PARP1（聚ADP核糖聚合酶1）

Q4 Medicine

Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-04-01 DOI:10.4267/2042/70775

S. Tunçer, K. Kavak

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引用次数: 3

摘要

PARP1（聚ADP核糖聚合酶1）是一种核蛋白，参与调节各种生物过程，包括细胞凋亡、维持基因组完整性的DNA修复、染色质的表观遗传学标记、高级染色质结构的组装、转录激活、分化、增殖和细胞周期。特别地，由于其在几种DNA修复途径中的决定性作用，PARP1的抑制已成为癌症治疗中的一个突出的治疗选择，通过提高化疗或放射治疗的效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PARP1 (poly(ADP-ribose) polymerase 1)

PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle. Particularly, due to its decisive role in several DNA repair pathways, the inhibition of PARP1 has emerged as a prominent therapeutic option in cancer treatment, by improving the efficiency of chemotherapeutics or radiation therapy.

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来源期刊

Atlas of Genetics and Cytogenetics in Oncology and Haematology Medicine-Oncology

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