Smart molecules : open access最新文献

Chiral covalent organic cages: Construction and chiral functions. 手性共价有机笼：结构和手性功能。

Smart molecules : open access Pub Date : 2025-03-25 eCollection Date: 2025-06-01 DOI: 10.1002/smo.20240038

Si-Dan Guo, Tianyu Jiao, Dong-Sheng Guo, Kang Cai

引用次数: 0

Recent progress on nanotechnologies for enhancing blood-brain barrier permeability. 增强血脑屏障通透性的纳米技术研究进展。

Smart molecules : open access Pub Date : 2025-03-20 eCollection Date: 2025-06-01 DOI: 10.1002/smo.20240052

Qibin Liu, Zhuoqian Chen, Anthony Guiseppi-Elie, Fanling Meng, Liang Luo

{"title":"Recent progress on nanotechnologies for enhancing blood-brain barrier permeability.","authors":"Qibin Liu, Zhuoqian Chen, Anthony Guiseppi-Elie, Fanling Meng, Liang Luo","doi":"10.1002/smo.20240052","DOIUrl":"10.1002/smo.20240052","url":null,"abstract":"The blood-brain barrier (BBB) is a substantial impediment to effectively delivering central nervous system (CNS) therapies. In this review, we provide a comprehensive dissection of the BBB's elaborate structure and function and discuss the inherent limitations of conventional drug delivery mechanisms due to its impermeability. We summarized the creative deployment of nanocarriers, the astute modification of small molecules to bolster their CNS penetration capabilities as well as the burgeoning potential of magnetic nanoparticles and optical techniques that are positioned to enable more precise and targeted drug delivery across the BBB and we discuss the current clinical application of some nanomedicines. In addition, we emphasize the indispensable role of artificial intelligence in designing novel materials and the paramount significance of interdisciplinary research in surmounting clinical challenges associated with BBB penetration. Our review meticulously integrates these insights to accentuate the impact of nanotechnological innovations in BBB research and CNS disease management. It presents a promising trajectory for the evolution of patient care in neurological disorders and suggests that these scientific strides could lead to more efficacious treatments and improved outcomes for those afflicted with such conditions.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 2","pages":"e20240052"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed-matrix membranes incorporating hierarchical ZIF-8 towards enhanced CO₂/N₂ separation. 采用层次化ZIF-8的混合基质膜增强CO2/N2分离。

Smart molecules : open access Pub Date : 2025-03-07 eCollection Date: 2025-06-01 DOI: 10.1002/smo.20240066

Ting Xia, Yuyang Wu, Taotao Ji, Wenjing Hu, Kunpeng Yu, Xinyu He, Ben Hang Yin, Yi Liu

{"title":"Mixed-matrix membranes incorporating hierarchical ZIF-8 towards enhanced CO2/N2 separation.","authors":"Ting Xia, Yuyang Wu, Taotao Ji, Wenjing Hu, Kunpeng Yu, Xinyu He, Ben Hang Yin, Yi Liu","doi":"10.1002/smo.20240066","DOIUrl":"10.1002/smo.20240066","url":null,"abstract":"Metal-organic framework (MOF) has been widely used as filler of mixed-matrix membranes (MMMs) because of their tunable pore sizes, large surface areas, and rich functional groups. However, a relatively high diffusion barrier in the framework of bulk MOF fillers inevitably reduces gas permeability. Introduction of hierarchically porous structure represents an effective method for reducing guest diffusion resistance with no compromise in gas selectivity. In this study, hierarchical ZIF-8 (H-ZIF-8) was prepared using carboxylated polystyrene (PS-COOH) nanospheres as a hard template. Owing to the introduction of carboxyl groups, electrostatic interaction between PS nanospheres and Zn2+ ions is enhanced, facilitating uniform embedment of PS nanospheres in bulk ZIF-8 filler. After dissolution of PS-COOH nanospheres with dimethylformamide solvents, H-ZIF-8 with tunable textural properties is readily obtained. Gas permeation results indicate that compared with bulk ZIF-8 filler, fast diffusion pathways for guest molecules are established in H-ZIF-8 filler, resulting in a CO2/N2 separation factor (SF) of 48.77 with CO2 permeability of 645.76 Barrer in terms of H-ZIF-8 MMMs with 6 wt % loading, which well exceeds the 2008 Robenson upper bound for CO2/N2 gas pair, thus showing promising prospects for high-efficiency CO2 capture from flue gas.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 2","pages":"e20240066"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A COVID-19 rapid antigen test employing upconversion nanoparticles. 采用上转化纳米颗粒的COVID-19快速抗原检测。

Smart molecules : open access Pub Date : 2025-01-05 eCollection Date: 2025-03-01 DOI: 10.1002/smo.20240042

Le Zhang, Jiajia Zhou, Olga Shimoni, Shihui Wen, Amani Alghalayini, Yuan Liu, Meysam Rezaeishahmirzadi, Jiayan Liao, Mahnaz Maddahfar, Roger Hunt, Murdo Black, Matt D Johansen, Phil M Hansbro, Lin Zhang, Martina Stenzel, Majid Warkiani, Stella M Valenzuela, Dayong Jin

{"title":"A COVID-19 rapid antigen test employing upconversion nanoparticles.","authors":"Le Zhang, Jiajia Zhou, Olga Shimoni, Shihui Wen, Amani Alghalayini, Yuan Liu, Meysam Rezaeishahmirzadi, Jiayan Liao, Mahnaz Maddahfar, Roger Hunt, Murdo Black, Matt D Johansen, Phil M Hansbro, Lin Zhang, Martina Stenzel, Majid Warkiani, Stella M Valenzuela, Dayong Jin","doi":"10.1002/smo.20240042","DOIUrl":"10.1002/smo.20240042","url":null,"abstract":"The COVID-19 pandemic has underscored the critical need for rapid and accurate diagnostic tools. Current methods, including Polymerase Chain Reaction and rapid antigen tests (RAT), have limitations in speed, sensitivity, and the requirement for specialized equipment and trained personnel. Nanotechnology, particularly upconversion nanoparticles (UCNPs), offer a promising alternative due to their unique optical properties. UCNPs can convert low-energy near-infrared light into higher-energy visible light, making them ideal for use as optical probes in single molecule detection and point of care applications. This study, initiated in early 2020, explores the opportunity of using highly doped UCNPs (40%Yb3+/4%Er3+) in lateral flow assay (LFA) for the early diagnosis of COVID-19. The UCNPs-based LFA testing demonstrated a minimum detection concentration of 100 pg/mL for SARS-CoV-2 antigen and 105 CCID50/mL for inactivated virus. Clinical trials, conducted in Malaysia and Western Australia independently, showed that the technique was at least 100 times more sensitive than commercial RAT kits, with a sensitivity of 100% and specificity of 91.94%. The development process involved multidisciplinary collaborations, resulting in the Virulizer device, an automated strip reader for point-of-care testing. This work sets a reference for future development of highly sensitive and quantitative RAT, aiming for the Limits of Detection in the range of sub-ng/mL.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 1","pages":"e20240042"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A β-galactosidase activated near-infrared fluorescent probe for tracking cellular senescence in vitro and in vivo. 一种β-半乳糖苷酶激活的近红外荧光探针用于体外和体内跟踪细胞衰老。

Smart molecules : open access Pub Date : 2025-01-05 eCollection Date: 2025-03-01 DOI: 10.1002/smo.20240062

Tian Su, Ruijun Shen, Dengchu Tu, Xiaoyue Han, Xianzhu Luo, Fabiao Yu

{"title":"A β-galactosidase activated near-infrared fluorescent probe for tracking cellular senescence in vitro and in vivo.","authors":"Tian Su, Ruijun Shen, Dengchu Tu, Xiaoyue Han, Xianzhu Luo, Fabiao Yu","doi":"10.1002/smo.20240062","DOIUrl":"10.1002/smo.20240062","url":null,"abstract":"Cellular senescence is a steady state of cell cycle arrest necessary to maintain homeostasis in organisms. However, senescent cells may cause senescence in neighboring healthy cells, inducing the onset of several diseases, such as inflammation, neurological disorders, and atherosclerosis. Therefore, early detection of cellular senescence is extremely important. β-Galactosidase (β-gal), as a critical marker of cellular senescence, can be monitored to facilitate early diagnosis of aging-related diseases. Furthermore, β-gal is mainly found in lysosomes, which have a pH value of about 4.5-5.5. Here, we developed a near-infrared fluorescent probe (QMOH-Gal) for tracking cell senescence in vitro and in vivo via the detection of β-gal. In addition, the probe displayed high sensitivity and specificity for β-gal with good fluorescence signal in the acidity range. Subsequently, this QMOH-Gal probe was successfully employed to differentiate between normal cells and senescent cells by monitoring β-gal. Furthermore, the probe not only realized the monitoring of β-gal in zebrafish but also the tracking of β-gal in palbociclib-induced breast tumor senescence. Overall, the probe shows great promise as an effective tool for imaging β-gal in vivo for studying the biology of aging in organisms.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 1","pages":"e20240062"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational design of deep eutectic solvents with low viscosities and multiple active sites for efficient recognition and selective capture of NH₃. 合理设计具有低粘度和多活性位点的深度共晶溶剂，以有效识别和选择性捕获NH3。

Smart molecules : open access Pub Date : 2025-01-05 eCollection Date: 2025-03-01 DOI: 10.1002/smo.20240045

Lu Zheng, Saisai Ju, Siqi Fang, Hongwei Zhang, Zhenping Cai, Kuan Huang, Lilong Jiang

{"title":"Rational design of deep eutectic solvents with low viscosities and multiple active sites for efficient recognition and selective capture of NH3.","authors":"Lu Zheng, Saisai Ju, Siqi Fang, Hongwei Zhang, Zhenping Cai, Kuan Huang, Lilong Jiang","doi":"10.1002/smo.20240045","DOIUrl":"10.1002/smo.20240045","url":null,"abstract":"Efficient recognition and selective capture of NH3 is not only beneficial for increasing the productivity of the synthetic NH3 industry but also for reducing air pollution. For this purpose, a group of deep eutectic solvents (DESs) consisting of glycolic acid (GA) and phenol (PhOH) with low viscosities and multiple active sites was rationally designed in this work. Experimental results show that the GA + PhOH DESs display extremely fast NH3 absorption rates (within 51 s for equilibrium) and high NH3 solubility. At 313.2 K, the NH3 absorption capacities of GA + PhOH (1:1) reach 6.75 mol/kg (at 10.7 kPa) and 14.72 mol/kg (at 201.0 kPa). The NH3 solubility of GA + PhOH DESs at low pressures were minimally changed after more than 100 days of air exposure. In addition, the NH3 solubility of GA + PhOH DESs remain highly stable in 10 consecutive absorption-desorption cycles. More importantly, NH3 can be selectively captured by GA + PhOH DESs from NH3/CO2/N2 and NH3/N2/H2 mixtures. 1H-NMR, Fourier transform infrared and theoretical calculations were performed to reveal the intrinsic mechanism for the efficient recognition of NH3 by GA + PhOH DESs.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 1","pages":"e20240045"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel Cu (I) π-complexation adsorbent for ultra-deep desulfurization from a carbon dioxide stream. 一种新型Cu (I) π络合吸附剂的研制及其在二氧化碳超深度脱硫中的应用。

Smart molecules : open access Pub Date : 2025-01-04 eCollection Date: 2025-03-01 DOI: 10.1002/smo.20240027

Huating Ju, Yongchun Zhang, Jikai Zhang, Ziqi Yu, Yige Zhang, Xiongfu Zhang, Xinwen Guo, Jiaxu Liu, Qing Mao, Qi Liu, Yiming Zhao, Tianqinji Qi, Xiao Jiang, Zhen Guo, Shaoyun Chen

{"title":"Development of a novel Cu (I) π-complexation adsorbent for ultra-deep desulfurization from a carbon dioxide stream.","authors":"Huating Ju, Yongchun Zhang, Jikai Zhang, Ziqi Yu, Yige Zhang, Xiongfu Zhang, Xinwen Guo, Jiaxu Liu, Qing Mao, Qi Liu, Yiming Zhao, Tianqinji Qi, Xiao Jiang, Zhen Guo, Shaoyun Chen","doi":"10.1002/smo.20240027","DOIUrl":"10.1002/smo.20240027","url":null,"abstract":"Desulfurization technology is rather difficult and urgently needed for carbon dioxide (CO2) utilization in industry. A new Cu(I)-based adsorbent was synthesized and examined for the capacity of removing carbonyl sulfide (COS) from a CO2 stream in an effort to solve the competitive adsorption between CO2 and COS and to seek opportunity to advance adsorption capacity. A wide range of characterization techniques were used to investigate the physicochemical properties of the synthesized Cu(I) adsorbent featuring π-complexation and their correlations with the adsorption performance. Meanwhile, the first principal calculation software CP2K was used to develop an understanding of the adsorption mechanism, which can offer useful guidance for the adsorbent regeneration. The synthesized Cu(I) adsorbent, prepared by using copper citrate and citric acid on the ZSM-5 (SiO2/Al2O3 = 25) carrier, outperformed other adsorbents with varying formulations and carriers in adsorption capacities. Through optimization of the preparation and adsorption conditions for various adsorbents, the breakthrough adsorption capacity (Q b ) for COS was further enhanced from 2.19 mg/g to 15.36 mg/g. The formed stable π-complex bonds between COS and Cu(I), as confirmed by density functional theory calculations, were verified by the significant improvement in the adsorption capacity after regeneration at 600°C. The above advantages render the novel synthesized Cu(I) adsorbent a promising candidate featuring cost-effectiveness, high efficacy and good regenerability for desulfurization from a CO2 stream.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 1","pages":"e20240027"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion. 荧光探针用于膜微域，变形和融合的可视化。

Smart molecules : open access Pub Date : 2024-12-30 eCollection Date: 2025-03-01 DOI: 10.1002/smo.20240059

Pei-Hong Tong, Tong-Yuan Wu, Mingle Li, Hai-Bin Wang, Feng Zheng, Lin Xu, Wei-Tao Dou

{"title":"Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion.","authors":"Pei-Hong Tong, Tong-Yuan Wu, Mingle Li, Hai-Bin Wang, Feng Zheng, Lin Xu, Wei-Tao Dou","doi":"10.1002/smo.20240059","DOIUrl":"10.1002/smo.20240059","url":null,"abstract":"The cell membrane, a fluid interface composed of self-assembled phospholipid molecules, is a vital component of biological systems that maintains cellular stability and prevents the invasion of foreign toxins. Due to its inherent fluidity, the cell membrane can undergo bending, shearing, and stretching, making membrane deformation crucial in processes like cell adhesion, migration, phagocytosis, and signal transduction. Within the plasma membrane are highly ordered dynamic structures formed by lipid molecules, known as \"lipid rafts,\" whose dynamic dissociation and reorganization are prerequisites for membrane deformation. Fluorescent probes have emerged as vital tools for studying these dynamic processes, offering a non-destructive, in situ, and real-time imaging method. By strategically designing these probes, researchers can image not only the microdomains of cell membranes but also explore more complex processes such as membrane fusion and fission. This review systematically summarizes the latest advancements in the application of fluorescent probes for cell membrane imaging. It also discusses the current challenges and provides insights into future research directions. We hope this review inspires further studies on the dynamic processes of complex cell membranes using fluorescent probes, ultimately advancing our understanding of the mechanisms underlying membrane dissociation, reorganization, fusion, and separation, and fostering research and therapeutic development for membrane-associated diseases.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 1","pages":"e20240059"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in single fluorescent probes for monitoring dual organelles in two channels. 双通道双细胞器单荧光探针的研究进展。

Smart molecules : open access Pub Date : 2024-12-15 eCollection Date: 2024-12-01 DOI: 10.1002/smo.20240040

Xiu-Zhi Yang, Shankun Yao, Jisong Wu, Jiajie Diao, Weijiang He, Zijian Guo, Yuncong Chen

{"title":"Recent advances in single fluorescent probes for monitoring dual organelles in two channels.","authors":"Xiu-Zhi Yang, Shankun Yao, Jisong Wu, Jiajie Diao, Weijiang He, Zijian Guo, Yuncong Chen","doi":"10.1002/smo.20240040","DOIUrl":"10.1002/smo.20240040","url":null,"abstract":"Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of the organelle networks are associated with multiple pathological processes. However, clearly and intuitively visualizing the highly dynamic interactions between ultrafine organelles is challenging. Fluorescence imaging technology provides opportunities due to the distinct advantages of facile, non-invasiveness and dynamic detection, making it particularly well-suited for applications in uncovering the mysterious veil of organelle interactions. Regrettably, the lack of ideal fluorescence agents has always been an obstacle in imaging the intricate behaviors of organelles. In this review, we provide a systematic discussion on the existing dual-color and dual-targetable molecular sensors used in monitoring organelle interactions, with a specific focus on their targeting strategies, imaging mechanisms and biological applications. Additionally, the current limitations and future development directions of dual-targetable probes and dual-emissives are briefly discussed. This review aims to provide guidance for researchers to develop more improved probes for studying organelle interactions in the biomedical field.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"2 4","pages":"e20240040"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anchoring group regulation in semiconductor/molecular complex hybrid photoelectrode for photoelectrochemical water splitting. 用于光电化学水分解的半导体/分子复合物杂化光电极的锚定基团调节。

Smart molecules : open access Pub Date : 2024-12-08 eCollection Date: 2025-06-01 DOI: 10.1002/smo.20240056

Xiangyan Chen, Fujun Niu, Tongxiang Ma, Qingyu Li, Shaopeng Wang, Shaohua Shen

引用次数: 0