Clinical Pathology最新文献

{"title":"<i>Chlamydia pneumoniae</i> is Prevalent in Symptomatic Coronary Atherosclerotic Plaque Samples Obtained From Directional Coronary Atherectomy, but its Quantity is Not Associated With Plaque Instability: An Immunohistochemical and Molecular Study.","authors":"Tomoyuki Otani,&nbsp;Kensaku Nishihira,&nbsp;Yoshinao Azuma,&nbsp;Atsushi Yamashita,&nbsp;Yoshisato Shibata,&nbsp;Yujiro Asada,&nbsp;Kinta Hatakeyama","doi":"10.1177/2632010X221125179","DOIUrl":"https://doi.org/10.1177/2632010X221125179","url":null,"abstract":"<p><strong>Aim: </strong>To clarify whether there is any association between the extent of <i>Chlamydia pneumoniae (C. pneumoniae</i>) infection and plaque instability or post-directional coronary atherectomy (DCA) restenosis, we determined the frequency of <i>C. pneumoniae</i> infection and its localization in symptomatic coronary atherosclerotic plaques using specimens obtained from DCA.</p><p><strong>Methods and results: </strong>Immunohistochemistry (IHC) and real-time polymerase chain reaction (RT-PCR) revealed the existence of <i>C. pneumoniae</i> in all 50 specimens of coronary atherosclerotic plaques obtained by DCA. <i>C. pneumoniae</i>-positive cell ratio determined with IHC or copy numbers of <i>C. pneumoniae</i> DNA detected by RT-PCR did not differ significantly between patients with stable angina pectoris and those with acute coronary syndrome (IHC: 16.4 ± 7.6% vs 18.0 ± 7.1%, <i>P</i> = .42; RT-PCR: no. of cases with high copy numbers 12/25 vs 10/25, <i>P</i> = .78), or between patients with subsequent post-DCA restenosis and those without (IHC: 17.1 ± 8.0% vs 18.0 ± 7.4%, <i>P</i> = .74; RT-PCR: 5/12 vs 10/21, <i>P</i> = 1.00).</p><p><strong>Conclusions: </strong><i>C. pneumoniae</i> was highly prevalent in coronary atherosclerotic plaques of patients who underwent DCA. However, the extent of <i>C. pneumoniae</i> infection in coronary atherosclerotic plaques was not associated with plaque instability or post-DCA restenosis.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221125179"},"PeriodicalIF":1.3,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/61/10.1177_2632010X221125179.PMC9513565.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40384120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"R306X Mutation in the <i>MECP2</i> Gene Causes an Atypical Rett Syndrome in a Moroccan Patient: A Case Report.","authors":"Wafaa Bouzroud,&nbsp;Amal Tazzite,&nbsp;Sarah Berrada,&nbsp;Bouchaïb Gazzaz,&nbsp;Hind Dehbi","doi":"10.1177/2632010X221124269","DOIUrl":"https://doi.org/10.1177/2632010X221124269","url":null,"abstract":"<p><p>Rett syndrome (RTT) is a rare X-linked syndrome that predominantly affects girls. It is characterized by a severe and progressive neurodevelopmental disorder with neurological regression and autism spectrum features. The Rett syndrome is associated with a broad phenotypic spectrum. It ranges from a classical Rett syndrome defined by well-established criteria to atypical cases with symptoms similar to other syndromes, such as Angelman syndrome. The first case of a Moroccan female child carrying a R306X mutation in the <i>MECP2</i> (Methyl-CpG-Binding Protein 2) gene, with an unusual manifestation of Rett syndrome, is presented here. She showed autistic regression, behavioral stagnation, epilepsy, unmotivated laughter, and craniofacial dysmorphia. Whole exome sequencing revealed a nonsense mutation (R306X), resulting in a truncated, nonfunctional MECP2 protein. The overlapping phenotypic spectrums between Rett and Angelman syndromes have been described, and an interaction between the <i>MECP2</i> gene and the <i>UBE3A</i> (Ubiquitin Protein Ligase E3A) gene pathways is possible but has not yet been proven. An extensive genetic analysis is highly recommended in atypical cases to ensure an accurate diagnosis and to improve patient management and genetic counseling.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221124269"},"PeriodicalIF":1.3,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/f9/10.1177_2632010X221124269.PMC9486266.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33478824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mast Cell Sarcoma of the Retroperitoneum With Concurrent Systemic Mastocytosis and an Undisclosed Associated Hematologic Neoplasm: A Case Report.","authors":"Ing Chen,&nbsp;Jia-Bin Liao,&nbsp;Jung-Chia Lin,&nbsp;Pin-Pen Hsieh,&nbsp;Ming-Yun Hsieh","doi":"10.1177/2632010X221123539","DOIUrl":"https://doi.org/10.1177/2632010X221123539","url":null,"abstract":"<p><p>Mastocytosis is a rare disorder affecting both children and adults by gathering of functionally defective mast cells in the body's tissues. The World Health Organization (WHO) classified mastocytosis into cutaneous mastocytosis, systemic mastocytosis (SM), and mast cell sarcoma (MCS). We hereby present a case of retroperitoneal MCS with concurrent systemic mastocytosis and an undisclosed associated hematological neoplasm (SM-undisclosed AHN). The diagnosis of MCS and SM was made after the second biopsy over retroperitoneal mass, lymph node, and ovary for rapidly progressive disease with the presentation of unexplained recurrent flushing, palpitation, and shock, in addition to abdominal pain. A clonal myeloid neoplasm was also suspected by the karyotype and hemogram data. Unfortunately, the patient succumbed to the disease quickly. Apart from this unique case, the previously reported cases of SM with MCS in the literature were also reviewed.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221123539"},"PeriodicalIF":1.3,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/3f/10.1177_2632010X221123539.PMC9476239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40367849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review.","authors":"Xue Yang,&nbsp;Ling Chen,&nbsp;Yan Shen","doi":"10.1177/2632010X221118056","DOIUrl":"https://doi.org/10.1177/2632010X221118056","url":null,"abstract":"<p><p>Metaplastic breast carcinoma (MBCs) is a rare heterogeneous group of malignancies. Herein, we report a case of metaplastic breast carcinoma, which had 2 components. One of them was typical invasive ductal carcinoma (IDC), the other one was presenting as osteosarcoma with lots of immature trabeculae. The results of immunohistochemistry showed different presentations between them. The majority of MBCs show triple-negativity for ER, PR, and HER-2 and are thus associated with poor prognosis. Our report shows that, it is necessary to describe the proportion of the components and the presentations of immunohistochemistry in the diagnosis, which will be important to develop specific and effective therapies.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221118056"},"PeriodicalIF":1.3,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/43/10.1177_2632010X221118056.PMC9425891.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40342390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic Syndrome in a Patient with HIV and Histoplasmosis: A not so Rare Correlation.","authors":"Monique Freire,&nbsp;Viviane Carvalho,&nbsp;Renata Spener,&nbsp;Christiane Rodrigues da Silva,&nbsp;João Ricardo da Silva Neto,&nbsp;Luiz Carlos Ferreira,&nbsp;Paulo Afonso Nogueira","doi":"10.1177/2632010X221118059","DOIUrl":"https://doi.org/10.1177/2632010X221118059","url":null,"abstract":"<p><p>Hemophagocytic lymphohistiocytosis (HLH) is a disorder that occurs due to unsuitable monocyte activation in a variety of infections. In human immunodeficiency virus (HIV) infections, patients with advanced immunossupression associated with opportunistic infections are at increased risk of developing HLH. We describe a clinical case of a 33-year-old male student diagnosed with HIV who was hospitalized for investigation of asthenia and dyspnea, accompanied by adynamia, decreased motor force in the left leg, dysphagia, and dysfluency. His general condition was regular, he was pale, feverish, and had normal cardiac and pulmonary auscultation. Physical examination revealed ulcerated lesions in the perianal region and hepatosplenomegaly without palpable lymph node enlargement. Laboratory parameters showed pancytopenia, a slight increase in liver function accompanied by high lactate dehydrogenase, and hiperferritinemia. The initial diagnosis was disseminated histoplasmosis, thus amphotericin B deoxycholate was empirically prescribed while waiting on myeloculture and blood cultures for fungi and mycobacteria. Other clinical procedures were blood transfusion, resumption of antiretroviral therapy (ART) and secondary prophylaxis. Myeloculture blood cultures of fungi and mycobacteria were negative. Patient evolved well in relation to the initial complaints and showed partial clinical and laboratory improvement. However, 23 days after hospitalization, he developed a febrile episode accompanied by chills and a convulsive crisis. The patient was transferred to the intensive unit care and developed septic shock and respiratory failure. He died 25 days after the onset of the condition. After the postmortem examination, histopathology revealed countless rounded fungal structures compatible with <i>Histoplasma</i> sp., which were observed in the peripancreatic lymph node, liver, and spleen, in addition to hemophagocytosis in the splenic parenchyma. We thus conclude that when the patient met criteria for HLH, such as fever, hepatosplenomegaly, hiperferritinemia, and pancytopenia, the evolution was fast due to the aggressive and rapidly fatal nature of HLH, despite anti-fungal and corticoid treatment. Therefore, this case report reinforces the need to consider hemophagocytic syndrome in patients with HIV and disseminated histoplasmosis, especially where histoplasmosis is highly endemic, in order for the treatment be started early when there is high clinical suspicion.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221118059"},"PeriodicalIF":1.3,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/65/10.1177_2632010X221118059.PMC9425888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40342389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaplastic Intraventricular Meningioma with Rhabdoid Features: An Unusual Tumor with Usual Clinical Presentation.","authors":"Preeti Agarwal,&nbsp;Nancy Gupta,&nbsp;Alok Srivastava,&nbsp;Madhu Kumar,&nbsp;Suarabh Kumar,&nbsp;Chhitij Srivastava","doi":"10.1177/2632010X221115157","DOIUrl":"https://doi.org/10.1177/2632010X221115157","url":null,"abstract":"<p><p>Meningiomas are tumors arising from leptomeninges. Malignant counterpart of them is known as anaplastic meningioma which are WHO grade III tumors. Intraventricular location of these tumors is rare and is clinic-radiologically challenging. Histopathology and immunohistochemistry are confirmatory. We present case of a 27-year-old girl, who presented with usual symptoms of intraventricular mass in emergency. After shunt surgery, clinical diagnosis of ependymoma was formed with differential of high-grade glioma. Squash tissue was difficult to crush displaying tight clusters of spindle cells with necrosis in background. Definitive histology revealed high grade spindle cell neoplasm disposed in sheets with brisk and atypical mitosis. Only focal whorling pattern was seen. Large cells with eccentric cytoplasm, reminiscent of rhabdoid cells were also seen. Immunohistochemistry was positive for vimentin and EMA, negative for GFAP. Final diagnosis of Anaplastic meningioma was dispatched. The histological pattern of the present case, young age of presentation and presence of Rhabdoid cells make it unusual. Though rare but intraventricular meningiomas must also be kept in clinical radiological differentials apart from the usual ependymoma at this location.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221115157"},"PeriodicalIF":1.3,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/bb/10.1177_2632010X221115157.PMC9340328.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40580121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological Abnormalities and Comorbidities Are Associated With the Severity of Kidney Disease: A Hospital-Based Cross-Sectional Study in Bangladesh.","authors":"Md Ashrafur Rahman,&nbsp;Yeasna Shanjana,&nbsp;Md Shakil Ahmed,&nbsp;Kuldeep Dhama,&nbsp;Mahadi Hasan Fahim,&nbsp;Tarif Mahmud,&nbsp;Arif Anzum Shuvo,&nbsp;Zahid Hossain Milan,&nbsp;Mohammad Saydur Rahman,&nbsp;Arpita Roy,&nbsp;Mohiuddin Ahmed Bhuiyan,&nbsp;Md Rabiul Islam","doi":"10.1177/2632010X221114807","DOIUrl":"https://doi.org/10.1177/2632010X221114807","url":null,"abstract":"<p><strong>Background: </strong>Abnormalities in hematology and comorbidities might have a role in chronic kidney disease (CKD) patients. However, the exact relationships between hematological parameters and the severity of CKD are not well understood. Also, the underlying mechanisms remain under investigation. The present study aimed to evaluate the association of different blood parameters and comorbidities among hospitalized CKD patients in Bangladesh.</p><p><strong>Methods: </strong>The present study enrolled admitted CKD patients at Evercare Hospital Ltd, Dhaka, Bangladesh, from January 1, 2021, to August 1, 2021. For this study, the demographic and clinical information of the patients were collected. Then some routine blood tests for the hematological profile of CKD patients were performed. Finally, several statistical methods were performed and data interpretations were done to evaluate the role of hematological changes on CKD patients.</p><p><strong>Results: </strong>Among 300 patients, early-stage CKD patients (ESCKDP) and advanced-stage CKD patients (ASCKDP) were 153 and 147, respectively. The decreased levels of hemoglobin (Hb) and red blood cell (RBC) in ASCKDP were observed. However, the present study found increased levels of corpuscular Hb in ASCKDP than ESCKDP. Also, the present study noticed correlations between these changes and the severity of CKD. Also, we observed a significant difference in age and body mass index between ESCKDP and ASCKDP.</p><p><strong>Conclusions: </strong>Based on our results, lower Hb and RBC levels may use in assessing the severity and the treatment decisions of CKD patients in the hospital setting. Therefore, our findings may assist with developing a treatment protocol for hospitalized CKD patients.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221114807"},"PeriodicalIF":1.3,"publicationDate":"2022-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/db/10.1177_2632010X221114807.PMC9310280.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40639494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dedifferentiated Liposarcoma: A Rare Case Report of Retroperitoneal Myxoid Soft Tissue Tumour with Diagnostic Dilemma.","authors":"Ritica Chaudhary,&nbsp;Mona Lisa,&nbsp;Payal Kumari,&nbsp;Aman Kumar","doi":"10.1177/2632010X221112455","DOIUrl":"https://doi.org/10.1177/2632010X221112455","url":null,"abstract":"<p><strong>Background: </strong>The retroperitoneum can host a wide spectrum of soft tissue lesions. These tumours pose a challenge to the pathologist as the morphology is not of much help and immunohistochemistry becomes a necessity.</p><p><strong>Case report: </strong>Sixty years old male presented with 2 months history of abdominal lump, pain and dyspepsia. The MRI revealed a heterogeneous mass in the retroperitoneum involving right para spinal muscle, right iliac fossa and right perinephric region with destruction of right transverse process and erosion of adjacent L3 vertebra. Trucut biopsy of the mass was reported as fibroliposarcoma at an outside lab. Patient underwent a wide local excision. Grossly the tumour gave an impression of a liposarcoma but the microscopy showed areas of spindle cells, epitheloid cells, focal areas of ganglion like cells and large areas of myxoid change. IHC panel of S-100, SMA, caldesmon, myogenin, myoglobin and Alk-1 was negative. MDM2, CDK4 and p16 IHC came positive proving it to be a dedifferentiated liposarcoma.</p><p><strong>Conclusion: </strong>We report a curious case of retroperitoneal soft tissue tumour with complex morphology and IHC features diagnosed as dedifferentiated liposarcoma based on MDM2, CDK and p16 positivity.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221112455"},"PeriodicalIF":1.3,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40645335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histo-Molecular Profile of Breast Cancer in Young Women in Togo.","authors":"Toukilnan Djiwa,&nbsp;Baumaney Koui,&nbsp;Panakinao Simgban,&nbsp;Bagassam Mézéwè Sama,&nbsp;Mayi Bombonne,&nbsp;Brahima Doukouré,&nbsp;Tchin Darré","doi":"10.1177/2632010X221112452","DOIUrl":"https://doi.org/10.1177/2632010X221112452","url":null,"abstract":"<p><strong>Introduction: </strong>The frequency of breast cancer in young women, corresponding to women under 40 years of age; varies from 5% to 7% in developed countries. The objective of this study was to contribute to the improvement of the management of breast cancer in young women in Togo, by establishing the molecular classification of these cancers.</p><p><strong>Methodology: </strong>This was a retrospective descriptive and analytical study from January 2010 to December 2020.</p><p><strong>Results: </strong>About 35 cases of breast cancer were identified in women under 40 years of age. The average age was 35.4 ± 3.5 years. The right breast was affected in 18 cases (51.43%). Histologically, 30 cases (85.72%) were invasive carcinoma of no special type (NST), 2 cases (5.71%) were invasive lobular carcinoma and micro-papillary carcinoma respectively, and 1 case (2.86%) was tubular carcinoma. There were 6 cases (17.1%) of grade I, 25 cases (71.4%) of grade II, and 4 cases (11.4%) of grade III. Molecularly, there were 20 cases (57.1%) of triple-negative subtype, 6 cases (17.1%) of Luminal B subtype, 05 cases (14.3%) of HER2-enriched subtype and 4 cases (11.4%) of Luminal A subtype.</p><p><strong>Conclusion: </strong>Breast cancers of young Togolese women express very weakly hormone receptors, with a predominance of a triple negative subtype.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221112452"},"PeriodicalIF":1.3,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/f0/10.1177_2632010X221112452.PMC9280847.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40602261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report.","authors":"Mădălina Boșoteanu,&nbsp;Raluca Ioana Vodă,&nbsp;Mariana Așchie,&nbsp;Luana-Andreea Bosoteanu,&nbsp;Gabriela Izabela Bălțătescu","doi":"10.1177/2632010X221105224","DOIUrl":"https://doi.org/10.1177/2632010X221105224","url":null,"abstract":"<p><p>We report a rare case of giant uterine leiomyosarcoma in a postmenopausal woman, whose diagnosis was initially suspected at the evaluation of the abdominal efusion, and confirmed after the pathological examination of the uterus in association with the ancillary tests. The evaluation of the abdominal fluid showed single or clusters of malignant, round or spindle-shaped cells. On microscopic examination of the surgical specimen, a dense cell proliferation of spindle cells, with moderate to severe nuclear pleomorphism and significant mitotic activity was observed. Immunohistochemical evaluation demonstrated the loss of myocytic differentiation by focal, weakly positive expression of smooth muscle actin and desmin. The data presented in this case emphasize the relevance of the cytological examination, although the latter has only indicative value, especially since it is an aggressive tumor, frequently associated with mutant expression of p53. In our case, the first indication of the presence of uterine sarcoma was given by the presence of atypical cells in the peritoneal fluid.</p>","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":"2632010X221105224"},"PeriodicalIF":1.3,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/fb/10.1177_2632010X221105224.PMC9240338.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40558901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}