Smart molecules : open access最新文献_第3页

A NIR light activated self-reporting carbon dots assembly as phototheranostics for tumor photodynamic therapy. 近红外光激活的自报告碳点组件作为肿瘤光动力治疗的光疗法。

Smart molecules : open access Pub Date : 2024-10-21 eCollection Date: 2025-06-01 DOI: 10.1002/smo.20240049

Ziyu Zhao, Tiejin Chen, Jian Li, Xiaokuang Xue, Jiechao Ge, Pengfei Wang

引用次数: 0

Exploring the interplay between zinc-induced protein dyshomeostasis and mitochondrial dysfunction using viscosity-sensitive sensor. 利用黏度敏感传感器探索锌诱导的蛋白质失衡与线粒体功能障碍之间的相互作用。

Smart molecules : open access Pub Date : 2024-10-12 eCollection Date: 2024-12-01 DOI: 10.1002/smo.20240047

Xuan He, Jiaqi Li, Wenye He, Jia Zhai, Yu Wei, Xin Zhang, Baoxing Shen, He Huang

{"title":"Exploring the interplay between zinc-induced protein dyshomeostasis and mitochondrial dysfunction using viscosity-sensitive sensor.","authors":"Xuan He, Jiaqi Li, Wenye He, Jia Zhai, Yu Wei, Xin Zhang, Baoxing Shen, He Huang","doi":"10.1002/smo.20240047","DOIUrl":"10.1002/smo.20240047","url":null,"abstract":"Mitochondria are crucial sites for protein quality control within cells. When mitochondrial stress is triggered by protein misfolding, it can accelerate abnormal protein aggregation, potentially inducing various diseases. This study developed a cascade-responsive sensor, named AggHX, to monitor the microenvironment of protein aggregation induced by zinc (II) ions and the accompanying mitochondrial dysfunction. The AggHX consists of two key components: (1) A Zn2+ recognition group for triggering a fluorescent enhance response, and (2) a near-infrared BODIPY scaffold that detects viscosity changes in cell aggregation via HaloTag. This sensor's mechanism of action is elucidated through photochemical and biochemical characterizations. To further investigate the relationship between protein aggregation and mitochondrial homeostasis, we employ fluorescence lifetime imaging microscopy to assess viscosity changes in protein aggregates under intracellular Zn2+ stress. This research provides insights into the dynamic behavior and spatial distribution of protein aggregates and mitochondria, contributing to a deeper understanding of their physiological roles in cellular processes and potential implications in disease pathology.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"2 4","pages":"e20240047"},"PeriodicalIF":0.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on renewable energy: Conversion and utilization of biomass. 可再生能源研究进展：生物质的转化与利用。

Smart molecules : open access Pub Date : 2024-10-10 eCollection Date: 2024-12-01 DOI: 10.1002/smo.20240019

Xinping Yang, Yongjia Zhang, Peiliang Sun, Chong Peng

{"title":"A review on renewable energy: Conversion and utilization of biomass.","authors":"Xinping Yang, Yongjia Zhang, Peiliang Sun, Chong Peng","doi":"10.1002/smo.20240019","DOIUrl":"10.1002/smo.20240019","url":null,"abstract":"The significant increase in demand for fuels and chemicals driven by global economic expansion has exacerbated concerns over fossil fuel consumption and environmental pollution. To achieve sustainable production of fuels and chemicals, biomass resources provide a rich repository for carbon-neutral, green renewable energy, and organic carbon. This paper reviews the transformation and utilization of lignocellulosic biomass and its derivatives, emphasizing their valorization into high-quality chemicals and biofuels. The advantages and disadvantages of various pretreatment methods are discussed based on the composition of lignocellulose. Furthermore, the methods and pathways for the valorization and conversion of cellulose, hemicellulose, and lignin are detailed according to the unique functional groups of different lignocellulosic platform molecules. However, the complex and resilient structure of biomass presents challenges for the disassembly and utilization of single components, and achieving high yields and selectivity for target products remains difficult. In conclusion, this paper comprehensively reviews the various types and pretreatment technologies of lignocellulose, focusing on the methods and pathways for the valorization of lignocellulosic biomass and its derivatives, thereby providing clear guidance and insights for optimizing lignocellulose utilization in the future.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"2 4","pages":"e20240019"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nile red-based AIEgen for highly fluorescent polymer particles and its application in light-scattering fluorescent films. 尼罗红基高荧光聚合物颗粒AIEgen及其在光散射荧光膜中的应用。

Smart molecules : open access Pub Date : 2024-09-28 eCollection Date: 2025-03-01 DOI: 10.1002/smo.20240032

Hongkun Jiang, Shengjie Chen, Weizhipeng Wu, Guan Wang, Xinggui Gu

{"title":"Nile red-based AIEgen for highly fluorescent polymer particles and its application in light-scattering fluorescent films.","authors":"Hongkun Jiang, Shengjie Chen, Weizhipeng Wu, Guan Wang, Xinggui Gu","doi":"10.1002/smo.20240032","DOIUrl":"10.1002/smo.20240032","url":null,"abstract":"Organic luminophores with superior solid-state luminescence are urgently required in various fields, such as lighting, display, sensing, and solar energy conversion. However, to achieve their highly efficient luminescence still remains a challenge. Herein, a newly designed Nile red derivative, Nile-DPA-VB, is successfully obtained to exhibit aggregation-induced emission characteristics with the photoluminescent quantum yield (PLQY) of 11.45%. Such PLQY could be further promoted to 53.45% when Nile-DPA-VB is polymerized undergoing precipitation polymerization process, where the confined aggregation microenvironment severely restricts the intramolecular motions of Nile-DPA-VB. Remarkably, Nile-DPA-VB is ultrasensitive to the polarity and steric effect, enabling the real-time monitoring of aggregation microenvironment evolution for precipitation polymerization. The microphase separation and dynamic hardening for the nucleation and growth processes are visually demonstrated, which contribute dominantly to the high-efficiency luminescence. Finally, by doping the as-prepared fluorescent polymeric particles into polymethyl methacrylate, functional films with high luminescence and high haze are achieved to show the potential in lighting. These findings clearly demonstrate the significant role of polymerization in constructing high-efficiency solid-state luminescent materials for practice.","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"3 1","pages":"e20240032"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0