Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.21357

Faridah BD Faridah BD, Lita Angelina Saputri, Iin Prima Fitriah, Lisa Rahmawati, N. Oktavia, Fithriani Armin

{"title":"Formulation and evaluation of antibacterial activity of hand sanitizers containing red betel (Piper crocatum) and white galangal (Alpinia galanga) extract","authors":"Faridah BD Faridah BD, Lita Angelina Saputri, Iin Prima Fitriah, Lisa Rahmawati, N. Oktavia, Fithriani Armin","doi":"10.30595/medisains.v22i1.21357","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.21357","url":null,"abstract":"Background: The COVID-19 outbreak has changed how people live worldwide, making hand hygiene a must, whether it involves hand sanitizer (HS). The majority of HS are made of alcohol. Several side effects of alcohol are dryness and allergies. Alternative natural ingredients and HS are needed. Red betel (Piper crocatum) and white galangal (Alpinia galanga) are familiar and easy to be found. These two plants have the potential to be the composition of HS because of their compounds, such as antioxidants, antibiotics, antifungals, and antivirals. However, there is a need for further research on their formulation and effectiveness in germ-killing.Purpose: To formulate and identify the antibacterial activity of HS containing red betel and white galangal extract.Method: This research was an in vitro laboratory experiment with several steps, including extraction, specific and nonspecific tests, formulation, and antibacterial activity tests.Results: Red betel and white galangal leaves had been extracted at a concentration of 10% and formulated into HS. The HS containing 10% red betel extract produced an inhibition zone of 0 mm against E. coli and 1.05 mm against S. aureus, and the HS containing 10% White galangal extract produced an inhibition zone of 1.47 mm against E. coli and 1.40 mm against S. aureus.Conclusion: The formulation of HS containing 10% of white galangal extract is more effective than the HS containing 10% of Red betel extract.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An innovative support pillow for diabetic foot wound care 用于糖尿病足伤口护理的创新型支撑枕

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.21428

Jebul Suroso, Aqilatun Zulfa, Nanda Cikal Gumelar, Rama Nanda Soleha, Siti Nuraeni, Ika Putri Febriyanti, Agus Santosa

{"title":"An innovative support pillow for diabetic foot wound care","authors":"Jebul Suroso, Aqilatun Zulfa, Nanda Cikal Gumelar, Rama Nanda Soleha, Siti Nuraeni, Ika Putri Febriyanti, Agus Santosa","doi":"10.30595/medisains.v22i1.21428","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.21428","url":null,"abstract":"Background: Treating diabetic foot ulcers (DFU) sometimes takes a long time. During treatment, the patient's feet are usually given a cushion (such as a sleeping pillow or bolster) to make the wound seen. This way, some patients reported that their feet tingled because they were not positioned rightly for an extended period. So far, no unique pillow is available for this function. This pillow would help in treating DFU and should be comfortable for patients. Thus, it is essential to research designing such a product.Purpose: To develop and test a special pillow for treating DFU.Methods: This research adopts Research and Development (R&D). This research is divided into two stages: designing and developing and product testing.Results: This pillow is made of multiplex and foam, covered with Polyester fabric. It is 75mm in length and 45mm in width. It is equipped with a foot care area and waste storage tank. The test results showed that the score for comfort for the patients was 92%, while the score from the nurse was 88%.Conclusion:The pillow product helps the nurse conduct the DFU treatment and is comfortable for the patients. ","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Butterfly hug therapy on reducing anxiety levels and stabilization hemodynamics in patient digital subtraction angiography 蝴蝶拥抱疗法对降低数字减影血管造影患者的焦虑水平和稳定血流动力学的作用

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.21484

Anis Wiji Astuti, F. Rosyid, S. Subrata

{"title":"Butterfly hug therapy on reducing anxiety levels and stabilization hemodynamics in patient digital subtraction angiography","authors":"Anis Wiji Astuti, F. Rosyid, S. Subrata","doi":"10.30595/medisains.v22i1.21484","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.21484","url":null,"abstract":"Background: Digital subtraction angiography can affect anxiety in patients so that it can worsen the patient's condition during catheterization, such as increased heart rate and breathing. One of the efforts to reduce anxiety that can improve hemodynamics is butterfly hug therapy. However, its effectiveness in reducing hemodynamic anxiety needs to be further investigated.Purpose: To evaluate butterfly hug therapy's effectiveness on anxiety and hemodynamics before digital subtraction angiography.Methods: This is a quasi-experiment study with a pretest-posttest control group design. Fifty-two respondents were selected using purposive sampling. A total of 26 respondents were given butterfly hug therapy, and 26 others were given standard therapy. The study implemented the Zung Self Rating Anxiety Scale Questionnaire and observation sheet. This research analysis uses the Independent T-test and Wilcoxon Test.Results: The anxiety level of the experimental group was lower than that of the control group (46.73 ± 2.08 vs. 53.84 ± 1.74; p<0.05). In hemodynamic stability (pulse, respiratory, and blood pressure) was stability than the control group (80.69 ± 2.44 vs. 89.11 ± 2.39; 20.65 ± 0.39 vs. 21.0 ± 0.53; 104.7 ± 1.46 vs. 109.5 ± 1.82; p <0.05).Conclusion: Butterfly hug therapy is effective in reducing anxiety and stabilizing hemodynamics among patients undergoing digital subtraction angiography.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Develop a web-based system using the Naïve Bayes algorithm to predict asphyxia neonatal 利用奈夫贝叶斯算法开发网络系统，预测新生儿窒息情况

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.19531

Elviga Arselatifa, Sri Sumarni, Kurnianingsih Kurnianingsih

{"title":"Develop a web-based system using the Naïve Bayes algorithm to predict asphyxia neonatal","authors":"Elviga Arselatifa, Sri Sumarni, Kurnianingsih Kurnianingsih","doi":"10.30595/medisains.v22i1.19531","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.19531","url":null,"abstract":"Introduction: Most cases of perinatal asphyxia are caused by conditions unrelated to labor. When asphyxia occurs during childbirth, it is usually caused by an obstetric emergency that was not detected during pregnancy. It is essential to prevent asphyxia by identifying the incidence of asphyxia during pregnancy. Several studies have been conducted to identify asphyxia problems developing by predictive models. However, there has been no development of a system for predicting birth asphyxia during pregnancy and carried out in primary health facilities.Purpose: Develop a web-based system using the Naïve Bayes (NB) algorithm to predict asphyxia neonatal using a dataset of antepartum risk factors in primary health facilities.Methods: This study employed research and development, which consists of 4 stages, namely literature study, development stage, expert validity, and trial.Results: A system that health workers in primary health facilities can use to predict asphyxia neonatal and recommend referrals for determining the place of childbirth has been successfully created. The system performance test predicted asphyxia neonatal with all NB evaluation values reaching more than 98%, and the prediction accuracy in the respondent test included in the High Accuracy category (MAPE value 9.06%).Conclusion: The development of a web-based system using the NB algorithm has been proven to be able to predict asphyxia neonatal and can be implemented for health workers as an effort to anticipate delays in handling cases of asphyxia neonatal because of the predicted results along with recommendations for focusing mothers with the risk of babies born asphyxia to find out possible childbirth places.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The innovation of Wolbachia mosquito technology to control dengue hemorrhagic fever 控制登革出血热的沃尔巴克氏蚊技术创新

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.21720

Roro Kushartanti, Aprin Wahyu Wijayanti

{"title":"The innovation of Wolbachia mosquito technology to control dengue hemorrhagic fever","authors":"Roro Kushartanti, Aprin Wahyu Wijayanti","doi":"10.30595/medisains.v22i1.21720","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.21720","url":null,"abstract":"Wolbachia is a bacterium that generally occurs naturally in 50% of insect species, lives in insect cells, and is passed from one generation to the next through insect eggs. Wolbachia in the mosquito's body can inhibit the replication of the Dengue virus or other viruses. Based on the Decree of the Minister of Health of the Republic of Indonesia Number 1341 concerning the Implementation of the Pilot Project for the Implementation of Wolbachia as a Dengue Management Innovation, the application of this technology was carried out in five cities, namely Semarang City, West Jakarta, Bandung City, Kupang City, and Bontang City. The effectiveness of Wolbachia itself has been proven and researched since 2011, when it was conducted in Yogyakarta. As a result, Wolbachia was proven to reduce dengue fever cases by up to 77% and reduce the proportion of hospital admissions by 86%. This method of spreading Wolbachia mosquitoes in several cities will reduce local transmission of infection in those areas. This reduction in local transmission of dengue infection occurs both in the rainy and dry seasons. Scientifically, the success of the Wolbachia method is apparent, but the controversy is due to confused information circulating, giving rise to concern among the public. Vector control using Wolbachia is an alternative disease control method that uses mosquito vectors and is quite effective. However, the application of Wolbachia in the community must be monitored continuously to determine its impact on humans, local mosquitoes, and the ecosystem.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo study of celery (Apium graveolens L) extract for regenerating pancreatic β-cell 芹菜（Apium graveolens L）提取物用于胰腺β细胞再生的体内研究

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.20079

Dina Dewi Sartika Lestari Ismail, Heri Kristianto, Setyoadi Setyoadi, Anissa Maydinah

{"title":"In vivo study of celery (Apium graveolens L) extract for regenerating pancreatic β-cell","authors":"Dina Dewi Sartika Lestari Ismail, Heri Kristianto, Setyoadi Setyoadi, Anissa Maydinah","doi":"10.30595/medisains.v22i1.20079","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.20079","url":null,"abstract":"Background: The celery plant (Apium graveolens L.) is a widely distributed herbal plant globally known for being a significant source of natural active products, including phenolic compounds and antioxidants demonstrating antidiabetic activity. Previous research findings have indicated the impact of celery leaf extract on reducing blood glucose levels. However, up to now, there is a dearth of research investigating the potential effect of celery leaf extract on the regeneration of pancreatic beta cells in mice with diabetes models.Objective: This study aims to determine the effect of the ethanol extract of celery leaves on the number of pancreatic cells in Streptozotocin (STZ)-induced mice.Method: This research method uses a randomized controlled group posttest only design. Experimental animals were divided into five groups, including a group of experimental animals in a healthy condition, the group with hyperglycemia, hyperglycemia group with celery extract at 200 mg/kg BW, hyperglycemia group with celery extract at 400 mg/kg, and hyperglycemia group with extract celery is 800 mg/kg BW. Termination was performed on day 60 after therapy and pancreas hematoxylin and eosin staining. They are counting the number of cells with a photo slide with 400x magnification in 5 fields of view—statistical analysis using One-Way ANOVA.Results: The study revealed that celery extract could increase the number of pancreatic cells compared to the control group (P<0.002). Notably, the highest increase in pancreatic cell count was observed in the group administered with 400 mg/BW of celery extract.Conclusion: Celery leaf extract effectively increased the number of beta cells in vivo.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of CD4+ levels and caspase-3 in condyloma acuminata with HIV reactive patients 尖锐湿疣与 HIV 反应患者 CD4+ 水平和 caspase-3 的相关性

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.21501

Elok Nurfaiqoh, P. Mawardi, Nugrohoaji Dharmawan, Indah Julianto, Endra Yustin Ellistasari

{"title":"Correlation of CD4+ levels and caspase-3 in condyloma acuminata with HIV reactive patients","authors":"Elok Nurfaiqoh, P. Mawardi, Nugrohoaji Dharmawan, Indah Julianto, Endra Yustin Ellistasari","doi":"10.30595/medisains.v22i1.21501","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.21501","url":null,"abstract":"Background: Human papillomavirus is an infection that causes malignancy because of persistency and modulation of apoptotic pathways, especially caspase-3. Factors that can increase persistency, recurrency, and malignancy of HPV infection include HIV infection with low CD4 levels. There is disagreement or deep molecular understanding of the induction and modulation of apoptosis in HIV-mediated CD4+ T cell depletion, especially in CA. However, it is necessary to see how CD4+ levels can influence caspase-3, so it may open up new avenues for supporting investigation to consider the presence of malignancy or therapeutic strategies regarding CD4+ can induce apoptosis.Purpose: This study aimed to determine whether there is a correlation between CD4+ levels and caspase-3 expression in condyloma acuminata with HIV reactive patients.Methods: This is an analytic observational study with a cross-sectional design. The research was conducted at Dr. Moewardi General Hospital from August to December 2023. Nineteen patients with condyloma acuminata and HIV reactive were included in this study with a consecutive sampling technique. The expression of caspase-3 was assessed using immunohistochemical staining, looking at the percentage of stained cell nuclei and cytoplasm and CD4+ levels with flow cytometry examination—data analysis using Pearson correlation.Results: Respondents in this study were primarily men, self-employed with heterosexual orientation and genito-genital-oral sexual intercourse. The statistical analysis showed no significant relationship (p: 0.300, r: -0.251) between CD4+ levels and caspase-3 expression.Conclusions: While not statistically significant, CD4+ level is reduced in correlation with increased caspase-3 expressions.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spiritual relaxation therapy to improve sleep quality for nurses working shifts who experience sleep problems: a quasi-experimental study 精神放松疗法改善轮班护士的睡眠质量：一项准实验研究

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.19834

Sudigdo Dwi Prasetyo, Mukhoirotin Mukhoirotin???

{"title":"Spiritual relaxation therapy to improve sleep quality for nurses working shifts who experience sleep problems: a quasi-experimental study","authors":"Sudigdo Dwi Prasetyo, Mukhoirotin Mukhoirotin???","doi":"10.30595/medisains.v22i1.19834","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.19834","url":null,"abstract":"Background: Impaired sleep quality is a common problem experienced by nurses working shifts, and if not treated properly, it can impact their work performance and overall health. Spiritual Emotional Freedom Technique (SEFT) therapy has been proven to improve sleep quality. However, its effectiveness has never been studied in nurses who experience sleep disorders due to working shifts.Objective: To investigate the influence of spiritual relaxation therapy on sleep quality among nurses experiencing sleep disturbances due to shift work.Method: This is a Quasi-Experimental study with a pre-test-posttest control group design. A total of 38 nurses who experience sleep disorders due to working shifts were included in this study. The PSQI questionnaire was utilized as the instrument to measure sleep quality. Data analysis involved the Mann-Whitney test.Results: The average sleep quality before the intervention was in the mild category; after the intervention, most were in the good category. The results showed that the sleep quality of nurses who received spiritual relaxation was better than the control group (p<0.001).Conclusion: Spiritual relaxation therapy effectively improves the sleep quality of nurses experiencing sleep disturbances due to shift work.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141051046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial activity and perineal wound healing of swallow’s gel extracts 燕子凝胶提取物的抗菌活性与会阴伤口愈合

Medisains Pub Date : 2024-05-01 DOI: 10.30595/medisains.v22i1.15197

Gustiyana Astiti, Runjati Runjati, Sudirman Sudirman

{"title":"Antibacterial activity and perineal wound healing of swallow’s gel extracts","authors":"Gustiyana Astiti, Runjati Runjati, Sudirman Sudirman","doi":"10.30595/medisains.v22i1.15197","DOIUrl":"https://doi.org/10.30595/medisains.v22i1.15197","url":null,"abstract":"Background: Swallow's nest has a glycol content of proteins, carbohydrates (25.62–27.26%), and proteins (62–63%); protein is an indispensable content for the healing process of perineal wounds, protein plays the main ingredient in cell formation, and repairs damaged tissues. In previous studies, swallow's nest extract against perineal wounds in mice obtained the results of accelerated healing on days 3 and 4. However, no studies have been conducted on human perineal injuries.Purpose: Knowing the effectiveness of the swallow's nest extract gel (Aerodramus Fuciphagus) 30% against wound healing and a decrease in the number of colonies of staphylococcus aureus bacteria in the perineal wounds of the postpartum mother.Methods: This experiment study has a post-test with a control group design. The sample comprised 34 postpartum maternal respondents divided into two groups randomly (intervention and control groups). The intervention group was given gel from swallow's nest extract while the control group carried out a dry clean treatment; both were treated to the wound. Perineal wound healing based on REEDA scores was analyzed using the Friedman test, while bacteria in perineal wounds were analyzed using the Man-Whitney test.Results: Based on the REEDA scale, the perineal wound healing rate in the intervention group was better, where healing had already occurred on day 5, compared to the control group that occurred on day 7 (p<0.0001). The number of bacteria in the perineal wounds of the intervention group was less, with an average of 0.06 CFU, compared to the control group's average control group's average of 1.11 CFU (p<0.05).Conclusion: Swallow's nest extract is influential and beneficial in healing perineal wounds in postpartum mothers and has antibacterial activity.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension 石榴提取物对妊娠期高血压患者血压和一氧化氮的影响

Medisains Pub Date : 2023-08-31 DOI: 10.30595/medisains.v21i2.17484

Farah Salsabila, S. Hadisaputro, Lanny Sunarjo

{"title":"Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension","authors":"Farah Salsabila, S. Hadisaputro, Lanny Sunarjo","doi":"10.30595/medisains.v21i2.17484","DOIUrl":"https://doi.org/10.30595/medisains.v21i2.17484","url":null,"abstract":"Background: As a complication of pregnancy, uncontrolled hypertension will continue to be a complication that harms both mother and baby. Pomegranate peel, which contains high antioxidants, is potentially used as an antihypertensive of adjuvant pharmacological therapy. However, there has been no research on the effect of pomegranate extract in lowering blood pressure, so it is necessary to do related research.Purpose: Analyze the effect of pomegranate peel extract on blood pressure and nitric oxide levels in gestational hypertension.Methods: This is a quasi-experiment design pre-post-test with the control group. Through purposive sampling techniques, 32 respondents were divided into two groups. During 14 days, the intervention group received nifedipine 10 mg/day with 500 mg of pomegranate peel extract, while another group was only given nifedipine 10 mg/day.Results: The blood pressure of the intervention group decreased compared to the control group (p<0.05). Meanwhile, the nitric oxide level of the intervention group is increased compared to the control group (p<0.05).Conclusions: Pomegranate peel extract can reduce blood pressure and enhance nitric oxide levels in gestational hypertension.","PeriodicalId":52913,"journal":{"name":"Medisains","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46085168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medisains最新文献