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Atlas of Genetics and Cytogenetics in Oncology and Haematology最新文献

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TPH1 (tryptophan hydroxylase 1) TPH1（色氨酸羟化酶1）
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-06-01 DOI: 10.4267/2042/70861
R. Gurbanov, Sevinç Karaçam
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引用次数: 1
CDC7 (cell division cycle 7) CDC7（细胞分裂周期7）
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-05-01 DOI: 10.4267/2042/70816
Passos Vicari Hugo, Machado-Neto João Agostinho
{"title":"CDC7 (cell division cycle 7)","authors":"Passos Vicari Hugo, Machado-Neto João Agostinho","doi":"10.4267/2042/70816","DOIUrl":"https://doi.org/10.4267/2042/70816","url":null,"abstract":"CDC7 is a serine-threonine kinase that participates in multiple cellular processes, including DNA replication, chromosomal segregation, S phase cell cycle progression, and DNA damage checkpoint. CDC7 is frequently highly expressed in several types of neoplasm, and it has been associated with cancer development and poor clinical outcomes. In different cancer models, functional studies indicated that CDC7 may be an attractive target for antineoplastic therapy, and CDC7 inhibitors have been developed. The present review on CDC7 contains data on DNA/RNA, the protein encoded, and the implication of this gene in cancer cell biology and clinical outcomes.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48227926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant pleural mesothelioma subtypes 恶性胸膜间皮瘤亚型
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-05-01 DOI: 10.4267/2042/70819
Benjamin J. Wadowski, Y. Hung, A. Rienzo
{"title":"Malignant pleural mesothelioma subtypes","authors":"Benjamin J. Wadowski, Y. Hung, A. Rienzo","doi":"10.4267/2042/70819","DOIUrl":"https://doi.org/10.4267/2042/70819","url":null,"abstract":"Review of histologic subtypes of mesothelioma, with associated clinical, pathologic, and molecular data.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42312904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Y RNA in cell cycle progression and cancer Y RNA在细胞周期进程和癌症中的作用
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-05-01 DOI: 10.4267/2042/70820
R. Piergentili
{"title":"Y RNA in cell cycle progression and cancer","authors":"R. Piergentili","doi":"10.4267/2042/70820","DOIUrl":"https://doi.org/10.4267/2042/70820","url":null,"abstract":"","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43116124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EEF1E1-BLOC1S5 EEF1E1-位置5
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-05-01 DOI: 10.4267/2042/70817
Cristiano Luigi
{"title":"EEF1E1-BLOC1S5","authors":"Cristiano Luigi","doi":"10.4267/2042/70817","DOIUrl":"https://doi.org/10.4267/2042/70817","url":null,"abstract":"","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46752533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Langerhans cell sarcoma 朗格汉斯细胞肉瘤
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-05-01 DOI: 10.4267/2042/70818
Dingbao Chen
{"title":"Langerhans cell sarcoma","authors":"Dingbao Chen","doi":"10.4267/2042/70818","DOIUrl":"https://doi.org/10.4267/2042/70818","url":null,"abstract":"","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47228376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
PARP1 (poly(ADP-ribose) polymerase 1) PARP1（聚ADP核糖聚合酶1）
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-04-01 DOI: 10.4267/2042/70775
S. Tunçer, K. Kavak
{"title":"PARP1 (poly(ADP-ribose) polymerase 1)","authors":"S. Tunçer, K. Kavak","doi":"10.4267/2042/70775","DOIUrl":"https://doi.org/10.4267/2042/70775","url":null,"abstract":"PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle. Particularly, due to its decisive role in several DNA repair pathways, the inhibition of PARP1 has emerged as a prominent therapeutic option in cancer treatment, by improving the efficiency of chemotherapeutics or radiation therapy.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45094960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
t(12;15)(p13;q25) ETV6/NTRK3 in Hematological malignancies t(12;15)(p13;q25) ETV6/NTRK3在血液恶性肿瘤中的作用
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-04-01 DOI: 10.4267/2042/70785
J. Huret
{"title":"t(12;15)(p13;q25) ETV6/NTRK3 in Hematological malignancies","authors":"J. Huret","doi":"10.4267/2042/70785","DOIUrl":"https://doi.org/10.4267/2042/70785","url":null,"abstract":"Review on t(12;15)(p13;q25), with data on clinics, and the genes involved.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47801951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
t(12;15)(p13;q25) ETV6/NTRK3 in solid tumors 实体瘤中的t（12；15）（p13；q25）ETV6/NTRK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-04-01 DOI: 10.4267/2042/70786
J. Huret
{"title":"t(12;15)(p13;q25) ETV6/NTRK3 in solid tumors","authors":"J. Huret","doi":"10.4267/2042/70786","DOIUrl":"https://doi.org/10.4267/2042/70786","url":null,"abstract":"Review on t(12;15)(p13;q25) in solid tumors, with data on clinics, and the genes involved.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47358900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EGFR (Epidermal Growth Factor Receptor) 表皮生长因子受体
Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-04-01 DOI: 10.4267/2042/70782
Ayca Circir Hatil, Esra Çiçek, Merve Oyken, A. E. Erson-Bensan
{"title":"EGFR (Epidermal Growth Factor Receptor)","authors":"Ayca Circir Hatil, Esra Çiçek, Merve Oyken, A. E. Erson-Bensan","doi":"10.4267/2042/70782","DOIUrl":"https://doi.org/10.4267/2042/70782","url":null,"abstract":"ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) (Singh, 2016). Ligand binding induces the dimerization of EGFR and autophosphorylation followed by a cascade of downstream phosphorylation events (Capuani et al., 2015). EGFR activation plays a key role in cell survival, proliferation, migration and differentiation (Purba, 2017).","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43561506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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