Open Pain Journal最新文献_第5页

A Mouse Model of Chronic Pancreatitis Induced by an Alcohol and High Fat Diet. 酒精和高脂肪饮食诱发慢性胰腺炎的小鼠模型

Open Pain Journal Pub Date : 2017-01-01 Epub Date: 2017-09-15 DOI: 10.2174/1876386301710010081

T Clinkinbeard, R H Kline, L P Zhang, S L McIlwrath, J F Watkins, K N Westlund

{"title":"A Mouse Model of Chronic Pancreatitis Induced by an Alcohol and High Fat Diet.","authors":"T Clinkinbeard, R H Kline, L P Zhang, S L McIlwrath, J F Watkins, K N Westlund","doi":"10.2174/1876386301710010081","DOIUrl":"10.2174/1876386301710010081","url":null,"abstract":"Background/aims: Study of acute pancreatitis in chemically-induced rodent models has provided useful data; models of alcoholic chronic pancreatitis have not been available in mice. The aim of the present study was to characterize a mouse model of chronic pancreatitis induced solely with an alcohol and high fat (AHF) diet.Methods: Mice were fed a liquid high fat diet containing 6% alcohol as well as a high fat supplement (57% total dietary fat) over a period of five months or as control, normal chow ad libitum. Pain related measures utilized as an index of pain included mechanical sensitivity of the hind paws determined using von Frey filaments and a smooth/rough textured plate. A modified hotplate test contributed information about higher order behavioral responses to visceral hypersensitivity. Mice underwent mechanical and thermal testing both with and without pharmacological treatment with a peripherally restricted μ-opioid receptor agonist, loperamide.Results: Mice on the AHF diet exhibited mechanical and heat hypersensitivity as well as fibrotic histology indicative of chronic pancreatitis. Low dose, peripherally restricted opiate loperamide attenuated both mechanical and heat hypersensitivity.Conclusion: Mice fed an alcohol and high fat diet develop histology consistent with chronic pancreatitis as well as opioid sensitive mechanical and heat hypersensitivity.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"10 1","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39258381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Pain Management 手术疼痛处理

Open Pain Journal Pub Date : 2016-12-30 DOI: 10.2174/1876386301609010039

Serge Marchand

引用次数: 1

Chronic Pain Management for the Hospitalized Patient 住院病人的慢性疼痛管理

Open Pain Journal Pub Date : 2016-12-30 DOI: 10.2174/1876386301609010038

Serge Marchand

引用次数: 0

The Complement System in Neuropathic and Postoperative Pain 神经性和术后疼痛中的补体系统

Open Pain Journal Pub Date : 2016-09-30 DOI: 10.2174/1876386301609010026

D. Fritzinger, D. E. Benjamin

引用次数: 22

Hyperuricemia is Associated with Musculo-skeletal Pain - Results from a Cross-sectional Study 高尿酸血症与肌肉骨骼疼痛有关——横断面研究结果

Open Pain Journal Pub Date : 2016-09-26 DOI: 10.2174/1876386301609010015

H. Comberg, S. Schach

引用次数: 2

Changes in Spinal Cord Following Inflammatory and Neuropathic Pain and the Effectiveness of Resiniferatoxin 炎性和神经性疼痛后脊髓的变化及树脂素毒素的疗效

Open Pain Journal Pub Date : 2016-03-14 DOI: 10.2174/1876386301609010001

Mruvil Abooj, M. Bishnoi, Christine A. Bosgraaf, L. Premkumar

{"title":"Changes in Spinal Cord Following Inflammatory and Neuropathic Pain and the Effectiveness of Resiniferatoxin","authors":"Mruvil Abooj, M. Bishnoi, Christine A. Bosgraaf, L. Premkumar","doi":"10.2174/1876386301609010001","DOIUrl":"https://doi.org/10.2174/1876386301609010001","url":null,"abstract":"Peripheral inflammation or nerve injury results in changes in the spinal cord, initiating a process of central sensitization. Although nociceptive Transient Receptor Potential (TRP) channels have been studied extensively, the role of these channels expressed at the central terminals in the spinal cord is not fully understood. Here, we studied the expression and function of TRPV1 channels at the spinal cord following induction of inflammatory pain by Complete Freund's Adjuvant (CFA) and neuropathic pain by Chronic Constriction Injury (CCI). Rats treated with CFA or subjected to CCI developed long-term thermal and mechanical hypersensitivity. Peripheral inflammation or injury induced an inflammatory response at the levels of spinal cord, which included activation of glia and increased levels of proinflammatory mediators. As a result, expression of TRPV1 was significantly increased and the associated function of TRPV1-mediated CGRP release was also significantly increased. Single intrathecal administration of resiniferatoxin (RTX), an ultrapotent TRPV1 agonist, selectively reversed inflammatory thermal hypersensitivity and the associated changes in TRPV1 expression and function without affecting mechanical hypersensitivity. In summary, peripheral nerve activity triggers an inflammatory response at the spinal dorsal horn, which results in enhanced expression and function of TRPV1 channels. Targeting TRPV1 expressed in the central terminals is a viable strategy to alleviate certain modalities of pain.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"9 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2016-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Ablation and Regeneration of Peripheral and Central TRPV1 Expressing Nerve Terminals and the Consequence of Nociception 外周和中枢表达TRPV1的神经末梢的消融和再生及痛觉的后果

Open Pain Journal Pub Date : 2015-03-31 DOI: 10.2174/1876386301508010001

Shuang-quan Yu, L. Premkumar

{"title":"Ablation and Regeneration of Peripheral and Central TRPV1 Expressing Nerve Terminals and the Consequence of Nociception","authors":"Shuang-quan Yu, L. Premkumar","doi":"10.2174/1876386301508010001","DOIUrl":"https://doi.org/10.2174/1876386301508010001","url":null,"abstract":"Transient Receptor Potential Vanilloid 1 (TRPV1) expressed in peripheral terminals is responsible for transducing thermal and chemical nociception. Role of TRPV1 expressed in the central terminals is not clear, however, its activation modulates synaptic transmission and contributes to central sensitization. In this study, we have determined the role of TRPV1 expressed in the peripheral and central terminals using resiniferatoxin (RTX), a potent TRPV1 agonist. A single intraplantar injection of RTX, within two days induced loss of capsaicin-induced nocifensive behavior and enhanced response latency to hot plate, which recovered over a period of two months. RTX treatment resulted in the ablation of peripheral TRPV1 expressing fibers in paw skin, which regenerated over the same time period. On the other hand, a single dose of intrathecal administration of RTX, within two days caused thermal hypoalgesia. RTX treatment ablated TRPV1 expressing central sensory nerve terminals. Intriguingly, in contrast to peripheral nerve terminal regeneration that occurred within two months, the central TRPV1 expressing nerve terminals did not regenerate even after five months. The present study demonstrates that TRPV1 in the peripheral and central terminals play a role in nociception and the peripheral terminals have the ability to regenerate, whereas the central terminals do not regenerate even after five months.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"8 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2015-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The Unbearable Heaviness of Being: Pain and Suffering in Anorexia 无法承受的生命之重:厌食症的痛苦和折磨

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010046

L. Canellopoulos

{"title":"The Unbearable Heaviness of Being: Pain and Suffering in Anorexia","authors":"L. Canellopoulos","doi":"10.2174/1876386301407010046","DOIUrl":"https://doi.org/10.2174/1876386301407010046","url":null,"abstract":"In anorexia which classically shows the difficulty in adolescence to link bodily transformations and sexuality, psychic suffering is undeniable and is embodied in the body while taking into account contemporary social data. Building on some elements of the psychoanalysis of a young anorexic girl, the article attempts to break through the wall of pain and get to perceive that in an order that is no longer governed by the paternal instance, which allows the representation, the subject can no longer support a phallusized image and the body is reduced to its reality. This results in a particularly painful female transmission in the clinic of anorexia, in which the contemporary world is not innocent. Pain is not the goal for the anorexic; it shows a willingness to feel the existence of the body. She seeks this nothing through which she attempts to capture the rift in the Other. But to achieve this nothing she must feel the pain of its absence. Pain is thus a claimed effect. The article ends with a reflection on the therapeutic work with the anorexic subject, which would be to allow the dis-completeness of the discourse concerning it, to reintroduce a relationship to its own image marked with a lack and offer the conditions of its own enunciation.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"7 1","pages":"46-55"},"PeriodicalIF":0.0,"publicationDate":"2014-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Subjective Aspects of Pain and its Objectivity in Research 疼痛的主观方面及其客观性研究

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010031

L. Croix

引用次数: 1

Pain as a Conversion Symptom or a Psychosomatic Phenomenon: Fake or Real? 疼痛是转化症状还是心身现象:假的还是真的?

Open Pain Journal Pub Date : 2014-11-24 DOI: 10.2174/1876386301407010056

K. Chatira

{"title":"Pain as a Conversion Symptom or a Psychosomatic Phenomenon: Fake or Real?","authors":"K. Chatira","doi":"10.2174/1876386301407010056","DOIUrl":"https://doi.org/10.2174/1876386301407010056","url":null,"abstract":"According to the psychoanalytical Freudian approach, the pain in a conversion symptom (hysterical pain), whether defined or indefinable, corresponds to a displacement of the intrapsychic conflict to the subject's physical body. The libidinal energy attached to the repressed representation is transformed into neurotic energy in organs or parts of the body so as to dramatically represent the desirable as well as the prohibitive. The body lends itself as a 'location' to the conversion disorder in order for the anguish of the intrapsychic conflict to be expressed in openly manipulative terms. Does this hysterical pain designate both the pleasure of the performance and the discontent of the psychological anguish? On the contrary, the psychosomatic pain manifests itself in the actual physical body of the organism and not in the illusory body of the hysteric. It is possible for the (psycho)somatic disorder to be expressed through the pain symptom upon an ex- isting, objective condition diagnosed in an organ or body part. But is it not the very nature of the psychosomatic disorder a unique differentiation criterion between the two types of the disorder? The rationale, the type of the psychological defense mechanisms and the nature of the impulsive dynamics which subdue each of those two types of painful symptoms consti- tute criteria of other differentiators within the psychopathological and psychoanalytic approach.","PeriodicalId":53614,"journal":{"name":"Open Pain Journal","volume":"48 1","pages":"56-58"},"PeriodicalIF":0.0,"publicationDate":"2014-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0