Sage open pathology最新文献_第3页

Oligometastatic Renal Ewing Sarcoma With FUS::ERG Fusion: A Case Report And Literature Review. 少转移性肾尤文氏肉瘤合并FUS: ERG融合1例并文献复习。

Sage open pathology Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.1177/30502098251336541

Dan T Nguyen, Trent Davidson, Fiona Maclean, Pranav Dorwal, Yeh Chen Lee, Min Ru Qiu

引用次数: 0

Manual Delineation of the Region of Interest Combined With Clinical Image Analysis to Predict the Ki-67 Expression Level in Non-small Cell Lung Cancer. 人工划定感兴趣区域结合临床图像分析预测非小细胞肺癌中Ki-67的表达水平。

Sage open pathology Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI: 10.1177/30502098251336608

Yizhi Li, Jia Zhang, Xiaodan Lin

{"title":"Manual Delineation of the Region of Interest Combined With Clinical Image Analysis to Predict the Ki-67 Expression Level in Non-small Cell Lung Cancer.","authors":"Yizhi Li, Jia Zhang, Xiaodan Lin","doi":"10.1177/30502098251336608","DOIUrl":"10.1177/30502098251336608","url":null,"abstract":"Background: The Ki-67 antigen, a marker of cell proliferation, serves as a biomarker for assessing tumor malignancy. However, measuring Ki-67 levels through immunohistochemistry is often challenging due to difficulties in specimen collection and individual health issues. Radiological analysis has emerged as a potential alternative for predicting Ki-67 levels, although its accuracy has been limited. This study aims to enhance the prediction of Ki-67 levels using chest X-rays by employing a refined approach that combines detailed, manually delineated radiological features with conventional imaging characteristics.Methods: This study collected X-ray images and Ki-67 expression data from 109 patients diagnosed with Non-Small Cell Lung Cancer (NSCLC). Seven radiological features related to tumor progression were annotated on each image by clinical professionals. Tumor areas were delineated using Python, resulting in the generation of 5 types of data from these regions. Data integration facilitated the development of predictive models utilizing Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF), and Deep Neural Networks (DNN), with feature selection processes applied.Results: Using the RF, 8 predictive features were selected from the datasets, of which 7 exhibited a linear correlation with Ki-67 levels (Mantel-Haenszel test, P < .05). The model demonstrated robust performance metrics: Accuracy: 0.818, Precision: 0.823, Recall: 0.849, and F1 Score: 0.783.Conclusions: This research underscores the effectiveness of integrating specific radiological features, manually delineated regions of interest (ROIs), with traditional imaging characteristics and machine learning techniques. This approach significantly enhances the predictive accuracy of chest X-rays for Ki-67 levels, offering a non-invasive method for Ki-67 estimation.","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"18 ","pages":"30502098251336608"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenalectomy Leading to Early Diagnosis of ALECT2 Amyloidosis. 肾上腺切除术对ALECT2淀粉样变的早期诊断。

Sage open pathology Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.1177/30502098251331780

Andrew C Hu, Jesse E Passman, Zubair Baloch, Heather Wachtel

引用次数: 0

Leiomyosarcoma of the Bone: A Case Report on the Critical Role of Biomarkers in Differential Diagnosis. 骨平滑肌肉瘤：生物标志物在鉴别诊断中的关键作用的病例报告。

Sage open pathology Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1177/30502098251327064

Nguyen Van Khanh, Tran Duc Thanh, Nguyen Tran Quang Sang, Dang Minh Quang, Fernandez Martinez Fernando Jose, Le The Hung, Tran Van Cong, Tran Tuyet Thanh Hai, Tran Duy Thanh, Vu Hai Son, Nguyen Xuan Hung, Tran Trung Dung

{"title":"Leiomyosarcoma of the Bone: A Case Report on the Critical Role of Biomarkers in Differential Diagnosis.","authors":"Nguyen Van Khanh, Tran Duc Thanh, Nguyen Tran Quang Sang, Dang Minh Quang, Fernandez Martinez Fernando Jose, Le The Hung, Tran Van Cong, Tran Tuyet Thanh Hai, Tran Duy Thanh, Vu Hai Son, Nguyen Xuan Hung, Tran Trung Dung","doi":"10.1177/30502098251327064","DOIUrl":"10.1177/30502098251327064","url":null,"abstract":"Leiomyosarcoma of the bone (LMSB) is a rare type of sarcoma characterized by smooth muscle differentiation arising within the bone. We present the case of a 38-year-old female patient diagnosed with LMSB in the left distal femur. Histological examination revealed spindle-shaped and pleomorphic cells, with no evidence of cartilage or bone matrix formation. Immunohistochemical analysis demonstrated the tumor cell were positive for Smooth Muscle Actin, Desmin, and H-caldesmon. The integration of clinical presentation, imaging, morphological, and immunohistochemical findings confirmed the diagnosis of high-grade leiomyosarcoma of the bone. Postoperative pathological analysis further validated this diagnosis. One year after surgery, the patient remains stable, with no signs of recurrence or metastasis. Diagnosing leiomyosarcoma of the bone is particularly challenging due to the limitations of core needle biopsy samples. However, immunohistochemical evidence of smooth muscle differentiation plays a critical role in establishing the diagnosis.","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"18 ","pages":"30502098251327064"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatofibrosarcoma Protuberans and SMARCA4/BRG1 Loss: Novel Molecular Change or Coincidental Association? 隆突性皮肤纤维肉瘤与SMARCA4/BRG1缺失：新的分子变化或巧合关联？

Sage open pathology Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.1177/30502098251318875

Huiyan Deng, Mingyang Li, Ying Jia, Hanxu Jiang, Keqi Jia, Xiaojie Fan, Yueping Liu

引用次数: 0

Chronic Recurrent Multifocal Osteomyelitis (CRMO): The Deceptive Disease That Mimics Sarcoma Radiologically but Promises a Complete Recovery. 慢性复发性多灶性骨髓炎（CRMO）：一种具有欺骗性的疾病，放射学上类似肉瘤，但承诺完全恢复。

Sage open pathology Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.1177/30502098251314782

Lalani De Silva, Sunil Wijayasinghe, Chandu de Silva

{"title":"Chronic Recurrent Multifocal Osteomyelitis (CRMO): The Deceptive Disease That Mimics Sarcoma Radiologically but Promises a Complete Recovery.","authors":"Lalani De Silva, Sunil Wijayasinghe, Chandu de Silva","doi":"10.1177/30502098251314782","DOIUrl":"10.1177/30502098251314782","url":null,"abstract":"Chronic recurrent multifocal osteomyelitis (CRMO) is a rare and distinct form of chronic non-bacterial osteomyelitis with an unknown etiology. This 11-year-old Asian girl presented with a painful swelling in her right arm, which was suspected to be a Ewing's sarcoma based on radiological findings. The lesion appeared as a unifocal destructive bone lesion in the proximal diaphyseal region of the right humerus, accompanied by periosteal reaction and soft tissue involvement. She was otherwise clinically well, except for the elevated C-reactive protein, erythrocyte sedimentation rate and alkaline phosphatase. Due to the clinical and radiological suspicion of sarcoma, repeated bone biopsies were performed. All the biopsies revealed mature lamellar bone, normocellular marrow with moderate mixed inflammation, and fibrosis, indicative of a chronic inflammatory process. Given the discordance between the clinical, radiological, and pathological findings, surgical management was withheld and the patient was closely monitored. Over the course of several months, her symptoms gradually improved without any medical or surgical interventions. A follow-up X-ray taken 3 years after the initial diagnosis showed that the lesion had significantly reduced in size, nearly returning to a normal bone contour.","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"18 ","pages":"30502098251314782"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editor-in-Chief's Commentary: Clinical Pathology Is Changing Its Title to Sage Open Pathology to Welcome a New Era of Pathology Professional Research, Engagement, Education, and Practice. 总编辑评论：临床病理学正在改变其标题为圣人开放病理学，以迎接病理学专业研究，参与，教育和实践的新时代。

Sage open pathology Pub Date : 2025-01-03 eCollection Date: 2025-01-01 DOI: 10.1177/30502098241310369

Rachele M Hendricks-Sturrup

引用次数: 0