Plague Antibacterial Therapy. Historical Aspects and Future Prospects.

The review includes the analysis of plague incidence throughout the world, in Russia and neighboring countries within the last 25-30 years, as well as the current state of the problem. The historical development of antibacterial therapy, experimental data and clinical observations are presented. The phenomenon of emergence of antibiotic resistance is described along with proposed ways of its prevention. The urgency of the problem nowadays is shown in regard to migration events and bioterrorism threat. Further perspectives are outlined for scientific approaches to solution of the problems of antibacterial therapy of plague infection.