Journal of Clinical and Aesthetic Dermatology最新文献

{"title":"Injections of Botulinic Neuroprotein Combined with Low Molecular Weight Hyaluronic Acid and Cluster of Lyophilized Amino Acids in One Syringe.","authors":"Evgeniya Shelemba, Elena Rumyantseva Mathey","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Intradermal injections of highly diluted botulinic neuroprotein is a popular aesthetic medicine procedure to improve the texture of the skin, enlarged pores, and fine lines.</p><p><strong>Objective: </strong>The authors present a case report of nine subjects who received treatment with botulinic neuroprotein combined with an amino acid cluster and low molecular weight hyaluronic acid.</p><p><strong>Methods: </strong>Nine women between the ages of 30 to 59 years old in a stable medical condition with moderate to severe lateral cantal wrinkles and smile lines at maximum expression and were recruited. The typical exclusion criteria for botulinum neurotoxin and hyaluronic acid injections were fulfilled.</p><p><strong>Results: </strong>No complications were observed. In all treated patients, there was clinical improvement in skin surface and texture, as well as attenuation of fine lines, with preserved natural facial mimetic activity. In two patients who were prone to rosacea, we noticed an improvement in erythema and flushing. Three patients with oily skin showed decreased oiliness and pore size.</p><p><strong>Conclusion: </strong>The Jalu-toxin technique is a safe and efficient method for skin quality enhancement.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 12","pages":"38-41"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subungual Giant Cell Tumor of the Tendon Sheath: An Unusual Location.","authors":"Neena Edupuganti, Joseph M Dyer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Giant cell tumors of tendon sheath (GCTTS), also known as synovialomas, are benign tumors that originate from the fibrous sheath, or soft tissue, that surround tendons. These tumors predominantly present on the hand, but can present in the wrist, ankle, knee, elbow, or hip. The classic presentation of GCTTS is a painless, firm, slow growing mass present for weeks to months. The pathogenesis of GCTTS remains unknown. Histopathological examination of the tumor is required to confirm the diagnosis. The preferred treatment is surgical excision with long-term follow up. To our knowledge, this is the third reported case of GCTTS originating in the subunguium and the first reported case of GCTTS in the subunguium of the toe.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 12","pages":"25-27"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Utility of a National Conference on Non-surgical Facial Aesthetics as an Educational Tool: A Survey-based Pilot Study.","authors":"Rohan Shankarghatta, Sarika Grover, Julia Bahja, Zeanab Chaer, Rahim Feddag, Can Celik, Felix Karst, James Olding","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Non-surgical facial aesthetics (NSFA) is a rapidly growing field involving the use of dermal fillers and botulinum toxin for aesthetic enhancement. The aesthetic injectables market is expanding, attracting interest from individuals seeking NSFA procedures. There has also been marked interest among healthcare professionals (HCPs) aspiring to become aesthetic practitioners. Conferences play a crucial role as educational platforms for HCPs venturing into NSFA. We used a national NSFA conference as an education tool for undergraduate and postgraduate healthcare students, assessing the utility of this conference in imparting knowledge on topics such as training pathways, regulations and complications in NSFA.</p><p><strong>Methods: </strong>The FACExpo conference, held in November 2022, was organized by both qualified and aspiring aesthetic practitioners. Pre- and post-conference questionnaires were administered to attendees to evaluate their interest in facial aesthetics and their knowledge before and after the conference.</p><p><strong>Results: </strong>A total of 68 delegates responded to the pre-and post-conference questionnaires. There was a statistically significant improvement in awareness of training pathways, regulations, and complications (<i>p</i><0.0001). Only 39.71 percent of delegates were aware of the NSFA regulations before the conference, which increased to 91.18 percent in the post-conference survey. Similarly, 38.24 percent of delegates were confident in their understanding of training pathways pre-conference which increased to 97.10 percent post-conference.</p><p><strong>Conclusion: </strong>This study demonstrates that facial aesthetic conferences can be used as an educational tool for aspiring practitioners and highlights the existing knowledge gap among current practitioners. Further research is needed to assess the overall impact of aesthetic conferences on the education of aspiring practitioners.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 12","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fitzpatrick Skin Type Self Reporting Versus Provider Reporting: A Single-center, Survey-based Study.","authors":"Anisha Bhanot, Jamalje Bassue, Sherifat Ademola, Brigitte Sallee, Pamela Allen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The authors sought to compare the results in Fitzpatrick Skin Type (FST) reporting among providers, trainees, and patients. They discussed the implications of discordance in FST reporting among these groups.</p><p><strong>Methods: </strong>This survey-based study was offered to all adult patients (18 years or older), dermatology residents, and dermatology faculty providers at University of Oklahoma Dermatology Clinic in Oklahoma City, Oklahoma. Deidentified information from the patient survey, provider-assigned FST, and provider credentials were consolidated, and data was analyzed by a biostatistician.</p><p><strong>Results: </strong>The provider-assigned FST was more accurate than the patient's own estimation of their own ability to tan versus burn. The patient's race played an important factor in a discrepancy between provider and patient described FST. Additionally, provider years in practice increased the odds of any discrepancy existing.</p><p><strong>Limitations: </strong>This study was conducted at one clinic location encompassing only the immediate geographic population.</p><p><strong>Conclusion: </strong>Despite being the most used skin tone classification system in dermatology, the FST system has many limitations. The classification system needs to be reevaluated or replaced with methods that more accurately, appropriately, and reliably describe skin tones and skin photo reactivity. Education is necessary for current trainees to avoid erroneous use of classifications such as the FST.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 12","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't Let Beauty Blind You: Unveiling Clinical Diagnoses During Cosmetic Dermatology Practice.","authors":"Miguel A Aristizabal, Tara Soto, Leila Tolaymat, Alison J Bruce","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There has been a notable rise in the prevalence of cosmetic dermatology services worldwide, involving a diverse range of providers. Patients presenting with cosmetic concerns should be thoroughly assessed and require meticulous attention because subtle, unexpected clinical cues might necessitate the application of dermatologic expertise. In this study, we present a case series involving patients who sought cosmetic care at an academic cosmetic dermatology center, revealing subsequent diagnoses of significant medical conditions. This underscores the critical importance of comprehensive training and substantial clinical exposure for practitioners in the highly nuanced field of dermatology.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 11-12 Suppl 1","pages":"S30-S33"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Psoriatic Patients Respond Faster to Dimethyl Fumarate: Age-related Differences in Efficacy and Adverse Events.","authors":"Martina Burlando, Adelaide Algeri, Ilaria Salvi, Emanuele Cozzani, Aurora Parodi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Dimethyl fumarate (DMF) is an oral treatment approved by the European Medicines Agency (EMA) to treat moderate-to-severe plaque psoriasis among adult patients.</p><p><strong>Objectives: </strong>This study aims to evaluate sociodemographic, anthropometric, and medical characteristics in patients with psoriasis without previous history of traditional systemic therapy and to observe if the efficacy or AEs of dimethyl fumarate correlate to any of the patients' characteristics.</p><p><strong>Methods: </strong>Ninety-two patients with mild-to-moderate psoriasis were enrolled. Each patient was reviewed at 4, 12, 24 and 36 weeks. The PASI score and any clinical side effects or blood count abnormalities were recorded.</p><p><strong>Results: </strong>After 4 weeks, a decrease in the median value of PASI index was already noticeable (p<0.001). After 12 weeks of treatment, 43.9% of patients reached PASI-50, 12.3% PASI-75. The patients achieving PASI-75 after 12 weeks of treatment were significantly younger than those who did not. Age, BMI index, gender and gastroprotection used were not significantly related to the occurrence of side effects.</p><p><strong>Conclusion: </strong>Profiling of patients could be useful in predicting the response to treatment. In our study, younger patients were found to respond better to dimethyl fumarate.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 11","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 12-week, Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of a Nutraceutical Supplement for Mild to Moderate Non-cystic Acne in Young Adults.","authors":"Glynis Ablon","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a chronic, inflammatory skin disease of the pilosebaceous unit frequently cited as the most common condition diagnosed and treated by dermatologists. Among the many therapies developed for treating acne, none are effective for all patients and new treatments are always being sought. A commercial nutraceutical formulated with vitamins, minerals and a proprietary blend of botanicals has been used as a safe and effective adjunctive therapy for non-cystic acne (Clear Skin Formula; VitaMedica®).</p><p><strong>Objective: </strong>The objective of this study was to evaluate the safety and efficacy of this nutraceutical for treating non-cystic acne.</p><p><strong>Methods: </strong>Subjects randomly received study product (n=26) or placebo capsules (n=14) which were taken daily for 84 days.</p><p><strong>Results: </strong>Treatment with the nutraceutical supplement decreased mean (SD) inflammatory lesions counts from 21.4 (9.3) to 10.4 (8.1) (<i>p</i>=0.0001), decreased non-inflammatory lesion counts from 35.0 (17.1) to 19.5 (13.2) (<i>p</i><0.0001) versus nonsignificant changes for placebo-treated subjects. Mean baseline IGA scores improved by nearly 1 grade from 2.3 (0.5) to 1.4 (0.6) after 84 days of treatment (<i>p</i><0.0001) versus no change for subjects treated with placebo. The clinical improvements corresponded with significant improvements in acne-related quality of life measures. The nutraceutical supplement was well-tolerated.</p><p><strong>Conclusion: </strong>These results demonstrate this nutraceutical to be safe and effective adjunctive therapy for patients with non-cystic acne. ClinicalTrial.gov Identifier NCT05879406.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 11","pages":"24-30"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Placebo-controlled Clinical Study Evaluating a Dietary Supplement for Hair Growth.","authors":"Jennifer Martin-Biggers, Maria Elisa Barbosa Bueno de Campos","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The desire for improved hair appearance, hair growth and strength are common drivers of supplementation for women experiencing thinning hair. This study examined the effect and safety of a gummy supplement containing B vitamins, zinc and botanical ingredients to improve hair growth, strength and perceived hair quality outcomes.</p><p><strong>Methods: </strong>Healthy females (n=65) ages 18 to 60 with thinning hair were enrolled. After obtaining consent, subjects were evaluated for hair density and tensile strength, then randomized to either a placebo or test product. The test product consisted of two gummies consumed daily. Subjects returned after six months and were again evaluated using phototrichogram for hair density and tensile strength assessment and completed a Self-Assessment Questionnaire reporting hair quality outcomes.</p><p><strong>Results: </strong>Subjects who consumed the test product showed increased hair density between baseline and 6 months (10.1% increase, <i>p</i><0.001) as well as compared to placebo (2% decrease) (<i>p</i><0.001). Hair strength tensile measurements were improved in the test group from baseline (10.2% improvement, <i>p</i><0.002) compared to placebo (9.3% improvement), yet the difference was not statistically significant between groups. Self-assessed improvements in shedding, strength, breakage and brightness were noted compared to the placebo group (<i>p</i><0.05). There were no adverse events or reactions.</p><p><strong>Limitations: </strong>This study did not assess hair for longer than a six-month period and utilized subject perception for outcomes that differ from clinical assessments.</p><p><strong>Conclusion: </strong>Daily use of a dietary supplement gummy was associated with significant improvement in hair growth as well as self-assessed improvements in hair strength, shedding, and appearance.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 11","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of ChatGPT's Responses to Patient Questions on Hidradenitis Suppurativa.","authors":"Kripa Ahuja, Peter Lio","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 11","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Shift during Treatment of Plaque Psoriasis with Ixekizumab.","authors":"Caroline Sulich-Moore, David Altman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a case of a patient with longstanding psoriasis vulgaris who developed an atopic dermatitis-like eruption following long-term IL-17A inhibitor therapy. Following many years of excellent disease control with secukinumab and later ixekizumab, he developed a de novo eczematous eruption, which showed spongiotic dermatitis upon biopsy. The patient was successfully treated for both psoriasis and atopic dermatitis with upadacitinib, a Janus kinase inhibitor. This case suggests an interplay between Th1/Th17 and IL-4/IL-13 immune axes during prolonged biologic therapy, potentially due to upregulation of IL-4 following IL-17 blockade. It highlights the complex immune interactions in inflammatory skin diseases and demonstrates the utility of broader cytokine inhibition in managing evolving presentations.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"17 11","pages":"32-33"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}