Sage open pathology最新文献

{"title":"A Case of Antineutrophil Cytoplasmic Antibody (ANCA) - Negative Eosinophilic Granulomatosis with Polyangiitis (EGPA) with Nasal Polyps and Peripheral Neuropathy.","authors":"Aleksandar Perić, Milica Labus, Biserka Vukomanović Đurđević","doi":"10.1177/30502098261451762","DOIUrl":"10.1177/30502098261451762","url":null,"abstract":"<p><p>Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing vasculitis that affects small and medium-sized blood vessels, characterized by asthma, blood and tissue hypereosinophilia, and the presence of extravascular eosinophilic granulomas. In 30% to 40% of patients, antineutrophil cytoplasmic antibodies (ANCAs) can be detected in the blood, which classifies the disease as ANCA-associated vasculitis. However, according to the classification criteria by the American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR), detecting ANCAs in the blood is not a criterion for this disease. We present a case of a 34-year-old woman with chronic rhinosinusitis (CRS) with nasal polyps, asthma, hyposmia, elevated body temperature, weakness, loss of sensation in the feet and hands, and difficulty walking. Neurological diagnostics pointed to an asymmetrical polyneuropathy. Histological analysis of tissue samples from the nasal cavity showed the presence of extravascular hypereosinophilia, where the accumulation of activated eosinophils was most pronounced in the tissue of nasal polyps. EGPA should be considered in cases of refractory CRS with nasal polyps, asthma, peripheral neuropathy, and histological findings of extravascular tissue eosinophilia.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098261451762"},"PeriodicalIF":0.0,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemotherapy Associated Nonocclusive Mesenteric Ischemia During Chemoradiation Therapy for Esophageal Cancer: A Case Report.","authors":"Satoshi Ikeda, Gen Suzuki, Shou Watanabe, Shinsuke Nagasawa, Kanako Kawabata, Takuya Kimoto, Koji Masui, Norihiro Aibe, Hideya Yamazaki, Akito Higashi, Osamu Dohi, Kei Yamada","doi":"10.1177/30502098261425062","DOIUrl":"10.1177/30502098261425062","url":null,"abstract":"<p><p>Nonocclusive mesenteric ischemia (NOMI) is a type of intestinal ischemia without organic vascular obstruction that carries high mortality rates, making it a critical condition with a poor prognosis. This report describes a case involving a 71-year-old man with esophageal cancer who developed NOMI during chemoradiation therapy. After initiation of chemoradiation therapy with combined 5-fluorouracil and cisplatin, the patient experienced acute abdominal pain and hypotension. Imaging findings suggested NOMI of the distal ileum. Early intervention rapidly decreased his symptoms and improved his vital signs, thereby avoiding surgical treatment. Thus, the patient received conservative treatment and completed his radiation therapy as scheduled without recurrence of symptoms, although chemotherapy was discontinued. To our knowledge, this is the first reported case of chemotherapy-associated NOMI successfully managed with conservative treatment alone, highlighting the potential effectiveness of early therapeutic intervention before the condition progresses to severe ischemia.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098261425062"},"PeriodicalIF":0.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147314570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-Microbiome Interactions: Characterization, Therapeutic Implications and Machine Learning.","authors":"Selina Mawunyo Ayivi-Tosuh, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Blessing Kwabena Gayi, Albert Fynn Aiduenu, Angelina Akomea, Susanna Awinsongya Anovunga, William Ekloh, Laud Anthony Basing","doi":"10.1177/30502098251415109","DOIUrl":"10.1177/30502098251415109","url":null,"abstract":"<p><p>The gut microbiome is vital in maintaining overall health, yet its complexity and dynamic interactions are still not fully understood. This diverse microbial community comprises bacteria, viruses, fungi, and archaea, contributing to metabolism, immune regulation, and disease susceptibility. However, imbalances in the gut microbiome (dysbiosis), have been linked to various diseases, underscoring the importance of understanding microbial interactions within the gut ecosystem. This review explores these interactions, focusing on biochemical and molecular mechanisms that shape microbial behavior and function. Additionally, it examines the therapeutic potential of the gut microbiome, particularly its involvement in disease progression, prevention, and treatment. The role of medicinal plants in influencing gut microbial composition is also discussed, given their potential to support microbiome health. Lastly, it highlights the integration of machine learning in microbiome research, offering new insights into microbial interactions, predictive disease modeling, and personalized medicine. By addressing these key areas, this review aims to deepen our understanding of gut-microbiome dynamics and their implications for human health and disease management.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098251415109"},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Medicine and Dentistry Through Clinical Pathology: A Call for Integration.","authors":"Tessho Maruyama","doi":"10.1177/30502098251415114","DOIUrl":"10.1177/30502098251415114","url":null,"abstract":"","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098251415114"},"PeriodicalIF":0.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriateness of Histopathology Specimen Containers and Completeness of Laboratory Request Forms in Uganda: A Case of Mbarara Regional Referral Hospital, South Western Uganda.","authors":"Yekosani Mitala, Raymond Atwine, Richard Dratu, Dianah Ishimwe, Francis Nsumba Kitenda, Joel Musayi, Isaac Keith Kasadha, Habert Tumwesigye, Vivian Naluzze, Simeon Eloba, Samuel Tumwesigire, Abraham Birungi, Brian Ssenkumba","doi":"10.1177/30502098251413817","DOIUrl":"10.1177/30502098251413817","url":null,"abstract":"<p><strong>Introduction: </strong>Laboratory request forms (LRFs) are pivotal to histopathologists as they are the only medium through which pathologists communicate with patients and clinicians. On many occasions, the LRFs are incompletely filled and do not paint the right picture of the patient.</p><p><strong>Methods: </strong>This was a cross-sectional study that audited 586 LRFs and specimen containers sent to the Mbarara University of Science and Technology (MUST) histopathology laboratory between July 2024 and September 2024 for their completeness and appropriateness. The main parameters considered were biodata, clinical history, clinician details, and hospital details.</p><p><strong>Results: </strong>Overall, only 3.6% (21/586) of LRFs were appropriately filled. Of the 4 main parameters, biodata was the most filled at 54.1%, hospital details at 18.1%, and clinical details at 7.5%, and the least completed was clinician details at 5.6%.</p><p><strong>Conclusion: </strong>The completion rate of the LRFs is unacceptably poor, and the used specimen containers are unbefitting. Patient age and name are the most completed parameters, while requesting the physician's signature was the least completed variable. Clinicians need to be constantly reminded of their role in histopathology diagnosis through continuous medical education and the introduction of laboratory standard operating procedures (SOPs) on the wards and operating theaters.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098251413817"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12819987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Clinical Workforce Shortage by Retaining the Tenured Laboratory Professionals.","authors":"Paul Z Chiou, Lotte Mulder","doi":"10.1177/30502098251415113","DOIUrl":"10.1177/30502098251415113","url":null,"abstract":"<p><strong>Introduction: </strong>An acute shortage of pathology and clinical laboratory workforce, worsened by the pandemic, has created ethical concerns, notably unequal access to pathology services. To date, efforts to alleviate these shortages have primarily focused on outreach and increasing the profession's visibility. However, a crucial aspect that has received insufficient attention is the retention of the more tenured workforce, a strategy that could directly impact the availability and equitable distribution of services.</p><p><strong>Objective: </strong>To assess the workplace presence and loyalty of a tenured workforce to the company compared to that of early-career workforce in lab medicine.</p><p><strong>Design: </strong>We analyzed a cross-sectional web-based survey to compare the tenure time at the current workplace (loyalty) and unexpected sick days taken (workplace presence) between the tenured workforce (ages 51-65) and the early-to mid-career workforce (ages 21-50). Additional characteristics such as job fulfillment and physical and emotional wellness were also assessed.</p><p><strong>Results: </strong>The study demonstrated that more senior laboratorians showed higher loyalty with significantly longer tenure at their current workplace at 20.5 years, compared to their younger cohort, who stayed a median of 3.0 years (<i>P</i> < .001). Moreover, the more senior professionals also displayed significantly higher workplace presence (<i>P</i> < .001), with fewer unexpected sick or mental days taken (0) compared to their counterparts (2). Finally, the 2 cohorts had no significant statistical differences in self-perceived levels of job fulfillment and physical or mental wellness.</p><p><strong>Conclusion: </strong>Instead of focusing mainly on high school and college recruitment, the study results suggest providing additional resources and efforts to retain the existing workforce. Specifically, successfully retaining tenured and more experienced laboratory professionals concurrent with current efforts may be a better strategy for closing the current workforce shortage gap in clinical lab medicine.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098251415113"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Lobe, Two Pathologies: First Report of an Intrathyroidal Parathyroid Adenoma Invaded by Papillary Thyroid Cancer and Review of the Literature.","authors":"Omar Aboul Hosn, Christophe Abi Zeid Daou, Lucien Khalil, Patrick Abou Raji Feghali, Marc Mourad","doi":"10.1177/30502098251407926","DOIUrl":"10.1177/30502098251407926","url":null,"abstract":"<p><p>Intrathyroidal parathyroid adenomas (ITPAs) are rare causes of primary hyperparathyroidism, with type III variants, being the rarest. Coexistence of ITPA and papillary thyroid carcinoma (PTC) in the same lobe is exceedingly rare. The pathogenesis of this rare coexistence is unclear, possibly related to embryologic displacement or local microenvironmental factors. No prior reports have documented direct invasion of ITPA by PTC. We report a 63-year-old woman with hypercalcemia and osteopenia. Imaging suggested a right lobe ITPA. Hemithyroidectomy revealed a type II ITPA and multifocal PTC, with histopathology confirming carcinoma invasion into the adenoma. Postoperatively, calcium and PTH normalized. Completion thyroidectomy revealed a contralateral PTC focus, and adjuvant radioactive iodine was planned. Including this case, only 7 reports exist of concurrent ITPA and PTC, primarily in women aged 50 to 70 with right-lobe involvement. Diagnosis is difficult due to imaging overlap with benign nodules; although 99mTc-sestamibi and 4D-CT improve localization, fine-needle aspiration remains limited. This case is the first to document direct PTC invasion of an ITPA and highlights the importance of surgical excision in suspected ITPA, both for definitive treatment and to uncover occult malignancy. This paper aims to present the first reported case of concurrent ITPA and PTC within the same lobe, with histologically confirmed direct carcinoma invasion into the adenoma, review the existing literature on this rare coexistence and highlight the associated diagnostic challenges and surgical considerations.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"19 ","pages":"30502098251407926"},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrapulmonary Schwannoma: A Rare Case Report and Review of the Literature.","authors":"Elham EntezarAlmahdi, Mehdi Jamalpour, Parviz Mardani, Zahra Beyzaei, Bita Geramizadeh","doi":"10.1177/30502098251410398","DOIUrl":"10.1177/30502098251410398","url":null,"abstract":"<p><p>Schwannoma is a benign, well-circumscribed, and encapsulated peripheral nerve sheath tumor that develops from Schwann cells. The growth pattern is usually slow, tending to clinical indolence. Primary pulmonary neuronal tumors are very rare, accounting for ~0.2% of all lung neoplasms, and are often misdiagnosed due to their nonspecific radiological features. A 50-year-old man presented with a large cystic mass in upper lobe of left lung discovered incidentally on chest X-ray during work up after a blunt chest trauma. Gross examination of the mass following surgical excision revealed a well-circumscribed, encapsulated creamy-gray cystic lesion with gelatinous material measuring 10.5 × 6 × 5.5 cm, attached to a segment of lung. Microscopically, the tumor showed hypo- and hypercellular areas with proliferation of elongated wavy cells in a myxoid background which is characteristic of Schwannoma. Despite intrapulmonary schwannomas' rarity, it is essential to consider schwannomas in the differential diagnosis of pulmonary masses, particularly when clinical and radiological findings suggest a well-defined, encapsulated lesion.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"18 ","pages":"30502098251410398"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12756555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenosynovial Giant Cell Tumours: A Clinicopathologic Study of a Case-Series.","authors":"Toukilnan Djiwa, Mayi Bombone, Bagassam Sama, Panakinao Simgban, T H Towoezim, Tchin Darré","doi":"10.1177/30502098251341137","DOIUrl":"10.1177/30502098251341137","url":null,"abstract":"<p><strong>Introduction: </strong>Tenosynovial giant cell tumours (TSGCT) are rare mesenchymal tumours that develop in joints, bursae and tendon sheaths. The aim of this study was to describe the epidemiological, clinical and histopathological aspects of this pathology in Togo.</p><p><strong>Methodology: </strong>This was a retrospective descriptive and analytical study of histologically confirmed cases of tenosynovial giant cell tumour from 1 January 2014 to 31 December 2023 in the Pathology Department of the Sylvanus Olympio Teaching Hospital in Lomé, Togo.</p><p><strong>Results: </strong>We identified 12 cases of tenosynovial giant cell tumours. We found 8 male subjects and 4 female subjects. The mean age of our patients was 24.2 ± 12.8 years. The tumour was located in the fingers in 9 cases (75%) and in the toes in 3 cases (25%). The mean time to diagnosis was 26.3 + 20.8 months. Pain and a palpable mass were the main symptoms. The nodular type was found in 7 cases (58.33%) and the diffuse type in 5 cases (41.67%).</p><p><strong>Conclusion: </strong>Tenosynovial giant cell tumour is a benign proliferative disorder of the synovium, the aetiopathogenesis of which remains undetermined.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"18 ","pages":"30502098251341137"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillosis Osteomyelitis of the Mandible: A Case Report and Literature Review.","authors":"Ikram Attouchi, Ghada Bouslama, Nour Sayda Ben Messaoud, Atig Amira, Zahra Kmira, Ben Youssef Yosra, Lamia Oualha, Badreddine Sriha, Souha Ben Youssef","doi":"10.1177/30502098251344770","DOIUrl":"10.1177/30502098251344770","url":null,"abstract":"<p><p>Aspergillosis is an uncommon fungal infection caused by Aspergillus species, predominantly affecting immunocompromised individuals. While pulmonary involvement is common, extrapulmonary manifestations such as osteomyelitis are uncommon. Aspergillus osteomyelitis of the mandible is an exceptionally rare and life-threatening condition, posing significant diagnostic and therapeutic challenges. We present the case of a 13-year-old immunocompromised patient diagnosed with this condition. The patient presented with persistent jaw pain, swelling, and radiographic evidence of extensive bone destruction. Diagnosis was confirmed through fungal cultures and histopathological examination, which identified Aspergillus species. The patient underwent surgical debridement and prolonged antifungal therapy, leading to clinical improvement. Aspergillus osteomyelitis of the mandible is exceedingly rare, with only a few cases reported in the literature. Early diagnosis is crucial to prevent further bone destruction and associated complications. This case underscores the importance of considering fungal infections in the differential diagnosis of osteomyelitis, particularly in at-risk populations. It also emphasizes the potential role of antifungal prophylaxis in reducing the severity of invasive fungal infections when they occur. Managing this condition presents significant challenges, including the need for aggressive antifungal therapy and the risk of recurrence.</p>","PeriodicalId":520893,"journal":{"name":"Sage open pathology","volume":"18 ","pages":"30502098251344770"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}