CDC7（细胞分裂周期7）

Q4 Medicine

Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-05-01 DOI:10.4267/2042/70816

Passos Vicari Hugo, Machado-Neto João Agostinho

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引用次数: 0

摘要

CDC7是一种丝氨酸-苏氨酸激酶，参与多种细胞过程，包括DNA复制、染色体分离、S期细胞周期进程和DNA损伤检查点。CDC7在几种类型的肿瘤中经常高表达，它与癌症的发展和不良的临床结果有关。在不同的癌症模型中，功能研究表明CDC7可能是抗肿瘤治疗的一个有吸引力的靶点，CDC7抑制剂已经被开发出来。目前关于CDC7的综述包含了DNA/RNA、编码蛋白的数据，以及该基因在癌细胞生物学和临床结果中的意义。

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CDC7 (cell division cycle 7)

CDC7 is a serine-threonine kinase that participates in multiple cellular processes, including DNA replication, chromosomal segregation, S phase cell cycle progression, and DNA damage checkpoint. CDC7 is frequently highly expressed in several types of neoplasm, and it has been associated with cancer development and poor clinical outcomes. In different cancer models, functional studies indicated that CDC7 may be an attractive target for antineoplastic therapy, and CDC7 inhibitors have been developed. The present review on CDC7 contains data on DNA/RNA, the protein encoded, and the implication of this gene in cancer cell biology and clinical outcomes.

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来源期刊

Atlas of Genetics and Cytogenetics in Oncology and Haematology Medicine-Oncology

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