Clinical Pathology最新文献

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Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience 非胆汁性肝硬化的胆管上皮内增生——来自100例肝移植的报告：单中心经验

IF 1.3

Clinical Pathology Pub Date : 2019-01-01 DOI: 10.1177/2632010X19876934

Maryam Zarei, Alireza Shasaeefar, K. Kazemi, M. Dehghani, S. Malekhosseini, B. Geramizadeh

{"title":"Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience","authors":"Maryam Zarei, Alireza Shasaeefar, K. Kazemi, M. Dehghani, S. Malekhosseini, B. Geramizadeh","doi":"10.1177/2632010X19876934","DOIUrl":"https://doi.org/10.1177/2632010X19876934","url":null,"abstract":"Background: Intrahepatic cholangiocarcinoma is a highly malignant tumor with a very short 5-year survival. Multistep carcinogenesis has been suggested as the main pathway for the development of this tumor. Main suggested precursors have been (1) biliary intraepithelial neoplasia (BilIN) and (2) intraductal papillary neoplasm of bile duct (IPNB). The former is flat and does not produce grossly and radiologically detectable mass lesion, but the latter produces grossly identifiable lesion. Objectives: The development of bile duct dysplasia (BilIN) in chronic biliary diseases has been investigated and proved, but the incidence of BilIN in non-biliary causes of cirrhosis such as hepatitis B and non-alcoholic steatohepatitis has very rarely been investigated. In this study, we have tried to find out the prevalence of BilIN in non-biliary cirrhosis. Patients and Methods: During the study period (2017-2018) in 100 explanted livers with the diagnosis of non-biliary cirrhosis, thorough sampling (at least 20 sections) was performed, and pathologic sections were studied for the presence of BilIN. Results: In the 100 studied livers with different diagnoses of non-biliary causes of cirrhosis, 31% of cases showed BilIN-1 and 2% of cases showed BiliIN-2. No case of BilIN-3 has been identified. Discussion and Conclusions: Non-biliary causes of cirrhosis should be considered as precursors of cholangiocarcinoma (BilIN); however, the incidence of this occurrence is low.","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":"12 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2632010X19876934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41341870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Malignant Solitary Fibrous Tumour of the Breast Mimicking a Benign Tumor 模仿良性肿瘤的乳腺恶性孤立性纤维瘤

IF 1.3

Clinical Pathology Pub Date : 2019-01-01 DOI: 10.1177/2632010X19868462

I. Barco, Clarisa González, E. Vallejo, A. Pessarrodona, N. Giménez, A. García-Fernández

引用次数: 6

A Case of Gastric Amphicrine Signet-Ring Cell Carcinoma 胃腺印戒细胞癌1例

IF 1.3

Clinical Pathology Pub Date : 2019-01-01 DOI: 10.1177/2632010X19880535

Y. Hanamatsu, Chiemi Saigo, Nami Asano, Yusuke Kito, K. Nakada, Y. Takeda, T. Takeuchi

{"title":"A Case of Gastric Amphicrine Signet-Ring Cell Carcinoma","authors":"Y. Hanamatsu, Chiemi Saigo, Nami Asano, Yusuke Kito, K. Nakada, Y. Takeda, T. Takeuchi","doi":"10.1177/2632010X19880535","DOIUrl":"https://doi.org/10.1177/2632010X19880535","url":null,"abstract":"“Amphicrine” (in Greek, amphi- means “both” or “double”) refers to cells that synchronously exhibit the endocrine and exocrine phenotypes. Gastric amphicrine carcinoma is very rare, and only a few case reports are found in the English literature; thus, its pathobiological features remain unclear. Here, we report a case of amphicrine gastric carcinoma. A woman in her sixth decade of life presented with anemia and underwent upper endoscopy, followed by histopathological examination of biopsy specimens. She appeared to have gastric cancer with a tumor measuring 5.0 cm × 4.0 cm in size. Subsequently, the patient underwent total gastrectomy with lymph node dissection. Histopathological examination revealed a poorly cohesive carcinoma that sparsely coexisted with signet-ring cell carcinoma cells with regional lymph node metastasis. Interestingly, synaptophysin immunoreactivity with the coexistence of Alcian blue was found in individual signet-ring cell carcinoma cells. Furthermore, the present amphicrine carcinoma cells immunohistochemically expressed CD44 variant 9, a functional cancer stem cell marker. We believe that the present case findings may support the idea of multipotent stem cells being an origin of amphicrine gastric cancers.","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2632010X19880535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43961750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

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