Open Pain Journal最新文献_第6页

The Pain of Egg-Donation 捐赠卵子的痛苦

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010041

Vassiliki Simoglou

引用次数: 1

Editorial: Psychological Approach of Pain 社论:疼痛的心理学方法

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010029

K. Chatira, Lissy Kanellopoulos

引用次数: 0

What Depression? Or The Elimination of the Subjective Causality of Pain? 沮丧什么?还是消除疼痛的主观因果关系?

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010059

Aikaterini Malichin

{"title":"What Depression? Or The Elimination of the Subjective Causality of Pain?","authors":"Aikaterini Malichin","doi":"10.2174/1876386301407010059","DOIUrl":"https://doi.org/10.2174/1876386301407010059","url":null,"abstract":"The spectrum of depressing affective disorder countries a crowd of clinical types and cases and summarizes various symptoms, criteria and phenomena that are not explained in their quality and their causality and that potentially are symptomic events and sentimental situations that can oscillate from the neurosis up to the psychosis. It is estimated by epidemiologic researches that the 6% of roughly general population suffers from clinically diagnosed depression. The common point of subjects that suffer or have been diagnosed with depression is the pain of existence, as a complicated emotional, psychical and physical situation, and the inhibition that this involves. The psychoanalytical clinic is based in the decoding of this pain in the particular signifying chain of each subject separately, but also through the localization of mental structure that belongs to each subject. While the depression is not a structure but a hyper- structure, but neither a symptom, it is an affective painful situation which should be treated by the clinical process in its singularity. Thus, through a concise regard of pain in the depressing situations, the pain of existence in the post- modern melancholies, the moral pain of melancholy as psychotic structure, and the intense pain of loss and mourning, presenting three clinical ex- amples, the author concludes and emphasizes the clinical and ethical importance of elaboration of subjective causality of pain and inhibition.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"7 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2014-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychic Pain in Chronic School Failure/Learning Disabilities: Evidence from a Projective Technique 慢性学业失败/学习障碍的心理疼痛:来自投射技术的证据

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010067

D. Nikolopoulos, K. Chatira

引用次数: 0

The Painful Analgesia of Cotard’s Syndrome 科塔尔综合征的疼痛性镇痛

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010036

Yorgos Dimitriadis

{"title":"The Painful Analgesia of Cotard’s Syndrome","authors":"Yorgos Dimitriadis","doi":"10.2174/1876386301407010036","DOIUrl":"https://doi.org/10.2174/1876386301407010036","url":null,"abstract":"In the present paper, we look into what is painful psychical analgesia in relation to what 19 th century clinicians have named \"moral pain\" in melancholia, and more particularly in the delusion of negation described by the French psy- chiatrist Jules Cotard in 1880, a form of delusion that can be seen mostly in cases of chronic anxious melancholia. This condition is characterized by a painful absence of emotions, which occurs when the subject, in the Lacanian sense of the word, ceases to be touched by the signifiers, and consequently ceases to exist as a subject. Hence, these patients often de- clare themselves to be already dead or incapable of dying. The psychoanalytical approach to this delusion allows an un- derstanding of the ''lack of lack'' concept, as these patients, having lost the lack, affirm that their body's orifices are clogged, that they have lost their mental vision, that they miss various visceral organs etc. The completeness of their body - the absence of orifices - can sometimes attain universal dimensions and these patients can thus identify themselves to the universe, which contains everything. The delusion of negation teaches us something important concerning the essence of desire, in relation to what has been named by Lacan area-between-two-deaths. This Lacanian concept refers essentially to the tragic hero, but also, more generally, to the lonely condition where anyone's desire should be able to exist beyond any narcissistic commitment, which means beyond the pleasure principle as well.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"7 1","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2014-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An NTS2 Analog Enhances the Analgesic Effects of Morphine in an Animal Model of Persistent Pain and Does not Exhibit Tolerance NTS2类似物在持续疼痛的动物模型中增强吗啡的镇痛作用，但不表现出耐受性

Open Pain Journal Pub Date : 2014-11-14 DOI: 10.2174/1876386301407010023

M. Boules, P. Fredrickson, E. Richelson

{"title":"An NTS2 Analog Enhances the Analgesic Effects of Morphine in an Animal Model of Persistent Pain and Does not Exhibit Tolerance","authors":"M. Boules, P. Fredrickson, E. Richelson","doi":"10.2174/1876386301407010023","DOIUrl":"https://doi.org/10.2174/1876386301407010023","url":null,"abstract":"The analgesic efficacy of neurotensin agonists depends on their activation of two receptor subtypes, NTS1 and/or NTS2. In this study we determined the role of NTS2 in an animal model of persistent pain (intraplantar injection of formalin) with the use of the NTS2-selective analog, NT79 and NTS2-knockout mice (NTS2 -/- ). Wild type (WT) and NTS2 -/- mice were pretreated with NT79 and tested for formalin-induced lifting and biting. Additionally, the effect of repeated administration of NT79 and morphine alone and in combination was determined in WT mice. Intraplantar injection of formalin produced the typical biphasic nociceptive response of this persistent pain model. Formalin evoked lower pain intensity in NTS2 -/- mice as compared to that for WT mice. Pretreatment with NT79 attenuated formalin- induced nociception throughout phase II in the WT mice, and in early phase II in the NTS2 -/- mice. Lifting and biting responses were attenuated, indicating spinal and supra-spinal modulation of persistent nociception. More importantly, repeated injection of NT79 enhanced, while that of morphine reduced their antinociceptive effects, respectively. Subchronic co-administration of NT79 and morphine enhanced the analgesic effect over either drug alone. These data support the role of NTS2 in modulating formalin-induced pain. Additionally, these data provide a rationale for the potential therapeutic role of NTS2-selective analogs in chronic pain management alone or in combination with morphine and without the development of tolerance.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"248 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2014-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Structural Basis of Joint Instability as Cause for Chronic Musculoskeletal Pain and Its Successful Treatment with Regenerative Injection Therapy (Prolotherapy) 关节不稳定引起慢性肌肉骨骼疼痛的结构基础及再生注射疗法的成功治疗

Open Pain Journal Pub Date : 2014-09-09 DOI: 10.2174/1876386301407010009

R. Hauser, P. Blakemore, J. Wang, D. Steilen

{"title":"Structural Basis of Joint Instability as Cause for Chronic Musculoskeletal Pain and Its Successful Treatment with Regenerative Injection Therapy (Prolotherapy)","authors":"R. Hauser, P. Blakemore, J. Wang, D. Steilen","doi":"10.2174/1876386301407010009","DOIUrl":"https://doi.org/10.2174/1876386301407010009","url":null,"abstract":"Joint dysfunctions and associated musculoskeletal pain are among the most common medical complaints presented to clinicians. Ligaments are collagenous fibrous structures that are primarily responsible for maintaining smooth joint motion, restraining excessive joint displacement, and providing stability across the joint. Ligaments also act as sensory organs for the joints and have significant input to pain sensation. When ligaments are subjected to forces beyond their normal range of motion, injury and failure occur, resulting in joint laxity (looseness or instability), and subsequent disruptions in the balance between joint mobility and joint stability. These dysfunctions can result in joint pain and the development of osteoarthritis. Several strategies have been employed over the years in attempts to improve joint instability from ligament injury; however, some of the standard therapeutic approaches (drugs, corticosteroid injections, and surgery) employed to address these problems have not been very effective because they often do not address the underlying cause of the problems, and in fact can inhibit ligament healing and restoration. For these reasons, there is current and growing interest among patients and clinicians in prolotherapy, an alternative therapeutic modality that can reduce or eliminate pain by stimulating the natural regenerative processes in and around the joint to facilitate the restoration of degenerated ligaments and tendons to a healthy state, improving joint support, function and reducing pain. This review presents current evidence from clinical studies demonstrating that prolotherapy is a significant and effective alternative treatment modality for people with ligament-related injuries and resultant joint instability.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"37 1","pages":"9-22"},"PeriodicalIF":0.0,"publicationDate":"2014-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia 脊髓是大麻素CB2受体激动剂JWH133抑制神经性疼痛的主要作用部位:可能涉及小胶质细胞

Open Pain Journal Pub Date : 2014-08-05 DOI: 10.2174/1876386301407010001

H. Shimoyama, M. Tsuda, Takahiro Masuda, Ryohei Yoshinaga, Keiko Tsukamoto, H. Tozaki-Saitoh, Kazuhide Inoue

{"title":"Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia","authors":"H. Shimoyama, M. Tsuda, Takahiro Masuda, Ryohei Yoshinaga, Keiko Tsukamoto, H. Tozaki-Saitoh, Kazuhide Inoue","doi":"10.2174/1876386301407010001","DOIUrl":"https://doi.org/10.2174/1876386301407010001","url":null,"abstract":"Neuropathic pain, a highly debilitating condition that commonly occurs after damage to the nervous system, is often resistant to commonly used analgesic agents such as non-steroidal anti-inflammatory drugs and even opioids. Several studies using rodent models reported that cannabinoid CB2 receptor (CB2R) agonists are effective for treating chronic pain. However, the analgesic mechanism of CB2R agonists in neuropathic pain states is not fully understood. In this study, we investigated the role of CB2Rs in the development and maintenance phases of neuropathic pain, and the mechanism of the CB2R-mediated analgesic effect on neuropathic pain. In a rat model of neuropathic pain, systemic administration of JWH133, a CB2R agonist, markedly improved tactile allodynia, and this effect was prevented by intrathecal pretreatment with AM630, a CB2R antagonist. The antiallodynic effect of intrathecally administered JWH133 was inhibited by intrathecal pretreatment with pertussis toxin or forskolin. In the spinal cord, CB2R expression was significantly increased on post-operative day 3, and persisted for 2 weeks. Furthermore, repeated intrathecal administration of JWH133 notably attenuated the development of tactile allodynia after peripheral nerve injury. In a culture of microglia activated by overexpressing interferon regulatory factor 8, a transcription factor crucial for neuropathic pain, JWH133 treatment suppressed the increased expression of interleukin-1� . Our findings suggest that activation of CB2Rs upregulated in the spinal cord after nerve injury alleviates existing tactile allodynia through the Gi/o- adenylate cyclase signaling pathway and suppresses the development of allodynia. This process may reduce the inflammatory response of microglia. Therefore, spinal CB2Rs may be a therapeutic target for the treatment of neuropathic","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"7 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2014-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Screening for Cancer-Related Neuropathic Pain in the Oncology Outpatient Setting in the United Kingdom 筛查癌症相关神经性疼痛在肿瘤门诊设置在英国

Open Pain Journal Pub Date : 2013-12-13 DOI: 10.2174/1876386301306010208

A. Birtle, S. Davidson, G. Atkinson, C. V. Litsenburg

{"title":"Screening for Cancer-Related Neuropathic Pain in the Oncology Outpatient Setting in the United Kingdom","authors":"A. Birtle, S. Davidson, G. Atkinson, C. V. Litsenburg","doi":"10.2174/1876386301306010208","DOIUrl":"https://doi.org/10.2174/1876386301306010208","url":null,"abstract":"This article reports the outcomes of a sub-analysis of United Kingdom (UK) data collected during a non- interventional, cross-sectional study conducted in five European countries. The primary aim was to estimate the preva- lence of cancer-related neuropathic pain (CRNP) in an outpatient sample of adult cancer patients visiting oncology clinics in the UK for standard care. Secondary aims were to report the nature and characteristics of the cancer and the pain in the patients with CRNP. This sub-analysis also assessed the usefulness of the PainDETECT screening tool as an aid for phy- sicians in identifying the neuropathic component of cancer-related pain in daily practice. Based on physicians' clinical judgment before reviewing the scores on the PainDETECT tool, the estimated number of outpatients with cancer experi- encing chronic pain and considered to have CRNP was 104 of 195 patients (53.3%; 95% confidence interval (CI): 46.3%- 60.3%). After reviewing patients' scores on the tool, the estimate was 90 of 195 patients (46.2%; 95% CI: 39.2%-53.2%). Physicians changed from a positive (yes) to a negative (no) diagnosis of CRNP for 16 of 127 patients who had a low PainDETECT end score (<13; indicating that neuropathic pain was unlikely). Of the 11 physicians who completed the usefulness of PainDETECT survey, eight indicated that they would use the questionnaire in future for at least some of their patients, although they also indicated that in the majority of cases (63%), the PainDETECT tool did not help them evaluate whether a patient had CRNP. Because of missing data arising from missing or incomplete survey responses, however, these data should be interpreted with caution, and further studies are required to assess the usefulness of this tool.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"6 1","pages":"208-216"},"PeriodicalIF":0.0,"publicationDate":"2013-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Prevalence and Nature of Cancer-Related Neuropathic Pain in Out-Patient Services in Spain 西班牙门诊服务中癌症相关神经性疼痛的患病率和性质

Open Pain Journal Pub Date : 2013-11-29 DOI: 10.2174/1876386301306010199

C. Garzón-Rodríguez, Luis Olay Gayoso, J. Sepúlveda, E. Martinez, I. Peláez, L. Merino, G. Atkinson, V. López-Gómez, M. P. Páramo, C. V. Litsenburg

{"title":"The Prevalence and Nature of Cancer-Related Neuropathic Pain in Out-Patient Services in Spain","authors":"C. Garzón-Rodríguez, Luis Olay Gayoso, J. Sepúlveda, E. Martinez, I. Peláez, L. Merino, G. Atkinson, V. López-Gómez, M. P. Páramo, C. V. Litsenburg","doi":"10.2174/1876386301306010199","DOIUrl":"https://doi.org/10.2174/1876386301306010199","url":null,"abstract":"Cancer patients with neuropathic pain have been shown to have higher levels of pain interference and impaired quality of life (QoL) compared with cancer patients without neuropathic pain. This article presents sub-analysis of data from a large non-interventional study conducted between 23 August 2010 and 22 July 2011 in Denmark, Germany, Greece, Spain and the UK. Descriptive data collected in 21 oncology or palliative care centers during patients' routine out-patient visits in Spain are reported here to further investigate the prevalence and nature of cancer-related neuropathic pain (CRNP). The prevalence of CRNP in 557 cancer patients with chronic pain in Spain was estimated at 30.9% (95% confidence interval (CI): 27.0-34.7) by physicians before considering scores on the PainDETECT questionnaire and 30.7% (95% CI: 26.9-34.5) after considering PainDETECT scores. Despite a similar overall number, there were shifts in the numbers of patients with or without a diagnosis of CRNP after physicians had had the opportunity to consider PainDETECT scores, particularly for patients who received an initial diagnosis of 'unknown'. In the opinion of the physicians, 92/171 (53.8%) of the CRNP population had mixed cancer-related pain with a neuropathic component, which can be difficult to identify and effectively manage. The self-reported responses to questions and scales in this Spanish sample indicated that many aspects of daily functioning were negatively impacted within the CRNP participants and that pain was not always controlled. These data highlight the need for national guidelines to identify and treat cancer-related pain with a neuropathic component.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"6 1","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"2013-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2