Vaccine Research最新文献_第4页

Sequence Diversity of FliC Protein from Enterobacteriaceae Family to Introducing a Promising Epitope-Delivery Platform 肠杆菌科FliC蛋白序列多样性及其表位递送平台的研究

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.85

Sepideh Fereshteh, F. Badmasti

引用次数: 0

Feeding Eggs from Hens Immunized with Specific KLH-Conjugated HIV Peptide Candidate Vaccines to Chicks Induces Specific Anti-HIV gp120 and gp41 Antibodies that Neutralize the Original HIV Antigens 将用特异性KLH结合HIV肽候选疫苗免疫的母鸡的蛋喂给鸡可诱导中和原始HIV抗原的特异性抗HIV gp120和gp41抗体

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.92

Justiz Vaillant, Ferrer Cosme, Fisher Smikle, O. Pérez

引用次数: 1

An Assessment of the 2017-2018 Post Measles Campaign Coverage Survey in the South-south Zone of Nigeria 尼日利亚南南区2017-2018年麻疹运动后覆盖率调查评估

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.41

O. Chime, Jennie Orji, C. Madu

引用次数: 0

The Skin Immune System and Intradermal Delivery of Vaccines: A Review 皮肤免疫系统和疫苗的皮内递送：综述

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.15

Silvia Angélica Carmona‐Cruz, María Teresa García‐Romero

{"title":"The Skin Immune System and Intradermal Delivery of Vaccines: A Review","authors":"Silvia Angélica Carmona‐Cruz, María Teresa García‐Romero","doi":"10.52547/vacres.7.2.15","DOIUrl":"https://doi.org/10.52547/vacres.7.2.15","url":null,"abstract":"The skin is considered as the largest organ in the body, functioning as a barrier providing protection from the outside environment, but also performing essential immune functions through a complex network of epidermal and dermal cells that interact with each other. The basic principle of the vaccines is to induce protection against pathogens by simulating its interaction with the immune system, allowing to generate a memory immune response. To achieve this protection, the interaction and binding of both innate and adaptive immune responses is required. Intradermal (ID) delivery of vaccines achieves direct injection of the antigen into the dermis, where the largest numbers of immune cells are found (macrophages, dendritic cells, Langerhans cells, B and T lymphocytes, and mast cells, among others). It is a novel route that elicits antibody responses equivalent to other routes of administration but at lower doses, a phenomenon known as \"dose saving\". This route also allows for better thermo-stability of the antigen, fewer booster immunizations and, as a consequence, increased adherence to the vaccination regimens with less burden on the medical personnel. There are currently several vaccines for the ID administration on the market, and several more under development; with good safety profiles and efficacy rates. In this article, we review the most important aspects of the immune system within the skin, the pathways by which vaccines are applied to the skin intradermally to produce an adequate immune response, and also their advantages and disadvantages. The skin has important immune machinery, thanks to which both innate and adaptive immune responses merge. This interaction allows for the basis of vaccination: development of memory responses to various antigens, providing protection for the future re-exposures.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":"7 2","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://vacres.pasteur.ac.ir/files/site1/user_files_612bc6/teresa-A-10-1505-1-9562518.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines 褪黑素增强平衡免疫反应的能力已得到广泛认可，迫切需要研究其在抗sars - cov -2疫苗中作为佐剂的用途

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.97

G. Maestroni

{"title":"The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines","authors":"G. Maestroni","doi":"10.52547/vacres.7.2.97","DOIUrl":"https://doi.org/10.52547/vacres.7.2.97","url":null,"abstract":"Vaccines are a major weapon to control the present COVID-19 pandemic. To achieve this goal, vaccines should confer a robust and long-lasting immunity against SARS-Cov-2. Breakthrough infections and waning immunity are currently observed in patients that recovered from COVID-19 as well as in the vaccinated people. Therefore, a highly effective vaccine is needed to control the present and future outbreaks. Exogenous Nacetyl- 5-methoxy-tryptamine or melatonin (MLT) is well known to potentiate an effective and equilibrated immune response in a variety of situation including viral and bacterial infections and vaccines against different microbial and cancer antigens. In regard to anti- SARS-Cov-2 vaccines, beside stimulating specific IgG production as well as specific CD4+ and CD8+ T cells, exogenous MLT might also enhance specific IgA and secretory IgA in the mucosae;hence, preventing the re-infection and/or asymptomatic transmission of the virus. Thus, a study is urgently proposed to evaluate the effects of MLT administration either before or after vaccination against SARS-Cov-2 to evaluate its effect on strength, quality and duration of the immunity. Las but not least, due to its powerful antioxidant and anti-inflammatory properties, MLT administration might minimize the occurrence of adverse events after the vaccination.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42066251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering and Development of VP4-VP7 Rotavirus Fusion Protein in Pichia pastoris 毕赤酵母中VP4-VP7轮状病毒融合蛋白的构建与开发

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.101

M. A. Bahnamiry, H. Kaghazian, S. D. Mousavi-Nasab, M. Aghasadeghi, G. Bahramali

引用次数: 0

Patients with COVID‐19‐Associated Hematologic Abnormalities and the Potential Role of the Cytokine Storm: A Case Series Study 新冠肺炎相关血液异常患者和细胞因子风暴的潜在作用：一项病例系列研究

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.9

Ali Asadollahi-Amin, F. Ghiasvand, M. Hasibi, Simin Seyedpour, A. Barzegary, F. Ghadimi, Seyedahmad Seyedalinaghi, O. Dadras

引用次数: 0

Ethical Considerations and Challenges Duringthe COVID-19 Vaccine Deployment: Experiences from an Indian Perspective 新冠肺炎疫苗部署过程中的伦理思考与挑战：来自印度的经验

Vaccine Research Pub Date : 2020-12-01 DOI: 10.52547/vacres.7.2.56

Basu Saurav

引用次数: 0

The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells 热休克蛋白对HIV-1 Nef抗原在哺乳动物细胞中传递的影响

Vaccine Research Pub Date : 2020-06-01 DOI: 10.29252/vacres.7.1.54

A. Milani, F. Rouhollah, Maryam Naseroleslami, A. Bolhassani

引用次数: 3

Parent’s Knowledge on Rotavirus Diarrhea and Vaccine in Indonesia 印尼家长对轮状病毒腹泻及疫苗的认识

Vaccine Research Pub Date : 2020-06-01 DOI: 10.29252/vacres.7.1.38

Arie Dwi Pratiwi, D. Endarti, T. Andayani, S. A. Kristina

{"title":"Parent’s Knowledge on Rotavirus Diarrhea and Vaccine in Indonesia","authors":"Arie Dwi Pratiwi, D. Endarti, T. Andayani, S. A. Kristina","doi":"10.29252/vacres.7.1.38","DOIUrl":"https://doi.org/10.29252/vacres.7.1.38","url":null,"abstract":"Introduction: Parent’s knowledge on rotavirus diarrhea and vaccine might influence the decision to vaccinate a child. The purpose of this study was to examine knowledge level and to determine the factors that influence parents’ knowledge on rotavirus diarrhea and vaccine. Methods: The study applied an observational study design with a multi-center cross-sectional approach. The research instrument used a questionnaire to determine the sociodemographic variables and knowledge of respondents. Results: Data were collected from a survey of 500 parents in 5 provinces including Province of Central Kalimantan, Lampung, Central Sulawesi, West Java, and Yogyakarta in Indonesia using convenience sampling technique. Parents’ knowledge in this study was quite good with the average score of 78.2 ± 16.81. However, out of 500 respondents, only 158 (31.6%) parents knew that the rotavirus vaccine was not included in Indonesia's national health insurance program. There was a significant difference in the average of knowledge between the characteristics groups of age, education, monthly expenditure and experience of hearing diarrhea and rotavirus vaccine, vaccinating and source of disease information and vaccine (p <0.05). Conclusion: This study suggests the need of health promotion related to rotavirus diarrhea and vaccine in order to achieve equitable distribution of information and increase public knowledge to support future immunization programs. Citation: Pratiwi A D, Endarti D, Andayani T M, Kristina S A. Parent’s Knowledge on Rotavirus Diarrhea and Vaccine in Indonesia. vacres. 2020; 7 (1) :38-43. DOI: 10.29252/vacres.7.1.38","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44890095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0