Duzce Medical Journal最新文献

{"title":"Wilson Hastalığının Nadir Bir Komplikasyonu: Hepatoselüler Karsinom","authors":"Laleş YANIK GÖKTÜRK, Çiğdem BUDAK ECE","doi":"10.47493/abantmedj.1160858","DOIUrl":"https://doi.org/10.47493/abantmedj.1160858","url":null,"abstract":"Bakır metabolizma bozukluğu olan Wilson hastalığı, klinik spektrumu oldukça geniştir. Birikim yaptığı organa spesifik bulgu vermektedir. Bu hastalar gastroenteroloji polikliniğinde asemptomatik transaminaz yüksekliği ile başvurabileceği gibi, ileri komplikasyonlardan olan siroz ve hepatoselüler karsinom şeklinde de prezente olabilmektedir. Olgu sunumunda siroz nedeniyle takipli olan Wilson hastasının rutin takiplerinde AFP (alfa-feto protein) yüksekliği olması nedeniyle ileri araştırmalar sonucunda HCC (hepatoselüler karsinom) tanısı alan hastayı sunmaktayız.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79270248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Phototherapy on Hematological Parameters in Newborns with Indirect Hyperbilirubinemia","authors":"F. H. Yılmaz, Buket Kara, Kubra Ertan","doi":"10.47493/abantmedj.1065601","DOIUrl":"https://doi.org/10.47493/abantmedj.1065601","url":null,"abstract":"Introduction: Indirect hyperbilirubinemia is an important problem in newborns and phototherapy has an important role in treatment. The aim of this study is to evaluate the effects of phototherapy on hematological parameters in newborns with indirect hyperbilirubinemia. \u0000Method: In the last three months, 60 newborns (term = 30 and preterm = 30) diagnosed and treated for indirect hyperbilirubinemia were included in this study. \u0000Results: Twelve of the neonatal terms (40%) had either Rh incompatibility (n = 3) or ABO incompatibility (n = 9), 10 of the preterm newborns (33%) had either Rh incompatibility (n = 3) or ABO incompatibility (n = 7). The median durations of phototherapy of term and preterm newborns were 24 (range, 6-40) and 11 hours (range, 4-36), respectively. After phototherapy, it was found that the counts of WBC and RBC, Hb, MCV and RDW values of term newborns decreased statistically (p values were .0187, .0007, 0001, .0036 and","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"155 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74893811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of the protective effects of Curcumin and Resveratrol against U87 Cells Induced by Beta-Amyloid","authors":"Ares Alizade, Gülüzar Özbolat","doi":"10.47493/abantmedj.1123424","DOIUrl":"https://doi.org/10.47493/abantmedj.1123424","url":null,"abstract":"Objective: This study was carried out to investigate the effects of curcumin and resveratrol antioxidant enzymes in β-amyloid (Aβ)-induced in vitro Alzheimer's Disease (AD) cell model. Methods: In the study three groups were created; The control group consisted of U87 cell lines, the Aβ group in which the in vitro AH model was formed including the β-amyloid-induced U-87 cell lines, and the Aβ+ Curcumin+ Resveratrol group by adding curcumin and resveratrol to the Aβ group. Cell viability in groups was evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test. Total Antioxidant Level (TAS), Superoxide dismutase (SOD), Total Oxidant Level (TOS) and Catalase (CAT) enzyme levels, results were analyzed to evaluate the antioxidant status. \u0000Results: When cell viability was evaluated, it was determined that curcumin and resveratrol did not have cytotoxic effects. TAS levels were found to be statistically higher in the Aβ+ curcumin and resveratrol group compared to the Aβ group (p","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89751883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Direct Association of Myelin Oligodendrocyte Glycoprotein (MOG) Gene Polymorphism (Val142leu) in Genetic Susceptibility to Migraine","authors":"Tugce Kaymaz, Ebru Önalan, İlay Buran Kavuran, Ayşe BERİLGEN GÜRGÖZE, B. Müngen","doi":"10.47493/abantmedj.1080234","DOIUrl":"https://doi.org/10.47493/abantmedj.1080234","url":null,"abstract":"Objective: Genes which are involved in immune response portray possible candidate genes in migraine. One of those genes is that myelin oligodendrocyte glycoprotein (MOG) that plays an important role in mediating the complement cascade. The purpose of our study is to show the effect of MOG G511C (Val142Leu; rs2857766) polymorphism in migraine attack frequency. \u0000Materials and Methods: In the cohort of 101 Turkish migraine patients and in a control group of 101 healthy subjects, MOG Val142Leu alleles’ distribution was examined. Restriction fragment length polymorphism (RFLP) was carried out to genotype this polymorphism. \u0000Results: Although MOG Leu allele frequency was determined as under-represented in migraine patients, any significant difference between the patient and control groups’ genotype, and allele frequencies were not obtained [OR=0.47 (0.21-1.08), p=0.053 for genotypes; OR=0.50 (0.23-1.11), p=0.060 for alleles]. However, a statistically significant relationship between MOG G511C (Val142Leu) polymorphism and the decreased migraine attack frequency was determined [OR=11.71 (1.32-103.77), p=0.013]. Val/Leu genotype frequency increrased in migraine patients with two or fewer attacks per month. \u0000Conclusion: Migraine attack frequency might be related with MOG Val142Leu heterozygote genotype. So we think that MOG gene might be related to genetic susceptibility to migraine in the human leukocyte antigen (HLA) region.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90259572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klippel-Trenaunay Sendromunda Alt Gastrointestinal Kanama, Mesane ve Dalakta Hemanjiomlar: Nadir Görülen Olgu Sunumu","authors":"Mehmet Emin Gönüllü, İsmet Özaydin, N. Altinsoy","doi":"10.47493/abantmedj.1196095","DOIUrl":"https://doi.org/10.47493/abantmedj.1196095","url":null,"abstract":"Klippel Trenaunay Sendromu(KTS); genellikle neonatal dönemde ortaya çıkan kutanöz hemanjiyom, doğuştan venöz anomaliler, kemik ve yumuşak dokuda hipertrofi ile karakterizedir. Çoğunlukla periferik bulgularla tanı alan KTS nadiren de olsa gastrointestinal sistemi (GİS) içeren vasküler malformasyonlar ile birlikte karşımıza çıkabilir. Bu yazıda rektal kanama ve anemi şikayeti ile başvuran, herhangi bir periferik bulgusu olmadan distal kolon, rektum, mesane ve dalak tutulumuyla karşımıza çıkan 45 yaşında erkek hasta sunulmuştur. Anemi tedavisi ve transfüzyona yanıt alınamayan hastada küratif tedavi olarak rektosigmoid rezeksiyon(anterior rezeksiyon) ve koloanal anastomoz ameliyatı uygulandı.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73437793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliographic Analysis of PostgraduateTheses Done in theField of LocalAnesthetics in Türkiye","authors":"E. Yıldız, Halil Yıldız, Sevilay Alkan, Özlem Arık","doi":"10.47493/abantmedj.941270","DOIUrl":"https://doi.org/10.47493/abantmedj.941270","url":null,"abstract":"Objective: Theaim of thestudy is toevaluatethethesesmade in thefield of localanesthesia (LA) in Turkeywith a bibliographicanalysismethod, with a holisticframeworkandthustoshedlight on futurestudies.Materials and Methods: Inthestudy, postgraduatethesesweresearched on thewebsite of thewebsite of theNationalThesis Center of theHigherEducationInstitutionbytypingthekeyword \"localanesthesia\" in the ‘’enter a searchterm’’ box. Thebibliographicevaluation of the105 thesesreached as a result of thisscreeningwasmade. Theses; year, content, institution, scientificmethod, sample size andcontent, advisor, ethicscommitteeapprovalstatus, andpublicationwereevaluated).Results: A total of 105 theseswerereached in thestudy. Thefulltext of 97 of thesethesescould be accessed. 78 (74.3%) of thetheseswere in specialty in medicine, 7 (6.7%) in specialty in dentistry, 11 (10.5%) in doctorate, 9 (8.6%) were in master'sfields. Looking at thepublicationyears of thetheses, it wasfoundthatthemosttheseswere in thefield of anaesthesiology in 2016 andafter. Consideringtheinstitutionswherethethesesweremade; (89.5%) weredone in a universityhospital, 11 (10.5%) in a trainingandresearchhospital. Consideringthecenterswheretheses on thesubject of thestudyweremade, therewere 9 (8.6%) in HealthSciencesUniversity, 7 (6.7%) in Atatürk University, 5 (4.8%) in Hacettepe University, 5 (4.8%) in Çukurova Universityand 5 (% in Selçuk University) 4.8), it wasdeterminedthat it wasdone. Thestudymethodwas not specified in 50 of them (47.6%), andthemostfrequentlyprospective (17.1%) andretrospective (14.3%) methodswereused. Ethicscommitteepermissionwasobtainedwhile 54 (51.4%) theseswerebeingprepared. 36 thesesdid not havethepermission of theethicscommittee.Conclusion: Whilethetheseswerebeingprepared, it wasobservedthatsome of thethesesdid not havethepermission of theethicscommitteeandveryfew of thetheseswerepublished. Weare of theopinionthatboththemethodologyandthepermitstatus of thethesesmade in thefield of LA should be paidmoreattention. As a result, webelievethatthecontribution of thesesandliteraturerelatedto LA should be increased.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90767842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sıçanlarda Bupropion ve Vareniklinin Morfin Yoksunluğu Sendromu Üzerine Etkileri","authors":"Oruç Yunusoğlu, Çagla Köse, Sibel Özyazgan, Andleeb Shahzadi̇, Bülent Demir, Burak Önal, A. Akkan","doi":"10.47493/abantmedj.1120849","DOIUrl":"https://doi.org/10.47493/abantmedj.1120849","url":null,"abstract":"Objective: Opioid dependence is a chronic and complex disorder characterized by relapse and remission. Chronic administration of morphine causes symptoms of physical and psychological dependence. The purpose of the present study was to investigate the effect of anti-addictive drugs such as bupropion and varenicline on morphine dependence and naloxone precipitated withdrawal syndrome in a rat model. \u0000Materials and Methods: To assess the physical dependence of morphine, Wistar albino rats were intraperitoneal (i.p.) administered increasing doses of morphine twice daily for 5 days, 4 hours after a single dose of morphine on day 6, and 15 minutes before subcutaneous (s.c.) naloxone (2 mg/kg, s.c.) administration to elicit withdrawal symptoms. Physical dependence was evaluated by giving intraperitoneal bupropion (5, 10 and 20 mg/kg, i.p.) and varenicline (0.5. 1 and 2 mg/kg, s.c) for 15 minutes.\u0000Results: The morphine-dependent rats had significantly more withdrawal symptoms than naive control rats. The results demonstrated administration of bupropion and varenicline during induction of morphine dependence attenuated the most of the severity of withdrawal symptoms. Co-administration of bupropion reduced withdrawal symptoms such as jumping, wet dog shaking, weight loss and total withdrawal symptoms. Co-administration of varenicline was found to be effective on withdrawal symptoms such as bupropion, but had no effect on weight loss.\u0000Conclusion: These outcomes provide preliminary data that bupropion and varenicline could be used as a candidate drugs to attenuate morphine withdrawal symptoms.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78745208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Toilet Habits in Children with Recurrent Urinary Tract Infections and Investigation of Risk Factors That Play a Role in The Development of Kidney Damage","authors":"N. Çetin, Aslı Kavaz Tufan","doi":"10.47493/abantmedj.1094312","DOIUrl":"https://doi.org/10.47493/abantmedj.1094312","url":null,"abstract":"Objective: Urinary tract infection is one of the common infections in children. The patients with recurrent infection are at risk for permanent renal damage in later life. In this study, it was aimed to investigate the toilet habits and risk factors for renal scarring in children with recurrent urinary tract infection without congenital anomalies of the kidney and urinary tract.Materials and Methods: Patients between the ages of 6 and 18 with a diagnosis of recurrent urinary tract infection who were toilet trained were included in this study. Data of patients with congenital anomalies of kidney and urinary tract were excluded from the study. The detailed information on the voiding postponement, infrequent voiding, holding maneuvers and renal scarring were obtained from file records.Results: The 208 patients (146 girls, 62 boys) were included in this study. The more than half of the patients (n=132, 63.5%) had a habit voiding postponement, and one third (n=65, 31.3%) had holding maneuver. There was infrequent voiding in 47 (22.6%) patients. Renal scarring was determined in 38 (18.3%) patients. The frequencies of voiding postponement, holding maneuver and infrequent voiding were higher in patients with renal scarring than those of without [30 (78.9%)/102 (60%), p=0.048; 12 (31.6%)/53 (21.2%), p=0.039; 15 (39.5%)/32 (18.8%), p=0.009, respectively]. It was determined a significant positive association between renal scarring and voiding postponement with infrequent voiding [Odds ratio=3.21, p=0.011; Odds ratio=1.46, p=0.021; Odds ratio=3.43, p=0.001, respectively]. Conclusion: Toilets habits should be questioned in routine follow-up program in children with recurrent urinary tract infection. The development of true toilet habits may be useful to prevent the development of renal scarring in children.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75642425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Spontaneous Basilar Artery Dissection: A Case Report","authors":"S. Özdemir, A. Özkan, H. Akça, A. Algın","doi":"10.47493/abantmedj.975660","DOIUrl":"https://doi.org/10.47493/abantmedj.975660","url":null,"abstract":"Cervical, vertebral and cranial artery dissection is a rare etiology of ischemic stroke. In this case report, we aimed to discuss a case of spontaneous basilar artery dissection presenting with pons stroke in the light of current literature. A 52-year-old male patient was brought to our clinic because of loss of consciousness after syncope. Physical examination showed he was unconscious and had Glasgow coma score of 9 (verbal 3, motor 3, eye 3). Brain computed tomography imaging with intravenous contrast was performed after orotracheal intubation. Thrombus formation at the level of the basilar artery and possible dissection phleb were observed in the brain computed tomography with intravenous contrast. Bacillary artery dissection was confirmed in the patient who underwent cranial digital subtraction angiography. The patient underwent endovascular thrombectomy. The patient was discharged after seventy-seven days of hospitalization. As a conclusion; basilar artery dissections are rare lesions associated with significant morbidity and death. The nature and treatment options of basilar artery dissection are significantly different from other dissections due to its perforating branches and localization.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88448097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nadir Medikolegal Bir Akut Batın Nedeni: Enteroenterik ve Enterokutanöz Fistüle Neden Olan Gossipiboma","authors":"Recep Çağlar","doi":"10.47493/abantmedj.1068806","DOIUrl":"https://doi.org/10.47493/abantmedj.1068806","url":null,"abstract":"Gossypiboma are surgical tampons that are forgotten in the operation area and cause serious complications in the patient. The most frequently forgotten foreign body in operations are surgical tampons. Early recognition of gossypiboma is important to minimize the risk of morbidity and mortality in the patient. While they may be asymptomatic, they may cause complications such as perforation, obstruction, peritonitis, intra-abdominal or enterocutaneous fistula, abscess and sepsis. In the differential diagnosis, hematoma, pseudocyst and tumors should be considered. In computed tomography (CT), the spongy appearance formed as a result of the air trapped in the cotton pad is characteristic. Its treatment is surgery. If possible, the use of radiopaque labeled tampons can be avoided by taking preventive measures such as careful counting of surgical materials before and after each surgical operation. It should be kept in mind in the differential diagnosis of gossypiboma in patients with a history of previous surgery and diagnosed with an intra-abdominal mass.","PeriodicalId":53622,"journal":{"name":"Duzce Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74400647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}