Plasma Medicine最新文献_第5页

The mechanism of LP-1 myeloma cell inactivation by DC-powered plasma treatment 直流电浆治疗LP-1骨髓瘤细胞失活的机制

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021040378

Dehui Xu, Zeyu Chen, Rui Feng, Zifeng Wang, Xinying Zhang, Miao Qi, Dingxin Liu

引用次数: 0

Reactive radical study using the polyvinyl alcohol–potassium iodide solution as a new chemical probe 聚乙烯醇-碘化钾溶液作为新型化学探针的活性自由基研究

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021040820

H. Matsuura, Nguyen Tran Trung, Bounyang Ouanthavinsak, J. Sakamoto, Y. Takemura, R. Asada, M. Furuta

引用次数: 0

Effect of mutation and disulfide bond formation on the catalytic site of monomeric cytoglobin: a molecular level insight 突变和二硫键形成对单体细胞红蛋白催化位点的影响:分子水平的洞察

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021041420

Jamoliddin Razzokov, Sunnatullo Fazliev, M. Yusupov, A. Sharipov, Zukhriddin Ruziev, Sh. I. Mamatkulov

{"title":"Effect of mutation and disulfide bond formation on the catalytic site of monomeric cytoglobin: a molecular level insight","authors":"Jamoliddin Razzokov, Sunnatullo Fazliev, M. Yusupov, A. Sharipov, Zukhriddin Ruziev, Sh. I. Mamatkulov","doi":"10.1615/plasmamed.2021041420","DOIUrl":"https://doi.org/10.1615/plasmamed.2021041420","url":null,"abstract":": Cytoglobin (Cygb) is a recently discovered member of the globin family. Cygb maintains a large apolar cavity with the heme group located in it. The main catalytic activity of Cygb takes place around this heme group, which is also considered as a ligand docking station. Biochemical experiments revealed that Cygb can scavenge reactive oxygen and nitrogen species, such as hydrogen peroxide, nitric oxide, and peroxinitrite, protecting the cell against oxidative and nitrosative stress. However, the effect of mutation, as well as its synergistic effect together with oxidation on scavenging activity of the Cygb, has not yet been studied in detail. Thus, in this research we perform molecular dynamics and docking simulations to study the impact of mutation and oxidation on the Cygb catalytic function. Our simulation results show that the mutation of lysine 80 residue to alanine in Cygb results in an opening of the access to the heme group, thereby increasing its scavenging function. Moreover, the combination of this mutation (i.e., Cygb (L80A) ) with the oxidation [namely, the disulfide bond formation in Cygb (i.e., Cygb S-S )] induces the complex conformational changes in its structure. As a result, these changes lead to even more opening of the access to the heme group, which in turn enhances the scavenging activity of Cygb to a more extent. The latter can be a hallmark of enhanced enzymatic function of the modified Cygb (i.e., Cygb (L80A) and Cygb S-S ).","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Characterization of Cold Atmospheric Pressure Plasma Technology and Its Application in Biomedicine 低温常压等离子体技术的特性及其在生物医学中的应用

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021040971

H. Baniya, P. Khadka, S. Pandey, Anusuya Nepal, R. P. Guragain, T. R. Lamichhane, S. Dhungana, B. Shrestha, D. Subedi

引用次数: 0

Exploring the Effects of Direct and Indirect Treatment Of Human Cells with Cold Atmospheric Plasma Devices 探讨低温常压等离子体装置直接和间接处理人体细胞的效果

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021039616

Cian D. Madigan, Fiona O'Neill, D. O’Sullivan, Darren F. Kavanagh, Liam O'neill

引用次数: 0

Transdermal delivery of Adenosine and Eosin Y using microplasma combined with FeSO4 and DMSO iontophoresis 微血浆联合FeSO4和DMSO离子导入经皮递送腺苷和伊红Y

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021040968

J. Krištof, Fariha Mustafa, A. Yahaya, M. Blajan, K. Shimizu

{"title":"Transdermal delivery of Adenosine and Eosin Y using microplasma combined with FeSO4 and DMSO iontophoresis","authors":"J. Krištof, Fariha Mustafa, A. Yahaya, M. Blajan, K. Shimizu","doi":"10.1615/plasmamed.2021040968","DOIUrl":"https://doi.org/10.1615/plasmamed.2021040968","url":null,"abstract":"One of the main roles of transdermal drug delivery is to overcome stratum corneum; the first barrier of the skin. We combined several types of treatments to investigate their effect on skin permeability and drug absorption. Franz diffusion cell was used to investigate the permeation and retention of adenosine through Yucatan micropig’s skin. The amount of the penetrated drug and the drug retained inside the skin was measured by HPLC. We compared adenosine permeation through the untreated skin, iontophoretically pre-treated skin with FeSO4∙7H2O in DMSO followed by microplasma treatment, iontophoretically pre-treated skin with FeSO4∙7H2O in water followed by microplasma treatment, and treated skin with DMSO. Eosin Y dye was used to analyze depth of the penetration after the treatment. Depth of penetration was displayed by microscopic observation and FE-SEM/EDS observation after skin sectioning. Absorption of eosin Y inside the skin measured by FE-SEM/EDS and optical microscope was consistent with absorption of adenosine measured by using Franz diffusion cell and HPLC. Iontophoretic pre-treatment followed by plasma treatment caused increased drug absorption in stratum corneum and plasma treatment itself increased drug penetration through the epidermal layer of the skin.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Decline of 20th Century High-Frequency Therapeutics 20世纪高频疗法的衰落

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021041385

Tal Horovitz, Nathan Monesa, Aviel Hanasab, R. Foulad

引用次数: 0

Efficacy of contact-type cold atmospheric plasma on skin rejuvenation in persons with aging skin 接触型冷大气等离子体对皮肤老化者皮肤年轻化的疗效观察

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021037904

Warumpa Suwannarat, Phannapat Intarit, S. Pitiporn, Wachana Tungkwampian, Piyapong Prasertsri, wicharn girdwichai

引用次数: 0

Accelerated healing of chronic wound under the combinatorial therapeutic regimen based on contact and non-contact styles of the cold atmospheric plasma jet 低温大气等离子体喷射接触式和非接触式联合治疗方案对慢性伤口加速愈合的影响

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021039083

S. Darmawati, N. Nasruddin, G. S. A. Putri, A. Iswara, P. Kurniasiwi, E. S. Wahyuningtyas, L. H. Nurani, Defi Nurul Hayati, T. Ishijima, T. Nakatani, J. Sugama

引用次数: 1

Collagen Coating of Titanium Implants Using Nonthermal Plasma 非热等离子体钛植入物胶原涂层研究

Plasma Medicine Pub Date : 2021-01-01 DOI: 10.1615/plasmamed.2021039685

L. O'Neill, B. Twomey, F. Tan, J. O'donoghue, John Junt

{"title":"Collagen Coating of Titanium Implants Using Nonthermal Plasma","authors":"L. O'Neill, B. Twomey, F. Tan, J. O'donoghue, John Junt","doi":"10.1615/plasmamed.2021039685","DOIUrl":"https://doi.org/10.1615/plasmamed.2021039685","url":null,"abstract":"Surface modification of implants is now an essential aspect of biocompatibility. A single-step process to attach biomolecules to implants represents a major advance, and plasma coating potentially achieves this. An aqueous solution of collagen was sprayed into a nonthermal plasma and deposited onto titanium surfaces. The plasma instantly transformed the liquid aerosol into a coagulated dry coating on the implant surface. Surface analysis confirmed the presence of a thin, conformal protein layer on the metal surface. Titanium fixation screws were coated first with hydroxyapatite and then with a layer of collagen and were implanted into the femurs of New Zealand white rabbits and compared to various control surfaces. Measurements of the rotational torque removal force indicated that the collagen coating enhanced bone fixation and created a more reproducible well-anchored, stable implant than the traditional plasma-sprayed hydroxyapatite coatings. Nonthermal plasma processing offers a single step route to the biological functionalization of implantable surfaces. The process requires no polymers, primers, or linkers and offers an opportunity to control biocompatibility and to tailor local response to the implant in vivo. This opens the door to a wide variety of novel biological surface coatings across all aspects of life sciences and medicine.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67348933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2