Cardiology Plus最新文献_第2页

Non-alcoholic fatty liver disease and risk of cardiovascular diseases: clinical association, pathophysiological mechanisms, and management 非酒精性脂肪肝与心血管疾病风险：临床关联、病理生理机制与管理

Cardiology Plus Pub Date : 2023-12-08 DOI: 10.1097/cp9.0000000000000067

Rong Yang, Jian-Gao Fan

引用次数: 0

Characteristics of patients undergoing percutaneous coronary intervention for chronically total occluded arteries: a single-center observational study in India 慢性全动脉闭塞患者经皮冠状动脉介入治疗的特点:印度的一项单中心观察性研究

Cardiology Plus Pub Date : 2023-10-05 DOI: 10.1097/cp9.0000000000000061

Abhijit Khadtare, Chandrashekhar Makhale, Shrish Hiremath, Purvez Grant

{"title":"Characteristics of patients undergoing percutaneous coronary intervention for chronically total occluded arteries: a single-center observational study in India","authors":"Abhijit Khadtare, Chandrashekhar Makhale, Shrish Hiremath, Purvez Grant","doi":"10.1097/cp9.0000000000000061","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000061","url":null,"abstract":"Background and purpose: Percutaneous coronary intervention (PCI) is the gold standard for managing chronic total occlusion (CTO), but data on characteristics of the patients undergoing PCI for CTO are scarce. The present study was designed to evaluate the clinical profile of the patients who underwent PCI to CTO. Methods: This single-center, prospective, and observational study included consecutive patients who successfully underwent PCI for angiographically confirmed CTO at author’s center from March 2017 to March 2019. Follow-up was conducted at 6 and 12 months. Results: The final analysis included a total of 108 patients. The mean age was 64.5 ± 8.2 years. Majority of the patients (72.2%) were men. The most common morbid risk factors were diabetes mellitus (56.5%), hypertension (53.7%), and dyslipidemia (52.8%). Mean left ventricular ejection fraction (LVEF) was 51% ± 0.0% and 73% had New York Heart Association (NYHA) class II. The most common site of CTO was the right coronary artery (34.3%). PCI was conducted using an antegrade approach, 75.9% of the cases. The majority of patients underwent wire escalation PCI technique (52.8%) followed by adverse drug reaction (34.3%), reverse-controlled antegrade and retrograde tracking (CART) (8.3%) and CART (4.6%). Stress test was negative in 63% and 64.8% of the patients at 6 and 12 months, respectively. The 6-month symptom-free survival rate was higher in patients without hypertension. Symptom-free survival rate was 96.9%, 95.9% and 88.9% in patients with Japanese Multicenter CTO Registry (J-CTO) score of 0, 1 and >3, respectively. The rate of abnormal electrocardiogram at 12 months was higher in patients with J-CTO score of 0 or 1 versus >3. Conclusion: PCI is a viable option for patients who are not willing to undergo coronary artery bypass grafting, particularly in those with low J-CTO score.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of cardiovascular disease to the burden of non-communicable diseases in Africa: an analysis of data from Global Burden of Disease database, 1990–2019 心血管疾病对非洲非传染性疾病负担的贡献:对1990-2019年全球疾病负担数据库数据的分析

Cardiology Plus Pub Date : 2023-07-25 DOI: 10.1097/cp9.0000000000000057

M. Maimaitiming, A. Kakunze, Yikai Feng, Minmin Wang, Na Li, Junyi Shi, Kepei Huang, Yinzi Jin, Zhijie Zheng

{"title":"Contribution of cardiovascular disease to the burden of non-communicable diseases in Africa: an analysis of data from Global Burden of Disease database, 1990–2019","authors":"M. Maimaitiming, A. Kakunze, Yikai Feng, Minmin Wang, Na Li, Junyi Shi, Kepei Huang, Yinzi Jin, Zhijie Zheng","doi":"10.1097/cp9.0000000000000057","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000057","url":null,"abstract":"\u0000 \u0000 Disease burden of non-communicable diseases (NCDs) has been increasing in low- and middle-income countries, especially in African countries. Cardiovascular disease (CVD) is a common NCDs and the leading cause of death in Africa. Yet, evidence on the contribution of CVD to the total NCDs burden is scarce. This study aimed to investigate the contribution of CVD to the total disease burden caused by NCDs in Africa between 1990 and 2019.\u0000 \u0000 \u0000 \u0000 Data on NCDs, including CVD, were extracted from the Global Burden of Disease (GBD) database. Disease burden was measured by disability-adjusted life years (DALYs) and deaths.\u0000 \u0000 \u0000 \u0000 From 1990 to 2019, the share of CVD in the total NCDs burden increased and remained as the first contributor. In 2019, NCDs caused 204 million DALYs and over 2.18 million deaths in the Africa Union, among which 49.1% of the total DALYs and 66.0% of deaths were caused by the traditional five NCDs, including CVD that accounted for the largest burden of NCDs (20.5% of DALYs and 35.2% of deaths). The proportion of CVD to the total NCDs burden was most considerable, reaching up to 32.4% and 52.4% in Northern Africa for DALYs and deaths, respectively. CVD were important contributors to NCDs burden in Africa, including ischemic heart disease (1334 DALYs per 100,000 and 27.79 deaths per 100,000) and intracerebral hemorrhage (632 DALYs per 100,000 and 13.53 deaths per 100,000) that were the top two causes of NCDs in 2019.\u0000 \u0000 \u0000 \u0000 CVD has been the biggest contributor to NCDs burden in the Africa Union over the thirty years. Given the increase in the share of NCDs burden attributable to CVD, it demands a close attention to implementing cost-effective policies and interventions for CVD to achieve an improvement in population health and reduction of health loss from NCDs.\u0000","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49229856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A transcatheter “sandwich” valve-in-valve implantation for pure aortic regurgitation: a report of 2 cases 经导管“夹层”瓣内植入治疗单纯主动脉反流2例报告

Cardiology Plus Pub Date : 2023-07-01 DOI: 10.1097/cp9.0000000000000059

Shasha Chen, Dawei Lin, Yiming Qi, Daxin Zhou, Wenzhi Pan, Junbo Ge

{"title":"A transcatheter “sandwich” valve-in-valve implantation for pure aortic regurgitation: a report of 2 cases","authors":"Shasha Chen, Dawei Lin, Yiming Qi, Daxin Zhou, Wenzhi Pan, Junbo Ge","doi":"10.1097/cp9.0000000000000059","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000059","url":null,"abstract":"The application of transcatheter aortic valve replacement (TAVR) for severe pure native aortic valve regurgitation (PNAR) remains limited. TAVR for PNAR using an off-label device is associated with acceptable procedural success but increased early mortality. For performing TAVR for PNAR patients, appropriate anatomy, especially a relatively small aortic annulus, is a necessary condition for successful procedure, and large aortic annulus is generally excluded. Here, we report using a new transcatheter “sandwich” valve-in-valve implantation technique with commercially available devices for treating two cases of PNAR, including one with a extremely large aortic annulus (namely aortic annulus perimeter over 91.1 mm, respectively, according to the industry instructions VitaFlow®). The conditions of both patients improved, and there were no complications during the follow-up periods. The new transcatheter “sandwich” valve-in-valve implantation technique using the commercially available self-expanding devices could be an option for treating PNAR patients with an extremely large annulus at high risk for surgery. This technique can also be an effective remedy for the first valve to be placed too high and jump up to the ascending aorta.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135804980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injury mechanism of COVID-19-induced cardiac complications. 新型冠状病毒感染心脏并发症的损伤机制

Cardiology Plus Pub Date : 2023-07-01 Epub Date: 2023-06-23 DOI: 10.1097/CP9.0000000000000055

Ling Leng, Xiu-Wu Bian

引用次数: 0

Diabetes and associated cardiovascular complications: The role of microRNAs 糖尿病和相关心血管并发症:microrna的作用

Cardiology Plus Pub Date : 2023-07-01 DOI: 10.1097/cp9.0000000000000062

Mirjana T. Macvanin, Esma R. Isenovic

{"title":"Diabetes and associated cardiovascular complications: The role of microRNAs","authors":"Mirjana T. Macvanin, Esma R. Isenovic","doi":"10.1097/cp9.0000000000000062","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000062","url":null,"abstract":"Diabetes mellitus (DM) refers to a complex cluster of metabolic disorders characterized by hyperglycemia caused by inadequate insulin secretion, insulin resistance, or excessive glucagon secretion. If not correctly treated, the prolonged effects of DM-associated metabolic perturbations lead to systemic vascular complications and cardiovascular disease (CVD), the principal cause of mortality among patients with DM. Given the increase in the global prevalence of diabetes, novel diagnostic and therapeutic procedures are necessary for its effective identification and treatment. Recent findings point to an important role of microRNA (miRNAs) in DM initiation and progression, as well as the occurrence of associated cardiovascular complications. miRNAs are short, highly conserved, single-stranded, non-coding RNAs that contribute to the maintenance of physiological homeostasis through the regulation of crucial processes such as metabolism, cell proliferation, and apoptosis. The increased availability of high-throughput methodologies for identifying and characterizing non-coding RNAs has led to considerable interest in miRNAs as potential biomarkers and therapeutic agents for DM. In this review, we first comprehensively detail the regulatory miRNAs involved in the pathophysiology of DM and diabetic cardiomyopathy (DCMP). Subsequently, we summarize findings regarding the utility of several of these miRNAs as potential prognostic and diagnostic biomarkers for DM and DM-associated CVD. Finally, we evaluate the potential of miRNA-based therapeutic approaches for treating DM and DCMP in the clinical setting.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135851621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative methylene diphosphonate scintigraphy in biopsy-confirmed hereditary transthyretin Ala117Ser cardiac amyloidosis: a case report 活组织检查证实遗传性甲状腺转蛋白Ala117Ser心脏淀粉样变性的二膦酸亚甲基显像阴性1例

Cardiology Plus Pub Date : 2023-07-01 DOI: 10.1097/cp9.0000000000000058

Zejia Wu, Shuang Xia, Dunliang Ma, Liwen Li

引用次数: 0

A multi-device robotic-assisted PCI system: a proof-of concept study for left main bifurcation stenting with culotte technique in a porcine model 一种多设备机器人辅助PCI系统:猪模型左主干分叉支架术的概念验证研究

Cardiology Plus Pub Date : 2023-07-01 DOI: 10.1097/cp9.0000000000000060

Wenzheng Han, Ming Wang, Shaofeng Guan, Qian Gan, Weiyi Fang, Kun Xia, Xinkai Qu

{"title":"A multi-device robotic-assisted PCI system: a proof-of concept study for left main bifurcation stenting with culotte technique in a porcine model","authors":"Wenzheng Han, Ming Wang, Shaofeng Guan, Qian Gan, Weiyi Fang, Kun Xia, Xinkai Qu","doi":"10.1097/cp9.0000000000000060","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000060","url":null,"abstract":"Background and purpose: Robotic-assisted percutaneous coronary intervention (PCI) has been increasingly used for simple lesion. For complex lesions, extensive manual intervention is still required. This study aims to verify the stability and safety of this robot system in complex lesion under fifth-generation (5G) network before clinical trial. Methods: We developed a robotic system that allows simultaneous remote control of multiple devices using a 5G wireless network. The key feature of the system is a bionic thumb along with two-bionic forefingers. The system was tested in eight pigs (six over 18.3 km and two over 1,100 km). Two stents were placed in the left main bifurcation using the culotte technique. All procedures, barring device loading onto the robot system, including manipulation of the guiding catheter, wire adjustments, stent or balloon positioning, and notably the final kissing step, were conducted remotely. Results: The rate of procedure success was 100%, with no device-related complications. In comparison to short-distance remote control, the delay with long-distance remote control was minimal (90.9 ± 1.5 vs. 81.5 ± 2.7 ms for command data transmission; 163.2 ± 1.3 vs. 161.0 ± 1.4 ms for image transmission). The procedure time was shorter when using two pairs versus a single pair of bionic fingers (104.3 ± 10.2 vs. 126.0 ± 3.9 min), primarily due to less time needed for device loading and exchange (33.1 ± 4.2 vs. 56.1 ± 4.0 min). Conclusions: With the 5G network, long distance was not a significant barrier for robotic-assisted PCI for chronic total occlusion. A design of the independent bionic finger module enabled final kissing balloon inflation with reduced requirement for manual intervention. Whether the system could be used beyond left main bifurcation lesions requires further investigation.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135804979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STAT3-CD163 cross-talk exhibits promising biomarkers for a progressive ischemic cardiomyopathy: integrative computational and gene expression profiling based on Gene Expression Omnibus datasets STAT3-CD163串音显示出进展性缺血性心肌病的有希望的生物标志物:基于基因表达综合数据集的综合计算和基因表达谱

Cardiology Plus Pub Date : 2023-07-01 DOI: 10.1097/cp9.0000000000000063

Mina W. Mohareb, Mohammed A. Kariem, Aly Tohamy, Noha M. Gamal, Rehab M. Mosaad, Nora N. Esmaiel, Alaaeldin G. Fayez

{"title":"STAT3-CD163 cross-talk exhibits promising biomarkers for a progressive ischemic cardiomyopathy: integrative computational and gene expression profiling based on Gene Expression Omnibus datasets","authors":"Mina W. Mohareb, Mohammed A. Kariem, Aly Tohamy, Noha M. Gamal, Rehab M. Mosaad, Nora N. Esmaiel, Alaaeldin G. Fayez","doi":"10.1097/cp9.0000000000000063","DOIUrl":"https://doi.org/10.1097/cp9.0000000000000063","url":null,"abstract":"Background and purpose: Ischemic heart disease frequently leads to heart failure, often resulting in death. In this study, we aimed to identify common hub mRNAs and pathways involved in the pathological progression of ischemic cardiomyopathy (ICM). Methods: Validation quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was carried out on peripheral blood and left ventricle specimens from patients in three groups with stable coronary artery disease (CAD), myocardial infarction (MI), and ICM and compared with corresponding controls. qRT-PCR was preceded by computational analysis of eight high-throughput RNA sequencing and microarray datasets from 499 patients and 233 controls, to determine possible common biologically meaningful differentially expressed genes (DEGs). To determine the potential pathological pathways, we performed Gene Ontology functional annotation, pathway enrichment analysis, protein–protein interaction (PPI) analysis, and constructed transcriptional factor/miRNA regulatory networks. Finally, approved drugs were screened. Results: Fifteen common DEGs with P < 0.01 were identified. STAT3, CEBPD, GLUL , and CD163 were hub-enriched mRNAs with an interaction score ≥ 0.50. Our qRT-PCR analysis showed an increased expression of STAT3 in all three patient groups and CD163 , mainly in cardiac samples, in a remarkably ascending manner. Interaction modules showed co-regulators supporting high STAT3-CD163 connectivity, suggesting a potential role for STAT3-CD163 cross-talk-mediated inflammatory responses in ICM progression. Conclusions: Our results provided a novel perspective for understanding the underlying mechanisms of ICM progression and exploring new therapeutic agents. Clinical trial registration: URL: www.clinicaltrials.gov. Unique identifier: NCT05508269.","PeriodicalId":52908,"journal":{"name":"Cardiology Plus","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135856484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer treatment-related cardiotoxicity: a focus on sacubitril/valsartan 癌症治疗相关的心脏毒性:关注苏比里尔/缬沙坦

Cardiology Plus Pub Date : 2023-06-26 DOI: 10.1097/cp9.0000000000000056

F. Hu, Huajiong Yu, Zhao-yang Chen, Lianglong Chen

引用次数: 0