Tessabella M. Magliochetti Cammarata, Sushan Gupta, Sai Sri Harsha Rallabhandi, Vishesh Paul
{"title":"Pulmonary Langerhans Cell Histiocytosis: An Unusual Differential for a Solitary Lung Nodule","authors":"Tessabella M. Magliochetti Cammarata, Sushan Gupta, Sai Sri Harsha Rallabhandi, Vishesh Paul","doi":"10.1155/2024/1315222","DOIUrl":"https://doi.org/10.1155/2024/1315222","url":null,"abstract":"Background. Pulmonary Langerhans cell histiocytosis (LCH) commonly presents as bilateral reticulonodular and cystic lung changes on chest imaging. Isolated lung nodule presentation is rare. Case Presentation. Our patient was an elderly male and an active smoker, who was referred to the pulmonology clinic for an incidental 19 mm lung nodule seen on a chest CT scan. A CT-guided transthoracic needle biopsy was performed to rule out malignancy. The biopsy sample showed marked inflammatory infiltrate with abundant eosinophils and epithelioid histiocyte-like cells suggestive of Langerhans cell histiocytosis. Antibodies against CD1a and Langerhans were positive which confirmed the diagnosis. During follow-ups, the patient had reduced smoking, and the lung nodule had decreased in size to 14 mm. Conclusion. An isolated lung nodule in a patient with a smoking history always warrants a malignancy workup. Characteristic pathological findings with immunostaining are necessary to differentiate pulmonary LCH in these cases. Failure to perform immunostaining in such cases may lead to missing this vital diagnosis.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"7 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanna Wieckowska, Nicholas Diloreto, Shannon Hood, Isabella Chojnacki, Dalia Zakri
{"title":"Hemoptysis and Unilateral Pulmonary Infiltrates due to Severe Acute Mitral Regurgitation from Papillary Muscle Rupture","authors":"Joanna Wieckowska, Nicholas Diloreto, Shannon Hood, Isabella Chojnacki, Dalia Zakri","doi":"10.1155/2024/5534308","DOIUrl":"https://doi.org/10.1155/2024/5534308","url":null,"abstract":"Acute mitral regurgitation typically presents with dyspnea, chest pain, and hemodynamic instability. It is an uncommon cause of hemoptysis. We present a case of a patient presenting with dyspnea and hemoptysis without hemodynamic instability along with right-sided infiltrate on chest radiography a few days after an acute inferolateral STEMI who was found to have posterior papillary muscle rupture resulting in acute mitral regurgitation. Our case illustrates that the aforementioned symptoms and signs should raise concern for acute mitral regurgitation and prompt cardiac evaluation in the appropriate clinical setting as they may mimic acute pulmonary processes and delay critical diagnosis and treatment.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"21 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Renal Embolism Associated with Foramen Ovale Coexisting Acute Pulmonary Embolism","authors":"Yanling He, Yi Xiao, Yanping Chen, Zhidong Li","doi":"10.1155/2023/6670080","DOIUrl":"https://doi.org/10.1155/2023/6670080","url":null,"abstract":"We report a singular case of renal embolism in a hitherto healthy 46-year-old female. The patient initially presented with symptoms of exertional distress and chest discomfort. Following an extensive diagnostic workup, she was subsequently diagnosed with acute pulmonary embolism. On the day succeeding her admission, the patient manifested sustained abdominal discomfort. Abdominal computed tomography angiography (CTA) subsequently revealed the presence of renal artery embolisms and infarctions. Concurrently, an echocardiographic evaluation disclosed a patent foramen ovale (PFO) and pulmonary hypertension. In this specific case, we hypothesize that the embolic event traversed through the PFO, ultimately localizing in the renal artery and culminating in renal embolism.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mina Aghamali, Abdolhassan Kazemi, Mohammad Asgharzadeh, Hossein Samadi Kafil
{"title":"COVID-19, HIV, and Cryptococcal Meningitis Coinfections with Abnormal Laboratory Findings.","authors":"Mina Aghamali, Abdolhassan Kazemi, Mohammad Asgharzadeh, Hossein Samadi Kafil","doi":"10.1155/2023/2868290","DOIUrl":"10.1155/2023/2868290","url":null,"abstract":"<p><strong>Background: </strong>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first introduced in China in 2019, and it has rapidly spread all around the world. <i>Cryptococcus neoformans</i> is the leading cause of fungal meningitis in human immunodeficiency virus- (HIV-) infected patients. A variety of laboratory tests have been introduced for rapid diagnosis of meningitis.</p><p><strong>Methods: </strong>Here, we report a case of coinfection with COVID-19 and cryptococcal meningitis in a HIV-positive patient with abnormal laboratory findings. In this case, COVID-19 was positive by polymerase chain reaction (PCR) and computerized tomography (CT) scan diagnosis. Cryptococcal antigen testing of CSF was negative, whereas India ink staining and cerebrospinal fluid (CSF) culture confirmed the presence of <i>C. neoformans</i>.</p><p><strong>Results: </strong>Although the patient was in a critical stage of illness, serum and CSF levels of procalcitonin were abnormally low, within normal limits. On the other hand, although initial lumbar puncture had showed elevated protein level, the repeat CSFs presented remarkably reduced protein levels. Our findings indicate that despite COVID-19 infection, procalcitonin level may remain normal in HIV-associated cryptococcal meningitis, and findings of an apparently normal procalcitonin level should not exclude the possibility of infection. Also, antigen testing may present false-negative result, and it should not be the sole laboratory method for diagnosis of infectious meningitis. Consequently, CSF culture and staining is recommended, even when antigen testing of organism is negative and CSF profile is unremarkable.</p><p><strong>Conclusion: </strong>Laboratory information should be combined with a good understanding of clinical manifestations of patient to determine if meningitis is present and confirmed COVID-19 should not ignore possibility of other infections for consideration.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2023 ","pages":"2868290"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Figueroa Rodriguez, Parminder Minhas, Houssein A. Youness
{"title":"Tunnel Vision: A Novel Approach for Blood Clot Retrieval Using Cryotherapy through a Flexible Bronchoscope","authors":"Fernando Figueroa Rodriguez, Parminder Minhas, Houssein A. Youness","doi":"10.1155/2023/6620825","DOIUrl":"https://doi.org/10.1155/2023/6620825","url":null,"abstract":"Cryoprobes inserted through a bronchoscope in the airways have frequently been used for the removal of foreign bodies and clots. We present a case of a 72-year-old man who presented with COVID-19 pneumonia and respiratory failure, requiring intubation and proning. During his stay, he developed pneumothoraces in the left hemithorax, which necessitated the placement of two large-bore chest tubes. However, the pneumothorax recurred. There was no air leak in either chest tube, and attempts to restore their patency through flushing or suctioning were unsuccessful. A disposable flexible bronchoscope was inserted into the chest tubes, allowing visualization of the source of occlusion and identification of a blood clot obstructing both tubes. These clots were successfully removed using a cryoprobe inserted through the working channel of the bronchoscope, leading to the restoration of chest tube patency and resolution of the pneumothorax.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"36 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary Arteriovenous Malformation Unmasked by Pregnancy: A Review of Pulmonary Arteriovenous Malformations and Cardiovascular and Respiratory Changes in Pregnancy.","authors":"Anita Lukic, Larisa Cmelak, Dominik Draženović, Hrvoje Kojundzic, Ivan Kresimir Lukic, Vicko Gluncic","doi":"10.1155/2023/5469592","DOIUrl":"https://doi.org/10.1155/2023/5469592","url":null,"abstract":"<p><p>Pulmonary arteriovenous malformations are abnormal, direct communications between the branches of the pulmonary artery and pulmonary veins, but without pulmonary capillaries between them. During pregnancy, PAVMs can enlarge and become symptomatic, causing even serious complications like haematothorax. To recognize the PAVM that becomes symptomatic in pregnancy, one must be able to distinguish the patient's symptoms caused by developing complications of PAVM, as in the case we present, from physiological changes accompanying a healthy pregnancy, including their degree in relation to the stage of pregnancy. The modified early obstetric warning score charts are a very helpful tool in the assessment of (ab)normal signs and symptoms in pregnant women, especially for physicians who rarely manage pregnant women.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2023 ","pages":"5469592"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9270764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exertional Dyspnea Incidentally Diagnosed as Sarcoidosis: A Teaching Hospital Experience.","authors":"Melvina Nartey, Kofi Ulzen-Appiah","doi":"10.1155/2023/8689352","DOIUrl":"https://doi.org/10.1155/2023/8689352","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis is a complex disease with nonspecific etiology and clinical presentation. Its diagnosis is often delayed due to the absence of a single specific investigation modality. A multidisciplinary approach is necessary for its diagnosis. <i>Report</i>. A 49-year-old male presented with recurrent dyspnea on exertion, easy fatigue, and chest pain after several visits to different health facilities over 5 months. A diagnosis of pulmonary sarcoidosis was made after a series of laboratory and imaging investigations were done revealing bilateral reticonodular opacifications, noncaseating granulomata, elevated serum ACE and calcium levels consistent with sarcoidosis.</p><p><strong>Conclusion: </strong>Sarcoidosis, although a rare presentation in our setting, may easily be overlooked or misdiagnosed if a holistic or multidisciplinary approach is not employed in its diagnosis. Nonspecificity of symptoms contributes to the delayed diagnosis.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2023 ","pages":"8689352"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10263012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felix Wuest, Andreas Gebhardt, Claudia Grosswendt, Sergej Griff, Antonina Zhilina, Samantha Taber, Jens Kollmeier, Torsten T Bauer
{"title":"Diffuse Alveolar Hemorrhage Associated with Epithelioid Angiosarcoma of the Lung: A Challenging Diagnosis.","authors":"Felix Wuest, Andreas Gebhardt, Claudia Grosswendt, Sergej Griff, Antonina Zhilina, Samantha Taber, Jens Kollmeier, Torsten T Bauer","doi":"10.1155/2023/5553209","DOIUrl":"https://doi.org/10.1155/2023/5553209","url":null,"abstract":"<p><p>A 68-year-old patient presented with persistent hemoptysis and weight loss. A CT scan showing diffuse bilateral ground-glass opacities and nodules was followed by bronchoscopy. While diffuse alveolar hemorrhage (DAH) could be seen, specimens obtained during bronchoscopy did not provide conclusive histological findings. The decision was made to conduct video-assisted wedge resection, after which histological examinations revealed the diagnosis of bifocal nodular manifestation of an epithelioid angiosarcoma in the lung. Being a rare entity even among sarcomas, these kinds of tumors can be primary lung tissue angiosarcomas or metastatic lesions with primaries in places like the skin, breast, and heart. Treatment usually includes chemotherapy, but prognosis remains grim. This case highlights that in DAH, uncommon causes should be considered, and sufficient probe gathering is the key to early diagnosis and treatment.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2023 ","pages":"5553209"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atulya Aman Khosla, Hollie Saunders, Scott Helgeson, Hiroshi Hikida, Nabeel Aslam, Fadi Salem, Sam Albadri, Hassan Baig
{"title":"The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.","authors":"Atulya Aman Khosla, Hollie Saunders, Scott Helgeson, Hiroshi Hikida, Nabeel Aslam, Fadi Salem, Sam Albadri, Hassan Baig","doi":"10.1155/2023/1461011","DOIUrl":"https://doi.org/10.1155/2023/1461011","url":null,"abstract":"<p><p>Hydralazine is a vasodilator used for the management of hypertension, heart failure, and hypertensive emergencies in pregnancy. It has been implicated in the causation of drug-induced lupus erythematosus (DLE) and rarely with ANCA-associated vasculitis (AAV), which may present as a pulmonary-renal syndrome and be rapidly fatal. Herein, we describe a case of hydralazine-associated AAV presenting as acute kidney injury with the use of early bronchoalveolar lavage (BAL) with serial aliquots to aid with diagnosis. Our case highlights how, in the correct clinical setting, BAL can act as a rapid diagnostic test to help guide quicker treatment to allow for better patient outcomes.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2023 ","pages":"1461011"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9395223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Management of Coronavirus Disease 2019-Related Respiratory Failure Using High-Flow Nasal Cannula Therapy in a Patient with Underlying Pulmonary Artery Hypertension.","authors":"Mariko Kotani, Tomoki Kohyama, Kiyoshi Moriyama, Tomoko Yorozu","doi":"10.1155/2022/1774796","DOIUrl":"https://doi.org/10.1155/2022/1774796","url":null,"abstract":"<p><p>A case involving a 50-year-old woman (height, 155 cm; weight, 79.6 kg), who was undergoing home oxygen therapy (3.5 L/min), with an oxygen saturation (SpO<sub>2</sub>) of approximately 91% due to pulmonary artery hypertension (PAH) with mixed connective tissue disease, is reported. The patient developed coronavirus disease 2019- (COVID-19-) related respiratory failure, with an SpO<sub>2</sub> of 78% on oxygen inhalation (3.5 L/min) and was admitted to the authors' hospital. In accordance with remdesivir, dexamethasone, and heparin treatment, high-flow nasal cannula (HFNC) therapy was selected to avoid intubation. At an initial HFNC setting of 70% oxygen with a flow rate of 50 L/min, SpO<sub>2</sub> improved to 92% and her subjective symptoms improved. She was weaned from HFNC on day 5 of admission (day 14 of COVID-19 onset) and discharged home on day 14 of admission. In patients with PAH, the beneficial effects of HFNC to avoid endotracheal intubation were evident in avoiding hemodynamic instability and worsening respiratory failure.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":" ","pages":"1774796"},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40477860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}