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Mevinphos: MAK Value Documentation, addendum - Translation of the German version from 2024. Mevinphos: MAK值文档，附录- 2024年起德语版本的翻译。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb778634e11_2ad
Andrea Hartwig
{"title":"Mevinphos: MAK Value Documentation, addendum - Translation of the German version from 2024.","authors":"Andrea Hartwig","doi":"10.34865/mb778634e11_2ad","DOIUrl":"https://doi.org/10.34865/mb778634e11_2ad","url":null,"abstract":"<p><p>Mevinphos [7786-34-7] is not approved in the European Union as an insecticide. The previous MAK Value documentation and addendum do not reflect the current data situ-ation of the substance. The MAK Commissiondecided that a new evaluation is not of high priority. The MAK value and the other classifications are therefore suspended and the substance is listed in the Section II c of the List of MAK and BAT Values for substances no longer evaluated.</p>","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc034"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2,2'-Dichlorodiethyl ether: MAK Value Documentation, addendum - Translation of the German version from 2023. 2,2'-二氯乙醚：MAK值文档，附录。2023年起德文版本的翻译
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb11144e11_2ad
Andrea Hartwig
{"title":"2,2'-Dichlorodiethyl ether: MAK Value Documentation, addendum - Translation of the German version from 2023.","authors":"Andrea Hartwig","doi":"10.34865/mb11144e11_2ad","DOIUrl":"10.34865/mb11144e11_2ad","url":null,"abstract":"<p><p>The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has re-evaluated the occupational exposure limit value (maximum concentration at the workplace, MAK value) for 2,2'-dichlorodiethyl ether [111-44-4] considering all toxicological end points. Relevant studies were identified from a literature search. In a study from 1933, 2,2'-dichlorodiethyl ether in concentrations of 100 ml/m<sup>3</sup> and above showed irritating effects in humans. At 35 ml/m<sup>3</sup> a clearly perceptible unpleasant odour was described and this concentration was irritating in guinea pigs. Reduced body weight gain was observed in rats in a chronic feeding study. This effect was more pronounced in female animals. In a combined repeated dose toxicity study screening also for reproduction/developmental toxicity in rats, the NOAEL for systemic effects was 15 mg/kg body weight and day, the highest dose tested. On this basis, the MAK value has been set at 0.5 ml/m<sup>3</sup>. As the critical effect of 2,2'-dichlorodiethyl ether is systemic, Peak Limitation Category II has been assigned with an excursion factor of 2. As substances with a higher irritation potency like monochloroacetic acid and 2-chloroethanol have similar or higher MAK values, the MAK value for 2,2'-dichlorodiethyl ether will also protect from irritation. Limited data show no genotoxic or carcinogenic potential for 2,2'-dichlorodiethyl ether. In a screening study, the NOAEL for perinatal toxicity in rats was 15 mg/kg body weight and day. As teratogenicity was not investigated, 2,2'-dichlorodiethyl ether has been assigned to Pregnancy Risk Group D. 2,2'-Dichlorodiethyl ether is not a skin sensitizer in a Local Lymph Node Assay in mice. According to skin absorption models, 2,2'-dichlorodiethyl ether is expected to be taken up via the skin in toxicologically relevant amounts. Therefore, 2,2'-dichlorodiethyl ether remains designated with \"H\".</p>","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc030"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fenthion: MAK Value Documentation, addendum - Translation of the German version from 2024. 倍硫磷：MAK值文档，附录- 2024年起德语版本的翻译。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb5538e11_2ad
Andrea Hartwig
{"title":"Fenthion: MAK Value Documentation, addendum - Translation of the German version from 2024.","authors":"Andrea Hartwig","doi":"10.34865/mb5538e11_2ad","DOIUrl":"https://doi.org/10.34865/mb5538e11_2ad","url":null,"abstract":"<p><p>Fenthion [55-38-9] is used as an insecticide and acaricide but is no longer approved in the European Union. The previous MAK value documentation and addendum do not reflect the current data situation of the substance. The MAK Commissiondecided that a new evaluation is not of high priority. The MAK value and the other classifications are therefore suspended and the substance is listed in the Section II c of the List of MAK and BAT Values for substances no longer evaluated.</p>","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc032"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEPP (O,O,O,O-tetraethyl-pyrophosphate): MAK Value Documentation, addendum - Translation of the German version from 2024. TEPP （O，O，O，O-四乙基焦磷酸）：MAK值文档，附录- 2024年起德语版本的翻译。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb10749e11_2ad
Andrea Hartwig
{"title":"TEPP (<i>O</i>,<i>O</i>,<i>O</i>,<i>O</i>-tetraethyl-pyrophosphate): MAK Value Documentation, addendum - Translation of the German version from 2024.","authors":"Andrea Hartwig","doi":"10.34865/mb10749e11_2ad","DOIUrl":"https://doi.org/10.34865/mb10749e11_2ad","url":null,"abstract":"<p><p>TEPP (<i>O</i>,<i>O</i>,<i>O</i>,<i>O</i>-tetraethylpyrophosphate) [107-49-3] is used as an insecticide and acaricide. In the European Union it has never been approved and it is not approved in Germany since 1967. The previous MAK value documentation and addendum do not reflect the current data situation of the substance. The MAK Commissiondecided that a new evaluation is not of high priority. The MAK value and the other classifications are therefore suspended and the substance is listed in the Section II c of the List of MAK and BAT Values for substances no longer evaluated.</p>","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc038"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demeton methyl: MAK Value Documentation, addendum - Translation of the German version from 2024. Demeton methyl: MAK值文档，附录- 2024年起德语版本的翻译。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb802200e11_2ad
Andrea Hartwig
{"title":"Demeton methyl: MAK Value Documentation, addendum - Translation of the German version from 2024.","authors":"Andrea Hartwig","doi":"10.34865/mb802200e11_2ad","DOIUrl":"https://doi.org/10.34865/mb802200e11_2ad","url":null,"abstract":"<p><p>Demeton methyl [8022-00-2] is used as an insecticide but is no longer approved in the European Union. The previous evaluation does not reflect the current data situation of the substance. The MAK Commissiondecided that a new evaluation is not of high priority. The MAK value and the other classifications are therefore suspended and the substance is listed in the Section II c of the List of MAK and BAT Values for substances no longer evaluated.</p>","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc029"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p-Chloroaniline - Derivation of a BAR: Assessment Values in Biological Material - Translation of the German version from 2026. 对氯苯胺。BAR的推导：生物材料的评估值。2026年起德文版本的翻译
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/bb10647e11_2or
Isabell Schönrath, Gabriele Leng, Hans Drexler, Andrea Hartwig
{"title":"p-Chloroaniline - Derivation of a BAR: Assessment Values in Biological Material - Translation of the German version from 2026.","authors":"Isabell Schönrath, Gabriele Leng, Hans Drexler, Andrea Hartwig","doi":"10.34865/bb10647e11_2or","DOIUrl":"10.34865/bb10647e11_2or","url":null,"abstract":"<p><p>The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area evaluated the data for 4-chloroaniline [106-47-8] to derive a biological reference value (BAR). p-Chloroaniline is an intermediate in organic synthesis and is used in the manufacture of pharmaceuticals, plant protection products and dyes. As a potent inducer of methaemoglobin formation, the hazards regarding its acute toxicity surpass the carcinogenic potential. Hence, several accidents with a consecutive cyanosis are reported. Besides the methaemoglobin level, two other, more specific biomarkers are known: p-chloroaniline set free from the haemoglobin adduct and p-chloroaniline in urine. p-Chloroaniline after hydrolysis represents the sum of all <i>N</i>-conjugated phase II metabolites which are then back-converted to their mother compound. Based on studies of the general population, a BAR of 1 µg p-chloroaniline (after hydrolysis)/l urine has been derived. The smoking status did not influence the urinary levels of p-chloroaniline.</p>","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc040"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethoxyquin – Bestimmung von 2,2,4-Trimethyl-6(2H)-chinolinon in Urin mittels UPLC-MS/MS: Biomonitoring-Methode. 使用UPLC-MS/MS生物监测方法测定尿液中2,2,4-三甲基-6(2H)-喹啉酮的乙氧基喹。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/bi9153d11_2or
Gerhard Scherer, Nikola Pluym, Max Scherer, Nadine Rögner, Markus Stoeckelhuber, Thomas Jäger, Thomas Göen, Andrea Hartwig
{"title":"Ethoxyquin – Bestimmung von 2,2,4-Trimethyl-6(2H)-chinolinon in Urin mittels UPLC-MS/MS: Biomonitoring-Methode.","authors":"Gerhard Scherer, Nikola Pluym, Max Scherer, Nadine Rögner, Markus Stoeckelhuber, Thomas Jäger, Thomas Göen, Andrea Hartwig","doi":"10.34865/bi9153d11_2or","DOIUrl":"10.34865/bi9153d11_2or","url":null,"abstract":"","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc041"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xylidin, Isomere (2,3-Xylidin, 2,5-Xylidin, 3,4-Xylidin, 3,5-Xylidin): MAK-Begründung, Nachtrag. 二甲亚胺，异构体（2,3-二甲亚胺，2,5-二甲亚胺，3,4-二甲亚胺，3,5-二甲亚胺）：MAK基础，补充。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb8759ismd11_2ad
Andrea Hartwig
{"title":"Xylidin, Isomere (2,3-Xylidin, 2,5-Xylidin, 3,4-Xylidin, 3,5-Xylidin): MAK-Begründung, Nachtrag.","authors":"Andrea Hartwig","doi":"10.34865/mb8759ismd11_2ad","DOIUrl":"10.34865/mb8759ismd11_2ad","url":null,"abstract":"","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc025"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schwangerschaftsgruppen, neue Gruppe B (Verdacht): MAK-Begründung. 新B组（怀疑）：MAK基础。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mbschwgrbverd11_2or
Andrea Hartwig
{"title":"Schwangerschaftsgruppen, neue Gruppe B (Verdacht): MAK-Begründung.","authors":"Andrea Hartwig","doi":"10.34865/mbschwgrbverd11_2or","DOIUrl":"10.34865/mbschwgrbverd11_2or","url":null,"abstract":"","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc026"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2-Butoxyethylacetat: MAK-Begründung, Nachtrag. 2-乙酸丁基乙酸酯：MAK基础，补充。
The MAK collection for occupational health and safety Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.34865/mb11207d11_2ad
Andrea Hartwig
{"title":"2-Butoxyethylacetat: MAK-Begründung, Nachtrag.","authors":"Andrea Hartwig","doi":"10.34865/mb11207d11_2ad","DOIUrl":"10.34865/mb11207d11_2ad","url":null,"abstract":"","PeriodicalId":521214,"journal":{"name":"The MAK collection for occupational health and safety","volume":"11 2","pages":"Doc022"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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