The MAK collection for occupational health and safety最新文献_第8页

Naphthalene: MAK Value Documentation, addendum - Translation of the German version from 2022. 萘：MAK值文档，附录- 2022年起德文版本的翻译

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb9120e10_2ad

Andrea Hartwig

{"title":"Naphthalene: MAK Value Documentation, addendum - Translation of the German version from 2022.","authors":"Andrea Hartwig","doi":"10.34865/mb9120e10_2ad","DOIUrl":"10.34865/mb9120e10_2ad","url":null,"abstract":"The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has summarized and re-evaluated the data for naphthalene [91-20-3] considering all toxicological end points. Relevant studies were identified from a literature search. The critical effects are the carcinogenic effects in rodents. No data in humans are available for these effects. In carcinogenicity studies, inhalation of naphthalene was found to cause neuroblastomas and adenomas in the noses of rats as well as bronchioloalveolar adenomas and carcinomas in mice. Naphthalene is not mutagenic in vitro, but robust data in vivo are not available. In general, DNA damage is induced in vitro and in vivo mostly at toxic doses. Mechanistic studies suggest that the carcinogenic potential arises from a non-genotoxic mechanism of action. This mechanism is initiated only at high concentrations by severe local inflammation leading to increased cell proliferation. However, a number of uncertainties remain. Thus, at present, a primary genotoxic mechanism of action cannot be ruled out completely for naphthalene. There are no studies from which an effect threshold in humans can be derived. Naphthalene thus remains classified in Carcinogen Category 2. As data for the accessibility of the germ cells are not available, naphthalene remains classified in Germ Cell Mutagen Category 3 B. No sensitizing potential can be derived from the available data. Naphthalene can be absorbed via the skin in toxicologically relevant amounts and remains designated with an \"H\".","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"10 2","pages":"Doc033"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon disulfide - Determination of carbon disulfide in workplace air using headspace gas chromatography (headspace-GC-FPD): Air Monitoring Method - Translation of the German version from 2024. 二硫化碳。使用顶空气相色谱法（顶空-气相色谱- fpd）测定工作场所空气中的二硫化碳：空气监测方法。2024年起德语版本翻译

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/am7515e10_2or

Andreas Grill, Claus-Peter Maschmeier, Ralph Hebisch, Uta Lewin-Kretzschmar, Andrea Hartwig

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引用次数: 0

Weinsäure – Bestimmung von L-(+)- und D-(–)-Weinsäure in der Luft am Arbeitsplatz mittels Ionenchromatographie (IC): Luftanalysen-Methode. 通过离子色谱（IC）测定工作场所空气中的L-(+)和D-(-)酒酸：空气分析方法。

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/am52683d10_2or

Ulrich Prott, Claus-Peter Maschmeier, Ralph Hebisch, Andrea Hartwig

引用次数: 0

Aldrin: MAK Value Documentation, addendum - Translation of the German version from 2023. Aldrin: MAK值文档，附录- 2023年起德语版本的翻译。

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb30900e10_2ad

Andrea Hartwig

引用次数: 0

Ethylformiat: MAK-Begründung, Nachtrag. 甲酸乙酯：MAK基础，补充。

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb10994d10_2ad

Andrea Hartwig

引用次数: 0

Mycotoxins - Determination of aflatoxins, ochratoxin A, free ochratoxin α, gliotoxin, citrinin, and dihydrocitrinone in urine by LC-MS/MS: Biomonitoring Method - Translation of the German version from 2025. 真菌毒素。用LC-MS/MS测定尿液中的黄曲霉毒素、赭曲霉毒素A、游离赭曲霉毒素α、胶质毒素、黄曲霉毒素和二氢黄曲霉酮：生物监测方法。2025年起德文版本翻译

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/bi116265e10_2or

Marion Berger, Max Deharde, Judith Neuhoff, Bernhard Monien, Solveigh Siodlaczek, Thomas Göen, Andrea Hartwig

{"title":"Mycotoxins - Determination of aflatoxins, ochratoxin A, free ochratoxin α, gliotoxin, citrinin, and dihydrocitrinone in urine by LC-MS/MS: Biomonitoring Method - Translation of the German version from 2025.","authors":"Marion Berger, Max Deharde, Judith Neuhoff, Bernhard Monien, Solveigh Siodlaczek, Thomas Göen, Andrea Hartwig","doi":"10.34865/bi116265e10_2or","DOIUrl":"10.34865/bi116265e10_2or","url":null,"abstract":"The working group \"Analyses in Biological Materials\" of the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) developed and verified the presented biomonitoring method. The aim of this method is the selective and sensitive quantitation of aflatoxins (aflatoxins B1, B2, G1, G2, M1), ochratoxin A (OTA), free ochratoxin α (OTα), gliotoxin (GT), citrinin (CIT) and dihydrocitrinone (DH‑CIT) in urine. Sample preparation comprises enrichment and purification of the analytes by solid-phase extraction using OASIS HLB cartridges. Calibration is performed with comparative standards prepared in pooled urine and treated analogously to the samples to be analysed. The aflatoxins, OTA, CIT, and DH‑CIT are quantified using isotope-labelled internal standards (ISTDs), whereas OTα and GT are quantified without an ISTD. Determination is carried out by high-performance liquid chromatography-tandem mass spectrometry (LC‑MS/MS). The method provides reliable and accurate analytical results, as shown by the good precision data with standard deviations below 9% for the aflatoxins, OTα, GT and CIT, below 13% for OTA, and below 20% for DH‑CIT. Good accuracy data were obtained with mean relative recoveries in the range of 93-107% for the aflatoxins, OTα, GT and CIT, in the range of 83-103% for OTA, and in the range of 81-108% for DH‑CIT. The method is both selective and sensitive, and has quantitation limits in the range of 0.013-0.022 μg/l for the aflatoxins and OTA and a quantitation limit of 1.0 μg/l for OTα, 1.5 μg/l for GT, 0.0075 μg/l for CIT, and 0.01 μg/l for DH‑CIT.","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"10 2","pages":"Doc045"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlordane: MAK Value Documentation, addendum - Translation of the German version from 2023. 氯丹：MAK值文档，附录- 2023年起德文版本翻译。

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb5774e10_2ad

Andrea Hartwig

引用次数: 0

Dieldrin: MAK Value Documentation, addendum - Translation of the German version from 2023. Dieldrin: MAK值文档，附录- 2023年起德语版本的翻译。

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb6057e10_2ad

Andrea Hartwig

引用次数: 0

Naphtha (Erdöl), mit Wasserstoff behandelte schwere: MAK-Begründung, Nachtrag. 石脑油，重氢处理：MAK基础，补充。

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb6474248yold10_2ad

Andrea Hartwig

引用次数: 0

DDT (Dichlorodiphenyltrichloroethane): MAK Value Documentation, addendum - Translation of the German version from 2023. 滴滴涕（二氯二苯三氯乙烷）：MAK值文件，附录。2023年起德文版本的翻译

The MAK collection for occupational health and safety Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.34865/mb5029e10_2ad

Andrea Hartwig

引用次数: 0