 90% and lowered the animal weight loss. The umifenovir treatment also decreased the virus titer by ≥ 2 logs and the viable bacteria counts in the lungs of the mice. The lungs of the mice treated with umifenovir had less severe histopathologic lesions compared to the control group.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33304857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative investigation of rheological characteristics of the original drug Triderm and its generics in the form of cream]. 【原料药Triderm与仿制药乳膏形式流变学特性的比较研究】。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
E I Molokhova, Iu V Sorokina
{"title":"[Comparative investigation of rheological characteristics of the original drug Triderm and its generics in the form of cream].","authors":"E I Molokhova,&nbsp;Iu V Sorokina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rheological properties of mild pharmaceutical formulations (creams) with glucocorticosteroids, such as Triderm (Belgium), Akriderm GK (Russia) and Kanizon plus (India) were studied. The study revealed differences in the structural-strength properties of the medicines (viscosity, critical shear stress). The necessity of rheological investigations during development of generic medicines was shown.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32943985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibiotic susceptibility and identification of clinical Pseudomonas fulva isolates]. [临床富氏假单胞菌的药敏及鉴定]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
E P Sivolodsky, G V Gorelova, S P Bogoslovskaya, E V Zueva
{"title":"[Antibiotic susceptibility and identification of clinical Pseudomonas fulva isolates].","authors":"E P Sivolodsky,&nbsp;G V Gorelova,&nbsp;S P Bogoslovskaya,&nbsp;E V Zueva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The earliest eight clinical strains of Pseudomonas fulva were identified in the culture collection of pseudomonads isolated in St. Petersburg in 1995-2005, that confirmed the medical importance of the species. A high level of the species identification of all the strains of P. fulva by MALDI-TOF mass-spectrometry with the use of Microflex device with database MALDI Biotyper (Bruker Daltonics Inc.) was shown. Tests for routine studies providing identification of P. fulva without the use of genetic methods were approved. The profile of the antibiotic susceptibility of the clinical strains of P. fulva was described. Acquired resistance of two P. fulva isolates to the 3rd generation cephalosporins and chloramphenicol was detected.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33304784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular imprinted polymers for macrolides, aminoglycosides and some other biosynthetic antibiotics]. [大环内酯类、氨基糖苷类和其他一些生物合成抗生素的分子印迹聚合物]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
M I Yakhkind, K R Tarantseva, M A Marynova, P A Storozhenko, M M Rasulov
{"title":"[Molecular imprinted polymers for macrolides, aminoglycosides and some other biosynthetic antibiotics].","authors":"M I Yakhkind,&nbsp;K R Tarantseva,&nbsp;M A Marynova,&nbsp;P A Storozhenko,&nbsp;M M Rasulov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular imprinted polymers (MIP) for macrolides, aminoglycosides and some other biosynthetic antibiotics described in the literature were analysed with a purpose of evaluating their possible use for the antibiotics sorption.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33304852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Action of antibiotics as signalling molecules]. [抗生素作为信号分子的作用]。
Antibiotiki i Khimioterapiya Pub Date : 2014-01-01
V G Bulgakova, K A Vinogradova, T I Orlova, P A Kozhevin, A N Polin
{"title":"[Action of antibiotics as signalling molecules].","authors":"V G Bulgakova,&nbsp;K A Vinogradova,&nbsp;T I Orlova,&nbsp;P A Kozhevin,&nbsp;A N Polin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It was thought that antibiotics should be produced by soil microorganisms to inhibit the growth of competitors in natural habitats. Yet it has been shown that antibiotics at subinhibitory concentrations may have a role as signalling molecules providing cell-to-cell communication in bacteria in the environment. Antibiotics modulate gene transcription and regulate gene expression in microbial populations. Subinhibitory concentrations of antibiotics may cause a number of phenotypic and genotypic changes in microorganisms. These transcription changes are dependent on the interaction of antibiotics with macromolecular receptors such as ribosome or RNA-polymerase. Antibiotic signalling and quorum-sensing system are important regulatory mechanisms in bacteria. It was demonstrated that antibiotics interfered with quorum-sensing system.</p>","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32527039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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