Journal of Clinical and Aesthetic Dermatology最新文献

{"title":"From the Masterclasses in Dermatology 2024 Meeting: Updates in Psoriasis Treatments.","authors":"Beth Childs, Sarah Romanelli, Joseph F Merola, Alice B Gottlieb","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Psoriasis (PsO) is an immune-mediated, chronic inflammatory skin disease that significantly impairs quality of life. Its treatment landscape is rapidly evolving, providing better disease control. Here, we highlight updates in biologics, obtaining coverage for biologics under Medicare, the PsO-to-psoriatic arthritis (PsA) transition, and orally administered drugs, as presented at the 2024 Masterclass in Dermatology in Puerto Rico. We provide a concise overview of the evolving therapeutic landscape and its impact on personalized care for patients with PsO. The toolkit of biologics is expanding, with agents that target interleukin (IL)-17 and IL-23 pathways addressing symptoms across multiple disease domains. Interchangeable biosimilars reduce financial barriers to access, particularly for tumor necrosis factor (TNF) inhibitors. An IL-36 receptor antibody, spesolimab, demonstrates efficacy in generalized pustular psoriasis. Further, Medicare has expanded coverage of certain biologics, addressing challenges to treating patients of this population. PsA is an important comorbidity that can significantly reduce quality of life. Recent studies suggest that biologic therapies-including TNF inhibitors, as well as anti-IL-17, anti-IL-23, and anti-IL-12/23 agents-protect against arthritis onset in PsO patients. In addition to traditional modes of delivery, novel formulations address widespread preference for orally administered therapies. Deucravacitinib, a tyrosine kinase (TYK) 2 inhibitor, is highly selective, effective, and safe. Additionally, JNJ-77242113, an investigational IL-23 receptor antagonist, constitutes an orally administered, targeted biologic therapy. Together, these developments are shaping the future for patients with PsO. It is our goal to simplify the complexities of emerging treatment options, offering clinicians a concise and useful guide for patient management.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 2","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Skin Deep: The Systemic Impact of Topical Corticosteroids in Dermatology.","authors":"Douglas DiRuggiero, Margaret DiRuggiero","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Corticosteroids are widely prescribed for a variety of dermatologic indications. However, since 2020, regulatory bodies from Canada and the United Kingdom, as well as academic and patient advocacy societies, are increasingly calling for limiting topical corticosteroid use due to safety concerns. This article reviews the variety and extent of both cutaneous adverse effects (i.e., steroid-induced damage) and systemic adverse effects from topical corticosteroids and explores alternative therapies. The risk of adverse effects increases with steroid potency, amount, duration, and frequency of use across indications, routes of administration, and prescribers (i.e., cumulative steroid dose). In order to reduce these safety risks, clinicians should prescribe steroids appropriately and counsel patients on appropriate use and consider combination topical corticosteroid therapy or newer alternative steroid-sparing treatments.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1-2 Suppl 1","pages":"S16-S20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videoconferencing Dysmorphia: The Impact on Self-perception and Desire for Cosmetic Procedures.","authors":"Payal M Patel, Mindy D Szeto, Kelly O'Connor, Henriette De La Garza, Kevin F Kennedy, Mayra B C Maymone, Neelam A Vashi","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The authors sought to examine the association between the increased use of videoconferencing and image-enhancing software filters during the COVID-19 pandemic and the corresponding rise in interest in cosmetic procedures. We aimed to discern if heightened exposure to one's digital self-image correlates with a greater inclination toward cosmetic interventions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this cross-sectional questionnaire survey study, adult participants living in the United States were recruited on Amazon's Mechanical Turk platform. Self-reported demographic data, videoconferencing usage, related behaviors, and attitudes concerning cosmetic procedures were assessed. Questionnaire prompts allowed participants to express in a Likert scale format their levels of agreement with certain statements. Frequencies and proportions of responses to each questionnaire item were collected, categorized, and recoded for comparison and analysis. Chi-squared tests were performed to examine associations between questionnaire responses and demographic characteristics, while significant predictors of videoconferencing and image-enhancing filter options were explored via multivariable logistic regression models.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The majority of study participants (n=505, 505/545 = 92.7% completion rate) were 18 to 39 years old (80.1%), female (68.1%), and non-White (58.2%). Income levels varied, and 89.2 percent had completed college or graduate school. Videoconferencing was frequent, with 88.6 percent using it more than three days a week, and 68.1 percent using \";touch-up my appearance\"; filters more than half the time. Videoconferencing influenced the desire for cosmetic procedures in 55.9 percent of participants, and 57.8 percent were influenced by filter use. Frequent self-viewing was reported by 67 percent, strongly associated with interest in cosmetic procedures. Significant predictors of filter use included higher income (OR 2.436, &lt;i&gt;p&lt;/i&gt;&lt;0.001) and frequent self-viewing behavior (OR 5.034, &lt;i&gt;p&lt;/i&gt;&lt;0.001). Notably, mask-wearing was associated with increased self-esteem (68.8%) and reduced desire for cosmetic procedures (67.4%) in frequent self-viewers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;Recall bias and the demographic composition of the study participant population may limit the generalizability of these self-reported responses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The data reflect the emergence of what may be termed 'videoconferencing dysmorphia,' indicating a significant association between videoconferencing, the application of filters, and the heightened interest in cosmetic procedures among users. This study suggests that digital self-viewing behavior instigates a distinct self-awareness that may drive individuals toward considering cosmetic interventions. These insights are vital for dermatologists in understanding patient motivations, managing expectations, and fostering realistic treatment outcomes.&lt;","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin-loaded Detachable Dissolvable Microneedles for Primary Axillary Hyperhidrosis: A Pilot Study on Efficacy and Safety.","authors":"Jidapa Triwatcharikorn, Kridipop Charoenchaipiyakul, Titiporn Sansureerungsikul, Nunthanach Chuenboonngarm, Kornphaka Kantikosum, Natcha Chottawornsak, Bussabong Chancheewa, Thanaporn Puaratanaarunkon, Ratchathorn Panchaprateep, Chanat Kumtornrut, Puttikorn Pukfukdee, Supason Wanichwecharungruang, Pravit Asawanonda","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Botulinum toxin injection is a well-established treatment for primary hyperhidrosis. The botulinum toxin-loaded detachable dissolvable microneedles (BoNT-MNs) were developed in a result of disadvantages of the intradermal procedure. This pilot study aims to evaluate the efficacy and safety of BoNT-MNs.</p><p><strong>Methods: </strong>This within-subject study included ten adults (N=10; 100% female) with mild primary axillary hyperhidrosis. BoNT-MNs patches were prepared and each microneedle patch contained 15 units of onabotulinum toxin. BoNT-MNs and placebo patches were randomly applied to different sides of axilla. Iodine-starch test, dermatologists' and patients' satisfaction scores were assessed at baseline and Weeks 1, 2, 3, 4, 8, 12, 16, 20, and 24.</p><p><strong>Results: </strong>All ten female subjects completed the trial. Notably, on the BoNT-MNs side, iodine starch scores exhibited an onset at Week 2, with a 57.14-percent reduction at Week 12, returning to baseline after Week 20. Dermatologists' and patients' satisfaction scores were consistently superior to the placebo side from Week 2 and Week 1, respectively, until Week 16, with statistical significance (<i>p</i><0.05) observed at Week 12 and Week 2.</p><p><strong>Limitations: </strong>This study involved a limited number of female participants and administered a single, small dosage of botulinum toxin in the BoNT-MNs.</p><p><strong>Conclusions: </strong>Botulinum toxin-loaded detachable dissolvable microneedles patches offer a safe and effective method for reducing axillary sweating.</p><p><strong>Clinical trial: </strong>This study was approved by the Institutional Review Board of Faculty of Medicine, Chulalongkorn University with IRB number 567/63, and registered in the Thai Clinical Trials Registry (Thaiclinicaltrials.org) under registration number TCTR20201230002.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"E61-E66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Internet and Social Media by Outpatient Dermatology Patients: A Prospective, Cross-sectional Study.","authors":"Autumn L Saizan, Simone N Montgomery, Li Ding, Arielle Carolina Mora Hurtado, Nada Elbuluk","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Online health-related information (HRI) has expanded access to medical knowledge. While there are benefits to the increasing availability of online HRI, there may be limitations to the accuracy, quality of information, and utilization across patient demographics.</p><p><strong>Methods: </strong>A survey was administered to dermatology outpatients at the Keck School of Medicine of the University of Southern California to examine the utilization of internet and social media for acquiring dermatology-related information (DRI).</p><p><strong>Results: </strong>A total of 200 patients completed the survey. A majority (90%) indicated utilizing the internet to research information about their dermatological condition. Approximately 74 percent researched their dermatological condition before visiting the dermatologist, and 80 percent researched their condition after seeing a dermatologist. Younger patients (ages 18-25) were more likely to utilize online HRI before and after their visit. When stratified by income level, those with an income of less than $20,000 a year were more likely to search online for symptom management. Overwhelmingly, patients (99%) preferred to receive DRI from a dermatologist over internet or social media.</p><p><strong>Limitations: </strong>A limitation of our study is the exclusion of individuals with dermatologic issues who do not seek in-person dermatologic care, which may contribute to selection bias.</p><p><strong>Conclusion: </strong>There are differences across demographics in the utilization of the internet and social media for obtaining DRI. Understanding patients' interactions with online HRI may allow providers and patients to work synergistically, leveraging online resources to support the dissemination of credible information and optimize patient outcomes.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recalcitrant Pediatric Facial Vitiligo Successfully Treated with Roflumilast Cream 0.3% Once Daily.","authors":"Kelly Warren, Sofia Sanchez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vitiligo is an autoimmune disorder that causes melanocyte damage and pigment loss. The clinical presentation of vitiligo consists of patchy areas of lighter skin and results from a loss of functioning melanocytes and may be more visible in darker skin toned patients. Vitiligo affects approximately 2 percent of children and adolescents in the United States, with half of the affected cases undiagnosed. Pediatric patients are at a high risk of experiencing psychosocial adverse events such as depression and anxiety if the vitiligo is not quickly or effectively treated due primarily to the visual presentation of the disease. These adverse events may be seen especially in patients with a darker skin tone. Treatments for pediatric vitiligo in the past has usually included phototherapy, topical corticosteroids, vitamin D and calcineurin inhibitors; topical ruxolitinib has been approved more recently for nonsegmental vitiligo in patients 12 years of age and older. In cases where disease is recalcitrant, the need for additional therapies is warranted. Roflumilast cream 0.3% is a highly selective, non-steroidal and potent topical phosphodiesterase 4 inhibitor approved in 2022 by the United States Food and Drug Administration for the treatment of psoriasis, in 2023 as a foam for the treatment of seborrheic dermatitis and in 2024, roflumilast cream 0.15% was approved for the treatment of atopic dermatitis, including in children down to six years of age. Topical roflumilast is well tolerated with a favorable safety profile among pediatric dermatology populations. We describe four cases of pediatric skin of color patients with facial vitiligo that were refractory to topical corticosteroids, ruxolitinib and phototherapy. All patients were started on roflumilast cream 0.3% once daily and demonstrated improvement in repigmentation.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"52-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevate-Derm West Conference Selected Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1-2 Suppl 1","pages":"S36-S52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Carboxytherapy for Skin Rejuvenation.","authors":"Ava Shamban, Wendy E Roberts, Vivian Bucay, Suneel Chilukuri, Eva Simmons-O'Brien, Diane Orlinsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Driven by public demand, new safe and effective approaches for achieving dermal rejuvenation are continuously being developed. Recently, there has been growing interest and advances in carbon dioxide therapy, or carboxytherapy. Based on the Bohr effect, carboxytherapy enhances the release of O₂ from the blood into the surrounding tissues in response to increased blood CO₂. Injections of CO₂ promote wound healing, reduced scar tissue, and increase collagen turnover, making it a useful tool for achieving a broad range of aesthetic benefits. A significant advancement in CO₂ technology is the development of a topical gel for the transcutaneous release of carbon dioxide (CO₂ Lift. Lumisque, Inc., Weston FL). Similar to the changes observed following CO₂ injections, the application CO₂ gel increases microcirculation and capillary growth. For example, applying a CO₂ gel mask after skin rejuvenation procedures, such as nanofractional radiofrequency therapy, is a safe and effective means to improve clinical outcomes and reduce treatment-related adverse events. The following manuscript is a review and discussion based on a roundtable discussion conducted at the Generational Dermatology Symposium in Rancho Mirage, California, on February 16-19, 2023. The use of carboxytherapy using a CO₂ gel represents a new multi-purpose new for medical, aesthetic, pediatric, and female health practitioners for improving patient skin health and appearance.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"55-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Topical Formulation Containing <i>Macrocystis Pyrifera</i> Ferment for Managing Barrier Damage After Mild-Moderate Skin Disruption from Cosmetic Dermatologic Procedures.","authors":"Uma Santhanam, Jaime Emmetsberger, Gregory Nole, Arisa Ortiz, Michael Gold, Claude Saliou","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of these studies was to evaluate the potential of a serum containing Macrocystis pyrifera ferment (MPF-Serum) to both strengthen the barrier of intact skin and enhance barrier recovery after a non-ablative laser procedure or glycolic acid chemical peel.</p><p><strong>Methods: </strong>Two whole-face clinical trials and three split-face, randomized, controlled clinical trials were conducted in women aged 31 to 65 years. The effect of MPF-Serum on barrier integrity and strength was assessed by transepidermal water loss measurement before and after controlled tape-stripping experiments and in-clinic 70% glycolic acid peel and non-ablative laser procedures.</p><p><strong>Results: </strong>Application of MPF-Serum twice daily for eight weeks on intact skin significantly increased mean moisturization by 16 percent and improved barrier integrity by 11 percent (<i>p</i>≤0.05 for both). Likewise, barrier strength across 8x tape-stripped skin showed a 30-percent improvement after eight weeks of treatment. In studies involving non-ablative laser procedures, MPF-Serum pre-treatment or post-treatment improved post-procedure barrier recovery to a greater extent than standard moisturizer. Likewise, in a study involving 70% glycolic peel, MPF-Serum pre-treatment improved post-procedure barrier recovery to a greater extent than no pre-treatment.</p><p><strong>Limitations: </strong>These clinical studies were conducted at a limited number of sites, with limited sample sizes and populations.</p><p><strong>Conclusion: </strong>This topical MPF-Serum effectively improves barrier integrity and strength and helps to reduce recovery time from dermatologic procedures such as glycolic acid peel and laser treatments.</p>","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trending Psychiatric Comorbidities in Patients with Alopecia Areata in the United States from 2002 to 2019.","authors":"Hannah Peterson, Kathleen L Miao, Margaret Y Huang, April W Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53616,"journal":{"name":"Journal of Clinical and Aesthetic Dermatology","volume":"18 1","pages":"18-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}