Cardiology Plus最新文献

{"title":"Air pollution and cardiovascular heath in a changing climate","authors":"H. Kan, Tiantian Li, Zhenyu Zhang","doi":"10.1097/cp9.0000000000000051","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000051","url":null,"abstract":"","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45966935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in medical practice: current status and future perspectives","authors":"Yuxiang Dai, Junbo Ge","doi":"10.1097/cp9.0000000000000040","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000040","url":null,"abstract":"","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44964547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality in moderate and severe COVID-19 patients with myocardial injury receiving versus not receiving azvudine: a propensity score-matched analysis.","authors":"Ru Chen,&nbsp;Yi Guo,&nbsp;Shan Deng,&nbsp;Jian Wang,&nbsp;Meng Gao,&nbsp;Hongli Han,&nbsp;Lin Wang,&nbsp;Hongwei Jiang,&nbsp;Kai Huang","doi":"10.1097/CP9.0000000000000049","DOIUrl":"10.1097/CP9.0000000000000049","url":null,"abstract":"<p><p>Omicron is currently the dominant strain of severe acute respiratory syndrome coronavirus 2, but little is known about the characteristics and management of omicron related myocardial injury, particularly the potential benefit of the antiviral agent azvudine.</p><p><strong>Methods: </strong>Patients with confirmed and suspected coronavirus disease 2019 (COVID-19) admitted to Wuhan Union Hospital from December 7, 2022, to December 30, 2022, were included in this study. Cox regression was conducted to identify risk factors for all-cause mortality. A propensity score-matched analysis was performed at a 1:1 ratio with a caliper of 0.1 pooled standard deviations of relevant confounders.</p><p><strong>Results: </strong>The final analysis included a total of 332 patients (167 confirmed cases and 165 suspected cases), 42.77% (142/332) of the patients were 80 years of age or older and 68.67% (228/332) of them were men, 158 patients were treated with azvudine. In the matched cohort, the total mortality was 30.30% (60/198), 40 (20.20%, 40/198) patients received noninvasive ventilation and 22 (11.11%, 22/198) received invasive ventilation, 34 (17.17%, 34/198) patients were admitted to intensive care unit (ICU). The rate of shock, multiple organ damages and arrhythmia were 11.62% (23/198), 20.20% (40/198), and 12.12% (24/198), respectively. There was no significant difference on these clinical outcomes in patients treated with azvudine or not. Azvudine reduced early mortality (within 14 days from admission) (hazard ratio: 0.37, 95% confidence interval: 0.18-0.77) even after adjusting for other treatments including glucocorticoids, immunoglobin and anticoagulant therapy, but not the final in-hospital mortality of patients.</p><p><strong>Conclusions: </strong>Patients with COVID-19-related myocardial injury had a high mortality of about 30.30% (60/198). Azvudine improved the early survival of the patients but not final mortality.</p>","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 2","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/df/cp9-8-103.PMC10364645.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9939473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating the effects of fine and coarse particulate air pollution on the onset of stable and unstable angina: a case-crossover study in 305 Chinese cities","authors":"Yixuan Jiang, Qingli Zhang, Xinlei Zhu, Xiaowei Xue, Qinglin He, Ya Gao, Renjie Chen","doi":"10.1097/CP9.0000000000000052","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000052","url":null,"abstract":"Background and purpose: Associations between fine and coarse particulate matters (i.e., PM2.5 and PM2.5–10, respectively) and the onset of angina have rarely been investigated. We aimed to systematically explore the impacts of PM2.5 as well as PM2.5–10 on the onset of stable and unstable angina at the hourly timescale. Methods: We performed a time-stratified case-crossover study among 995,734 angina patients from 1,655 hospitals in 305 Chinese cities from January 2015 to December 2021. Concentrations of PM2.5 and PM2.5–10 were collected at the hourly timescale from nearby fixed-site monitoring stations. Hourly onset information of unstable and stable angina was obtained from the Chinese Cardiovascular Association Database-Chest Pain Center. We applied conditional logistic regressions combined with polynomial distributed lag models to explore the lagged exposure–response associations. Subgroup analyses were performed to explore potential effect modifiers including age, sex, season, and region. Results: Transient exposure to PM2.5 was significantly associated with elevated risk of unstable and stable angina onset. The associations occurred immediately in the concurrent hour of exposure, attenuated thereafter, and turned to null at approximately lag 12 h for unstable angina and 9 h for stable angina. Each interquartile range increase in the PM2.5 concentrations over 0 to 12 h was associated with 1.32% (95% confidence interval [95% CI]: 0.94%–1.70%) and 1.69% (95% CI: 0.99%–2.39%) increase in the onset risk of unstable and stable angina, respectively. The results remained similar after controlling for co-pollutants. Greater magnitudes of associations were found among females and during cold season. Null associations were observed between PM2.5–10 and any type of angina. Conclusion: Our study indicates that acute exposure to PM2.5, rather than PM2.5–10, was significantly associated with the onset of both unstable and stable angina, underscoring the need of continued efforts in controlling particulate matter air pollution.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 1","pages":"126 - 133"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45603153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 infection with complicated fulminant myocarditis: a case report.","authors":"Kun Miao,&nbsp;Jinsheng Lai,&nbsp;Feng Wang,&nbsp;Luyun Wang,&nbsp;Chunxia Zhao,&nbsp;Dao Wen Wang","doi":"10.1097/CP9.0000000000000050","DOIUrl":"10.1097/CP9.0000000000000050","url":null,"abstract":"<p><p>Herein, we report the case of a young female patient who suffered from myositis and heart failure due to fulminant myocarditis induced by the 2019 coronavirus disease (COVID-19). After receiving intra-aortic balloon pump (IABP) and immunomodulatory treatment, her vital signs gradually stabilized and the IABP was removed. Cardiac and muscle magnetic resonance imaging confirmed extensive myocardial and skeletal muscle edema. Though it is not uncommon for COVID-19 infection to be complicated by myocarditis and myositis, such serious muscle injury warrants clinical vigilance.</p>","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 2","pages":"144-148"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/fa/cp9-8-144.PMC10364644.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9939472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ambient air pollution and cardiovascular symptoms: a systematic review and meta-analysis","authors":"Shiyu Zhou, Fangchao Liu, Hanrui Liu, Sihan Huang, Xiangfeng Lu, Jianfeng Huang","doi":"10.1097/CP9.0000000000000054","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000054","url":null,"abstract":"Background and purpose: Cardiovascular disease is the leading cause of disease burden globally. Previous studies have suggested that air pollution is a risk factor for cardiovascular symptoms, however, the results are controversial. Thus, we conducted this study to systematically review available evidence quantifying the relationship between exposure to ambient gaseous and particulate air pollutants and cardiovascular symptoms. Methods: Three databases were searched up to September 10, 2022, for articles investigating the association of air pollutants including sulfur dioxide, nitrogen dioxide, ozone, carbon monoxide, and particulate matter with aerodynamic diameters of ≤10 μm and ≤2.5 μm (PM10 and PM2.5) with cardiovascular symptoms of chest pain, shortness of breath, respiratory distress, and palpitation. Random-effects model was used to calculate the pooled odds ratio (OR) and 95% confidence interval (95% CI) for chest pain in association with PM2.5. Egger test was used to assess publication bias in the included studies. Results: Of the 16 studies that were included in the systematic review, 10 were used to calculate the pooled OR for chest pain. Most of them were from developed countries, where air pollution levels were relatively low. Short-term exposure to air pollutants may increase the risk of chest pain, with the pooled OR 1.016 (95% CI 1.003–1.030) per 10 μg/m³ increment of PM2.5. Conclusions: Air pollution is a potential risk factor for cardiovascular symptoms, especially chest pain. However, most current studies are conducted in low-pollution regions. More studies from high-pollution regions are needed to confirm the role of ambient air pollution in cardiovascular symptoms and reveal the underlying health effects.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 1","pages":"134 - 143"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47847294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding COVID-19-related myocarditis: pathophysiology, diagnosis, and treatment strategies.","authors":"Hongyang Shu,&nbsp;Chunxia Zhao,&nbsp;Dao Wen Wang","doi":"10.1097/CP9.0000000000000046","DOIUrl":"10.1097/CP9.0000000000000046","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) disease has infected nearly 600 million people, resulting in > 6 million deaths, with many of them dying from cardiovascular diseases. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is caused by a combination of the virus surface spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. In addition to being highly expressed in the lungs, ACE2 is widely distributed in the heart, mainly in myocardial cells and pericytes. Like other types of viruses, SARS-CoV-2 can cause myocarditis after infecting the myocardial tissue, which is attributed to the direct damage of the virus and uncontrolled inflammatory reactions. Patients with chest tightness, palpitation, abnormal electrocardiogram, and cardiac troponin elevation, should be suspected of myocarditis within 1-3 weeks of COVID-19 infection. When the hemodynamics change rapidly, fulminant myocarditis should be suspected. Cardiac ultrasound, myocardial biopsy, cytokine detection, cardiac magnetic resonance imaging, 18F-fluorodeoxyglucose positron emission tomography, and other examination methods can assist in the diagnosis. Although scientists and clinicians have made concerted efforts to seek treatment and prevention measures, there are no clear recommendations for the treatment of COVID-19-related myocarditis. For most cases of common myocarditis, general symptomatic and supportive treatments are used. For COVID-19-related fulminant myocarditis, it is emphasized to achieve \"early identification, early diagnosis, early prediction, and early treatment\" based on the \"life support-based comprehensive treatment regimen.\" Mechanical circulatory support therapy can rest the heart, which is a cure for symptoms, and immune regulation therapy can control the inflammatory storms which is a cure for the disease. Furthermore, complications of COVID-19-related myocarditis, such as arrhythmia, thrombosis, and infection, should be actively treated. Herein, we summarized the incidence rate, manifestations, and diagnosis of COVID-19-related myocarditis and discussed in detail the treatment of COVID-19-related myocarditis, especially the treatment strategy of fulminant myocarditis.</p>","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 2","pages":"72-81"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/89/cp9-8-072.PMC10364646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9939474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient PM2.5 and acute incidence of myocardial infarction in China: a case-crossover study and health impact assessment","authors":"J. Ban, Runmei Ma, An Liu, Qing Wang, Chen Chen, Qinghua Sun, Yanwen Wang, Jianlin Hu, Tiantian Li","doi":"10.1097/CP9.0000000000000047","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000047","url":null,"abstract":"Background and purpose: Evidence investigating the association between ambient fine particulate matter (PM2.5) and acute incidence of myocardial infarction in developing countries is limited. This study aims to investigate linear and nonlinear patterns for the association between PM2.5 and acute incidence of myocardial infarction based on multicounty registry dataset and evaluate the reduction of premature myocardial infarction incidence under different pollution control objectives in China. Methods: Thirty-six thousand six hundred and seventy-nine registered myocardial infarction incidence cases from 15 Chinese counties from January 1, 2013, to December 31, 2017, were obtained. We adopted a time-stratified case-crossover design with conditional logistic regression models. Results: With a 10 μg/m3 increase in PM2.5 exposure, there was an increase of 0.98% (95% CI: 0.40%–1.57%) in acute incidence risk of myocardial infarction. The corresponding values for males and individuals aged over 74 years were 1.58% (95% CI: 0.82%–2.35%) and 1.19% (95% CI: 0.35%–2.05%) respectively, indicating higher risks than other groups. The nonlinear concentration–response curve indicated a steeper slope under daily exposure below 50 μg/m3 and the marginal avoided premature morbidity became larger under the current air quality standard. Conclusions: The robust findings from this study may suggest the necessity for a continuous reduction of PM2.5 exposure concentration from the perspectives of public health.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 1","pages":"111 - 117"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41613821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of PM2.5 from agriculture sources and acute myocardial infarction onset: results from 2015 to 2018 in China","authors":"P. Du, Kailai Lu, Can-Jing Zhang, Ting Liu, Jianlin Hu, Tiantian Li","doi":"10.1097/CP9.0000000000000048","DOIUrl":"https://doi.org/10.1097/CP9.0000000000000048","url":null,"abstract":"Background and purpose: Acute myocardial infarction (AMI) is a manifestation of coronary artery disease. Fine particulate matter (PM2.5) has been regarded as a risk factor for AMI-related mortality and hospitalizations. Agricultural activities contribute greatly to PM2.5 formation, indicating potential health risks of PM2.5 in agricultural areas. Health effect studies on agricultural source remain scarce, and currently available evidence is controversial. This study investigated the health effects of short-term exposure to PM2.5 from agricultural sources on AMI onset using a nationwide analysis in China. Methods: We reviewed case records from the China Cardiovascular Association Database and extracted the data of 355,815 patients with AMI onset from 1,653 hospitals for the period 2015 to 2018. We obtained daily concentrations of PM2.5 from agricultural sources using the source-oriented Community Multiscale Air Quality model. Moreover, we proposed a time-stratified case-crossover study to examine associations between exposure to PM2.5 from agricultural sources and AMI onset and determined lag effects with a maximum of 3 days. Additionally, we conducted multiple subgroup and sensitivity analyses. Results: Exposure to PM2.5 from agricultural sources caused a significantly increased risk of the onset of AMI and its subtypes. Short-term exposure to PM2.5 from agricultural sources on the current day (lag 0) was positively associated with a 4.4% (95% confidence interval [95% CI]: 3.3%–5.5%), 4.9% (95% CI: 3.5%–6.3%), and 3.4% (95% CI: 1.5%–5.4%) increase in the odds of AMI, ST-elevation myocardial infarction (STEMI), and non-STEMI (NSTEMI), for each 10 μg/m3 increase. Meanwhile, higher risk estimations were pronounced in individuals who were aged above 65 years, who lived in southern China, and who resided in the rural area setting, and significant differences were mostly found in NSTEMI onsets. Conclusions: Short-term exposure to PM2.5 from agricultural sources may trigger the onset of AMI and its two subtypes. Improving agriculture management through ammonia emission abatement can help in achieving PM2.5 reduction and protecting public health.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 1","pages":"118 - 125"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49574316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2023 Chinese expert consensus on the impact of COVID-19 on the management of cardiovascular diseases.","authors":"Feng Bai, Jun Pu, Wenliang Che, Jiyan Chen, Mao Chen, Wei Chen, Xiaoping Chen, Yundai Chen, Xianwu Cheng, Xiang Cheng, Hongliang Cong, Cuilian Dai, Dali Fan, Guosheng Fu, Lei Gao, Chuanyu Gao, Wei Gao, Junbo Ge, Ben He, Tao Hu, Congxin Huang, Jing Huang, Yong Huo, Shaobin Jia, Jun Jiang, Zhicheng Jing, Xiangqing Kong, Lang Li, Yan Li, Yigang Li, Zhijuan Li, Chun Liang, Xianhe Lin, Xianxia Liu, Xuebo Liu, Chengzhi Lu, Genshan Ma, Yitong Ma, Wei Mao, Xia Mei, Zhongping Ning, Jiafu Ou, Shaderdin Slaj, Chengxing Shen, Haiming Shi, Hong Shi, Bei Shi, Xi Su, Ningling Sun, Qizhu Tang, Fang Wang, Changqian Wang, Jin Wang, Yanqing Wu, Yongjian Wu, Yunlong Xia, Dingcheng Xiang, Pingxi Xiao, Ping Xie, Dingding Xiong, Yawei Xu, Jiefu Yang, Lixia Yang, Zaixin Yu, Zuyi Yuan, Haitao Yuan, Guogang Zhang, Heng Zhang, Jian Zhang, Li Zhang, Ruiyan Zhang, Shuning Zhang, Shuyang Zhang, Zheng Zhang, Guoan Zhao, Xianxian Zhao, Jingang Zheng, Haoyi Zheng, Daxin Zhou, Shenghua Zhou, Yujie Zhou","doi":"10.1097/CP9.0000000000000043","DOIUrl":"10.1097/CP9.0000000000000043","url":null,"abstract":"<p><p>The primary site of infection in COVID-19 exhibit is the respiratory system, but multiple organ systems could be affected. The virus could directly invade cardiomyocytes. Alternatively, cytokine storm could lead to myocardial injury. More importantly, the management of existing cardiovascular diseases must be re-examined in COVID-19 due to, for example, interaction between antiviral agents and with a wide variety of pharmacological agents. The Branch of Cardiovascular Physicians of Chinese Medical Doctor Association organized a panel of experts in cardiovascular and related fields to discuss this important issue, and formulated the \"2023 Chinese Expert Consensus on the Impact of COVID-19 on the Management of Cardiovascular Diseases.\" The Consensus was drafted on the basis of systematic review of existing evidence and diagnosis and treatment experience, and covers three major aspects: myocardial injury caused by COVID-10 and COVID-19 vaccine, the impact of COVID-19 on patients with cardiovascular disease, and the impact of COVID-19 on the cardiovascular system of healthy people, and rehabilitation guidance recommendations. The Consensus involves 11 core clinical issues, including incidence, pathogenesis, clinical manifestations, treatment strategies, prognosis, and rehabilitation. It is our hope that this Consensus will provide a practical guidance to cardiologists in the management of cardiovascular diseases in the new era of COVID-19 pandemic.</p>","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"8 2","pages":"82-102"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/59/cp9-8-082.PMC10358441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9856057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}