Klinichescheskaya Laboratornaya Diagnostika最新文献

{"title":"CLINICAL AND LABORATORY CHARACTERISTICS OF COXYELLOSIS IN CHILDREN","authors":"","doi":"10.51620/0869-2084-2023-68-5-261-265","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-5-261-265","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135893517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Сorynebacterium spp.: differences in pheno- and genotypic markers of pathogenicity of isolates from patients with inflammatory diseases of the respiratory tract and practically healthy individuals","authors":"","doi":"10.51620/0869-2084-2023-68-10-604-611","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-10-604-611","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135107495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Сontribution of platelet contractility to the laboratory parameters that characterize platelet function","authors":"","doi":"10.51620/0869-2084-2023-68-9-544-552","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-9-544-552","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a set of reagents for the isolation of nucleic acids from clinical material based on magnetic adsorption","authors":"","doi":"10.51620/0869-2084-2023-68-10-650-657","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-10-650-657","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthrogryposis: clinical laboratory diagnosis and the role of infections (review of literature)","authors":"","doi":"10.51620/0869-2084-2023-68-10-612-619","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-10-612-619","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"162 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The research of relationship between immune response to xeno- and endobiotics and polymorphic loci of gene biotransformation enzymes in women with congenital malformations in the fetus","authors":"","doi":"10.51620/0869-2084-2023-68-9-559-569","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-9-559-569","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum zonulin in patients with bowel disease","authors":"","doi":"10.51620/0869-2084-2023-68-10-582-587","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-10-582-587","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135107748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the lower normal limits for the TREC and KREC indicators in newborn using the «TREC/KREC-AMP PS» reagent set","authors":"","doi":"10.51620/0869-2084-2023-68-10-644-649","DOIUrl":"https://doi.org/10.51620/0869-2084-2023-68-10-644-649","url":null,"abstract":"","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135107772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative blood markers for prediction of recurrence-free survival after surgical treatment of patients with stage III lung adenocarcinoma.","authors":"A D Tahanovich,&nbsp;N N Kauhanka,&nbsp;D I Murashka,&nbsp;A V Kolb,&nbsp;V I Prokhorova,&nbsp;O V Got'ko,&nbsp;L A Derzhavets","doi":"10.51620/0869-2084-2022-67-11-640-646","DOIUrl":"https://doi.org/10.51620/0869-2084-2022-67-11-640-646","url":null,"abstract":"<p><p>The possibility of the preoperative level of 42 indicators characterizing the cellular composition and metabolism in blood of patients with stage III lung adenocarcinoma (AC) to predict their relapse-free survival was studied. Blood samples of 451 patients with newly diagnosed AK stage III after their surgical treatment (resection volume - R0) have been investigated. The duration of the relapse-free period (period of observation - 1 year), cellular composition of the blood, concentration of C-RP, albumin, Cyfra 21-1 antigens, SCC, TPA, chemokines CXCL5, CXCL8, pyruvate kinase TuM2 PK isoenzyme, HIF-1α and hyaluronic acid in blood serum so as the proportion of blood cells with CXCR1 and CXCR2, CD44V6 receptors in blood serum were measured. To determine the dependence of the duration of the relapse-free period after the treatment on the observation time, Kaplan-Meier graphs were built. The relationship between the determined parameters and survival was judged using single- and multi-factor Cox proportional hazard models. Comparison of groups with different risk of AK recurrence was performed using the Log Rank test and χ2. The assessment of the predictive information content of laboratory tests was carried out using ROC analysis. It was shown that the concentration of monocytes, eosinophilic leukocytes, the relative quantity of lymphocytes with CXCR1 receptor, the level of Cyfra 21-1 before surgical treatment were associated with the duration of the relapse-free period. A regression equation was compiled, which included the level of Cyfra 21-1, relative content of lymphocytes with CXCR1, and the eosinophilic leukocytes / monocytes ratio. Based on the threshold value Y=0,597, a Kaplan-Meier plot of patient survival was built and the results of it correspond to the TNM stratification. The prognostic sensitivity of the results of the equation - 85,7%, the specificity - 94,7%.</p>","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"67 11","pages":"640-646"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of screening methods for the determination of antinuclear antibodies using indirect immunofluorescence on HEp-2 cells and enzyme immunoassay in autoimmune liver diseases.","authors":"Aleksey Sergeevich Dorofeev,&nbsp;E N Aleksandrova,&nbsp;A A Novikov,&nbsp;K G Saliev,&nbsp;Yu G Sandler,&nbsp;E V Vinnitskaya","doi":"10.51620/0869-2084-2022-67-11-652-657","DOIUrl":"https://doi.org/10.51620/0869-2084-2022-67-11-652-657","url":null,"abstract":"<p><p>Antinuclear antibodies (ANA) are a heterogeneous group of autoantibodies that react with various components of the cell nucleus and cytoplasm. ANA is the main serological marker for autoimmune liver disease (AILD). The aim of the study was to compare the diagnostic value of two methods of screening for the determination of ANA (indirect immunofluorescence reaction on HEp-2 cells (IIF -HEp-2) and enzyme-linked immunosorbent assay (ELISA) in the sera of AILD patients. The sera of 118 patients with AILD (51 with autoimmune hepatitis - AIH, 19 with primary biliary cholangitis - PBC, 48 with overlapping syndrome - OVERLAP), 30 patients with non-alcoholic fatty liver disease (NAFLD) and 30 healthy donors (HD) were studied. Determination of ANA by the IIF-HEp-2 method was carried out by visual assessment of samples under an AXIOSKOP 40 microscope, by ELISA - on an Alegria automatic analyzer. A weak degree of agreement between the positive and negative results of the ANA screening study using IIF-HEp-2 and ELISA (Cohen's kappa coefficient æ=0.4) was noted. Screening determination of ANA in patients with AILD by the IIF-HEp-2 method was distinguished by greater diagnostic sensitivity (DS) (68.6%) and a lower frequency of false negative results (31.4%) compared with ELISA (35.6% and 64.4 % respectively, p<0.05). The overall diagnostic specificity (DS) of the ANA study in IIF-HEp-2 was lower than with ELISA (66.7% and 86.7%, respectively, p<0.05). Both screening methods for determining ANA (IIF-HEp-2 and ELISA) were useful for diagnosing AILD (positive likelihood ratio - LR+: 2.1 and 2.6, respectively). In terms of the negative likelihood ratio (LR-), screening for ANA by the IIF-HEp-2 method, in contrast to ELISA, served as a \"useful\" test to exclude the diagnosis of AILD (0.5 and 0.8, respectively). The determination of ANA using IIF-HEp-2 is the most sensitive and \"useful\" screening test for the diagnosis of AILD, and ELISA is classified as a less \"useful\" screening method due to low diagnostic sensitivity and a high false-negative rate.</p>","PeriodicalId":52451,"journal":{"name":"Klinichescheskaya Laboratornaya Diagnostika","volume":"67 11","pages":"652-657"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}