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Journal of Biomedical Photonics and Engineering最新文献

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Combined Fluorescence and Bright Field Imaging via a Single CMOS Detector Without Filters to Improve on Patient Safety during Endoscopic Procedures – An Experimental Study Analysing the Output of both LASER and LED Near Infrared Sources on In Vitro Samples 通过无滤波器的单个CMOS检测器进行荧光和亮场组合成像，以提高内窥镜手术期间的患者安全性——一项分析体外样品上激光和LED近红外光源输出的实验研究
Journal of Biomedical Photonics and Engineering Pub Date : 2020-12-01 DOI: 10.18287/jbpe20.06.040303
Angharad Curtis, Kang Li, M. A. Roula, N. Copner
{"title":"Combined Fluorescence and Bright Field Imaging via a Single CMOS Detector Without Filters to Improve on Patient Safety during Endoscopic Procedures – An Experimental Study Analysing the Output of both LASER and LED Near Infrared Sources on In Vitro Samples","authors":"Angharad Curtis, Kang Li, M. A. Roula, N. Copner","doi":"10.18287/jbpe20.06.040303","DOIUrl":"https://doi.org/10.18287/jbpe20.06.040303","url":null,"abstract":"Many endoscopic systems combine white light and NIR light via LED multiplexing in order to image tissue stained with Near Infrared (NIR) fluorescent markers such as Indocyanine Green (ICG). This can result in unnecessary  in vivo  energy exposure which can cause irreversible damage to tissue. A simple, single detector system is proposed in this work comprising a single excitation channel at a wavelength of 780 nm. We have demonstrated that a single 1.6 Megapixel CMOS camera with quantum efficiency of less than 30% is appropriate to capture both fluorescent and non-fluorescent landmarks at NIR wavelengths. Experimental results indicate that a LASER source generating between up to 10 mW of optical power at 780 nm could be considered as an alternative to LED.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43085514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive Approach to Simulation of Malignant Neoplasms Using the Monte Carlo Method 蒙特卡罗方法模拟恶性肿瘤的加法方法
Journal of Biomedical Photonics and Engineering Pub Date : 2020-09-30 DOI: 10.18287/jbpe20.06.030302
I. Matveeva, O. Myakinin, V. Vinokurov, Y. Khristoforova, I. Bratchenko, A. Moryatov, S. Kozlov, V. Zakharov
{"title":"Additive Approach to Simulation of Malignant Neoplasms Using the Monte Carlo Method","authors":"I. Matveeva, O. Myakinin, V. Vinokurov, Y. Khristoforova, I. Bratchenko, A. Moryatov, S. Kozlov, V. Zakharov","doi":"10.18287/jbpe20.06.030302","DOIUrl":"https://doi.org/10.18287/jbpe20.06.030302","url":null,"abstract":"The paper is devoted to additive simulation of Raman light scattering by skin cancer using the Monte Carlo method. Raman light scattering from normal skin, malignant melanoma and basal cell carcinoma is investigated. Based on the photon transport algorithm proposed by L. Wang and S. L. Jacques, a two-stage algorithm for simulating Raman light scattering from skin has been developed. A method for additive modeling of skin pathologies is proposed. The main idea of this method is a hypothesis that an experimental Raman spectrum of normal skin, obtained by averaging in vivo Raman spectra of normal skin, may be served as a “substrate” for the feature simulated Raman spectrum. Thus, the pathology, for their part, may be “grown” by adding on this “substrate” Raman specific components set related to a tumor type. Additive simulation of malignant melanoma on various stages and basal cell carcinoma has been carried out. The possibility of using the developed algorithm to determine the component composition of the skin by the in vivo Raman spectrum of skin is discussed. An attempt to evaluate the change in the concentration of skin components during the development of cancer has been made.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48542795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Issue Info: J of Biomedical Photonics & Eng 6(2) 期刊信息:J . Biomedical Photonics & engineering 6(2)
Journal of Biomedical Photonics and Engineering Pub Date : 2020-06-30 DOI: 10.18287/jbpe20.06.020001
{"title":"Issue Info: J of Biomedical Photonics & Eng 6(2)","authors":"","doi":"10.18287/jbpe20.06.020001","DOIUrl":"https://doi.org/10.18287/jbpe20.06.020001","url":null,"abstract":"","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47415380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UV-NIR efficiency of the refractive index matching mechanism on colorectal muscle during treatment with different glycerol osmolarities 不同甘油渗透浓度对结直肠肌折射率匹配机制的UV-NIR效率
Journal of Biomedical Photonics and Engineering Pub Date : 2020-06-26 DOI: 10.18287/jbpe20.06.020307
Nelma M. Gomes, V. Tuchin, L. Oliveira
{"title":"UV-NIR efficiency of the refractive index matching mechanism on colorectal muscle during treatment with different glycerol osmolarities","authors":"Nelma M. Gomes, V. Tuchin, L. Oliveira","doi":"10.18287/jbpe20.06.020307","DOIUrl":"https://doi.org/10.18287/jbpe20.06.020307","url":null,"abstract":"The evaluation of the optical clearing mechanisms in tissues provides information about the efficiency of the clearing treatment. One of such mechanisms is the refractive index matching, which is created by the partial replacement of tissue water by an optical clearing agent with higher refractive index, better matched to the index of tissue scatterers. With the objective of evaluating the refractive index matching mechanism for a wide spectral range and comparing its magnitude between treatments with different clearing agent osmolarities, thickness and collimated transmittance measurements were obtained from human colorectal muscle samples under treatment with 20%-, 40% and 60%-glycerol. Such measurements were used in a calculation model to obtain the refractive index kinetics for the interstitial fluid and for the whole tissue. The calculation results show that the refractive index matching has a stronger effect in the ultraviolet and that such matching is more effective for higher agent concentrations in the treating solutions.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42418769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Optical Trap Combined with Raman Spectroscopy to Probe Red Blood Cell Behaviour in Certain Intravenous Fluids 光学陷阱结合拉曼光谱探测某些静脉输液中的红细胞行为
Journal of Biomedical Photonics and Engineering Pub Date : 2019-12-31 DOI: 10.18287/jbpe19.05.040302
J. Lukose, G. Mohan, N. Mithun, S. Shastry, C. Santhosh
{"title":"Optical Trap Combined with Raman Spectroscopy to Probe Red Blood Cell Behaviour in Certain Intravenous Fluids","authors":"J. Lukose, G. Mohan, N. Mithun, S. Shastry, C. Santhosh","doi":"10.18287/jbpe19.05.040302","DOIUrl":"https://doi.org/10.18287/jbpe19.05.040302","url":null,"abstract":". Systematic studies on a live, individual human red blood cell without any chemical fixation can be realized with the aid of optical tweezers. In the present work, the behavior of human red blood cell in dextrose containing intravenous fluids and blood plasma were investigated and compared using a home-made near-IR Laser Tweezers Raman spectrometer. Significant spectral variations in Raman signatures exist between the RBCs in plasma and dextrose containing intravenous fluids, which mainly comprise of the hemoglobin oxygenation-deoxygenation transition as well as the heme aggregation markers . © 2019 Journal of Biomedical Photonics & Engineering.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46388903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Modelling Of PAFC Based Scattering Monitoring System for the Characterization of the Therapeutic Micro-Bubbles 基于PAFC的治疗性微泡散射监测系统建模
Journal of Biomedical Photonics and Engineering Pub Date : 2019-09-30 DOI: 10.18287/JBPE19.05.030303
Vibhor Kumar Bhardwaj, S. Maini
{"title":"Modelling Of PAFC Based Scattering Monitoring System for the Characterization of the Therapeutic Micro-Bubbles","authors":"Vibhor Kumar Bhardwaj, S. Maini","doi":"10.18287/JBPE19.05.030303","DOIUrl":"https://doi.org/10.18287/JBPE19.05.030303","url":null,"abstract":"In recent years, researchers are eagerly developing the Ultrasound Cavity Agents (UCA) as a therapeutic agent, so that they can deliver the drugs to an intended place in a guided manner with minimal invasiveness and maximum effectiveness. However, control dissolution of the drug is still an issue because the shell of the micro-bubble sometimes collapses instantaneously and start releasing the drug at a faster rate. This sudden rise in the pressure's level can rupture the capillaries and sometimes blood vessels also. Therefore, in such cases, it is a great challenge to examine the dynamics of the micro-bubble as well as the health of the blood vessel. In this essence, this paper presents a study based on the finite element method to examine the potential use of Photo-Acoustic Flow Cyclometery (PAFC) to resolve this issue. The presented model is based on the study of the intensity variations of the optical scatterings engender by the micro-bubbles through PAFC. The results of the study reveal that the proposed model has the potential to be used as a new mechanism to examine the growth of the micro-bubble as well as the health of the blood vessel. Moreover, by analysing the scattering pattern, one can also able to predict the value of the cavitation threshold and the size of the micro-bubble. Hence, the authors envisioned that the modified PAFC system can lead the path of a low-cost and real-time examiner for accurate target drug delivery as well as for the health of the blood vessel. Which in turn potentially increases the localized concentration of the drug to reduce the concerned side-effects of medicine on the other part of the body.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47208974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Clearing of the Gastric Mucosa Using 40%-glucose Solution 40%葡萄糖溶液对胃粘膜的光学清除作用
Journal of Biomedical Photonics and Engineering Pub Date : 2019-09-30 DOI: 10.18287/JBPE19.05.030302
V. Genin, E. Genina, S. Kapralov, V. A. Grishaev, V. Tuchin, E. Lazareva, A. Bashkatov
{"title":"Optical Clearing of the Gastric Mucosa Using 40%-glucose Solution","authors":"V. Genin, E. Genina, S. Kapralov, V. A. Grishaev, V. Tuchin, E. Lazareva, A. Bashkatov","doi":"10.18287/JBPE19.05.030302","DOIUrl":"https://doi.org/10.18287/JBPE19.05.030302","url":null,"abstract":"The kinetics of collimated transmittance of the gastric mucosa under the action of an aqueous 40%-glucose solution was experimentally investigated. Based on the analysis of the transmittance kinetics, the value of the effective diffusion coefficient of glucose in the gastric mucosa was estimated and amounted to (1.59±0.96)×10 -6 cm 2 /s. The permeability coefficient of the mucosa for glucose, calculated using the first Fick diffusion law, was estimated as (2.81±0.90)×10 -5 cm/s. It was shown that the introduction of the glucose solution into the mucosa reduced the light scattering coefficient by approximately 5–10%. The increase in the depth of light penetration was from 5% to 15%, depending on the selected spectral range. The results can be used to develop new methods of diagnosis and treatment of stomach diseases.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49092742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Capabilities of Autodyne Reception in Medical СО2 Laser Devices 医疗激光设备中的自激接收能力СО2
Journal of Biomedical Photonics and Engineering Pub Date : 2019-08-01 DOI: 10.18287/JBPE19.05.030301
A. Dmitriev, A. Konovalov, V. Kortunov, V. A. Ul’yanov
{"title":"Capabilities of Autodyne Reception in Medical СО2 Laser Devices","authors":"A. Dmitriev, A. Konovalov, V. Kortunov, V. A. Ul’yanov","doi":"10.18287/JBPE19.05.030301","DOIUrl":"https://doi.org/10.18287/JBPE19.05.030301","url":null,"abstract":"The generation characteristics and the capabilities of autodyne reception in single mode CO 2 lasers with pulse-periodic pumping of the active medium used in medical laser devices are investigated. It has been demonstrated that medical laser device based on CO 2 laser model DIAMOND C-30A (Coherent Сo.) has the best long-term laser power stability ((2–3)%), while the setup with CO 2 laser model 48–2W (Synrad Сo.) has the best short-term stability (0.62%). Amplitude-frequency characteristics of autodyne reception were studied for lasers of these devices. Power spectra of the autodyne signal appearing during evaporation of fat and muscle tissues under CO 2 laser radiation of the three types of laser devices were recorded. It has been shown that all these laser devices allow to detect the autodyne signal during evaporation of biological tissues. The medical laser setup with CO 2 laser model 48–2W has the highest signal-to-noise ratio during detection of laser backscattered radiation. This is due to the fact that this laser has larger autodyne amplification and better short-term power stability. The results can be used in the development of smart laser surgical systems with feedback.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41656525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cover: Special Issue. Laser and optical technologies in biomedicine and ecology 封面:特刊。生物医学和生态学中的激光和光学技术
Journal of Biomedical Photonics and Engineering Pub Date : 2019-06-30 DOI: 10.18287/JBPE18.04.010000
O. Myakinin
{"title":"Cover: Special Issue. Laser and optical technologies in biomedicine and ecology","authors":"O. Myakinin","doi":"10.18287/JBPE18.04.010000","DOIUrl":"https://doi.org/10.18287/JBPE18.04.010000","url":null,"abstract":"","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41472584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Years in Optoacoustics: 70th Anniversary of Prof. Vladimir P. Zharov 光声学年：弗拉基米尔·P·扎罗夫教授70周年
Journal of Biomedical Photonics and Engineering Pub Date : 2019-03-31 DOI: 10.18287/JBPE19.05.010101
E. Galanzha, D. Gorin, V. Tuchin
{"title":"Years in Optoacoustics: 70th Anniversary of Prof. Vladimir P. Zharov","authors":"E. Galanzha, D. Gorin, V. Tuchin","doi":"10.18287/JBPE19.05.010101","DOIUrl":"https://doi.org/10.18287/JBPE19.05.010101","url":null,"abstract":"","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47072393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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