Journal of Clinical and Aesthetic Dermatology最新文献

{"title":"Positioning and Protecting the Patient is Essential for Safe, Quality, Efficient Surgery.","authors":"Roger I Ceilley, Shandhan Sureshbabu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Optimizing ergonomics and patient positioning is essential for enhancing patient safety and improving outcomes in dermatologic surgery. Proper patient positioning can prevent provider strain, improve surgical accuracy, and increase overall efficiency. Key strategies include maintaining a neutral body plane, providing neck and knee support, and shielding the eyes to reduce patient stress. Adjustments in limb positioning can enhance skin laxity and tension management, facilitating better wound closure and healing. Equally important is the surgeon's ergonomics, with proper posture, adjustable seating, and strategic breaks to reduce fatigue and improve performance. Attention to these factors supports both patient comfort and long-term sustainability of high-quality care.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"21-22"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 Pandemic on the Diagnosis and Treatment of Cutaneous Melanoma in a Public Health Service in Brazil.","authors":"Ana Carolina da Silva Carvalho, Carolina de Magalhães Ledsham Lopes, Amanda Ribeiro Lobo, Isabela Almeida de Assis, Helena Lourenço de Medeiros, Ana Paula Drummond-Lage","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The authors sought to evaluate the impact of the COVID-19 pandemic on the incidence, tumor thickness, and time between diagnosis and first treatment of cutaneous melanoma patients.</p><p><strong>Methods: </strong>A retrospective observational study was conducted based on the analysis of electronic medical records of patients treated at a reference service in Cutaneous Oncology within the scope of the Unified Health System in Belo Horizonte, Brazil. The population was evaluated according to the date of diagnosis and was classified into three periods: 1) pre-pandemic period (January 2019 to March 2020), 2) pandemic period 1 (April 2020 to June 2021), and 3) pandemic period 2 (July 2021 to September 2022). Sociodemographic characteristics of the study population, tumor characteristics, and the time interval between diagnosis and first treatment were evaluated.</p><p><strong>Results: </strong>Seventy-six patients were evaluated, 25 (32.89%) diagnosed in the pre-pandemic period, 22 (28.94%) in pandemic period 1, and 29 (38.15%) in pandemic period 2. No significant differences were observed between the sociodemographic characteristics of the population, tumor thickness, and the presence of ulceration in the three periods analyzed. There was also no delay between diagnosis and the first treatment during the pandemic.</p><p><strong>Limitations: </strong>The size of the population, and the use of retrospective data extracted from medical records, without a systematized record of information.</p><p><strong>Conclusion: </strong>The COVID-19 pandemic did not impact the incidence, thickness of melanomas, or the time between diagnosis and first treatment. This study demonstrated the importance of adapting the routine of health services and adapting the flow of oncology care in times of health crisis.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"E61-E65"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Dermocosmetic Serum Containing a Multi-acid Complex and Niacinamide in Japanese Women with Mild Acne.","authors":"Atsuyuki Igarashi, Masatoshi Abe, Yurie Gunji, Osamu Nemoto, Kuniko Kawamura, Mayumi Yokozeki, Atsushi Saito, Akira Ookawara","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Acne is a common inflammatory dermatosis in all parts of the world, including Japan. While effective prescription treatments are available, patients often prefer to try to manage their acne, particularly when it is mild, using over-the-counter (OTC) approaches.</p><p><strong>Objective: </strong>This open-label study evaluated the efficacy and safety of an OTC serum containing a multi-acid complex and niacinamide (niacinamide 2%, lactic acid 1%, hydroxyethylpiperazine ethane sulfuric acid [HEPES] 0.5%, phytic acid 0.2%, and salicylic acid 0.2%) used twice daily for eight weeks in Japanese women aged 16 to 34 years with acne.</p><p><strong>Methods: </strong>An eight-week, split-face, open-label study of multi-acid complex and niacinamide containing dermocosmetic used twice daily in Japanese women aged 16 to 34 years was conducted. Participants had mild-to-moderate inflammatory acne (up to 20 inflammatory lesions on half the face) and assessments included number and severity of acne lesions as well as standard safety assessments.</p><p><strong>Results: </strong>A total of 50 women enrolled, with 46 eligible for evaluation at Week 8. Significant improvements in acne severity, the number of inflammatory lesions, and skin texture as indicated by pore size were observed (<i>P</i><0.05 for all). In addition, patients' quality of life significantly improved from baseline to Week 8 (<i>P</i><0.01). The serum was well tolerated. Four cases of skin discomfort were reported; all were mild in severity and resolved spontaneously.</p><p><strong>Conclusion: </strong>This multi-acid/niacinamide OTC serum effectively improved acne in Japanese women.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"41-43"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Recalcitrant Hailey-Hailey Disease with Dupilumab: A Case Report.","authors":"Caroline Sulich-Moore, David Altman, Stuart Gildenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hailey-Hailey disease is a rare autosomal dominant genodermatosis clinically characterized by recurrent flaccid bullae, erosive plaques, and linear epidermal tears primarily affecting intertriginous areas. This case report describes a 34-year-old White female with a 15-year history of severe, treatment-refractory Hailey-Hailey disease affecting multiple intertriginous areas. After failing numerous topical and systemic therapies, the patient initiated dupilumab therapy with a 600mg loading dose followed by 300mg administered every two weeks as maintenance. Within four months, the patient demonstrated approximately 80 percent clinical improvement with significant reduction in pain and pruritus. The authors speculate dupilumab's efficacy may extend beyond calcium homeostasis regulation, potentially addressing an unrecognized autoimmune component of Hailey-Hailey disease wherein desmosomal disruption may expose normally protected epitopes to immune surveillance. The rapid clinical response to dupilumab in this previously treatment-refractory case warrants further investigation into the immunopathogenesis of Hailey-Hailey disease and supports dupilumab as a promising therapeutic option for this debilitating condition.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"18-20"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Non-randomized, Open-label, Multicenter Study to Evaluate the Safety and Tolerability of 10% Aminolevulinic Acid Gel in the Expanded Field-directed Treatment of Actinic Keratosis on the Face and Scalp with Red Light Photodynamic Therapy.","authors":"Joel L Cohen, John H Tu, Megan P Couvillion, S Sasha Jazayeri, Nathalie C Zeitouni, Sherrif F Ibrahim, Edward L Lain, C William Hanke, Corinna Zogel, Beate Schmitz, Marie-Theres Zeuner, Todd Schlesinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Dermatologists regularly encounter patients having expanded fields with numerous actinic keratosis (AK) lesions on the face and scalp. Field-directed red light photodynamic therapy (PDT) is a well-established treatment, yet published data on the safety of PDT on large areas is scarce. We aimed to evaluate the safety and tolerability of red light PDT in treating expanded AK fields on the face and scalp.</p><p><strong>Methods: </strong>This was a non-randomized, open-label, multicenter study. After lesion preparation, 6g of 10% aminolevulinic acid (ALA) gel were applied to the treatment field (60 cm²) and incubated for three hours under a light-blocking, occlusive dressing before 10-minute illumination with a red light lamp (~635nm, 37 J/cm²). Safety and tolerability were assessed throughout the study.</p><p><strong>Results: </strong>All participants (n=100) had adverse reactions. No previously unknown effects, serious adverse events, or deaths were reported. The most frequent application site reactions were pain/burning (96.0%), exfoliation (87.0%), and erythema (86.0%). Most treatment-emergent adverse events were of mild to moderate severity and lasted slightly longer compared to those experienced after treatment of smaller areas. The mean maximum pain during PDT was 7.4±2.1 on an 11-point numeric rating scale. A transient increase in blood pressure on the day that PDT was performed was not clinically significant.</p><p><strong>Limitations: </strong>Although the allowed use of pain-reducing measures might have influenced evaluation of pain, it reflects how the procedure is managed in current practice.</p><p><strong>Concklusion: </strong>PDT with 10% ALA gel and red light illumination on an expanded treatment field was generally well tolerated.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"44-50"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Fixed-dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel in Black Participants with Moderate to Severe Acne.","authors":"Valerie D Callender, Andrew F Alexis, Neal Bhatia, Julie C Harper, Hilary Baldwin, Eric Guenin, Leon H Kircik","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel-the only approved fixed-dose, triple-combination acne treatment-demonstrated superior efficacy to vehicle and component dyads, with favorable safety/tolerability in Phase 2 and Phase 3 studies. In order to examine efficacy and safety of CAB in patients with darker skin phototypes, a post hoc analysis of clinical trial data of participants who self-identified as \"Black or African American\" was conducted.</p><p><strong>Methods: </strong>Data were pooled from two Phase 2 and two Phase 3, double-blind, 12-week studies (NCT03170388, NCT04892706, NCT04214639, NCT04214652). Eligible participants aged ≥9 years (≥12 years in NCT04892706) were randomized to once-daily CAB or vehicle. Endpoints included ≥2-grade reduction from baseline in Evaluator's Global Severity Score and clear/almost clear skin (treatment success) and inflammatory/noninflammatory lesion counts. Treatment-emergent adverse events (TEAEs) and cutaneous safety/tolerability were also assessed.</p><p><strong>Results: </strong>Of 1,115 participants randomized to CAB or vehicle, 156 (14%) were Black. At Week 12, 32.0 percent of CAB-treated participants achieved treatment success versus 18.3 percent with vehicle (<i>P</i>=0.07). Inflammatory and noninflammatory lesion reductions were significantly greater with CAB versus vehicle (68.8% vs. 51.4% and 57.8% vs. 45.5%, respectively; <i>P</i><0.05, both). TEAE severity was mild to moderate, and hyperpigmentation mean scores remained at/below baseline value (0.7; 1=mild).</p><p><strong>Limitations: </strong>Studies were not powered to detect significant differences between CAB and vehicle for Black participants; therefore, <i>P</i> values are for informative purposes only.</p><p><strong>Conclusion: </strong>CAB gel was efficacious and well tolerated in Black participants with acne.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Bias in Topical Minoxidil Labeling and Pricing.","authors":"Jesse Salas, Ahuva Cices","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Does it Mean to Be Beautiful? Exploring the Limits of AI-Driven Beauty Assessment.","authors":"Emmaline Ashley, Lee Walker, Priyanka Chadha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper examines the multifaceted nature of beauty, encompassing evolutionary, biological, neurological, cultural, and individual factors. It explores the limitations of objective assessments, such as artificial intelligence (AI) algorithms like the Facial Aesthetic Index and Facial Youthfulness Index, which often fail to capture the diversity of individual preferences and cultural standards. While AI tools can provide valuable insights into facial features, their use in aesthetic medicine should be approached with caution, recognizing the importance of subjective perceptions. We emphasize the need for a collaborative approach that integrates AI insights with clinical expertise and patient involvement to achieve personalized and satisfying outcomes in aesthetic medicine. Ultimately, beauty is a complex and subjective experience that cannot be fully defined or assessed objectively, and successful aesthetic interventions require a holistic approach that values both objective data and individual perspectives.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race Reporting in Dermabrasion Clinical Trials: A Systematic Review.","authors":"Sana Kamboj, Travis W Blalock","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The authors sought to determine the frequency and methods of race reporting in dermabrasion clinical trials.</p><p><strong>Methods: </strong>A PubMed search for terms: \"dermabrasion,\" \"derm-abrasion,\" and \"derm abrasion\" was conducted, yielding 1,786 papers. The \"Clinical Trial\" and \"Randomized Control Trial\" filters were applied. Non-English manuscripts were excluded. Remaining manuscripts were manually screened. Forty-one papers met final inclusion criteria.</p><p><strong>Results: </strong>Forty-six percent (n=19) of studies included mention of race, skin color, or Fitzpatrick skin type (FST). Four studies reported FST of 78 dermabrasion participants. Of these, 19 percent had FST I, 27 percent had FST II, 32 percent had FST III, 17 percent had FST IV, and 1 percent had FST V. Three patients (4%) were lost to follow-up and did not have FSTs reported. Twenty-two percent (n=9) of the studies including 513 patients reported race or skin color. The races of 107 (21%) could be definitively extracted. Of these 107 patients, 94 percent were White, five percent were Black, and one percent were Asian.</p><p><strong>Limitations: </strong>Our search was limited to PubMed-indexed articles which were categorized as 1) clinical trials or 2) randomized control trials. Articles that were incorrectly indexed in accordance with the search tool may have been inadvertently excluded.</p><p><strong>Conclusion: </strong>Our analysis suggests that the collection and reporting of racial demographic information has been rare in dermabrasion clinical trials. The absence of this demographic information limits the generalizability of the results. Given the health disparities that arise due to racism, investigators should collect and report participant races to improve risk stratification and transparency.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes: A Comprehensive Review for the Practicing Dermatologist.","authors":"Rami H Mahmoud, Erik Peterson, Evangelos V Badiavas, Michael Kaminer, Ariel E Eber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This clinical review examines what is known about exosomes and their applicability to aesthetic dermatology. Exosomes are extracellular vesicles with crucial roles in intercellular communication. Their biogenesis is complex and not completely understood, but they are generally formed intracellularly in the endosomal compartment of a cell or through direct plasma membrane release. Several mechanisms of exosome uptake have been described and are dependent on the molecular characteristics of the recipient cell and exosome membrane. Furthermore, there are a multitude of exosome isolation and characterization techniques, each with their own potential advantages and disadvantages. Exosomes have demonstrated promise in preclinical models across various domains of aesthetic dermatology, including as anti-aging and anti-inflammatory therapies and as therapeutics for wound healing, scar reduction, and hair regeneration. However, clinical studies are lacking, and there are substantial safety concerns, such as the potential risk of infections, unwanted inflammatory response, and promotion of malignancy. Further research is needed to develop more precise analytical techniques to better understand the composition of exosomes, their safety profiles, and their potential applications to patient care.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 4","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}