International Medical Journal Malaysia最新文献_第8页

New Coumarinic Azo-Derivatives of Metoclopramide and Diphenhydramine: Synthesis and In Vitro Testing for Cholinesterase Inhibitory Effect and Protection Ability Against Chlorpyrifos 甲氧氯普胺和苯海拉明新香豆素偶氮衍生物的合成及其对毒死蜱胆碱酯酶抑制和保护作用的体外测试

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.486

Ahmed A. J. Mahmood, Yasser Fakri Mustafa, M. Abdulstaar

{"title":"New Coumarinic Azo-Derivatives of Metoclopramide and Diphenhydramine: Synthesis and In Vitro Testing for Cholinesterase Inhibitory Effect and Protection Ability Against Chlorpyrifos","authors":"Ahmed A. J. Mahmood, Yasser Fakri Mustafa, M. Abdulstaar","doi":"10.31436/IMJM.V13I1.486","DOIUrl":"https://doi.org/10.31436/IMJM.V13I1.486","url":null,"abstract":"ABSTRACT Introduction: This study aims to synthesize new coumarin azo compounds of metoclopramide and diphenhydramine and to evaluate their in vitro cholinesterase inhibitory effects and protection abilities against chlorpyrifos. Methods: Two series of azo coumarin compounds were synthesized. Series I compound resulted from the diazotization of metoclopramide and then coupling with coumarin and 4-methyl coumarin to give compounds 1 and 2 respectively. Series II compound resulted from the diazotization of 7-aminocoumarin and 7-amino 4-methyl coumarin and then coupling with diphenhydramine to give compounds 3 and 4 respectively. The new compounds were tested for their in vitro cholinesterase inhibitory effect and protection ability against chlorpyrifos using the modified Elman electrometric method. Results: Metoclopramide derivatives with coumarin show selectivity protection for ChE against chlorpyriphos inhibitory effect as protect BChE and increase the inhibition of the AChE, or the opposite. Conclusion: Diphenhydramine derivatives with coumarin show more protective ability for both BChE and AChE as one of them shows the maximum protection for all concentration. However, the other derivative shows different manner as the low concentrations act as metoclopramide derivatives while the high concentration act as first diphenhydramine derivative (protect both AChE and BChE). KEYWORDS: Coumarinic azo-derivatives, metoclopramide, diphenhydramine, cholinesterase, chlorpyrifos.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42746147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Is Assisted Reproductive Technique Shari'aa-compliant? A Case Study at a Fertility Centre in Malaysia 辅助生殖技术是否符合伊斯兰教法?马来西亚生育中心个案研究

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I2.473

Z. AhmadMurad, Zailin Shah Yusoff, Sulaiman Mansor, Ahmad Irfan Ih, L. Abdullah

{"title":"Is Assisted Reproductive Technique Shari'aa-compliant? A Case Study at a Fertility Centre in Malaysia","authors":"Z. AhmadMurad, Zailin Shah Yusoff, Sulaiman Mansor, Ahmad Irfan Ih, L. Abdullah","doi":"10.31436/IMJM.V13I2.473","DOIUrl":"https://doi.org/10.31436/IMJM.V13I2.473","url":null,"abstract":"To investigate the questions that Muslim patients, embryologists, paramedics, clinical counsellor and doctors may have pertaining to the compliance of Assisted Reproductive Technique (ART) to Shari’aa. Methods: As a preliminary study, an open-ended survey was administered to participants. Participants for the survey comprised of 21 patients, 2 embryologists, 2 doctors, 4 paramedics and 1 counsellor. Results: Data analysis showed that most of the participants posed questions that fall into six classifications which are: Munakahat (Family Law), social Hukm, Fiqh Ibadah, Fiqh Qadha (Islamic Hukm), General Fiqh and Usul Fiqh. Conclusion: It is clear that even though the participants were rather familiar with some of the existing Fatwas pertaining to ART and IVF in Malaysia, there are still remaining doubts which need to be clarified. This indicates that there are challenges faced in seeking and providing ART treatment to Muslim patients. This needs to be addressed perhaps in the form of Shari’aa-compliant guidelines to provide a clear explanation of each process and procedure in fertility treatment.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":"13 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45649572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilomatrixoma: A Diagnostic Pitfall on Fine-Needle Aspiration Cytology of Benign ‘Neck Metastases’ 毛基质瘤:细针穿刺细胞学诊断良性“颈部转移瘤”的一个缺陷

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I2.481

Z. A. Asha’ari, Muhd Izani Shiyuti, Kahairi Abdullah, Arfahiza Selimin, K. Sathananthar

引用次数: 0

A case report of pyomyoma: radiological diagnosis of a potentially fatal complication of uterine leiomyoma. 子宫肌瘤的病例报告：子宫肌瘤潜在致命并发症的放射学诊断。

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V7I2.787

Mubarak My, Noordini

引用次数: 3

Multiple Renal Arteries with an Ascending Upward Renal Vein of the Right Kidney: a Case Report 多肾动脉伴右肾上行肾静脉1例

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.493

S. Al-Shibli

{"title":"Multiple Renal Arteries with an Ascending Upward Renal Vein of the Right Kidney: a Case Report","authors":"S. Al-Shibli","doi":"10.31436/IMJM.V13I1.493","DOIUrl":"https://doi.org/10.31436/IMJM.V13I1.493","url":null,"abstract":"ABSTRACT As it is known; the majority of the human subjects has two renal arteries arising from the abdominal aorta; each will supply one kidney but in 30% of individuals, certain variations can be found. Accessory renal arteries constitute the most common and clinically important of these variations. For our case report, we are presenting one of these different variations that can be found in the blood supply of the kidneys. During dissecting the abdomen of an approximately 65 years-old male cadaver, multiple variations were found. There were double right renal arteries with prehilar branching of the upper renal artery. We found also that the right renal vein ascended upwards obliquely before ending in the lateral aspect of the inferior vena cava. Variation in the renal vessels is relatively common, especially multiple renal arteries, and can go smoothly without any abnormalities with the function of the kidney, but in some situations like renal transplantations, vascular reconstructions, and various surgical and radiological diagnostic techniques, the study of the anatomy of these variations is of crucial importance to decrease the patient morbidity during surgical procedures. KEYWORDS: Renal artery, renal vein, anatomical variation.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47375312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'I can't pray' - The spiritual needs of Malaysian Muslim patients suffering from depression “我不能祈祷”——马来西亚穆斯林抑郁症患者的精神需求

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V15I1.415

A. Mr, Saini Sm, Nasrin N, Bahari R, Sharip S

{"title":"'I can't pray' - The spiritual needs of Malaysian Muslim patients suffering from depression","authors":"A. Mr, Saini Sm, Nasrin N, Bahari R, Sharip S","doi":"10.31436/IMJM.V15I1.415","DOIUrl":"https://doi.org/10.31436/IMJM.V15I1.415","url":null,"abstract":"Introduction : The mainstay of treatment of depression relies on pharmacological and psychological treatments. On top of that, evidence also recognizes the vital role of spirituality for human wellness which leads to growing interest in its utilization to treat depression. However, research on spirituality among Muslims in relation to depression is relatively scarce. The aim of this study is to explore the understanding of spirituality among Muslim patients with depression, and to explore their spiritual needs. Methods : This is a qualitative study conducted on 10 depressed Muslim patients at the UKM Medical Centre. Purposive sampling was done to ensure diversity of subjects. Individual in-depth interviews were conducted using semi-structured questionnaire guidelines. The data were transcribed verbatim and analysed using a thematic approach. Result : Out of 10 patients, almost all of them expressed spiritual needs. Two major themes emerged in relation to the spiritual needs which are (i) religious needs; need for worship, religious knowledge and guidance, religious reminders, and (ii) existential needs; need for calmness, sensitivity and empathy, self-discipline, certainty, hope , physical help, ventilate and meaning of illness. These needs are essential for patients during the time of crisis. Conclusion: The majority of patients expressed spiritual needs which are required during the process of recovery and this provides an opportunity to incorporate spiritual approaches in the treatment of depression. However, more studies are needed to demonstrate its scientific basis and to design an effective psycho-spiritual treatment modality so that the ‘holistic’ or ‘bio-psychosocial-spiritual’ treatment can be integrated by health care professionals to those in need.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":"15 1","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49005988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Allergic Reaction Following Insertion of Vancomycin Loaded in Bone Cement 骨水泥中加入万古霉素后的过敏反应

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.494

K. L. Goh, N. M. Yusof, C. L. Ong

引用次数: 3

Electronic Cigarettes: Friend or Foe? 电子烟:是敌是友?

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V15I1.399

A. Mohamed

引用次数: 1

Knowledge and Attitude towards HIV/AIDS among transsexuals in Kuantan, Pahang 彭亨州关丹市变性人对爱滋病的知识与态度

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V15I1.406

S. D., Razman Mr, Ramli M, M. Ma, M. S., Muhamad Shaiful Lizam Ma, Muhammad Salman Mh, Mohamad Faqihuddin H

{"title":"Knowledge and Attitude towards HIV/AIDS among transsexuals in Kuantan, Pahang","authors":"S. D., Razman Mr, Ramli M, M. Ma, M. S., Muhamad Shaiful Lizam Ma, Muhammad Salman Mh, Mohamad Faqihuddin H","doi":"10.31436/IMJM.V15I1.406","DOIUrl":"https://doi.org/10.31436/IMJM.V15I1.406","url":null,"abstract":"Introduction: Lack of knowledge and negative attitude towards HIV/AIDS may be the risk factors for HIV infection among transsexuals. Research on knowledge and attitude towards HIV infection in transsexual communities is very limited at both local and international levels. This study aimed to assess the knowledge and attitude towards HIV infection among the male-to-female transsexual community in Kuantan, Pahang. Methods: A cross-sectional study was carried out from July to August 2014 among 33 male-to-female transsexuals in Kuantan, Pahang. Convenience sampling was used. Participants who gave consent answered a self-administered questionnaire. Data obtained was analyzed with descriptive statistics, χ2-test, and independent sample t test. Results: The majority of the subjects in this study were 29 years and below (48.5%), Muslims (93.9%), and had completed up to secondary education (60.6%). Most of them were sex workers (60.6%), and had relatively low income (no income to RM 3000, mean of RM1528). A total of 87.9% of the subjects demonstrated good knowledge and also positive attitude towards HIV/AIDS. Level of education was significantly associated with scores in knowledge (p=0.01). Conclusions: Despite the positive outcome from this study, misconceptions towards HIV/AIDS still exist among transsexuals. Education and interventions from multiple directions on HIV/AIDS are essential to deliver the correct information to this population, so as to emphasize prevention, early detection, and holistic medical care. Transsexuals also require attention from religious bodies and non-governmental organizations to help them in employment, financial, spiritual, and psycho-social issues.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":"15 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44376547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

C-kit proto-oncogene expression in uterine leiomyosarcomas: case series C-kit原癌基因在子宫平滑肌肉瘤中的表达：病例系列

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V7I2.784

V. Naik, J. Hasnan

{"title":"C-kit proto-oncogene expression in uterine leiomyosarcomas: case series","authors":"V. Naik, J. Hasnan","doi":"10.31436/IMJM.V7I2.784","DOIUrl":"https://doi.org/10.31436/IMJM.V7I2.784","url":null,"abstract":"ABSTRACT Introduction: The proto-oncogene c-kit is the cellular homologue of the oncogene v-kit of HZ4 feline sarcoma virus. It is located on chromosome 4 (4q11-12) in the human genome. Interaction between the c-kit receptor and its ligand, stem cell factor, is essential in the development of tissues. C-kit expression has been identified in a number of different neoplasms like seminoma/dysgerminoma, and gastrointestinal stromal tumors (GIST). Recently it has been reported that c-kit is also present in leiomyosarcomas. Tyrosine kinase inhibitors (TKIs) are a promising new therapy in the treatment of cancer. These agents target cellular proteins like kit and its related homologues decreasing cellular proliferation and survival. TKIs may be helpful in treating leiomyosarcomas expressing c-kit. Materials and Methods: In this study a total of 6 cases diagnosed as leiomyosarcomas at Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Malaysia, were investigated for reactivity for c-kit using immunohistochemical stain. Stain was considered positive if more than 10 percent of the cells showed membrane or cytoplasmic positivity. Results: Two leiomyosarcomas stained faintly with c-kit and in less than 10 percent of the cells. The other 4 cases showed no staining. The control showed good membrane and cytoplasmic positivity. Conclusion: Uterine leiomyosarcomas did not express c-kit. The reason for this could be that the tumors are inherently c-kit negative. More study using larger number of cases is required to validate these findings and further molecular characterization of these mesenchymal tumors is needed to identify the true nature of these sarcomas. KEYWORDS: Leiomyosarcoma, Uterus, C-kit protein, Immunohistochemistry.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41684739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1