Xiangping Li, Haoxu Yu, D. Li, Wang Fujun, Yanling Tian, Yuan Tian, Faze Chen
{"title":"An aircell hydrogel for ultra-sensitive human-machine interaction","authors":"Xiangping Li, Haoxu Yu, D. Li, Wang Fujun, Yanling Tian, Yuan Tian, Faze Chen","doi":"10.1088/2631-7990/ae0538","DOIUrl":"https://doi.org/10.1088/2631-7990/ae0538","url":null,"abstract":"Abstract Porous hydrogel sensors have attracted significant attention in fields such as smart wearables and medical monitoring due to their high sensitivity. However, existing fabrication methods typically degrade the surface smoothness of hydrogels when introducing porous structures and face significant challenges in removing fillers completely. To address these challenges, we herein introduce a novel one-step, thermosensitive spray-coating technique for the preparation of aircell hydrogel (ACH). This method leverages the rapid cooling of a thermoresponsive gelatin methacryloyl solution through atomization, enabling rapid cross-linking within seconds and air bubbles encapsulated in situ. Additionally, the transient flow of the pre-gel facilitates the repair of voids formed by ruptured surface bubbles, leading to the creation of the ACH with uniformly distributed inner air bubbles and a smooth outer surface. The mold-free fabrication method is independent of substrate surface properties, enabling the creation of a porous hydrogel film with a thickness as thin as 163 μm. Furthermore, the dual-crosslinked network endows the ACH with excellent anti-swelling properties, and the physical crosslinking between gelatin molecules allows the ACH to self-heal. The ACH exhibits excellent sensitivity in deformation sensing and can even successfully track minor external forces, which enables it to effectively complete various tasks such as facial expression recognition, pitch differentiation, and motion detection. By integrating the ACH into a sensing glove, we also demonstrate the significant potential of the ACH for applications in human-machine interaction and tactile sensing. Ultimately, the ACH sensors are also applied to motion mapping and machine tactile feedback, indicating their promising potential in human-machine interaction.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"8 1","pages":"015505-015505"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iopscience.iop.org/article/10.1088/2631-7990/ae0538/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chao Chen, Sijia Guo, Long Zhang, Bingrui Liu, Zhaoxin Lao, S. Li, Yanlei Hu, Dong Wu
{"title":"All-flexible self-cleaning hydrogel smart window with multifunctionality based on an electro-thermal manipulator","authors":"Chao Chen, Sijia Guo, Long Zhang, Bingrui Liu, Zhaoxin Lao, S. Li, Yanlei Hu, Dong Wu","doi":"10.1088/2631-7990/ae00fe","DOIUrl":"https://doi.org/10.1088/2631-7990/ae00fe","url":null,"abstract":"Abstract Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system. Despite immense achievements having been made in drophobic smart windows, unfortunately, the limitations of inferior transparency, unsatisfactory flexibility, and scarce functionality greatly hinder their practical applications. Here, a multifunctional, all-flexible and slef-cleaning electrothermal-actuated (SETA) module with superior transparency is developed by sandwiching the hydrophobic SiO 2 nanoparticles decorated silver nanowires thin-film heater and the thermo-responsive hydrogel. Through loading/discharging an electric stimulus of 5 V, the optical visibility of SETA could be in situ switched between an opaque state ( T 550 = 11.0%) and a transparent state ( T 550 = 84.9%) relying on the dynamically collapsed and swollen transition of hydrogel on planar and three-dimensional curved surfaces. Moreover, SETA chipset is able to repel diverse liquids, including organic and inorganic species, showcasing an excellent self-cleaning capability. Lastly, all-in-one multifunctionalities, including pixelated display, thermal regulation, defogging, and self-cleaning on a single SETA chipset, are successfully deployed. Compared to the previous windows, the current SETA chipset is more competent for optical switching in reality, owing to its portable, energy-efficient, flexible, highly-transparent, and on-demand manipulating advantages. This work provides inspirations for self-cleaning greenhouse, tunable optics, intelligent vehicles, and so on.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"8 1","pages":"015501-015501"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bee-stings-inspired intelligently-sensitive electroactive microneedle with serrated structure for advanced electrical-stimulation-intervened chronic wound-management","authors":"Huie Jiang, Jiamin Zhang, Lijuan Chen, Qian Zhang, Fengqian Yang, Yifan Fei, Xing Chen, Xinhua Liu","doi":"10.1088/2631-7990/adeb0f","DOIUrl":"https://doi.org/10.1088/2631-7990/adeb0f","url":null,"abstract":"Abstract Rapidly-advancing microneedle-based bioelectronics integrated with electrical stimulation (ES) therapy exhibit significant potential for improving chronic wound management. Herein, bio-inspired by the serrated structure of bee-stingers, we developed a temperature-sensitive, two-stage microneedle-based electroactive platform (GP-PPy/PLA-MN) featuring rivet-like microstructures that integrates intelligent, precise drug-releasing, ES-transmission, and real-time wound-assessment monitoring for comprehensive chronic wound-management and diagnostic therapy. The bionic-design mechanically anchors the microneedle beneath the skin’s dermis, while GP-PPy/PLA-MN demonstrates versatile therapeutic characteristics, including outstanding biocompatibility, antimicrobial properties, and antimigratory origins. The GP-PPy/PLA-MN enables the sustained release of insulin at body temperature for up to 24 hours through the poly-N-isopropyl acrylamide grafted amidated-gelatin-based thermo-sensitive hydrogel at the needle-tip, thereby providing long-term stable blood glucose control. GP-PPy/PLA-MN indicates its potential as a novel bioelectronics-based patch to record the temperature and humidity during the wound-healing process, realizing significant wound diagnosis and real-time wound assessment, and fundamentally facilitating the therapeutic efficacy by supplying solid data to protect the clinical practice. Extensive in vitro and in vivo studies have demonstrated that GP-PPy/PLA-MN can provide effective ES and sustained drug release, thereby promoting chronic wound healing and increasing the wound healing rate by 20% compared to the control group after 14 days of treatment. This innovative approach combines bioelectronics with intelligent drug delivery and microneedling technology to effectively address the critical challenges of chronic wound management, offering promising prospects for precision diagnostics and therapeutic interventions.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 6","pages":"065501-065501"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148394127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanyong Wei, Yang Hu, Ming Yang, Chaoyang Shi, Chengzhi Hu
{"title":"A magnetic patch robot with photothermal-activated multi-modality for targeted anti-postoperative adhesion","authors":"Tanyong Wei, Yang Hu, Ming Yang, Chaoyang Shi, Chengzhi Hu","doi":"10.1088/2631-7990/add2de","DOIUrl":"https://doi.org/10.1088/2631-7990/add2de","url":null,"abstract":"Abstract Adhesive patches offer an effective approach for wound closure, making them highly suitable for biomedical applications. However, conventional patches often face limitations such as dual-sided adhesion, lack of shape adaptability, and limited maneuverability, which restrict their applications in deeper tissues. In this paper, we develop a magnetic patch robot (PatchBot), for targeted Janus adhesion with tissues. The PatchBot features a unique triple-layer structure, with adhesive, shape-morphing, and anti-adhesive layers, each fulfilling roles to support targeted attachment, enable shape transformation, and prevent unwanted adhesion to surrounding tissues. The Janus adhesion of the PatchBot was extensively demonstrated across a variety of tissues. A localized near-infrared (NIR) laser irradiation was used to induce programmable shape transformations. Magnetic actuation of the PatchBot for targeted adhesion was successfully demonstrated in ex vivo porcine stomach tissue. NIR light-activated shape-morphing and multimodal magnetic actuation significantly enhance its maneuverability and adaptability in confined in vivo environments while ensuring the structural integrity of the adhesive surface during deployment. This proof-of-concept study demonstrates the feasibility of using PatchBot for targeted wound adhesion, showing its potential for minimally invasive, precision therapies in complex in vivo environments.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 5","pages":"055502-055502"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piao Qu, Guozhen Liang, Muhammad Irfan Hussain, Muhammad Hanif, Muhammad Hamza, Kaibin Huang, Yan Lou, Zhangwei Chen
{"title":"Low-temperature fabrication of high-specific strength SiC-based ceramics via photopolymerization 3D printing with controllable anisotropy","authors":"Piao Qu, Guozhen Liang, Muhammad Irfan Hussain, Muhammad Hanif, Muhammad Hamza, Kaibin Huang, Yan Lou, Zhangwei Chen","doi":"10.1088/2631-7990/add2e1","DOIUrl":"https://doi.org/10.1088/2631-7990/add2e1","url":null,"abstract":"Abstract The combination of silicon carbide (SiC) ceramics and stereolithography technology shows promise for manufacturing complex-shaped SiC components, expanding application possibilities. However, high sintering temperature and structural-performance anisotropy limit the practical use of 3D-printed SiC components. Herein, a novel method is introduced to produce high-specific-strength SiC-based ceramics at a relatively low temperature of 1 100 ℃. A mixed SiC/SiO 2 slurry (30% SiO 2 and 70% SiC by volume) with a solid loading of up to 40% was prepared to improve UV light penetration and printability. Additionally, incorporating a high content of methyl-phenyl-polysiloxane (PSO) solution (75% by weight) enabled low-temperature pyrolysis of SiC/SiO 2 /PSO ceramics. The SiC/SiO 2 /PSO ceramic lattices after pyrolysis achieved a specific strength as high as (1.03 × 10 5 ) N·m·kg −1 and a density of 1.75 g·cm −3 , outperforming similar SiC-based lattices structures of similar porosities. The bending strength of (95.49 ± 8.79) MPa was comparable to that of ceramics sintered at 1 400 ℃ or higher. Notably, the addition of the silicon carbide oxide (SiOC) phase reduced anisotropy, lowering the transverse and longitudinal compression strength ratios from 1.87 to 1.08, and improving mechanical properties by 79%. This improvement is attributed to SiOC shrinkage, promoting a uniform distribution of sintered components, resulting in a more robust and balanced material structure. This method offers valuable insight into the additive manufacturing (AM) of SiC-based ceramics at lower temperatures and provides new guidance for controlling anisotropy in 3D-printed ceramic parts.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 5","pages":"055002-055002"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acoustofluidic pick-and-place operation for label-free spatial assembly of cellular spheroid","authors":"Qiu Yin, Keke Chen, Chenyang Zhou, Yimeng Su, Xianglin Yu, Shiwei Feng, Xiaolin Wang, Zhichao Ma, Wenming Zhang","doi":"10.1088/2631-7990/adbb34","DOIUrl":"https://doi.org/10.1088/2631-7990/adbb34","url":null,"abstract":"Abstract Cellular spheroids, closely resembling native tissue microenvironments, have emerged as pivotal constructs in biomedicine as they can facilitate complex cell-cell and cell-matrix interactions. However, current methods for constructing spheroid assembloids with spatial arrangement or heterogeneous structures are limited, which has become a barrier for studying tissue engineering and in vitro disease modeling. Here, we demonstrate an acoustofluidic pick-and-place operation system capable of spatially assembling of spheroids into desired patterns in both two dimensional (2D) and three dimensional (3D) spaces. The underlying physical mechanism of the device is systematically studied to explain the interrelationship between trapping cell spheroids, acoustic streaming, and the acoustic radiation force (ARF) induced by the acoustically activated microneedle. We exploit these mechanisms to successfully transfer cellular spheroids into hydrogel solutions, enabling them to be precisely patterned and fused into assembloids of predefined shapes. Besides, we demonstrate arranging MC3T3-E1 cellular spheroids into a ring shape to fabricate the osteogenic tissues. Besides, a co-culture model involving tumor cells (MCF-7) and normal human dermal fibroblasts (NHDFs) is constructed to validate our method’s ability to reconstruct heterogeneous tumor model, revealing that the fibroblast spheroids promote tumor spheroid invasion. Our method holds significant potential prospects in regenerative medicine, disease model construction and drug screening.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 4","pages":"045501-045501"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iopscience.iop.org/article/10.1088/2631-7990/adbb34/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng Zhu, Dandan Gao, Zhuo Huang, Wei‐Chiao Chang, Bin Wu, Kaihao Zhang, Minghan Sun, Hengxu Song, Robert O. Ritchie, Tuo Wang, Wei Huang, Huamin Zhou
{"title":"Cryogenic 3D printing of damage tolerant hierarchical porous ceramics","authors":"Zheng Zhu, Dandan Gao, Zhuo Huang, Wei‐Chiao Chang, Bin Wu, Kaihao Zhang, Minghan Sun, Hengxu Song, Robert O. Ritchie, Tuo Wang, Wei Huang, Huamin Zhou","doi":"10.1088/2631-7990/adb9a8","DOIUrl":"https://doi.org/10.1088/2631-7990/adb9a8","url":null,"abstract":"Abstract Fabricating damage tolerant porous ceramics with efficient energy absorption and impact-resistant capability has been a challenge because of the brittle nature of ceramic materials. In nature, mineralized tissues or organisms such as cuttlebones and diatoms have evolved with hierarchical porous structures to overcome this difficulty. A bioinspired design of ceramic lattice structure with pores at multiple length scales, ranging from few nanometers to hundreds of micrometers, is proposed in the present work. These ceramic lattices with hierarchical porous structures were successfully fabricated via 3D cryogenic printing. Under quasi-static compressions, the printed ceramic lattices showed unprecedented long plateau strain (∼60%) and a specific energy absorption of ∼10 kJ·kg ‒1 with a porosity of ∼90%. The resulting energy absorption capability was comparable with most composites and metals, thus overcoming the brittle nature of traditional porous ceramics. This was attributed to the delayed destruction of the lattice structure, as well as the gradual collapse of pores at multiple length scales. Similar trends have also been observed under split Hopkinson pressure bar (SHPB) tests, indicating excellent energy absorption under high strain-rate impacts. The proposed 3D printing technique that produces hierarchical pores was also demonstrated to apply to other functional materials, such as silicon carbide, barium titanate, hydroxyapatite, and even titanium alloy, thus opening up new possibilities for fabricating bioinspired hierarchical porous structures.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 4","pages":"045002-045002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaikai Li, Yingxi Xie, Pengyu Shen, Min Yu, Jiao Gao, Junming Bi, Long Wang, Longsheng Lu
{"title":"Micro/nano-manufacturing of bioinspired blood-repellent surfaces for extreme application in surgical electrodes","authors":"Kaikai Li, Yingxi Xie, Pengyu Shen, Min Yu, Jiao Gao, Junming Bi, Long Wang, Longsheng Lu","doi":"10.1088/2631-7990/adb9a7","DOIUrl":"https://doi.org/10.1088/2631-7990/adb9a7","url":null,"abstract":"Abstract Surgical electrodes are frequently associated with disadvantages such as high surface adhesion and severe thermal damage to adjacent normal tissues, which threaten operation quality and patient safety. In this study, by mimicking the micromorphology and bio-anti-adhesion of shark skin, we proposed a strategy that utilized nanoscale aluminium oxide (Al 2 O 3 ) films deposited on bioinspired shark skin (BSS) microstructures to design a composite surface (Al 2 O 3 @BSS) and integrated it into both flat sides of the surgical electrodes. Micro/nano-manufacturing of the Al 2 O 3 @BSS surface was sequentially accomplished using nanosecond laser texturing, atomic layer deposition, and low-temperature annealing, endowing it with excellent blood-repellent properties. Visualisation experiments revealed that the tensile stress gradient of the blood coagulum with increasing thickness under a thermal field prompted it to separate from the Al 2 O 3 @BSS surface, resulting in anti-adhesion. Furthermore, it was observed for the first time that Al 2 O 3 films could transiently excite discharge along a dielectric surface (DADS) to ablate tissues while suppressing Joule heat, thereby minimising thermal damage. A combination of ex vivo tissue and living mouse experiments demonstrated that the Al 2 O 3 @BSS electrodes exhibited optimal comprehensive performance in terms of anti-adhesion, damage minimisation, and drag reduction. In addition, the Al 2 O 3 @BSS electrodes possessed remarkable antibacterial efficacy against E. coli and S. aureus . The proposed strategy can meet the extreme application requirements of surgical electrodes to improve operation quality and offer valuable insights for future studies.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 4","pages":"045503-045503"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guangbin Zhao, Yanlong Wu, Bochen Li, Hang Tian, Bo Li, Xiao Li, Xu Chen, Tao Zhou, Yaning Wang, Yichao Gong, Dingchang Hou, Yaxiong Liu, Xuewen Zong, Bingheng Lu
{"title":"Digital light processing three-dimensional printing with acrylic–titanium composite powders for multiscale porous scaffolds","authors":"Guangbin Zhao, Yanlong Wu, Bochen Li, Hang Tian, Bo Li, Xiao Li, Xu Chen, Tao Zhou, Yaning Wang, Yichao Gong, Dingchang Hou, Yaxiong Liu, Xuewen Zong, Bingheng Lu","doi":"10.1088/2631-7990/ada979","DOIUrl":"https://doi.org/10.1088/2631-7990/ada979","url":null,"abstract":"Abstract Porous metals fabricated via three-dimensional (3D) printing have attracted extensive attention in many fields owing to their open pores and customization potential. However, dense internal structures produced by the powder bed fusion technique fails to meet the feature of porous materials in scenarios that demand large specific surface areas. Herein, we propose a strategy for 3D printing of titanium scaffolds featuring multiscale porous internal structures via powder modification and digital light processing (DLP). After modification, the titanium powders were composited with acrylic resin and maintained spherical shapes. Compared with the raw powder slurries, the modified powder slurries exhibited higher stability and preferable curing characteristics, and the depth sensitivity of the modified powder slurries with 45 vol% solid loading increased by approximately 72%. Green scaffolds were subsequently printed from the slurries with a solid loading reaching 45 vol% via DLP 3D printing. The scaffolds had macropores (pore diameters of approximately 1 mm) and internal open micropores (pore diameters of approximately 5.7–13.0 μ m) after sintering. Additionally, these small-featured (approximately 320 μ m) scaffolds retained sufficient compressive strength ((70.01 ± 3.53) MPa) even with high porosity (approximately 73.95%). This work can facilitate the fabrication of multiscale porous metal scaffolds with high solid loading slurries, offering potential for applications requiring high specific surface area ratios.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 3","pages":"035003-035003"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Deniz Derman, Taino Rivera, Laura Garriga Cerda, Yogendra Pratap Singh, Shweta Saini, Hasan Erbil Abaci, Ibrahim T Ozbolat
{"title":"Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.","authors":"I Deniz Derman, Taino Rivera, Laura Garriga Cerda, Yogendra Pratap Singh, Shweta Saini, Hasan Erbil Abaci, Ibrahim T Ozbolat","doi":"10.1088/2631-7990/ad878c","DOIUrl":"10.1088/2631-7990/ad878c","url":null,"abstract":"<p><p>This comprehensive review explores the multifaceted landscape of skin bioprinting, revolutionizing dermatological research. The applications of skin bioprinting utilizing techniques like extrusion-, droplet-, laser- and light-based methods, with specialized bioinks for skin biofabrication have been critically reviewed along with the intricate aspects of bioprinting hair follicles, sweat glands, and achieving skin pigmentation. Challenges remain with the need for vascularization, safety concerns, and the integration of automated processes for effective clinical translation. The review further investigates the incorporation of biosensor technologies, emphasizing their role in monitoring and enhancing the wound healing process. While highlighting the remarkable progress in the field, critical limitations and concerns are critically examined to provide a balanced perspective. This synthesis aims to guide scientists, engineers, and healthcare providers, fostering a deeper understanding of the current state, challenges, and future directions in skin bioprinting for transformative applications in tissue engineering and regenerative medicine.</p>","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":"7 1","pages":"012009"},"PeriodicalIF":25.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}