Cardiology Plus最新文献_第10页

A Survey of knowledge on and attitudes toward cardiopulmonary resuscitation and automated external defibrillators in China 中国居民对心肺复苏和自动体外除颤器的知识和态度调查

Cardiology Plus Pub Date : 2021-04-01 DOI: 10.4103/2470-7511.320317

Mingwei Wang, Xin-yan Fu, Wen Wen, Chun-yi Wang, Jie Ni, Jing-jie Jiang, Minjua Wu, Zhao Xu, Yong-Ran Cheng, Meng-yun Zhou, L. Ye, Zhanhui Feng, Juan Chen, Xing-wei Zhang

{"title":"A Survey of knowledge on and attitudes toward cardiopulmonary resuscitation and automated external defibrillators in China","authors":"Mingwei Wang, Xin-yan Fu, Wen Wen, Chun-yi Wang, Jie Ni, Jing-jie Jiang, Minjua Wu, Zhao Xu, Yong-Ran Cheng, Meng-yun Zhou, L. Ye, Zhanhui Feng, Juan Chen, Xing-wei Zhang","doi":"10.4103/2470-7511.320317","DOIUrl":"https://doi.org/10.4103/2470-7511.320317","url":null,"abstract":"Objectives: The aim of this study was to determine the current knowledge levels on cardiopulmonary resuscitation and automated external defibrillators of Chinese citizens. Methods: A face-to-face questionnaire survey on the knowledge of and attitudes toward the use of CPR and AEDs during an OHCA event was conducted in three high-traffic train stations in Hangzhou and Taizhou, China. The survey included questions on previous experience with CPR, recognition of cardiac arrest, CPR-related concerns, and AED knowledge. Results: A total of 6268 participants were surveyed about their knowledge of and attitudes toward the use of CPR and AEDs. A total of 5981 valid questionnaires, including 3008 from female respondents (50.2%) and 2973 from male respondents (49.8%), were retrieved. The participants were geographically distributed as follows: 18.5% from western China, 19.5% from central China, and 77.0% from eastern China. The educational level, regular residence, and sex of the respondents, as well as legislative policies, were relevant to the knowledge of and attitudes toward the use of CPR and AEDs for OHCA events. The results showed that men were more active than women in terms of CPR training and implementation, as well as had more knowledge and used AEDs more often. More people in eastern and central China had witnessed CPR performance, would pay for CPR training, and would be willing to perform CPR if there was a related legislative policy. Moreover, educational level was crucial to the knowledge of and attitudes toward the use of CPR and AEDs during OHCA events. Conclusions: Chinese citizens lack CPR and AED knowledge and training compared with people in developed countries. We recommend that the state should increase public awareness of CPR and AEDs in China. Mass education, policy implementation, specialized training, and legislative action should be carried out.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"121 - 131"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43080853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initiating and secondary mechanisms of hypertension along the time course 高血压的发病机制和继发机制

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312598

Zhiyi Ma

引用次数: 0

Bioinformatics analysis identifies potential biomarkers for the prediction and treatment of myocardial infarction 生物信息学分析确定了预测和治疗心肌梗死的潜在生物标志物

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312597

Yu-yao Ji, Siang Wei, R. Xu, Runda Wu, K. Yao, Y. Zou

{"title":"Bioinformatics analysis identifies potential biomarkers for the prediction and treatment of myocardial infarction","authors":"Yu-yao Ji, Siang Wei, R. Xu, Runda Wu, K. Yao, Y. Zou","doi":"10.4103/2470-7511.312597","DOIUrl":"https://doi.org/10.4103/2470-7511.312597","url":null,"abstract":"Objectives: The aim of this study was to identify differentially expressed genes (DEGs) related to myocardial infarction (MI), which may serve as research and therapeutic targets. Methods: MI expression profiles were obtained from the Gene Expression Omnibus (GEO) database. DEGs were screened using GEO2R, and DEGs in multiple datasets were identified using Venn diagrams. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment analyses were performed using the Database for Annotation, Visualization, and Integrated Discovery v6.8. A protein-protein interaction (PPI) network was constructed using STRING and Cytoscape 3.7.2. Coexpedia was used for gene coexpression network analysis and functional annotation. Results: We identified 50 DEGs in the four datasets, including 29 with important roles in the PPI network. GO functional enrichment analysis revealed the involvement of DEGs in biological processes such as cytokine activation, peptidase inhibition, and chemokine activation. KEGG analysis revealed enrichment in chemokine signaling and cytokine-cytokine receptor interactions. Gene coexpression network analysis identified nine hub genes involved in the occurrence and development of MI including tissue inhibitor of metalloproteinase 1; CD44 antigen; lysyl oxidase; formyl peptide receptor 2; matrix metallopeptidase 3; formyl peptide receptor 1; serine (or cysteine) peptidase inhibitor, clade E, member 1; prostaglandin-endoperoxide synthase 2; and elastin. Conclusions: The hub genes identified may play important roles in MI-related biological processes and represent potential diagnostic and therapeutic targets. Therefore, this study lays a foundation for further exploration of the molecular mechanisms of MI.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"48 - 55"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41391187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine in coronary artery disease: Time for implementation into practice 冠状动脉疾病的精准医学:实施实践的时机

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312600

Yuxiang Dai, J. Ge

引用次数: 2

Evidence of superiority of sacubitril/valsartan versus angiotensin-converting enzyme inhibitors or angiotensin ii receptor blockers in the heart failure with reduced ejection fraction patient's journey 沙库必曲/缬沙坦与血管紧张素转换酶抑制剂或血管紧张素ii受体阻滞剂在射血分数降低的心力衰竭患者旅程中的优势证据

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312591

M. Gori, E. D’Elia, M. Senni

引用次数: 1

2020 expert consensus on the prevention and treatment of heart failure after myocardial infarction 2020年心肌梗死后心力衰竭防治专家共识

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312595

引用次数: 3

FURIN promoter methylation predicts the risk of incident hypertension: A prospective analysis of the Gusu cohort FURIN启动子甲基化预测高血压事件的风险:姑苏队列的前瞻性分析

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312596

Shengqi Ma, Jinhua Zhu, Lei Wu, Yan He, Liyun Ren, Bin Shen, Jia Yu, Rongyan Zhang, Jing Li, Mingzhi Zhang, Hao Peng

{"title":"FURIN promoter methylation predicts the risk of incident hypertension: A prospective analysis of the Gusu cohort","authors":"Shengqi Ma, Jinhua Zhu, Lei Wu, Yan He, Liyun Ren, Bin Shen, Jia Yu, Rongyan Zhang, Jing Li, Mingzhi Zhang, Hao Peng","doi":"10.4103/2470-7511.312596","DOIUrl":"https://doi.org/10.4103/2470-7511.312596","url":null,"abstract":"Objectives: Furin has been associated with hypertension through unclear underlying mechanisms. FURIN promoter methylation may participate in the underlying mechanisms, but no evidence supports this possibility. Here, we performed a prospective analysis to study the association between FURIN promoter methylation and incident hypertension. Methods: DNA methylation levels in the FURIN promoter were quantified by target bisulfite sequencing using peripheral blood from 1043 participants in the Gusu cohort (mean age: 50 years, 30% men) who were free of hypertension at baseline. After an average of 4 years of follow-up, 149 (14.3%) participants developed hypertension. Multiple testing was controlled for by measuring the false-discovery rate. Results: Of the eight CpG loci assayed, DNA methylation levels at Chr15: 91416118 were significantly associated with incident hypertension after adjusting for covariates and multiple testing (hazard ratio [HR] = 1.38, 95% confidence interval [CI]: 1.17–1.64, q = 0.001). The weighted truncated-product method, which combines single CpG associations, revealed that DNA methylation at multiple CpG sites was jointly associated with incident hypertension (P < 0.001). Using the average methylation level of all CpG sites as a surrogate for FURIN promoter methylation revealed a similar association (HR = 1.36, 95% CI: 1.08–1.72, P = 0.009). Almost all CpG methylations negatively correlated with serum furin levels, which mediated approximately 29.44% of the association between FURIN promoter methylation and incident hypertension. Conclusions: These results suggest that FURIN promoter hypermethylation is associated with an increased risk for hypertension in Chinese adults, partially through suppressing furin expression or excretion.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"56 - 64"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48165708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gut microbiota, metabolites, and cardiovascular diseases 肠道微生物群、代谢产物和心血管疾病

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312593

Yi-qiong Zhang, Yichao Hua, Chenxia Li, Beidi Lan, Xiao-Ke Wang, Qi Wang, Z. Yuan, Lu Ma, Yue Wu

引用次数: 0

Potential adverse effects of coronavirus disease 2019 on the cardiovascular system. 2019 年冠状病毒疾病对心血管系统的潜在不利影响。

Cardiology Plus Pub Date : 2021-01-01 Epub Date: 2021-03-30 DOI: 10.4103/2470-7511.312592

Bing-Yin Wang, Bin-Quan You, Feng Liu

引用次数: 0

Clinical and genetic characteristics of coronary artery disease in Chinese young adults: Rationale and design of the prospective Genetic characteristics of coRonary Artery disease in ChiNese young aDults (GRAND) study 中国年轻人冠状动脉疾病的临床和遗传特征:中国年轻人冠状动脉疾病前瞻性遗传特征(GRAND)研究的基本原理和设计

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312594

Shali Shalaimaiti, Yuxiang Dai, Hongyi Wu, J. Qian, Yan Zheng, K. Yao, J. Ge

{"title":"Clinical and genetic characteristics of coronary artery disease in Chinese young adults: Rationale and design of the prospective Genetic characteristics of coRonary Artery disease in ChiNese young aDults (GRAND) study","authors":"Shali Shalaimaiti, Yuxiang Dai, Hongyi Wu, J. Qian, Yan Zheng, K. Yao, J. Ge","doi":"10.4103/2470-7511.312594","DOIUrl":"https://doi.org/10.4103/2470-7511.312594","url":null,"abstract":"Background: Emerging evidence indicates that the worldwide incidence of early-onset coronary artery disease (EOCAD) is increasing. The genetic background has been assumed to harbor pathogenic risk, although the existing findings are mainly restricted to Caucasians. Little is known regarding the clinical profiles of patients with EOCAD and the extent to which genetic factors are related to disease susceptibility and outcomes in Asian people, especially ethnic Chinese. Methods and Results: The Genetic characteristics of coRonary Artery disease (CAD) in ChiNese young aDults (GRAND) study is a multicenter, hospital-based observational clinical study, combined of case-control design and longitudinal prospective cohort. Six thousand nationally representative patients who underwent coronary angiography at 38 centers have been enrolled since May 2017. Clinical data of patients with EOCAD (aged ≤45 years) are collected at the baseline to delineate conventional risk factors, clinical profiles, and therapeutic options of EOCAD and compared with data for patients with late-onset CAD (aged ≥65 years) and age-matched controls without CAD. The patients are followed for 3 years to trace major adverse cardiovascular (CV) events: cardiac death, nonfatal myocardial infarction, and ischemia-driven revascularization. Functional variants contributing to EOCAD risk are identified by high-depth whole-exome sequencing. The genetic profiles are further linked to disease severity and prognosis. A multi-dimensional risk score is established to predict prevalent EOCAD and incident CV events among young Chinese adults. Conclusions: The GRAND study will generate a thorough understanding of the clinical characteristics and genetic basis of EOCAD and may pave the way for genetic screening, early prevention, and future drug discovery for CAD in young Chinese generations.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"65 - 72"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46969860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1