eJournal of Oral Maxillofacial Research最新文献

{"title":"Late Oral Complications Caused by Head and Neck Radiotherapy: Clinical and Laboratory Study.","authors":"Adriane C Martinez,&nbsp;Isabela M V Silva,&nbsp;Soraya A Berti Couto,&nbsp;Rinaldo F Gandra,&nbsp;Edvaldo A R Rosa,&nbsp;Aline C B R Johann,&nbsp;Paulo H Couto Souza","doi":"10.5037/jomr.2020.11303","DOIUrl":"https://doi.org/10.5037/jomr.2020.11303","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of presented cross-sectional and observational study was to determine the prevalence of late oral complications of patients with head and neck cancer who underwent radiotherapy, by clinical and laboratory analyses.</p><p><strong>Material and methods: </strong>Fifty-five patients, 43 (78.2%) men and 12 (21.8%) women, mean age 60; range 38 to 87 years, who have completed radiotherapy for head and neck cancer for at least 6 months were enrolled. The presence of xerostomia, hyposalivation, oral candidiasis, and type of oral yeasts were correlated with post-radiotherapy period. A control group, age and gender matched, was used for comparisons. The Pearson's Chi-square or Fischer's exact test was used at a significance level of 5%.</p><p><strong>Results: </strong>The mean post-radiotherapy period was 32 months. The oral complications found were xerostomia (45/55, [81.8%]), hyposalivation (44/55 [80%]) and oral candidiasis (15/55 [27.2%]). Xerostomia and hyposalivation was statistically higher in the study group when compared to the control group (P < 0.05). The presence of yeast occurred in 39 (70.9%) of the patients in the study group, and <i>Candida albicans</i> was the most prevalent etiological agent in 25 (64.1%) of those patients (P < 0.05).</p><p><strong>Conclusions: </strong>Xerostomia and hyposalivation were the more prevalent late oral complications related to radiotherapy. Oral candidiasis was also observed, although its prevalence was lower. The need for long-term dental follow-up of patients who underwent radiotherapy of the head and neck cancer is mandatory.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 3","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/44/jomr-11-e3.PMC7644270.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38665993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harvesting of Autogenous Bone Graft from the Ascending Mandibular Ramus Compared with the Chin Region: a Systematic Review and Meta-Analysis Focusing on Complications and Donor Site Morbidity.","authors":"Thomas Starch-Jensen,&nbsp;Daniel Deluiz,&nbsp;Sagar Deb,&nbsp;Niels Henrik Bruun,&nbsp;Eduardo Muniz Barretto Tinoco","doi":"10.5037/jomr.2020.11301","DOIUrl":"https://doi.org/10.5037/jomr.2020.11301","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this systematic review was to test the hypothesis of no difference in complications and donor site morbidity following harvesting of autogenous bone graft from the ascending mandibular ramus compared with the chin region.</p><p><strong>Material and methods: </strong>MEDLINE (PubMed), Embase and Cochrane Library search in combination with a hand-search of relevant journals was conducted including human studies published in English through June 26, 2020. Randomized and controlled trials were included. Outcome measures included pain, infection, mucosal dehiscence, altered sensation or vitality of adjacent tooth/teeth, neurosensory disturbances and patient-reported outcome measures. Risk of bias was assessed by Cochrane risk of bias tool and Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Ten controlled trials of high-quality fulfilled inclusion criteria. Risk of infection and mucosal dehiscence seems to be comparable with the two treatment modalities. However, harvesting from the chin seems to be associated with increased risk of pain, altered sensation or loss of tooth vitality, and neurosensory disturbances. Willingness to undergo the same treatment again was reported with both treatment modalities, but significant higher satisfaction, lower discomfort and acceptance of the surgical procedure was reported following harvesting from the ascending mandibular ramus.</p><p><strong>Conclusions: </strong>The hypothesis was rejected due to higher prevalence and severity of complications and donor site morbidity following harvesting of autogenous bone graft from the chin region. Dissimilar evaluation methods and various methodological confounding factors posed serious restrictions for literature review in a quantitative systematic manner. Conclusions drawn from results of this systematic review should therefore be interpreted with caution.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 3","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/52/jomr-11-e1.PMC7644273.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38665989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary Sinus Floor Augmentation with Autogenous Bone Graft Alone Compared with Alternate Grafting Materials: a Systematic Review and Meta-Analysis Focusing on Histomorphometric Outcome.","authors":"Thomas Starch-Jensen,&nbsp;Daniel Deluiz,&nbsp;Niels Henrik Bruun,&nbsp;Eduardo Muniz Barretto Tinoco","doi":"10.5037/jomr.2020.11302","DOIUrl":"https://doi.org/10.5037/jomr.2020.11302","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of present systematic review was to test the hypothesis of no difference in histomorphometric outcome after maxillary sinus floor augmentation with autogenous bone graft alone compared with alternate grafting materials applying the lateral window technique.</p><p><strong>Material and methods: </strong>MEDLINE (PubMed), Embase and Cochrane library search in combination with hand-search of relevant journals were conducted. Human studies published in English until the 25^th of March, 2020 were included. Histomorphometric outcomes were evaluated by descriptive statistics and meta-analysis including 95% confidence interval (CI).</p><p><strong>Results: </strong>Electronic search and hand-searching resulted in 1902 entries. Sixteen randomized controlled trials with unclear risk of bias fulfilled the inclusion criteria. Descriptive statistics showed comparable or improved histomorphometric outcomes with autogenous bone graft. Meta-analysis revealed a mean difference of -7.1% (CI = -11.0 to -3.2) indicating a significant higher amount of bone after maxillary sinus floor augmentation with autogenous bone graft compared with alternate grafting materials. Subgroup analysis demonstrated a non-significantly differences of -3.7% (CI = -10.9 to 3.4), -11.5% (CI = -25.9 to 2.8), 2.2% (CI = -16.9 to 21.3), and -4.6% (CI = -14.4 to 5.2), when autogenous bone graft was compared with allogeneic bone graft, xenograft, composite grafting materials involving xenograft or synthetic biomaterial mixed with autogenous bone graft, respectively.</p><p><strong>Conclusions: </strong>Maxillary sinus floor augmentation with autogenous bone graft seems to facilitate improved histomorphometric outcomes compared with alternate grafting materials. However, the included studies were characterised by an unclear risk of bias and various methodological confounding factors. Hence, the conclusions drawn from the results of present study should be interpreted with caution.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 3","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/c4/jomr-11-e2.PMC7644272.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38665990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of Dental Treatment among Paediatric Oncological Patients: a Case Report.","authors":"Egle Aida Bendoraitiene,&nbsp;Vilija Andruskeviciene,&nbsp;Gabriele Kscenaviciute,&nbsp;Evelina Srebaliene,&nbsp;Ieva Maciulaityte","doi":"10.5037/jomr.2020.11305","DOIUrl":"https://doi.org/10.5037/jomr.2020.11305","url":null,"abstract":"<p><strong>Objectives: </strong>According to the National Cancer Institute of Lithuania, cancer is diagnosed for almost 100 children each year. Oncological patients suffer from complications during and after treatment. Radiation therapy also affects dental hard tissues. Many oncological patients lose motivation to take care of their oral hygiene because they are focused on cancer diagnosis. This case report discusses prevention and dental treatment severity after radiation therapy treatment.</p><p><strong>Material and methods: </strong>A 9-year-old boy with cancer diagnosis visited a dentist in 2017. The patient was complaining about poor aesthetic quality of the teeth, but there were no complaints about teeth sensitivity or pain. Different stages of active caries, poor oral hygiene, visible abundant plaque, swollen, red and bleeding gums were observed during appointment. A motivational interview explaining the importance of oral hygiene was conducted. Non-surgical caries treatment was prescribed during the first visit. Restorative treatment was performed after 1 month.</p><p><strong>Results: </strong>The motivational interview explaining the importance of oral hygiene was conducted during every appointment per 3-year period. Unfortunately, oral hygiene is still poor due to the lack of motivation. Active-cavitated caries lesions were restored with glass ionomer cement and composite resin. The aesthetics of teeth was improved.</p><p><strong>Conclusions: </strong>Oncological and recovered patients after radiation therapy should be assigned to a high risk of caries. These patients should be treated individually by the algorithm. Psychological or psychotherapeutic assistance is necessary for patients due to motivation for treatment and oral care.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 3","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/52/jomr-11-e5.PMC7644269.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38666440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Collagen Membranes Coated with Testosterone and Alendronate to Improve Guided Bone Regeneration in Mandibular Bone Defects in Minipigs.","authors":"Bart A J A van Oirschot,&nbsp;John A Jansen,&nbsp;Cindy J J M van de Ven,&nbsp;Edwin J W Geven,&nbsp;Jan A Gossen","doi":"10.5037/jomr.2020.11304","DOIUrl":"https://doi.org/10.5037/jomr.2020.11304","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of the present <i>in vivo</i> study was to evaluate whether pericard collagen membranes coated with ancillary amounts of testosterone and alendronate in a poly-lactic glycolic acid (PLGA) carrier as compared to uncoated membranes will improve early bone regeneration.</p><p><strong>Material and methods: </strong>In each of 16 minipigs, four standardized mandibular intraosseous defects were made bilaterally. The defects were filled with Bio-Oss^® granules and covered with a non-coated or coated membrane. Membranes were spray-coated with 4 layers of PLGA containing testosterone and alendronate resulting in 20, 50 or 125 μg/cm² of testosterone and 20 µg/cm² alendronate (F20, F50, F125). Non-coated membranes served as controls (F0). Animals were sacrificed at 6 and 12 weeks after treatment. Qualitative and quantitative histological evaluations of bone regeneration were performed. Differences between groups were assessed by paired Student's t-test.</p><p><strong>Results: </strong>Light microscopical analysis showed new bone formation that was in close contact with the Bio-Oss^® surface without an intervening non-mineralized tissue layer. Histomorphometric analysis of newly formed bone showed a significant 20% increase in area in the F125 coated membrane treated defects (40 [SD 10]%) compared to the F0 treated defects after 6 weeks (33 [SD 10]%, P = 0.013). At week 12, the total percentage of new bone was increased compared to week 6, but no increase in newly formed bone compared to F0 was observed.</p><p><strong>Conclusions: </strong>The data from this <i>in vivo</i> study indicate that F125 collagen membranes coated with testosterone and alendronate resulted in superior bone formation (+24%) when normalized to control sites using uncoated membranes.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 3","pages":"e4"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/6b/jomr-11-e4.PMC7644271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38663408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reliability and Influence of Body Position on Acoustic Pharyngometry and Rhinometry Outcomes.","authors":"Sofie Wilkens Knappe,&nbsp;Liselotte Sonnesen","doi":"10.5037/jomr.2020.11401","DOIUrl":"https://doi.org/10.5037/jomr.2020.11401","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this cross sectional study was to analyze the method error and reliability in acoustic pharyngometry and rhinometry and to analyze the difference between standing and sitting position in acoustic pharyngometry and rhinometry.</p><p><strong>Material and methods: </strong>The sample comprised 38 healthy subjects (11 men and 27 women) as part of a control group in another study. The subjects underwent repeated measures of acoustic pharyngometry and rhinometry in standing and sitting position. Upper airway dimensions in terms of volume, minimum cross-sectional areas (MCA) and distances were evaluated using the Eccovision^® Acoustic Pharyngometer and Rhinometer. Method error and reliability were analyzed using paired t-test, Dahlberg's formula and the Houston reliability coefficient, and differences between body positions were analyzed using paired t-test.</p><p><strong>Results: </strong>There was no systematic error in the repeated measures except for the distance to MCA in the left nostril in sitting position (P = 0.041). The method error for the pharyngometry ranged between 0.001 to 0.164 cm/cm²/cm³ and the reliabity was 0.99. The method error for rhinometry ranged between 0.001 to 0.37 cm/cm²/cm³ and the reliability between 0.99 to 1. Difference between standing and sitting position was found only in the pharyngeal airway in terms of volume (P = 0.025) and mean area (P = 0.009) with smaller airway in sitting position.</p><p><strong>Conclusions: </strong>The results indicate that acoustic pharyngometry and rhinometry are reliable methods to perform repeated measures of the upper airway dimensions especially in the standing mirror position. It may be essential to perform the measures with the patient positioned in the same body position each time.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 4","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/1b/jomr-11-e1.PMC7875104.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10639780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Implant Placement in Non-Infected Sockets versus Infected Sockets: a Systematic Review and Meta-Analysis.","authors":"Aza Saijeva,&nbsp;Gintaras Juodzbalys","doi":"10.5037/jomr.2020.11201","DOIUrl":"https://doi.org/10.5037/jomr.2020.11201","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this systematic review is to compare immediate implant placement in infected extraction sockets with non-infected extraction sockets in terms of implant survival and function.</p><p><strong>Material and methods: </strong>An electronic search was conducted in PubMed, ScienceDirect, ISI Web of Knowledge and Google Scholar between January 2010 and February 2020. Studies evaluating implant survival rate and main clinical parameters were included for a qualitative and quantitative analysis.</p><p><strong>Results: </strong>In total, nine studies were included and a pool of 2281 sockets were analysed. Compared with the non-infected group, the infected group showed no significant differences in implant survival rates (risk ratio [RR] = 0.99; 95% confidence interval [CI] = 0.98 to 1; P = 0.08). No significant statistical differences were found in marginal bone level (mean difference [MD] = -0.03; 95% CI = -0.1 to 0.04; P = 0.41), marginal gingival level (MD = -0.07; 95% CI = -0.17 to 0.04; P = 0.23), probing depth (MD = 0.06; 95% CI = -0.24 to 0.36; P = 0.7), modified bleeding index (MD = -0.00162196; 95% CI = -0.09 to 0.09; P = 0.97) and slight but significant changes were seen in width of keratinized gingiva (MD = 0.25; 95% CI = -0.3 to 0.8; P = 0.38) between the groups at the latest follow-up.</p><p><strong>Conclusions: </strong>There were no significant difference in implant survival rates, marginal bone level, marginal gingival level, modified bleeding index and probing depth between infected sockets and non-infected sockets. However, slight but significant changes were seen in width of keratinized gingiva favouring the non-infected group.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 2","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/6a/jomr-11-e1.PMC7393932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38244613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Soprolife^® in Detecting <i>in Vitro</i> Remineralization of Early Caries Lesions.","authors":"Mona Zeitouny,&nbsp;Frédéric Cuisinier,&nbsp;Hervé Tassery,&nbsp;Hussein Fayyad-Kazan","doi":"10.5037/jomr.2020.11206","DOIUrl":"https://doi.org/10.5037/jomr.2020.11206","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized controlled <i>in vitro</i> 4-arm trial study aimed to evaluate the efficacy of SoproLife^® in detecting and quantifying <i>in vitro</i> remineralization with early caries lesions.</p><p><strong>Material and methods: </strong>Sixty human teeth were randomly assigned into four equal groups. Groups 1 and 2 were prophylactically cleaned; groups 3 and 4 were not. Group 1 received treatment with MI Varnish^® and Recaldent™ for 30 days. Group 2 was treated similarly, but without MI Varnish^®. Group 3 was treated as 1 and Group 4 as 2. Mineral composition was obtained using scanning electron microscopy with energy dispersive X-ray analysis SoproLife^® camera images on the occlusal surfaces were analysed for grey value distribution and difference in mean intensity values (DI). Paired t-test and Mann-Whitney-U test were used for intragroup comparison between baseline and T1. Kruskal-Wallis followed by Mann-Whitney-U tests were used for inter-group comparisons at T1.</p><p><strong>Results: </strong>All groups exhibited a significant increase in calcium content and calcium-to-phosphorus ratio (P < 0.05), except Group 4 (Group 1 showed the greatest increase, then Groups 3 and 2). Grey intensity values decreased in all groups (P < 0.05). Group 1 showed the greatest change in DI (16.82 [SD 12.07]), followed by Group 3 (12.46 [SD 9.41]), 2 (10.45 [SD 7.76]), and 4 (6.46 [SD 6.21]). The difference in DI was different between the compared groups (P = 0.038); Groups 1 and 3 exhibited a greater DI compared with 4 (P < 0.01).</p><p><strong>Conclusions: </strong>Within the limitations of this study, SoproLife^® is effective for early detection and for longitudinally monitoring the remineralization after Recaldent™ therapy.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 2","pages":"e6"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/9a/jomr-11-e6.PMC7393931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38243624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Surface Modification Treatment for Porous Titanium.","authors":"Reiko Kobatake, Kazuya Doi, Yoshifumi Oki, Yusuke Makihara, Hanako Umehara, Takayasu Kubo, Kazuhiro Tsuga","doi":"10.5037/jomr.2020.11205","DOIUrl":"10.5037/jomr.2020.11205","url":null,"abstract":"<p><strong>Objectives: </strong>This study was to investigate suitable surface treatment methods for porous titanium by <i>ex vivo</i> study of material properties and calcium phosphate deposition in simulated body fluid.</p><p><strong>Material and methods: </strong>Porous titanium with acid (H₂SO₄ and HCl mixed acid) or alkali (NaOH) treatment was prepared. The surfaces were observed, and the weight change ratio (after and before surface treatment) and compression strength were measured. To investigate the apatite formation ability, each sample was immersed in simulated body fluid (SBF). Surface observations were performed, and the weight change ratio (before/after immersing SBF) and calcification (by alizarin red staining) were measured.</p><p><strong>Results: </strong>The acid group showed a martensitic micro-scale rough structure and the weight and mechanical strength greatly decreased compared to the other groups. The alkali group exhibited a nano-scale roughness structure with similar weight and mechanical strength. Following immersion in SBF, an apatite-like crystal layer in the alkali group was observed. The weight of all samples increased. The change in weight of the samples in the alkali, acid, and control groups were significantly different, showing the following trend: alkali group (1.6%) > acid group (1.2%) > control group (0.8%). Calcium precipitation values were higher in the samples from alkali group than in those from the acid and control groups.</p><p><strong>Conclusions: </strong>Alkali treatment was found to be a suitable surface modification method for porous titanium, resulting in good mechanical strength and apatite formation ability in simulated body fluid.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 2","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/ef/jomr-11-e5.PMC7393927.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38243621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Botulinum Toxin A in the Management of Trigeminal Neuralgia: a Systematic Literature Review.","authors":"Anton Rubis, Gintaras Juodzbalys","doi":"10.5037/jomr.2020.11202","DOIUrl":"10.5037/jomr.2020.11202","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this article is to systematically review the use, efficacy, differences between botulinum toxin type A doses and side effects of botulinum toxin type A therapy in patients with trigeminal neuralgia.</p><p><strong>Material and methods: </strong>The search for the performed reviews was done in PubMed and Cochrane library in English language from January 2010 up to February 2020. Inclusion criteria: full-text studies in English language, in which visual assessment scale (VAS) was present, in which patients with trigeminal neuralgia (TN) were participated and the comparison between botulinum toxin type A (BT-A) and saline was done.</p><p><strong>Results: </strong>The review included 4 randomized, double-blind, placebo-controlled trials with 8 to 12 weeks follow-up to observe changes in VAS and in frequency of TN attacks, differences between dosages of BT-A in therapy and side effects. Mean VAS of BT-A group decreased by approximately 68% and of palcebo group decreased by approximately 21.6% after the therapy. Mean frequency of TN attacks in 3 studies of BT-A group decreased by 85%, while in palcebo by only 15.9%.</p><p><strong>Conclusions: </strong>Botulinum toxin type A injection therapy is a safe and effective method in management of trigeminal neuralgia. No differences between dosages of botulinum toxin type A were found. Maximum efficacy was noticed between 6 weeks and 3 months after the procedure. Side effects were mostly facial asymmetry after injection, headaches, haematoma, which disappeared in one week.</p>","PeriodicalId":53254,"journal":{"name":"eJournal of Oral Maxillofacial Research","volume":"11 2","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/ba/jomr-11-e2.PMC7393930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38244615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}