International Medical Journal Malaysia最新文献_第8页

New Coumarinic Azo-Derivatives of Metoclopramide and Diphenhydramine: Synthesis and In Vitro Testing for Cholinesterase Inhibitory Effect and Protection Ability Against Chlorpyrifos 甲氧氯普胺和苯海拉明新香豆素偶氮衍生物的合成及其对毒死蜱胆碱酯酶抑制和保护作用的体外测试

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.486

Ahmed A. J. Mahmood, Yasser Fakri Mustafa, M. Abdulstaar

{"title":"New Coumarinic Azo-Derivatives of Metoclopramide and Diphenhydramine: Synthesis and In Vitro Testing for Cholinesterase Inhibitory Effect and Protection Ability Against Chlorpyrifos","authors":"Ahmed A. J. Mahmood, Yasser Fakri Mustafa, M. Abdulstaar","doi":"10.31436/IMJM.V13I1.486","DOIUrl":"https://doi.org/10.31436/IMJM.V13I1.486","url":null,"abstract":"ABSTRACT Introduction: This study aims to synthesize new coumarin azo compounds of metoclopramide and diphenhydramine and to evaluate their in vitro cholinesterase inhibitory effects and protection abilities against chlorpyrifos. Methods: Two series of azo coumarin compounds were synthesized. Series I compound resulted from the diazotization of metoclopramide and then coupling with coumarin and 4-methyl coumarin to give compounds 1 and 2 respectively. Series II compound resulted from the diazotization of 7-aminocoumarin and 7-amino 4-methyl coumarin and then coupling with diphenhydramine to give compounds 3 and 4 respectively. The new compounds were tested for their in vitro cholinesterase inhibitory effect and protection ability against chlorpyrifos using the modified Elman electrometric method. Results: Metoclopramide derivatives with coumarin show selectivity protection for ChE against chlorpyriphos inhibitory effect as protect BChE and increase the inhibition of the AChE, or the opposite. Conclusion: Diphenhydramine derivatives with coumarin show more protective ability for both BChE and AChE as one of them shows the maximum protection for all concentration. However, the other derivative shows different manner as the low concentrations act as metoclopramide derivatives while the high concentration act as first diphenhydramine derivative (protect both AChE and BChE). KEYWORDS: Coumarinic azo-derivatives, metoclopramide, diphenhydramine, cholinesterase, chlorpyrifos.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42746147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Is Assisted Reproductive Technique Shari'aa-compliant? A Case Study at a Fertility Centre in Malaysia 辅助生殖技术是否符合伊斯兰教法?马来西亚生育中心个案研究

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I2.473

Z. AhmadMurad, Zailin Shah Yusoff, Sulaiman Mansor, Ahmad Irfan Ih, L. Abdullah

{"title":"Is Assisted Reproductive Technique Shari'aa-compliant? A Case Study at a Fertility Centre in Malaysia","authors":"Z. AhmadMurad, Zailin Shah Yusoff, Sulaiman Mansor, Ahmad Irfan Ih, L. Abdullah","doi":"10.31436/IMJM.V13I2.473","DOIUrl":"https://doi.org/10.31436/IMJM.V13I2.473","url":null,"abstract":"To investigate the questions that Muslim patients, embryologists, paramedics, clinical counsellor and doctors may have pertaining to the compliance of Assisted Reproductive Technique (ART) to Shari’aa. Methods: As a preliminary study, an open-ended survey was administered to participants. Participants for the survey comprised of 21 patients, 2 embryologists, 2 doctors, 4 paramedics and 1 counsellor. Results: Data analysis showed that most of the participants posed questions that fall into six classifications which are: Munakahat (Family Law), social Hukm, Fiqh Ibadah, Fiqh Qadha (Islamic Hukm), General Fiqh and Usul Fiqh. Conclusion: It is clear that even though the participants were rather familiar with some of the existing Fatwas pertaining to ART and IVF in Malaysia, there are still remaining doubts which need to be clarified. This indicates that there are challenges faced in seeking and providing ART treatment to Muslim patients. This needs to be addressed perhaps in the form of Shari’aa-compliant guidelines to provide a clear explanation of each process and procedure in fertility treatment.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":"13 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45649572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilomatrixoma: A Diagnostic Pitfall on Fine-Needle Aspiration Cytology of Benign ‘Neck Metastases’ 毛基质瘤:细针穿刺细胞学诊断良性“颈部转移瘤”的一个缺陷

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I2.481

Z. A. Asha’ari, Muhd Izani Shiyuti, Kahairi Abdullah, Arfahiza Selimin, K. Sathananthar

引用次数: 0

A case report of pyomyoma: radiological diagnosis of a potentially fatal complication of uterine leiomyoma. 子宫肌瘤的病例报告：子宫肌瘤潜在致命并发症的放射学诊断。

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V7I2.787

Mubarak My, Noordini

引用次数: 3

Multiple Renal Arteries with an Ascending Upward Renal Vein of the Right Kidney: a Case Report 多肾动脉伴右肾上行肾静脉1例

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.493

S. Al-Shibli

{"title":"Multiple Renal Arteries with an Ascending Upward Renal Vein of the Right Kidney: a Case Report","authors":"S. Al-Shibli","doi":"10.31436/IMJM.V13I1.493","DOIUrl":"https://doi.org/10.31436/IMJM.V13I1.493","url":null,"abstract":"ABSTRACT As it is known; the majority of the human subjects has two renal arteries arising from the abdominal aorta; each will supply one kidney but in 30% of individuals, certain variations can be found. Accessory renal arteries constitute the most common and clinically important of these variations. For our case report, we are presenting one of these different variations that can be found in the blood supply of the kidneys. During dissecting the abdomen of an approximately 65 years-old male cadaver, multiple variations were found. There were double right renal arteries with prehilar branching of the upper renal artery. We found also that the right renal vein ascended upwards obliquely before ending in the lateral aspect of the inferior vena cava. Variation in the renal vessels is relatively common, especially multiple renal arteries, and can go smoothly without any abnormalities with the function of the kidney, but in some situations like renal transplantations, vascular reconstructions, and various surgical and radiological diagnostic techniques, the study of the anatomy of these variations is of crucial importance to decrease the patient morbidity during surgical procedures. KEYWORDS: Renal artery, renal vein, anatomical variation.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47375312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'I can't pray' - The spiritual needs of Malaysian Muslim patients suffering from depression “我不能祈祷”——马来西亚穆斯林抑郁症患者的精神需求

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V15I1.415

A. Mr, Saini Sm, Nasrin N, Bahari R, Sharip S

{"title":"'I can't pray' - The spiritual needs of Malaysian Muslim patients suffering from depression","authors":"A. Mr, Saini Sm, Nasrin N, Bahari R, Sharip S","doi":"10.31436/IMJM.V15I1.415","DOIUrl":"https://doi.org/10.31436/IMJM.V15I1.415","url":null,"abstract":"Introduction : The mainstay of treatment of depression relies on pharmacological and psychological treatments. On top of that, evidence also recognizes the vital role of spirituality for human wellness which leads to growing interest in its utilization to treat depression. However, research on spirituality among Muslims in relation to depression is relatively scarce. The aim of this study is to explore the understanding of spirituality among Muslim patients with depression, and to explore their spiritual needs. Methods : This is a qualitative study conducted on 10 depressed Muslim patients at the UKM Medical Centre. Purposive sampling was done to ensure diversity of subjects. Individual in-depth interviews were conducted using semi-structured questionnaire guidelines. The data were transcribed verbatim and analysed using a thematic approach. Result : Out of 10 patients, almost all of them expressed spiritual needs. Two major themes emerged in relation to the spiritual needs which are (i) religious needs; need for worship, religious knowledge and guidance, religious reminders, and (ii) existential needs; need for calmness, sensitivity and empathy, self-discipline, certainty, hope , physical help, ventilate and meaning of illness. These needs are essential for patients during the time of crisis. Conclusion: The majority of patients expressed spiritual needs which are required during the process of recovery and this provides an opportunity to incorporate spiritual approaches in the treatment of depression. However, more studies are needed to demonstrate its scientific basis and to design an effective psycho-spiritual treatment modality so that the ‘holistic’ or ‘bio-psychosocial-spiritual’ treatment can be integrated by health care professionals to those in need.","PeriodicalId":53575,"journal":{"name":"International Medical Journal Malaysia","volume":"15 1","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49005988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Allergic Reaction Following Insertion of Vancomycin Loaded in Bone Cement 骨水泥中加入万古霉素后的过敏反应

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.494

K. L. Goh, N. M. Yusof, C. L. Ong

引用次数: 3

Electronic Cigarettes: Friend or Foe? 电子烟:是敌是友?

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V15I1.399

A. Mohamed

引用次数: 1

Prediction model for peak expiratory flow among children in Kocaeli, Turkey 土耳其Kocaeli儿童呼气流量峰值预测模型

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V7I2.782

Z. Gundogdu, O. Gundogdu

引用次数: 1

A case of eosinophilic granulomatosis with polyangiitis (churg-strauss, EGPA) presenting with relapsed mononeuritis multiplex 嗜酸性肉芽肿病合并多血管炎(churg-strauss, EGPA) 1例，表现为复发性多发性单神经炎

International Medical Journal Malaysia Pub Date : 2020-11-09 DOI: 10.31436/IMJM.V13I1.496

Hilmi Abdullah, M. Ainon

引用次数: 0