Journal of Carcinogenesis最新文献

{"title":"Assessment of Carbon Sequestration to describe the conservation potential of sacred groves from Ratnagiri District, Maharashtra, India","authors":"Gayatri Oak, Bharat Bhushan Sharma","doi":"10.64149/j.carcinog.24.4s.701-708","DOIUrl":"https://doi.org/10.64149/j.carcinog.24.4s.701-708","url":null,"abstract":"Sacred groves are widely recognised for their contributions to gene pool preservation and biodiversity conservation. Their capacity to provide crucial ecological services—particularly carbon sequestration should also be considered in the context of small, traditionally protected forest patches. This study evaluates the carbon sequestration potential of sacred groves in Ratnagiri District, Maharashtra, through tree stock assessments conducted via field surveys. Despite their small size, these groves show considerable carbon storage, reinforcing their ecological significance. By highlighting the sequestration value of small sacred groves, the research shows the necessity to explore small sacred groves for their carbon sequestration potential. The paper suggests sustainable conservation strategies that integrate carbon management with cultural and ecological stewardship, and calls for policy interventions that align conservation efforts with community welfare","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"24 4s","pages":"701-708"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://carcinogenesis.com/index.php/JOC/article/download/615/1912","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Work–Life Balance, Social Support, and Professional Quality of Life in End-of-Life Care Nurses: A Comprehensive Review","authors":"","doi":"10.64149/j.carcinog.24.3s.404-410","DOIUrl":"https://doi.org/10.64149/j.carcinog.24.3s.404-410","url":null,"abstract":"","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"1 3s","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis and Mechanistic Perspectives of Novel Coumarin Derivatives in Cancer Therapy","authors":"Noel Vinay Thomas, A Salomy Monica Diyya, Deepika Modi, Santosh Fattepur, D. Thangamani, Mayur Porwal, Sneha Anand, Parag Anilkumar Rabara, Manjunatha T O","doi":"10.64149/j.carcinog.24.2s.541-549","DOIUrl":"https://doi.org/10.64149/j.carcinog.24.2s.541-549","url":null,"abstract":"Coumarins, a class of naturally occurring benzopyrone derivatives, have emerged as promising scaffolds in the development of novel anticancer therapeutics. Their diverse biological activities are attributed to the structural flexibility of the coumarin nucleus, which allows extensive functionalization at different positions of the aromatic ring. This study reports the rational design and synthesis of novel coumarin derivatives and evaluates their mechanistic potential in cancer therapy. A series of substituted coumarin analogs were synthesized via Pechmann condensation and subsequent functional modifications, including halogenation, nitration, and Schiff base formation. The compounds were characterized by FTIR, NMR, and LC-MS analyses. In silico molecular docking studies revealed significant interactions of selected derivatives with key oncogenic targets, including topoisomerase II, tubulin, and VEGFR-2. In vitro cytotoxicity assays (MTT method) against MCF-7, HeLa, and A549 cancer cell lines demonstrated promising activity of halogenated and Schiff base–coupled coumarins with IC₅₀ values in the micromolar range. Mechanistic insights indicated apoptosis induction via caspase activation, cell cycle arrest at G2/M phase, and suppression of angiogenesis-related pathways. Collectively, these findings highlight the therapeutic potential of coumarin scaffolds in anticancer drug development and pave the way for future clinical translation.","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://carcinogenesis.com/index.php/JOC/article/download/438/581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Outcomes Among Youth: Influence of GAD-7, Lifestyle, and Mental Health Quality in Higher Secondary and University Students","authors":"Suresh Chandra Ch, M Radha Krishna, Sarita Satpathy, S Ashalatha, T Sanjeev Kumar, Nimala Singh Rathore, Johnsi Priya, Kothakonda Rekha","doi":"10.64149/j.carcinog.24.7s.531-543","DOIUrl":"https://doi.org/10.64149/j.carcinog.24.7s.531-543","url":null,"abstract":"The research paper is based on the ICSSR sponsored Research Project on Vision Viksit Bharat@2047. The study explores the awareness, practices, and quality dimensions of mental health among youth in select states of South India. The objectives include examining the demographic profile of respondents and its association with institutional category, analyzing awareness levels across selected mental health dimensions, and assessing the impact of mental health quality on youth lifestyle. A total of 25,020 respondents formed the sample, with primary data collected through a structured questionnaire and supported by secondary sources such as youth reports, NITI Aayogreports, and relevant research literature.  The analysis reveals significant differences between higher secondary and undergraduate students. Intervention preferences varied, with Higher secondary institutions, while undergraduates favored counselling. Disclosure patterns also differed, with higher secondary students sharing concerns mainly with parents and undergraduates turning to friends. Stress experiences were age-sensitive, yet both groups were statistically found mental health as highly important. Chi-square results confirmed strong associations between institutional category and awareness. The assessment of mental health quality dimensions highlighted independence as the strongest domain, reflecting students’ confidence in managing academics, career choices, and hobbies. Self-image was also statistically found positively correlated, whereas emotional well-being and physical-mental wellness showed moderate challenges. Attitudinal health emerged as the weakest dimension, marked by high-risk behaviors and greater variability.Overall, the study concludes that while youth demonstrate strengths in independence and self-image, significant challenges persist in emotional regulation, wellness, and behavioral health. The findings emphasize that enhancing mental health quality of life is the most critical factor for effective interventions, while addressing anxiety and promoting healthier lifestyles are essential for sustaining positive outcomes.","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://carcinogenesis.com/index.php/JOC/article/download/1121/881","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular classification and stratification of adult diffuse gliomas: A tertiary care center study.","authors":"Nidhi Anand,&nbsp;Nuzhat Husain,&nbsp;Renu Varshney,&nbsp;Kiran Preet Malhotra,&nbsp;Mohammad Kaif","doi":"10.4103/jcar.jcar_17_21","DOIUrl":"https://doi.org/10.4103/jcar.jcar_17_21","url":null,"abstract":"<p><strong>Background: </strong>Diffuse gliomas in the adult population are the most common primary central nervous system (CNS) tumors. The World Health Organization incorporated isocitrate dehydrogenase (IDH) mutations and 1p/19q co-deletion with histopathological features into an \"integrated diagnosis\" in the revised classification of tumors of CNS. These molecular subgroups of diffuse gliomas are found to stratify patients into prognostically distinct groups better than the histological classification. The objectives of the current study were to assess the frequency of IDH mutation, ATRX expression loss, p53 overexpression, and 1p/19q co-deletion detection in adult diffuse gliomas (Grade II, III, and IV) and to correlate them with clinicopathological and histopathological features.</p><p><strong>Materials and methods: </strong>The current study was a tertiary care hospital-based retrospective case series of 112 cases of adult diffuse gliomas. Immunohistochemistry (IHC)-based molecular detection was performed for IDH-1, ATRX, and p53 and fluorescent <i>in situ</i> hybridization (FISH) was performed for 1p/19q co-deletion detection.</p><p><strong>Results: </strong>IDH-1 mutation was present in 30.4% (<i>n</i> = 34/112) cases, ATRX expression was lost in 18% (<i>n</i> = 19/104) cases, p53 was mutated in 39.3% (<i>n</i> = 42/107) cases and 1p19q was co-deleted in 25% (<i>n</i> = 4/16) cases. In the IDH1 mutant cases, with retained ATRX, FISH for 1p/19q co-deletion was performed and was co-deleted in four cases.</p><p><strong>Conclusion: </strong>The results of the present study indicate that IHC including IDH1/2, ATRX, and p53 is useful for the molecular classification of diffuse gliomas, which could be useful for the evaluation of prognosis, especially Grade III and II. Although the immunohistochemical approach does not replace genetic testing completely, it is a practical and powerful means of assessing molecular genetic changes. IDH mutations are the established markers of better prognosis in diffuse gliomas.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39585067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of Src-family tyrosine kinases by Srcasm and c-Cbl: A comparative analysis.","authors":"Vivian Lee,&nbsp;Thomas D Griffin,&nbsp;Yoko Suzuki-Horiuchi,&nbsp;Lily Wushanley,&nbsp;Yerin Kweon,&nbsp;Christine Marshall,&nbsp;Weijie Li,&nbsp;Elias Ayli,&nbsp;Adele Haimovic,&nbsp;Aliya Hines,&nbsp;John T Seykora","doi":"10.4103/jcar.jcar_13_21","DOIUrl":"https://doi.org/10.4103/jcar.jcar_13_21","url":null,"abstract":"<p><strong>Aim: </strong>Elevated Src-Family tyrosine kinase (SFK) activity drives carcinogenesis <i>in vivo</i> and elevated SFK activity is found ubiquitously in human cancers. Although human squamous cell carcinomas (SCCs) demonstrate increased SFK activity, in silico analysis of SCCs demonstrates that only 0.4% of lesions contain mutations that could potentially increase SFK activity; similarly, a low frequency of activating SFK mutations is found in other major cancers. These findings indicate that SFK activation in cancers likely is not due to activating mutations but alternative mechanisms. To evaluate potential alternative mechanisms, we evaluated the selectivity of c-Cbl and Srcasm in downregulating native and activated mutant forms of SFKs.</p><p><strong>Materials and methods: </strong>We co-transfected native and activated forms of Src and Fyn with c-Cbl and Srcasm into HaCaT cells and monitored the ability of Srcasm and c-Cbl to downregulate native and activated forms of SFKs by Western blotting. The mechanism of downregulation was probed using mutant forms of Srcasm and c-Cbl and using proteosomal and lysosomal inhibition.</p><p><strong>Results: </strong>The data indicate that Srcasm downregulates native Fyn and Src more effectively than c-Cbl, whereas c-Cbl preferentially downregulates activated SFK mutants, including Fyn Y528F, more effectively than Srcasm. Srcasm downregulates SFKs through a lysosomal-dependent mechanism while c-Cbl utilizes a proteosomal-dependent mechanism.</p><p><strong>Conclusion: </strong>Given the rarity of activating SFK mutations in human cancer, these data indicate that decreasing Srcasm level/function may represent a mechanism for increasing SFK activity in SCC and other human tumors.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39585068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of routine histopathological examination of gallbladder specimen following elective laparoscopic cholecystectomy.","authors":"Ashesh Kumar Jha,&nbsp;Ashraf Ali,&nbsp;Manoj Kumar,&nbsp;Manoj Kumar,&nbsp;Punam Prasad Bhadani,&nbsp;Niroop B S Murthy,&nbsp;Kumar Chandrakant","doi":"10.4103/jcar.jcar_19_21","DOIUrl":"https://doi.org/10.4103/jcar.jcar_19_21","url":null,"abstract":"<p><strong>Background: </strong>Gallstone disease is one of the commonest surgical ailments encountered in our setup. Its prevalence in India varies from 2% to 29%. Although cholelithiasis accounts for more than 95% of gall bladder related disease, routine histopathological examination (HPE) is vital. It reveals a myriad of benign as well as the malignant surgical pathology of the gallbladder (GB). This part of the world is considered as an endemic region for GB carcinoma as well as gallstone disease. This study intends to evaluate the outcome of the routine HPE of laparoscopic cholecystectomy specimens.</p><p><strong>Methods: </strong>This retrospective observational study evaluated the results of the routine HPE of elective laparoscopic cholecystectomy specimens of single tertiary care center. Patients suspected or diagnosed with carcinoma gall bladder were excluded. Demographic data such as age, sex, and pathology results were recorded.</p><p><strong>Results: </strong>From January 2017 to December 2019, HPEs of 921 patients who had undergone laparoscopic cholecystectomy specimens were analyzed. 97.6% specimens had benign lesion of which chronic calculus cholecystitis was predominantly high (95.01%) followed by cholesterosis (9.9%) and xanthogranulomatous cholecystitis (6.51%). Incidental carcinoma gall bladder was observed in 17 specimens accounting for 1.85%. Mean age of patients who underwent cholecystectomy was 43.10 ± 13.90 with female to male ratio of 3.23:1.</p><p><strong>Conclusion: </strong>Chronic calculus cholecystitis was the most common gall bladder disease with high female preponderance to all GB pathologies. This study affirms the importance of routine HPE after cholecystectomy as early incidental detection of carcinoma gall bladder alters the postoperative management approach and patients are expected to have a better outcome with it.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39689893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome.","authors":"Jinxin Miao,&nbsp;Rong Li,&nbsp;Arnaud J Van Wettere,&nbsp;Haoran Guo,&nbsp;Alexandru-Flaviu Tabaran,&nbsp;M Gerald O'Sullivan,&nbsp;Timothy Carlson,&nbsp;Patricia M Scott,&nbsp;Kuisheng Chen,&nbsp;Dongling Gao,&nbsp;Huixiang Li,&nbsp;Yaohe Wang,&nbsp;Zhongde Wang,&nbsp;Robert T Cormier","doi":"10.4103/jcar.jcar_18_21","DOIUrl":"https://doi.org/10.4103/jcar.jcar_18_21","url":null,"abstract":"<p><strong>Background: </strong>The <i>TP53</i> tumor suppressor gene is the most commonly mutated gene in human cancers. Humans who inherit mutant <i>TP53</i> alleles develop a wide range of early onset cancers, a disorder called Li-Fraumeni Syndrome (LFS). <i>Trp53</i>-deficient mice recapitulate most but not all of the cancer phenotypes observed in <i>TP53</i>-deficient human cancers, indicating that new animal models may complement current mouse models and better inform on human disease development.</p><p><strong>Materials and methods: </strong>The recent application of CRISPR/Cas9 genetic engineering technology has permitted the emergence of golden Syrian hamsters as genetic models for wide range of diseases, including cancer. Here, the first cancer phenotype of <i>TP53</i> knockout golden Syrian hamsters is described.</p><p><strong>Results: </strong>Hamsters that are homozygous for <i>TP53</i> mutations become moribund on average ~ 139 days of age, while hamsters that are heterozygous become moribund at ~ 286 days. <i>TP53</i> homozygous knockout hamsters develop a wide range of cancers, often synchronous and metastatic to multiple tissues, including lymphomas, several sarcomas, especially hemangiosarcomas, myeloid leukemias and several carcinomas. <i>TP53</i> heterozygous mutants develop a more restricted tumor spectrum, primarily lymphomas.</p><p><strong>Conclusions: </strong>Overall, hamsters may provide insights into how <i>TP53</i> deficiency leads to cancer in humans and can become a new model to test novel therapies.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39689892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization of lung carcinomas: A study on diagnostic, predictive, and prognostic markers using immunohistochemical analysis at a Tertiary Care Center in Uttarakhand, India.","authors":"Shalinee Rao,&nbsp;Michael Leonard Anthony,&nbsp;Nilotpal Chowdhury,&nbsp;Rajesh Kathrotia,&nbsp;Mayank Mishra,&nbsp;Manisha Naithani,&nbsp;Girish Sindhwani,&nbsp;Neha Singh","doi":"10.4103/jcar.jcar_14_21","DOIUrl":"https://doi.org/10.4103/jcar.jcar_14_21","url":null,"abstract":"<p><strong>Introduction: </strong>Focused studies in different geographic regions would delineate the underlying biological differences and molecular alterations in non-small cell lung cancer (NSCLC) worldwide. Previous studies in literature have documented limited characterization by studying a minimal number of biological markers. This study was done to evaluate expression of multiple immunomarkers including diagnostic, prognostic, and predictive markers in NSCLC for its characterization.</p><p><strong>Materials and methods: </strong>This was an observational study conducted on 60 consecutive cases of NSCLC. Immunomarkers comprising of p63, p40, TTF-1, napsin A, B-Raf, c-Met, phospho-AKT (P-AKT), PTEN, anaplastic lymphoma kinase (ALK), epidermal growth factor receptor (EGFR) and K-Ras, synaptophysin, chromogranin and pan-cytokeratin were evaluated on paraffin-embedded tissue sections of NSCLC.</p><p><strong>Results: </strong>Age of patients with NSCLC in our study ranged from 35 to 90 years, and 93.3% of them were chronic smokers. 93.3% of cases presented in late stages (Stages III and IV) and 78% of cases were squamous cell carcinoma (SCC). EGFR positivity was noted in 83.3% of cases. ALK was positive in one case while C-Met and PTEN immunopositivity was noted in only two cases. Ten cases showed positivity for K-Ras and 90% of these were SCC. Ten cases were positive for B-Raf and 80% of these were SCC. 30% of cases showed immunopositivity for P-AKT. None of the molecular markers was found to have statistically significant correlation with clinicopathological parameters.</p><p><strong>Conclusion: </strong>SCC is the predominant histological subtype of NSCLC in the region of Uttarakhand, India, with a high proportion of cases harboring EGFR mutation. Variable expression of K-Ras, P-AKT, ALK 1, and PTEN in NSCLC signifies that molecular profile of every case is individualistic and independent. We attribute this to ethnicity, influence of implicated substance or metabolite in tobacco, and variable mutations incurred in tumor cells over a period of time.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39689891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis.","authors":"Anagha A Motgi,&nbsp;Mrinal V Shete,&nbsp;Mahesh S Chavan,&nbsp;Nikkhiel N Diwaan,&nbsp;Rashmi Sapkal,&nbsp;Pallavi Channe","doi":"10.4103/jcar.jcar_8_21","DOIUrl":"https://doi.org/10.4103/jcar.jcar_8_21","url":null,"abstract":"<p><strong>Background: </strong>Oral submucous fibrosis (OSMF) is a premalignant condition with a greater prevalence in countries such as India. Various classifications have been put forth by multiple authors to determine the clinical, functional, and histopathological grade of the disease. The classification systems have greatly helped to determine the treatment modality for the patients. Understanding the correlation between the various classifications will help us determine the course of the disease, management, and prognosis of OSMF. This study assesses the correlation between clinical, functional, and histopathological grading of OSMF.</p><p><strong>Aim: </strong>To assess the correlation between clinical staging, functional staging, and histopathological grading of OSMF.</p><p><strong>Materials and methods: </strong>Thirty patients with clinical and histopathological diagnosis of OSMF were assigned into clinical stage, functional stage, and histopathological grade. The correlation between these three stages assigned was studied.</p><p><strong>Statistical analysis: </strong>The degree of agreement between the clinical, functional, and histopathological classifications was quantified by the Weighted Kappa statistics. Correlation between the three classifications was done using Kendall's tau and Spearman's correlation coefficient.There was a good agreement and statistically significant correlation between clinical and functional grading. There was a poor agreement and no significant correlation between clinical and histopathological grading. There was a poor agreement and no significant correlation between functional and histopathological grading.</p>","PeriodicalId":52464,"journal":{"name":"Journal of Carcinogenesis","volume":"20 ","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39689890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}