Vaccine Research最新文献

Vaccine Innovation for Dengue, Chikungunya, Zika and Yellow Fever: Accelerating Global Development Agenda and Partnerships in Post-COVID Era 登革热、基孔肯雅热、寨卡和黄热病疫苗创新:加快后covid时代的全球发展议程和伙伴关系

Vaccine Research Pub Date : 2022-06-01 DOI: 10.52547/vacres.9.1.1

C. Possas, A. Antunes, A. Oliveira, S. Schumacher, E. Marques, A. Homma

{"title":"Vaccine Innovation for Dengue, Chikungunya, Zika and Yellow Fever: Accelerating Global Development Agenda and Partnerships in Post-COVID Era","authors":"C. Possas, A. Antunes, A. Oliveira, S. Schumacher, E. Marques, A. Homma","doi":"10.52547/vacres.9.1.1","DOIUrl":"https://doi.org/10.52547/vacres.9.1.1","url":null,"abstract":"applicants of of different different Methods: From a patent landscape approach, we defined methodological strategies for a hybrid search in two different databases (Derwent Innovation Index and Cortellis Drug Discovery Intelligence) that allowed us to identify the stages of technological development of the vaccines to prevent/treat these four arboviral diseases, making it possible to identify the successful ones that go to clinical trials and the partnerships among private and public institutions, which promote continuity of the development/production process. Results: Our results confirm these gaps for Dengue, Chikungunya, Zika and Yellow Fever vaccines, with only 13% of these vaccines still under active development and prospect to reach the final stages of development. They also indicate that, in spite of this constraint, innovative platforms such as RNA-based vaccines are increasingly being used to prevent/ treat these diseases. Conclusion: We propose urgently strengthening funding and incentive mechanisms in a Global Strategic Plan supported by new business models and community participation to accelerate vaccine development for these four neglected arboviral diseases, a dramatic and concerning global issue in post-COVID-19 era.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42435027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles and Functions of Toll-Like Receptors in Coronavirus Infections: Forthcoming Vaccine and Therapeutic Strategies for Confronting COVID-19 Toll-Like受体在冠状病毒感染中的作用和功能：即将推出的疫苗和应对新冠肺炎的治疗策略

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.17

A. Zahmatkesh, M. Bagheri

引用次数: 0

Basic characteristics of patients with COVID-19 after SARS‐CoV‐2 vaccine: One cross-sectional study in Iran 新冠肺炎患者接种SARS冠状病毒2型疫苗后的基本特征：伊朗的一项横断面研究

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.88

Arezoo Chouhdari, Yasamin Khosravani-Nezhad, Termeh Tarjoman, M. Zangeneh

引用次数: 0

The Healthcare Workers’ Vaccination – current Policy and Recommendations 卫生保健工作者的疫苗接种-目前的政策和建议

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.62

Merlyn Joseph, B. Joseph

引用次数: 0

Acceptance of COVID-19 Vaccination at Different Hypothetical Efficacy and Safety Levels in Nigeria: A Cross-Sectional Web-based Survey 尼日利亚对不同假设效力和安全水平的COVID-19疫苗的接受程度:一项基于网络的横断面调查

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.93

R. Akele, Seyi S. Enitan, E. Adejumo, E. Ezigbo, A. Durosinmi, G. Itodo, Adedeji Abdulsalam, M. Dada, O. Edafetanure-Ibeh, Oyekan Oyedoyin, Polit U. Yelpoji, Abah Idoko, Ogunwola Opeyemi, Ogbuji Nmesomachi, Edwin N. Okafor, A. Oyekale

引用次数: 0

The Optimization of Faecalibacterium prausnitzii Extracellular Vesicle Concentrations on PPARγ and FIAF Expression in the Caco-2 Cell Culture Model Caco-2细胞培养模型中丙酸杆菌胞外囊泡浓度对PPARγ和FIAF表达的优化

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.39

Seyedeh Marzieh Moosavi, A. Akhavan Sepahi, Seyed Fazlollah Mousavi, F. Vaziri, S. Siadat

{"title":"The Optimization of Faecalibacterium prausnitzii Extracellular Vesicle Concentrations on PPARγ and FIAF Expression in the Caco-2 Cell Culture Model","authors":"Seyedeh Marzieh Moosavi, A. Akhavan Sepahi, Seyed Fazlollah Mousavi, F. Vaziri, S. Siadat","doi":"10.52547/vacres.8.2.39","DOIUrl":"https://doi.org/10.52547/vacres.8.2.39","url":null,"abstract":"extracellular (EVs) a novel communication between microbiota the are capable of imposing positive effects on the host. Recently, EV-based treatments have been evaluated in different studies, and using EVs derived from microbiota has been recommended in recent studies as post-vaccination adjuvants. Accordingly, in the present study, the effects of various EV concentrations on the mRNA expression of peroxisome proliferator-activated receptor γ ( PPARγ ) and fasting-induced adipose factor (FIAF) genes were evaluated and optimized in the human epithelial colorectal adenocarcinoma (Caco-2) cell line. Methods: The effects of the extracted EVs from F. prausnitzii on the PPARγ and FIAF gene expression were investigated in the Caco-2 cell line via cell culture and quantitative real-time PCR. The obtained outcomes were then compared with those of our previous study (concentrations of 50 and 100 µg/ml). Results: It was shown that F. prausnitzii EVs (150 µg/ml) significantly increased PPARγ and FIAF gene expression in the Caco-2 cell line, relative to previous studies conducted by our team. Conclusion: Considering the positive impact of F. Prausnitzii EVs on the studied genes’ expression in the present study, the EVs of the bacterium will be proposed as new post-vaccination adjuvants in people suffering from intestinal barrier disorders such as inflammatory bowel disease patients. However, more studies should be performed in this respect.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43896789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Effect of HSV-tk/GCV Adenoviral Vector Vaccine Candidate in Inhibiting the Growth of Myeloma Tumors by Inducing Autophagy in BALB/c Mice 评价HSV-tk/GCV腺病毒候选载体疫苗诱导BALB/c小鼠自噬抑制骨髓瘤肿瘤生长的作用

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.44

Shima Poorghobadi, K. Baesi, S. M. Sadat, A. Abdoli, S. Irani

{"title":"Evaluation of the Effect of HSV-tk/GCV Adenoviral Vector Vaccine Candidate in Inhibiting the Growth of Myeloma Tumors by Inducing Autophagy in BALB/c Mice","authors":"Shima Poorghobadi, K. Baesi, S. M. Sadat, A. Abdoli, S. Irani","doi":"10.52547/vacres.8.2.44","DOIUrl":"https://doi.org/10.52547/vacres.8.2.44","url":null,"abstract":"Introduction: The aim of this study was to evaluate the effects of an adenoviral vector vaccine candidate containing HSV-TK gene on tumor reduction and autophagy mechanism in animal model. Methods: Myeloma tumor was created in mouse models using myeloma SP2/0 cell line. Three groups of negative control, positive control and target group of BALB/c mice were formed. Candidates for the Ad-HSV-tk /GCV vaccine at high titer (10 8 ) were then injected three times every 72 hours at target mice and metformin was injected into the control group for 12 consecutive days. Tumor size was measured in all 15 mice studied every three days, and finally, three days after the last dose of the vaccine, the tumors were removed for Western blotting and LC3B expression. Results: Examination of tumor size showed that injection of the vaccine and autophagy-inducing drug reduced tumor size compared to the negative control group. Western blotting indicated that LC3B expression was significantly higher in the target and positive control groups than in the negative control group. (Mean Diff: -0.4921; P value < 0.05; q: 7.911). Conclusion: The results suggest that Ad-HSV-tk/GCV vaccine candidate was able to induce autophagy and reduce the growth of tumor cells in the animal model studied due to the ability of adenovirus to induce the immune system response, the anti-myeloma nature of adenovirus and the function of HSV-tk suicide gene. suicide gene in adenovirus vector to make a viral vaccine, we investigated the effect of this vaccine on tumor cell growth and autophagic cell death.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46378106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on Corneal Graft Rejection after COVID-19 Vaccination: Our Experience and Concerns 新冠肺炎疫苗接种后角膜移植排斥反应述评：我们的经验和担忧

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.26

R. Natarajan, Swetha Ravichandran

引用次数: 0

In-silico Analysis of Pneumococcal Heat-Shock Protein (DnaJ) to Predict Novel Multi-Epitope Vaccine Candidates 肺炎球菌热休克蛋白（DnaJ）的计算机分析预测新的多表位候选疫苗

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.65

Elnaz Afshari, Reza Ahangari Cohan, F. Sotoodehnejadnematalahi, Seyed Fazlollah Mousavi

引用次数: 2

An Update on Pathogenesis, Diagnosis and Treatment of COVID-19-Related Cytokine Storm covid -19相关细胞因子风暴的发病机制、诊断和治疗进展

Vaccine Research Pub Date : 2021-12-01 DOI: 10.52547/vacres.8.2.48

M. Soy, P. Atagunduz, G. Keser

{"title":"An Update on Pathogenesis, Diagnosis and Treatment of COVID-19-Related Cytokine Storm","authors":"M. Soy, P. Atagunduz, G. Keser","doi":"10.52547/vacres.8.2.48","DOIUrl":"https://doi.org/10.52547/vacres.8.2.48","url":null,"abstract":"CoronaVirus Disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), which is globally influential and has killed more than 6 million patients until today. Hyper-secretion of pro-inflammatory cytokines triggered by the viral infection that cannot be eliminated by the immune system and an ongoing hyper-inflammatory state primarily in the lung seem to be the major causes of death. The mechanisms proposed to explain the pathogenesis of the cytokine storm associated with COVID-19 included poor viral clearance and persistent robust cytokine response despite inadequate antiviral immunity. The diagnosis can be made easily by clinical features, imaging techniques, and nasopharyngeal PCR. The diagnosis of this hyper-inflammatory state in a patient with COVID-19 can be made with rapid deterioration in clinical features, and laboratory findings including abnormally high serum CRP, ferritin and D-dimer levels, and rapidly progressive pulmonary radiological findings. In addition to the anti-viral and supportive treatments, corticosteroids, IL-1, or IL-6 receptor blockers are frequently used to suppress the increased cytokine response.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45448784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5