Global Journal of Transfusion Medicine最新文献_第10页

Therapeutic Plasma Exchange using Continuous Flow Cell Separator Machine in a Neuromyelitis Optica Patient Outcome and Analysis 连续流式细胞分离机治疗性血浆置换治疗视神经脊髓炎的疗效与分析

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_106_21

S. Mukherjee, S. Das, Subrata Sen

引用次数: 0

Blood is a drug and drugs controller is the right regulatory authority for licensing and monitoring blood transfusion services - Our view 血液是一种药物，而药物监管机构是颁发牌照和监督输血服务的合适监管机构-我们的观点

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_21_22

N. Bandara

引用次数: 0

Comparative Evaluation of heat-inactivated ABO isoagglutinin titers with solid-phase red cell adhesion titers 热灭活ABO异凝集素滴度与固相红细胞粘附滴度的比较评价

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_65_21

S. Ranjan, P. Pandey, D. Setya, S. Kumari

{"title":"Comparative Evaluation of heat-inactivated ABO isoagglutinin titers with solid-phase red cell adhesion titers","authors":"S. Ranjan, P. Pandey, D. Setya, S. Kumari","doi":"10.4103/gjtm.gjtm_65_21","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_65_21","url":null,"abstract":"Background and Objectives: Measurement of actual concentration of IgG requires methods like heat inactivation (HI) of serum. This study was aimed at comparing of heat-treated ABO titers performed by conventional test tube technique (CTT) and column agglutination technique (CAT) with hemagglutination (HA)/solid-phase red cell adherence (SPRCA). Methods: This was a prospective, observational study conducted between October 2019 and March 2020. All consecutive A, B, and O group donors who gave consent for participation in the project were included. All samples were tested by CTT and CAT before and after HI (post DTT treatment performed by CTT [pCTT] and post DTT treatment performed by CAT [pCAT]) and with HA/SPRCA. Results: A total of 300 donors were included: 100 each with A, B, and O blood groups. For group O, IgG titers were higher than IgM titers among group O, whereas that among group A and group B, IgM titer was found to be higher than IgG titer by both HA/SPRCA and pCTT. The titer values among all the three blood groups were highest when the test was performed by pCAT, though the results of pCTT and SPRCA, pCTT, and pCAT were significant in group O donors. For groups A and B, results of pCTT and pCAT, pCAT, and HA/SPRCA were found to be statistically significant. Conclusion: Results obtained by HA/SPRCA were closer to pCTT, with respect to time consumption, expertise required, and lack of inter-observer variation. Titers obtained by pCAT were higher in comparison to pCTT obviously due to its relative higher sensitivity. Hence, these methods cannot be used interchangeably.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"2013 1","pages":"54 - 59"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88181201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Transfusion Medicine in the Republic of North Macedonia 北马其顿共和国输血医学的发展

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_27_22

E. Velkova, T. Makarovska-Bojadzieva, V. Dejanova-Ilijevska, E. Petković, E. Ristovska, S. Drakulevska, L. Mitevska

引用次数: 0

Gene therapy – Principles and applications 基因治疗。原理和应用

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_87_21

Sangeeta Pathak

{"title":"Gene therapy – Principles and applications","authors":"Sangeeta Pathak","doi":"10.4103/gjtm.gjtm_87_21","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_87_21","url":null,"abstract":"The concept of gene therapy dates back to the 1960s and 1970s and it is yet to come of age, as there is a paucity of reliable, long-term data on the safety and efficacy of this novel therapy. It is fast emerging as a promising approach to treat, cure or prevent genetic based diseases by correction of defective genes that are responsible for disease development. Gene therapy is a key treatment strategy for disorders caused by a missing or faulty gene. It involves introduction of functional genes into appropriate cells so that they can produce sufficient amounts of proteins, encoded by the transferred gene or turn off genes that are causing problems and eventually resulting in permanent correction of the disorder. While the concept of gene replacement therapy is mostly suitable for recessive diseases, novel strategies have been suggested that are capable of also treating conditions with a dominant pattern of inheritance. Gene therapy treatments are of broadly two types, Germline gene therapy, & Somatic Germline gene therapy. There are two methods for administering gene therapy -Ex vivo & in-vivo. There are two main parts to gene replacement: Genes and Vectors. Gene therapy is useful for hematologic conditions as Hemoglobinopathies, Hemophilia and Inherited bone marrow failure. Future Prospective of Gene Therapy in Transfusion Medicine ,work is being done to explore ex vivo generation of RBCs utilizing various cell fractions, including hematopeitic progenitor cells from cord blood and adult sources. Cost of therapy and ethical issues are the limiting factors for the use of Gene therapy.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"44 36","pages":"3 - 6"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72390728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cw alloimmunization in multitransfused thalassemic patients of North India: Prevalence and approach to transfusion 北印度多次输血的地中海贫血患者的Cw同种异体免疫:患病率和输血方法

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_89_21

S. Pahuja, S. Sehgal, Geetika Sharma, J. Chandra, N. Parakh, M. Singh, R. Yadav

{"title":"Cw alloimmunization in multitransfused thalassemic patients of North India: Prevalence and approach to transfusion","authors":"S. Pahuja, S. Sehgal, Geetika Sharma, J. Chandra, N. Parakh, M. Singh, R. Yadav","doi":"10.4103/gjtm.gjtm_89_21","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_89_21","url":null,"abstract":"Background and Objectives: The C Willis or Cw antigen is a low-incidence antigen of Rh system. The antibody against the Cw antigen (anti-Cw) is an IgG antibody which may occur naturally or may be immune in nature. The identification of Cw antibody is important since it has the potential to cause hemolytic disease of the newborn as well as hemolytic transfusion reaction. This study was conducted with the aim of determining the prevalence of Cw antibody in multitransfused thalassemic patients enrolled in a Regional Blood Transfusion Center (RBTC) of North India. Methods: A retrospective descriptive observational study was conducted at the Department of Immunohematology and Blood Transfusion, LHMC and Associated Hospitals. All transfusion-dependent thalassemic (TDT) patients and non-TDT (NTDT) patients enrolled in the RBTC of the hospital till December 2018 were included in the study. Antibody screening was performed in all recipients before each transfusion. The prevalence of anti-Cw was estimated. Results: A total of 567 thalassemic patients (including TDT and NTDT) were registered in RBTC, LHMC till December 2018. On pretransfusion antibody screening and identification, 3 out of 567 thalassemic patients were found to have alloimmunization against Cw antigen. The prevalence of anti-Cw in multitransfused thalassemics was 0.53%. Conclusion: The prevalence of anti-Cw is variable in different populations and it is not a very commonly reported antibody in patients with thalassemia. One should be aware of the approach to transfusion in thalassemic patients who develop Cw alloimmunization.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"124 1","pages":"51 - 53"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89663373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood is a drug and drug controller is the right regulatory authority for licensing and monitoring blood transfusion services - Contrary view 血液是一种药物，药物管制者是颁发许可证和监测输血服务的正确监管机构-相反的观点

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_23_22

S. Hussain, Manzoor Ahmed

引用次数: 0

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_103_21

M. Raturi, Reshma Nambiyar, Mansi Kala, N. Bansal

{"title":"U is dissimilar to u for human immunodeficiency virus transmission through the infected whole blood unit","authors":"M. Raturi, Reshma Nambiyar, Mansi Kala, N. Bansal","doi":"10.4103/gjtm.gjtm_103_21","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_103_21","url":null,"abstract":"It is a known fact that antiretroviral treatment (ART) is highly efficacious in reducing the sexual transmission of human immunodeficiency virus (HIV). In addition, it is clear now that those infected and living with HIV and having an undetectable viral load below 200 copies per mL, measured 4 to 6 monthwise, do not transmit it sexually to their partners. Therefore, U = U (Undetectable = Untransmittable; where symbol = means similar to) campaign is the message of a new UNAIDS explainer. The authors herein report the blood donation made by an HIV-I positive Indian male under the existing policy of confidential unit exclusion at their blood center. It was alarming because he was driven by an incorrect belief that being in a state of sexual nontransmissibility, due to the regular intake of ART, his donated blood was safe and suitable for blood transfusion too. He firmly believed that the ART he was receiving was highly efficacious in reducing the transmission of HIV through sexual intercourse and misconstrued the same for blood transfusion. After a thorough consultation and discussion with the transfusion medicine specialist, the individual could understand that U = U certainly, does not ascribe to the blood transfusion-related transmission due to a bigger inoculum and the intravenous route of administration.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"6 1","pages":"80 - 81"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90155370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Blood donors and their deferral pattern in a university hospital, Nepal 尼泊尔一所大学医院的献血者及其延迟模式

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/gjtm.gjtm_11_22

S. Koju, R. Bhatt, R. Shankhadev, R. Twitwi

{"title":"Blood donors and their deferral pattern in a university hospital, Nepal","authors":"S. Koju, R. Bhatt, R. Shankhadev, R. Twitwi","doi":"10.4103/gjtm.gjtm_11_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_11_22","url":null,"abstract":"Background and Objectives: Blood transfusion is a life-saving procedure and the selection of healthy blood donors is essential steps for safe blood transfusion. Proper selection of blood donors is needed for the safety of both blood donors and recipients. The aim of this study was to assess the demographic profile of blood donors and determine the frequency and reason of donor deferral in a university hospital of Nepal. Methods: This hospital-based retrospective study was carried out in the Blood Bank Unit of the tertiary care center of Nepal. Data were collected from the record book maintained in the blood bank from January 2016 to December 2020. Data were analyzed using Microsoft Office Excel 2010 for descriptive analysis. Results: A total of 3697 individuals came for blood donation during the study period; among them, 2802 (75.8%) were male and 895 (24.2%) were female. Total number of voluntary donation were 2175 (58.8%), while 1522 (41.2%) were family/replacement donation. Among all donors, 351 (9.5%) donors were deferred for different reasons. The most common cause of donor deferral was hypertension (15.0%), followed by medication (14.0%), while anemia (32.8%) was the leading cause of deferral in female donors. Out of total deferral cases, 92.6% of donors were temporary deferral, while 7.4% were deferred permanently. Conclusion: Most deferrals were temporarily due to hypertension, medication, and anemia. Awareness about these causes of deferral can increases the donor pool.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"18 1","pages":"23 - 27"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87690340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Changing transfusion policies and perspectives with changing times 随着时代的变化而改变输血政策和观点

Global Journal of Transfusion Medicine Pub Date : 2022-01-01 DOI: 10.4103/2468-8398.317182

Shivaram Chandrashekar

引用次数: 0