Cardiology Plus最新文献_第10页

Dapagliflozin Regulates Cardiac Metabolic Remodeling Partially via Uncoupling Protein 3 in a Nondiabetic Thoracic Aortic Constriction-Induced Mouse Model 在非糖尿病胸主动脉收缩小鼠模型中，达格列净通过解偶联蛋白3部分调节心脏代谢重塑

Cardiology Plus Pub Date : 2021-04-01 DOI: 10.4103/2470-7511.320318

L. Bao, Rongchen Liu, Fangying Yan, Huizhi Fan, Guomin Huang, Xiu-fang Gao, Kun Xie, Yong Li, Hai-ming Shi

{"title":"Dapagliflozin Regulates Cardiac Metabolic Remodeling Partially via Uncoupling Protein 3 in a Nondiabetic Thoracic Aortic Constriction-Induced Mouse Model","authors":"L. Bao, Rongchen Liu, Fangying Yan, Huizhi Fan, Guomin Huang, Xiu-fang Gao, Kun Xie, Yong Li, Hai-ming Shi","doi":"10.4103/2470-7511.320318","DOIUrl":"https://doi.org/10.4103/2470-7511.320318","url":null,"abstract":"Objectives: We aimed to examine the protective effects of dapagliflozin (dapa) on thoracic aortic constriction (TAC)-induced heart failure in a nondiabetic mouse model. More specifically, we determined the effects of dapa on uncoupling protein 3 (UCP3) activation and subsequent metabolic remodeling. Methods: Sixty C57BL/6J mice were divided into six groups for TAC surgery and received different doses of dapa via gavage for 4 weeks. Echocardiography was performed to evaluate cardiac structure and function. Histological and molecular markers of cardiac remodeling and metabolic changes were assessed through staining assays, RT-PCR, western blot, and ELISA. HL-1 cells were used to explore the role of UCP3 in metabolic remodeling through transfection with UCP3 siRNA. Results: Mice that received TAC exhibited elevated heart weight/body weight ratios (HW/BW), left ventricular (LV) hypertrophy, impaired LV ejection fraction, and increased rates of fibrosis and apoptosis, unlike mice that received sham operation. Treatment with dapa after TAC restored HW/BW, improved LV parameters, and reduced fibrosis and apoptosis. dapa changed the expression levels of enzymes involved in glucose and fatty acid (FA) metabolism, such as pyruvate dehydrogenase lipoamide kinase isozyme 4, glucose transporter 4, carnitine palmitoyltransferase-1α, carnitine O-acetyltransferase, carnitine O-octanoyltransferase, acyl-CoA thioesterase 1, acyl-CoA thioesterase 2, peroxisome proliferator-activated receptors α and β, proliferator-activated receptor-gamma coactivator-1α, and UCP3, relative to the levels in mice in the TAC group. UCP3 siRNA reduced the expression of AMP-activated protein kinase and of factors involved in FA oxidation in vitro. Conclusions: Dapa exhibits cardioprotective effects in the model and augments expression of UCP3, which may be involved in metabolic remodeling in the failing heart.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"109 - 120"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45504774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential diagnosis of PRKAG2 Cardiac syndrome in hypertrophic cardiomyopathy patients of han nationality 汉族肥厚型心肌病患者PRKAG2心脏综合征的鉴别诊断

Cardiology Plus Pub Date : 2021-04-01 DOI: 10.4103/2470-7511.320319

Xuejie Li, Nianwei Zhou, Huiyuan Xie, Wen Liu, C. Pan, Xianghong Shu

{"title":"Differential diagnosis of PRKAG2 Cardiac syndrome in hypertrophic cardiomyopathy patients of han nationality","authors":"Xuejie Li, Nianwei Zhou, Huiyuan Xie, Wen Liu, C. Pan, Xianghong Shu","doi":"10.4103/2470-7511.320319","DOIUrl":"https://doi.org/10.4103/2470-7511.320319","url":null,"abstract":"Objectives: This study aimed to diversify the spectrum of PRKAG2 variants and explore its clinical features in a Chinese Han population with hypertrophic cardiomyopathy (HCM). Methods: Whole-exome sequencing was performed on 200 patients diagnosed with HCM, and four causative PRKAG2 variants were identified in the probands and their relatives using Sanger sequencing. Their clinical manifestations, laboratory examinations, therapeutic methods, and outcomes were documented and analyzed. Results: Four variants were identified in six probands and seven of their relatives. Left ventricular hypertrophy was present in all probands. Five probands had sinus bradycardia, three had implanted pacemakers (PM), one developed heart failure, two had ventricular preexcitation, and one had atrial fibrillation. Conclusions: PRKAG2 cardiac syndrome (PCS) is a rare autosomal dominant disease characterized by ventricular hypertrophy, preexcitation, and progressive conduction defects, resulting in a high incidence of PM implantation. Genetic testing provides robust information for distinguishing PCS from sarcomeric HCM, which will be beneficial in guiding therapy and improving prognosis.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"132 - 140"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44022035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital heart defects: A morphological approach 先天性心脏缺陷:形态学方法

Cardiology Plus Pub Date : 2021-04-01 DOI: 10.4103/2470-7511.320323

Siew Ho

引用次数: 0

Updated algorithm of chronic total occlusion percutaneous coronary intervention from chronic total occlusion club China 慢性全闭塞经皮冠状动脉介入治疗的更新算法来自中国慢性全闭塞俱乐部

Cardiology Plus Pub Date : 2021-04-01 DOI: 10.4103/2470-7511.320320

J. Ge, L. Ge, Y. Huo, Ji-yan Chen, Wei-min Wang, On Behalf of Chronic Total Occlusion Club

引用次数: 1

A Survey of knowledge on and attitudes toward cardiopulmonary resuscitation and automated external defibrillators in China 中国居民对心肺复苏和自动体外除颤器的知识和态度调查

Cardiology Plus Pub Date : 2021-04-01 DOI: 10.4103/2470-7511.320317

Mingwei Wang, Xin-yan Fu, Wen Wen, Chun-yi Wang, Jie Ni, Jing-jie Jiang, Minjua Wu, Zhao Xu, Yong-Ran Cheng, Meng-yun Zhou, L. Ye, Zhanhui Feng, Juan Chen, Xing-wei Zhang

{"title":"A Survey of knowledge on and attitudes toward cardiopulmonary resuscitation and automated external defibrillators in China","authors":"Mingwei Wang, Xin-yan Fu, Wen Wen, Chun-yi Wang, Jie Ni, Jing-jie Jiang, Minjua Wu, Zhao Xu, Yong-Ran Cheng, Meng-yun Zhou, L. Ye, Zhanhui Feng, Juan Chen, Xing-wei Zhang","doi":"10.4103/2470-7511.320317","DOIUrl":"https://doi.org/10.4103/2470-7511.320317","url":null,"abstract":"Objectives: The aim of this study was to determine the current knowledge levels on cardiopulmonary resuscitation and automated external defibrillators of Chinese citizens. Methods: A face-to-face questionnaire survey on the knowledge of and attitudes toward the use of CPR and AEDs during an OHCA event was conducted in three high-traffic train stations in Hangzhou and Taizhou, China. The survey included questions on previous experience with CPR, recognition of cardiac arrest, CPR-related concerns, and AED knowledge. Results: A total of 6268 participants were surveyed about their knowledge of and attitudes toward the use of CPR and AEDs. A total of 5981 valid questionnaires, including 3008 from female respondents (50.2%) and 2973 from male respondents (49.8%), were retrieved. The participants were geographically distributed as follows: 18.5% from western China, 19.5% from central China, and 77.0% from eastern China. The educational level, regular residence, and sex of the respondents, as well as legislative policies, were relevant to the knowledge of and attitudes toward the use of CPR and AEDs for OHCA events. The results showed that men were more active than women in terms of CPR training and implementation, as well as had more knowledge and used AEDs more often. More people in eastern and central China had witnessed CPR performance, would pay for CPR training, and would be willing to perform CPR if there was a related legislative policy. Moreover, educational level was crucial to the knowledge of and attitudes toward the use of CPR and AEDs during OHCA events. Conclusions: Chinese citizens lack CPR and AED knowledge and training compared with people in developed countries. We recommend that the state should increase public awareness of CPR and AEDs in China. Mass education, policy implementation, specialized training, and legislative action should be carried out.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"121 - 131"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43080853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initiating and secondary mechanisms of hypertension along the time course 高血压的发病机制和继发机制

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312598

Zhiyi Ma

引用次数: 0

Bioinformatics analysis identifies potential biomarkers for the prediction and treatment of myocardial infarction 生物信息学分析确定了预测和治疗心肌梗死的潜在生物标志物

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312597

Yu-yao Ji, Siang Wei, R. Xu, Runda Wu, K. Yao, Y. Zou

{"title":"Bioinformatics analysis identifies potential biomarkers for the prediction and treatment of myocardial infarction","authors":"Yu-yao Ji, Siang Wei, R. Xu, Runda Wu, K. Yao, Y. Zou","doi":"10.4103/2470-7511.312597","DOIUrl":"https://doi.org/10.4103/2470-7511.312597","url":null,"abstract":"Objectives: The aim of this study was to identify differentially expressed genes (DEGs) related to myocardial infarction (MI), which may serve as research and therapeutic targets. Methods: MI expression profiles were obtained from the Gene Expression Omnibus (GEO) database. DEGs were screened using GEO2R, and DEGs in multiple datasets were identified using Venn diagrams. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment analyses were performed using the Database for Annotation, Visualization, and Integrated Discovery v6.8. A protein-protein interaction (PPI) network was constructed using STRING and Cytoscape 3.7.2. Coexpedia was used for gene coexpression network analysis and functional annotation. Results: We identified 50 DEGs in the four datasets, including 29 with important roles in the PPI network. GO functional enrichment analysis revealed the involvement of DEGs in biological processes such as cytokine activation, peptidase inhibition, and chemokine activation. KEGG analysis revealed enrichment in chemokine signaling and cytokine-cytokine receptor interactions. Gene coexpression network analysis identified nine hub genes involved in the occurrence and development of MI including tissue inhibitor of metalloproteinase 1; CD44 antigen; lysyl oxidase; formyl peptide receptor 2; matrix metallopeptidase 3; formyl peptide receptor 1; serine (or cysteine) peptidase inhibitor, clade E, member 1; prostaglandin-endoperoxide synthase 2; and elastin. Conclusions: The hub genes identified may play important roles in MI-related biological processes and represent potential diagnostic and therapeutic targets. Therefore, this study lays a foundation for further exploration of the molecular mechanisms of MI.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"6 1","pages":"48 - 55"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41391187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine in coronary artery disease: Time for implementation into practice 冠状动脉疾病的精准医学:实施实践的时机

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312600

Yuxiang Dai, J. Ge

引用次数: 2

Evidence of superiority of sacubitril/valsartan versus angiotensin-converting enzyme inhibitors or angiotensin ii receptor blockers in the heart failure with reduced ejection fraction patient's journey 沙库必曲/缬沙坦与血管紧张素转换酶抑制剂或血管紧张素ii受体阻滞剂在射血分数降低的心力衰竭患者旅程中的优势证据

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312591

M. Gori, E. D’Elia, M. Senni

引用次数: 1

2020 expert consensus on the prevention and treatment of heart failure after myocardial infarction 2020年心肌梗死后心力衰竭防治专家共识

Cardiology Plus Pub Date : 2021-01-01 DOI: 10.4103/2470-7511.312595

引用次数: 3