Jiwon Lee, Kaylyssa Philip, Duminda N Wijeysundera, Hance Clarke, Cheryl Pritlove, Joel Katz, Paul Ritvo, Akash Goel, Muhammad Ishrat Husain, Karim S Ladha
{"title":"Prospective Preference Assessment for the Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN (PEACE-PAIN) Trial.","authors":"Jiwon Lee, Kaylyssa Philip, Duminda N Wijeysundera, Hance Clarke, Cheryl Pritlove, Joel Katz, Paul Ritvo, Akash Goel, Muhammad Ishrat Husain, Karim S Ladha","doi":"10.1080/24740527.2024.2406285","DOIUrl":"https://doi.org/10.1080/24740527.2024.2406285","url":null,"abstract":"<p><strong>Background: </strong>Negative perceptions of psilocybin and challenges of participant enrollment may represent barriers to conducting a randomized controlled trial examining psilocybin for chronic neuropathic pain.</p><p><strong>Aim: </strong>Prior to trial initiation, we aimed to examine patient attitudes toward the trial via a prospective preference assessment.</p><p><strong>Methods: </strong>Twenty-six patients with chronic neuropathic pain participated in a prospective preference assessment comprising quantitative (survey) and qualitative (interview) components. Content analysis was used to inductively and deductively identify factors that would motivate or discourage participation in the proposed trial. Demographics, clinical characteristics, and perceptions of psilocybin were collected to explore differences in characteristics between patients who were willing and unwilling to participate.</p><p><strong>Results: </strong>Survey results showed that most participants (76.9%) were willing to participate in the PEACE-PAIN trial. \"Willing\" participants reported higher prior psychedelic use (75%) as compared to the \"maybe willing\" (0%) and \"not willing\" participants (0%). Interviews indicated that the top two factors that motivated participation included the need for new treatment options (31.7%) and benefits to personal pain management (31.7%). The top two discouraging factors included practical difficulties of research participation (16.7%), and adverse events associated with psilocybin (16.7%).</p><p><strong>Conclusions: </strong>The PEACE-PAIN trial study design is supported by patient survey responses but may benefit from modifications, namely incorporating thorough discussions of the current evidence for efficacy, safety, tolerability, and approaches to address adverse effects of psilocybin. Additionally, the interest in participation by individuals with prior psychedelic use holds important methodological implications for the inclusion/exclusion criteria of the trial.</p>","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2406285"},"PeriodicalIF":2.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angela Mailis, Amna Rafiq, Amol Deshpande, S Fatima Lakha
{"title":"Assessing Quality of Referrals to a Community-Based Chronic Pain Clinic.","authors":"Angela Mailis, Amna Rafiq, Amol Deshpande, S Fatima Lakha","doi":"10.1080/24740527.2024.2402700","DOIUrl":"https://doi.org/10.1080/24740527.2024.2402700","url":null,"abstract":"<p><strong>Introduction: </strong>Because patients with chronic pain are complex, with significant medical and psychiatric comorbidities, referrals to specialty pain clinics are often necessary. The present study explores the quality of information submitted and the profile of referring physicians associated with rejected patient referrals by a community pain clinic.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted on a series of consecutive new patient referrals rejected by a noninterventional community pain clinic (November 2021-June 2022). Data were collected on the reasons for rejected referrals and physicians responsible for these referrals using the public database of the College of Physicians and Surgeons of Ontario.</p><p><strong>Results: </strong>During the study period, 120 new referrals made by 99 physicians (88% primary care providers, or PCPs; male : female ratio 1:1.2; 53% Canadian university graduates) were rejected because of inadequate information (62%) or because they were inappropriate (38%). Only 46% of the rejected referrals were resubmitted within a median of 7 days (range 0-96 days) and accepted. Half of the non-resubmitted referrals could have been accepted if the referring provider had sent in the missing information.</p><p><strong>Conclusion: </strong>A significant number of referrals to our pain clinic (primarily from PCPs) are rejected for mainly avoidable reasons. The process of rejected referrals and resubmissions requires 92 to 126 h of additional staff time/year. Without additional health care resources, our study highlights simple but effective improvements in the referral process that could facilitate patient care, avoid unnecessary delays, and decrease possible sources of patient complaints.</p>","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2402700"},"PeriodicalIF":2.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula A Forgeron, Jennifer Stinson, Kathryn Birnie, G Allen Finley, Abbie Jordan, Pamela Qualter, Ligyana Candido, Michelle Lamont, Cassidy Bradley, Delane Linkiewich, Trinity Lowthian, Samuel McNally, Natasha Trehan, Bruce Dick
{"title":"The Influence of Loneliness on Pain Outcomes for Adolescents: A Cross-Sectional Survey.","authors":"Paula A Forgeron, Jennifer Stinson, Kathryn Birnie, G Allen Finley, Abbie Jordan, Pamela Qualter, Ligyana Candido, Michelle Lamont, Cassidy Bradley, Delane Linkiewich, Trinity Lowthian, Samuel McNally, Natasha Trehan, Bruce Dick","doi":"10.1080/24740527.2024.2404615","DOIUrl":"https://doi.org/10.1080/24740527.2024.2404615","url":null,"abstract":"<p><strong>Background: </strong>Loneliness, the perception that one's social relationships do not meet the desire for social connection, is a risk factor for poor mental and physical health. Adolescents with chronic pain experience higher rates of peer loneliness which persists over time. Previous studies used a single loneliness measure, limiting our understanding of the nature of their loneliness. This study describes the types of peer loneliness (intimate, relational, and collective) experienced by these adolescents and the impact that peer loneliness has on pain-related outcomes.</p><p><strong>Methods: </strong>A cross-sectional online survey was completed by 128 Canadian adolescents aged 12-18 years who experienced pain for at least 3 months. Validated measures captured demographics, pain-related characteristics, types of peer-related loneliness, measures of social well-being, and mental and physical health outcomes.</p><p><strong>Results: </strong>Friedman's tests of z-scores indicate that participants equally experienced dyadic, relational, and collective peer loneliness. MANCOVA revealed that those who identify as Black were lonelier after controlling for socioeconomic status. Multiple regression showed that loneliness was a robust predicter of worse scores on social well-being and mental health outcomes with males and females equally impacted by loneliness. Despite moderate correlations between loneliness and pain interference and pain intensity, loneliness did not predict school absences, suggesting that loneliness' influence on physical pain outcomes may be temporally earlier (e.g. contribute to pain chronification).</p><p><strong>Conclusions: </strong>Peer loneliness among adolescents with chronic pain negatively impacts their social well-being and mental health outcomes. Interventions addressing loneliness to target all three types of peer loneliness may be key to improving pain-related outcomes.</p>","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2404615"},"PeriodicalIF":2.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Enhancing Chronic Pain Management: Exploring the Essential Contribution of Primary Care Nurses].","authors":"Andréanne Bernier, Marie-Eve Poitras, Anaïs Lacasse","doi":"10.1080/24740527.2024.2394207","DOIUrl":"https://doi.org/10.1080/24740527.2024.2394207","url":null,"abstract":"","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2394207"},"PeriodicalIF":2.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nida Mustafa, Shreeyaa Ramana, Margaret MacNeill, Judy Watt-Watson, Gillian Einstein
{"title":"Chronic pain experiences of immigrant Indian women in Canada: A photovoice exploration.","authors":"Nida Mustafa, Shreeyaa Ramana, Margaret MacNeill, Judy Watt-Watson, Gillian Einstein","doi":"10.1080/24740527.2024.2390355","DOIUrl":"https://doi.org/10.1080/24740527.2024.2390355","url":null,"abstract":"<p><strong>Background: </strong>Over the past two decades, the prevalence of chronic pain has significantly increased globally, with approximately 20% of the world's population living with pain. Although quantitative measures are useful in identifying pain prevalence and severity, qualitative methods, and especially arts-based ones, are now receiving attention as a valuable means to understand lived experiences of pain. Photovoice is one such method that utilizes individuals' own photography to document their lived experiences.</p><p><strong>Aims: </strong>The current study utilized an arts-based method to explore immigrant Indian women's chronic pain experiences in Canada and aimed to enhance the understanding of those experiences by creating a visual opportunity for them to share their stories.</p><p><strong>Methods: </strong>Twelve immigrant Indian women captured photographs and participated in one-on-one interviews exploring daily experiences of chronic pain.</p><p><strong>Results: </strong>Women's photographs, and description of these photographs, provided a visual entry into their lives and pain experiences. Three themes emerged from our analysis: (1) bodies in pain, (2) traversing spaces including immigration, and (3) pain management methods. Findings revealed that women's representations of pain were shaped by a clash between culturally shaped gender role expectations and changing gender norms due to immigration processes. The use of photovoice visually contextualized and represented pain experiences, proving to be a valuable tool for self-reflection.</p><p><strong>Conclusions: </strong>This research uncovers the multifaceted nature of chronic pain and identifies the influence of immigration, gender, and social relations on the exacerbation of pain in immigrant Indian women.</p>","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 2","pages":"2390355"},"PeriodicalIF":2.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Randomized controlled trial investigating the effectiveness of a multimodal mobile application for the treatment of chronic pain.","authors":"Cynthia J Thomson, Hanna Pahl, Luisa V Giles","doi":"10.1080/24740527.2024.2352399","DOIUrl":"10.1080/24740527.2024.2352399","url":null,"abstract":"<p><strong>Background: </strong>Until recently, treatments for chronic pain commonly relied on in-person interventions, and despite more hybrid care options today, capacity for delivery remains challenged. Digital programs focusing on the psychosocial aspects of pain may provide low-barrier alternatives.</p><p><strong>Aims: </strong>Through a randomized controlled trial, we investigated the effectiveness of a multimodal mobile application.</p><p><strong>Methods: </strong>Participants (<i>n = </i>198; 82% women, mean age = 46.7 [13.1] years; mean pain duration 13.6 [11.2] years) with nonmalignant chronic pain were randomized to either a 6-week intervention (<i>n</i> = 98) or a wait-listed usual care group (<i>n</i> = 100). The intervention involved regular engagement with a user-guided mobile application (Curable Inc.) informed by the biopsychosocial model of pain that included pain education, meditation, cognitive behavioral therapy, and expressive writing. The co-primary outcomes were pain severity and interference at 6 weeks.</p><p><strong>Results: </strong>We observed significant improvements in the intervention group compared to the control group with estimated changes of -0.67 (95% confidence interval [CI] -1.04 to -0.29, <i>P</i> < .001, <i>d</i> = 0.43) and -0.60 (95% CI -1.18 to -0.03, <i>P</i> = .04, <i>d</i> = 0.27) for pain severity and interference, respectively. There were significant improvements across secondary outcomes (Patient-Reported Outcome Measurement Information System pain interference; pain catastrophizing; anxiety, depression; stress). Frequency of app use was correlated with improved pain interference (<i>P</i> < .001) and pain catastrophizing <i>(P</i> = 0.018), and changes from baseline persisted in the intervention group at 12 weeks (<i>P</i> < .05).</p><p><strong>Conclusions: </strong>A short-term mobile app intervention resulted in significant improvements across physical and mental health outcomes compared to wait-listed usual care.</p>","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2352399"},"PeriodicalIF":2.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mission Critical, a Call to Action for Implementation of the Recommendations of the Canadian Pain Task Force.","authors":"Mary Lynch","doi":"10.1080/24740527.2024.2346253","DOIUrl":"10.1080/24740527.2024.2346253","url":null,"abstract":"","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2346253"},"PeriodicalIF":2.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Statement of Retraction: Role of dynorphin in memory deficits associated with chronic pain.","authors":"","doi":"10.1080/24740527.2024.2337608","DOIUrl":"https://doi.org/10.1080/24740527.2024.2337608","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1080/24740527.2022.2088027.].</p>","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2337608"},"PeriodicalIF":2.4,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11020554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Importance of Good Measurement: Development and Validation of a Measure of Disordered Eating Among Adults with Chronic Pain.","authors":"E Lamoureux, M G Pagé","doi":"10.1080/24740527.2023.2284815","DOIUrl":"10.1080/24740527.2023.2284815","url":null,"abstract":"","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2284815"},"PeriodicalIF":2.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can we use the tools we already have to help patients in need? Evaluating practice-based evidence of analgesic effects from intermittent theta burst stimulation for treatment of depression.","authors":"P Maxwell Slepian","doi":"10.1080/24740527.2024.2310806","DOIUrl":"https://doi.org/10.1080/24740527.2024.2310806","url":null,"abstract":"","PeriodicalId":53214,"journal":{"name":"Canadian Journal of Pain-Revue Canadienne de la Douleur","volume":"8 1","pages":"2310806"},"PeriodicalIF":2.4,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10950276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}