Antibiotiki i Khimioterapiya最新文献_第9页

[Antibiotic Resistance and Serotype Pattern of Streptococcus pneumoniae Isolated from Children in St. Petersburg in 2010-2013]. [2010-2013年圣彼得堡儿童肺炎链球菌耐药性及血清型分析]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

O S Kalinogorskaya, S S Belanov, M O Volkova, V V Gostev, S V Sidorenko

{"title":"[Antibiotic Resistance and Serotype Pattern of Streptococcus pneumoniae Isolated from Children in St. Petersburg in 2010-2013].","authors":"O S Kalinogorskaya, S S Belanov, M O Volkova, V V Gostev, S V Sidorenko","doi":"","DOIUrl":"","url":null,"abstract":"The surveillance of the serotype pattern and antibiotic resistance of S. pneumoniae in various geographical regions is required for the validity of rational etiotrophic therapy of pneumococcal infections and the choice of the optimal vaccines for their prophylaxis. 250 S. pneumoniae isolates from children with acute otitis or pneumonia and healthy carriers in St. Petersburg in 2010-2013 were investigated. The analysis of the serotype pattern of the pneumococci showed that 13-valent conjugate vaccine was the most active (86.1% of pneumococci causing pneumonia and 86.4% of pneumococci causing acute otitis). The isolates were higly resistant to beta-lactams and macrolides. By the EUCAST criteria, the decrease in the susceptibility to penicillin, cefotaxime, erythromycin and ceftarolin was observed in 32.4%, 14%, 33.2 and 6% of the isolates respectively. 22.4% of the isolates showed associate resistance to penicillin and erythromycin.. No resistance to moxifloxacin was detected. The frequency of resistance to tetracycline, co-trimoxasole and chloramphenicol in various patients ranged within 30-50%. The prevalence of the antibiotic resistance was mainly characteristic of the isolates serotypes 19A, 19F, 14 and serogroup 6.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34283243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Methods and Means for Defense from Collateral Action of Vaccine Virus after Vaccination Against Spallpox]. [预防痘后疫苗病毒附带作用的方法和手段]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

N K Chernikova, T A Bondareva, S V Borisevich, V N Podkujko, A L Khmelyev, T V Dorokhina

引用次数: 0

[Antibiotic Resistance of Microbial Isolates from Long-Term Healing Wounds Exposed to Light of Various Wave Lengths]. [不同波长光照下长期愈合伤口微生物分离物的抗生素耐药性]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

M M Rasulov, I G Motorina, G G Yushkov, O M Drozdova, N V Korsakova

引用次数: 0

[Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times]. 【急性脑卒中不同时间CT表现的临床与病理生理相关性】

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

S A Rumyantseva, E V Silina, N A Gomboeva, V A Stupin, Yu D Vasiliev, A L Kovalenko, E N Kabaeva

{"title":"[Clinical and Pathophysiological Correlations in Acute Stroke, CT Visualized at Different Times].","authors":"S A Rumyantseva, E V Silina, N A Gomboeva, V A Stupin, Yu D Vasiliev, A L Kovalenko, E N Kabaeva","doi":"","DOIUrl":"","url":null,"abstract":"Two hundred twenty one patients aged 32-93 years with brain infarction, admitted to a Vascular Neurology Center in the first 3-48 hours (mean 6 hours) after the onset of the symptoms of stroke with computed tomography (CT) verified diagnosis were enrolled in the study. According to the timing of the CT-verification the patients were divided into 2 groups: \"early\" visualization (EV 50.2%) and \"late\" visualization (LV, 49.8%). In the EV group the lesion was visualized by CT on the admission (3-6 hours after the admission), in the LV group it was visualized only when CT was repeated 2-3 days after the admission. The patients in the LV group demonstrated increased severity of the underlying pathology, increased mortality and unfavourable functional outcomes correlating with the stroke lesion volume vs. the EV group. There was observed pathophysiological correlation of the blood enzymatic spectrum and acid-base balance parameters, explaining the late lesion visualization by delayed and more pronounced intracellular energy synthesis stabilization mechanisms failure in the aerobic and anaerobic glycolysis cycles.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34284206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Results of Investigation of MRSA Susceptibility to Vancomycin in Clinical Units of Large Multifunctional Hospital and Recommendations on Optimization of Antibacterial Therapy of Staphylococcal Infection]. [大型综合性医院临床单位MRSA对万古霉素敏感性调查结果及葡萄球菌感染抗菌治疗优化建议]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

V A Verikovsky, O E Minakov, O I Denisova, E V Bondarenko

引用次数: 0

[ERCC1 as a Marker of Ovarian Cancer Resistance to Platinum Drugs]. [ERCC1作为卵巢癌对铂类药物耐药的标志物]。

Antibiotiki i Khimioterapiya Pub Date : 2015-01-01

T A Bogush, A S Popova, E A Dudko, E A Bogush, A S Tyulyandina, S A Tyulyandin, M I Davydov

引用次数: 0

[Efficiency of antibiotics in children with acute respiratory infection complicated by pneumonia dependent on the acetylation type in the Far North regions]. [远北地区急性呼吸道感染合并肺炎患儿抗生素疗效与乙酰化类型的关系]。

Antibiotiki i Khimioterapiya Pub Date : 2014-01-01

A V Erbasskaia, V V Ivanova, L V Govorova, V V Belova, L N Bulovskaia

{"title":"[Efficiency of antibiotics in children with acute respiratory infection complicated by pneumonia dependent on the acetylation type in the Far North regions].","authors":"A V Erbasskaia, V V Ivanova, L V Govorova, V V Belova, L N Bulovskaia","doi":"","DOIUrl":"","url":null,"abstract":"Clinical characteristics of some diseases are defined by the phenotype of metabolic reactions, for example N-acetylation. Genetic polymorphism due to the activity of N-acetyltransferase (N-AT) is common in the majority of human populations. Consequently, persons with \"slow\" or \"fast\" acetylation phenotype should be identified. N-AT catalyzes acetylation of a number of medical products. Efficiency of pharmacotherapy is mostly associated with the specific features of medical products biotransformation. The processes of biotransformation with participation of acetyltransferase, monooxygenase or other ferment systems are under the gene control. The aim of the study was to characterize the features of the clinical course of acute respiratory infection complicated by pneumonia as dependent on the acetylation phenotype to predict the character of the disease and optimize the used antibiotic therapy among the native population (Yakut) and the arrived (Russian) in the Far North Regions (Sakha, Yakutia). 112 children with acute respiratory infections complicated by pneumonia and 49 practically healthy ones were examined. For the children with low N-AT activity (less than 30%) it was recommended to be treated with gentamicin which directly takes part in the acetylation and provides the antibiotic therapy efficiency in 80% of the cases. The use of cephalosporin antibiotics (beta-lactams), the metabolism of which is not directly connected with acetylation reactions provided the efficiency in 20% of the cases.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32527037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Hepatoprotective effects of extracts and polysaccharides from seaweed]. [海藻提取物和多糖的肝保护作用]。

Antibiotiki i Khimioterapiya Pub Date : 2014-01-01

N N Besednova, T S Zaporozhets, T A Kuznetsova, S P Kryzhanovskiĭ, N N Kovalev, T N Zviagintseva

引用次数: 0

[Antimycoplasmic Activity of Fermentation Broth of Trichoderma harzianum Rifai F-180, an Organism Producing L-Lysine-α-Oxidase, an Antitumor and Antiviral Enzyme]. [一种产生l -赖氨酸-α-氧化酶的抗肿瘤和抗病毒酶哈茨木霉F-180发酵液的抗支原体活性]。

Antibiotiki i Khimioterapiya Pub Date : 2014-01-01

I P Smirnova, I V Rakovskaya

引用次数: 0

[Kinetics of decamethoxine, an antimicrobial agent]. [一种抗菌剂十甲氧辛的动力学]。

Antibiotiki i Khimioterapiya Pub Date : 2014-01-01

G K Paliĭ, A A Nazarchuk, A I Kulakov, G G Nazarchuk, D V Paliĭ, B N Bereza, D P Oleĭnik

引用次数: 0