The Journal of clinical endocrinology and metabolism最新文献

{"title":"Letter to the Editor from Maino et al.: \"Prevalence and Management of Complications of Laser Ablation for Benign Thyroid Nodules: A Systematic Review of Literature and Meta-Analysis\".","authors":"Fabio Maino, Elisa Mattii, Maria Grazia Castagna","doi":"10.1210/clinem/dgaf411","DOIUrl":"https://doi.org/10.1210/clinem/dgaf411","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myofibrillar protein synthesis rates do not differ with low and high estradiol concentrations across the menstrual cycle.","authors":"Marianna C A Apicella, Tom S O Jameson, Alistair J Monteyne, George F Pavis, Doaa R Abdelrahman, Andrew J Murton, Nima Alamdari, Marlou L Dirks, Benjamin T Wall, Francis B Stephens","doi":"10.1210/clinem/dgaf410","DOIUrl":"https://doi.org/10.1210/clinem/dgaf410","url":null,"abstract":"<p><strong>Context: </strong>Skeletal muscle can respond and adapt to sex hormones; however, the degree to which fluctuations in endogenous estradiol across the menstrual cycle (MC) influences rates of myofibrillar protein synthesis (MyoPS) is not clear.</p><p><strong>Objective: </strong>We compared MyoPS in postabsorptive and postprandial postexercise states, during the early follicular (EF; low estradiol) and late follicular (LF; high estradiol) phases of the MC.</p><p><strong>Design, setting, participants and intervention: </strong>Seventeen healthy females (age: 28±7 y; BMI: 24±3 kg.m2), participated in a randomized, cross-over trial, during the EF (day 4±1; estradiol, 183±78 pmol.L-1) and LF (day 15±3; estradiol, 855±571 pmol.L-1) phases. Following a resistance exercise bout, participants ingested an amino acid (AA) drink. Blood and muscle samples were collected, pre and postexercise and AA ingestion.</p><p><strong>Main outcome measure: </strong>Following primed-continuous infusion of L-[ring-2H5]-phenylalanine, MyoPS was measured prior to and during a 4 h postprandial postexercise period.</p><p><strong>Results: </strong>MyoPS increased above postabsorptive rates between 0-2 h to 0.111±0.049 and 0.117±0.058 %⋅h-1, (P<0.001) but not between 2-4 h (P=0.522), for EF and LF, respectively, with no interactions observed (P=0.971). Moderate correlations were shown between total and free testosterone and 0-4 h MyoPS (r=0.364, P=0.048; r=0.369, P=0.045, respectively). Expression of several genes associated with protein synthesis, muscle remodeling and inflammation were increased in LF vs EF (P<0.050), whereas protein breakdown genes were decreased.</p><p><strong>Conclusions: </strong>Despite a gene expression profile consistent with muscle growth, MyoPS did not differ with elevated estradiol concentrations. Hence, estradiol does not seem to be important for acutely regulating muscle mass in eumenorrheic females.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor from Maino et al.: \"Prevalence and Management of Complications of Laser Ablation for Benign Thyroid Nodules: A Systematic Review of Literature and Meta-Analysis\".","authors":"Lorenzo Scappaticcio, Nicole Di Martino, Pamela Ferrazzano, Maria Ida Maiorino, Paola Caruso, Alessandra Volatile, Miriam Longo, Giovanni Docimo, Eduardo Iervolino, Pierpaolo Trimboli, Katherine Esposito, Giuseppe Bellastella","doi":"10.1210/clinem/dgaf412","DOIUrl":"https://doi.org/10.1210/clinem/dgaf412","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of high expression of circulating miR-222-3p in patients with unilateral primary aldosteronism.","authors":"Kentaro Okamoto, Masakatsu Sone, Daisuke Taura, Youichi Ohno, Ichiro Yamauchi, Yohei Ueda, Takuro Hakata, Mika Tsuiki, Masanori Murakami, Daisuke Yabe, Nobuya Inagaki, Mitsuhide Naruse","doi":"10.1210/clinem/dgaf408","DOIUrl":"https://doi.org/10.1210/clinem/dgaf408","url":null,"abstract":"<p><strong>Context: </strong>The significance of circulating miRNAs in primary aldosteronism (PA) is still largely unknown.</p><p><strong>Objective: </strong>We compared the profiles of circulating miRNAs between unilateral primary aldosteronism (UPA) and bilateral hyperaldosteronism (BHA) and investigated the potential role of a newly identified UPA-related miRNA in the pathogenesis of PA.</p><p><strong>Methods: </strong>We initially conducted a comprehensive expression analysis of circulating miRNAs using a qPCR panel in a small number of cases matched for background factors, followed by validation analysis with a larger sample size for the candidate miRNAs.</p><p><strong>Results: </strong>The expression level of one single miRNA, miR-222-3p, was significantly higher in UPA than in BHA, both in the adrenal veins and the inferior vena cava. Moreover, it was significantly higher in the adrenal vein on the tumor side compared to the non-tumor side within the same UPA patients. In primary cultured adrenal cells, miR-222-3p mimics appeared to increase CYP11B2 expression, although the effect was not statistically significant. However, transfection with miR-222-3p mimics significantly increased cell proliferation, while transfection with miR-222-3p inhibitors decreased it. CDKN1B was identified as a predicted target gene of miR-222-3p. Additionally, the expression level of miR-222-3p exhibited a significant positive correlation with tumor diameter and plasma aldosterone concentration after saline infusion test.</p><p><strong>Conclusions: </strong>The present results demonstrated higher expression of circulating miR-222-3p in UPA than in BHA, providing a biochemical marker for subtype diagnosis of PA. Moreover, the correlation of miR-222-3p with adrenal cell proliferation and aldosterone secretion indicated its significant involvement in the pathogenesis of PA.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to Editor from Yeap et al: \"Endogenous sex steroid hormones, sex hormone-binding globulin, and risk of all-cause and cause-specific mortality: A systematic review and dose-response meta-analysis of prospective cohort studies\".","authors":"Hamidreza Raeisi-Dehkordi, Mojgan Amiri, Sara Beigrezaei, Hugo G Quezada-Pinedo, Marinka Steur, Angeline Chatelan, Trudy Voortman, Oscar H Franco, Taulant Muka","doi":"10.1210/clinem/dgaf415","DOIUrl":"https://doi.org/10.1210/clinem/dgaf415","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor from Yeap et al: \"Endogenous sex steroid hormones, sex hormone-binding globulin, and risk of all-cause and cause-specific mortality: A systematic review and dose-response meta-analysis of prospective cohort studies\".","authors":"Bu B Yeap, Ross J Marriott, Leen Antonio, Leon Flicker, Gary A Wittert, Frederick C W Wu, Kevin Murray","doi":"10.1210/clinem/dgaf414","DOIUrl":"https://doi.org/10.1210/clinem/dgaf414","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A PTH Value at 6 Hours Post-Surgery Predicts the Diagnosis of Transient and Permanent Hypoparathyroidism.","authors":"Ana Segarra-Balao, Juan de Dios Barranco-Ochoa, María de Damas-Medina, Beatriz Andrea Sánchez-Arquelladas, Eva Antonaya-Rubia, Carmen Rosa-Garrido, María Josefa Martínez-Ramírez, Alberto José Moreno-Carazo","doi":"10.1210/clinem/dgaf416","DOIUrl":"https://doi.org/10.1210/clinem/dgaf416","url":null,"abstract":"<p><strong>Context: </strong>Parathyroid hormone (PTH) levels after thyroid surgery are generally used to detect patients at risk of developing postoperative hypoparathyroidism. However, there is still a lack of consensus about the threshold value regarding its evaluation, the definition of gland function recovery and the classification of hypoparathyroidism as permanent.</p><p><strong>Objective: </strong>PTH levels (determined 6 hours after total thyroidectomy) could be effective for early prediction of the risk of post-surgical hypocalcemia and intravenous calcium requirements during hospitalization, comparing it with the predictive capacity of serum calcium levels at 24 and 48 hours after surgery. We also aim to study the efficacy of the measurement of PTH levels for the predictive diagnosis of permanent hypoparthyroidism.</p><p><strong>Design: </strong>Prospective cohort study between September 2021 and November 2023.</p><p><strong>Setting: </strong>A public tertiary care hospital (Jaén, Spain).</p><p><strong>Patients: </strong>We collected data on 105 patients undergoing total thyroidectomy.</p><p><strong>Main outcome measures: </strong>PTH levels were measured 6 hours postoperatively (PTH6h). Additionally, corrected calcium levels, adjusted for total protein, were measured at 24 hours (Ca24h) and 48 hours (Ca48h) post-surgery.</p><p><strong>Results: </strong>In our study, a PTH value at 6 hours post-surgery < 10.10 pg/ml, suggests, with high sensitivity and specificity, to be a very effective measure for identifying patients who would develop either transient (AUC=0.991, 95% CI 0.978-1) and permanent hypoparathyroidism (AUC=0.961, 95% CI 0.952-0.997).</p><p><strong>Conclusions: </strong>Measuring PTH levels at 6 hours post-thyroidectomy is an accurate method for predicting which patients are at risk of developing transient and/or permanent hypoparathyroidism.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: \"Temple Syndrome: Comprehensive Clinical Study in Genetically Confirmed 60 Japanese Patients\".","authors":"","doi":"10.1210/clinem/dgaf398","DOIUrl":"https://doi.org/10.1210/clinem/dgaf398","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Term Survivors of Anaplastic Thyroid Cancer: A Genomic Predictive Model.","authors":"Benjamin C Greenspun, Daniel Aryeh Metzger, Sally Lee, Bradley E Pearson, Jin H Li, Shuibing Chen, Rasa Zarnegar, Thomas J Fahey Iii, Brendan M Finnerty","doi":"10.1210/clinem/dgaf391","DOIUrl":"https://doi.org/10.1210/clinem/dgaf391","url":null,"abstract":"<p><strong>Context: </strong>Longer-term survival is possible for some patients with Anaplastic Thyroid Cancer (ATC). However, genomic factors associated with improved survival are poorly characterized.</p><p><strong>Objective: </strong>To develop a mathematical model to predict mutation-based survival risk in ATC.</p><p><strong>Design: </strong>Retrospective cohort study of 204 ATC samples from the cBioPortal database, divided into 80% training and 20% validation cohorts. Multivariate analysis identified prognostic genes, used to construct a point-based risk model. KEGG pathway enrichment and BRAF subanalyses were performed.</p><p><strong>Setting: </strong>Multi-institutional, international genomic database.</p><p><strong>Patients or other participants: </strong>Samples were included if sequencing and survival data were available (N=204).</p><p><strong>Intervention(s): </strong>Not applicable.</p><p><strong>Main outcome measure(s): </strong>The prespecified primary outcome was overall survival.</p><p><strong>Results: </strong>Fourteen genes were associated with increased risk - TET1, MAPK12, ATP10A, PIK3CA, MUC4, PNPLA2, PLD4, EGLN2, BSN, FLNC, RADIL, ZMYND8, FRAS1, RECQL4. More aggressive (n=37) and less aggressive cohorts (n=128) were determined using the maximally selected rank statistic, yielding a point threshold of 0.27. The predictive performance of the risk model demonstrated a C-index of 0.74. On Kaplan Meier analysis, 1-year survival differed for more aggressive patients (0%) compared to less aggressive patients (32%). For the validation cohort, survival remained significantly different between risk cohorts and on BRAF subanalysis. Each risk cohort subsequently underwent KEGG pathway enrichment analysis which showed significantly increased enrichment across several pathways for more aggressive tumors.</p><p><strong>Conclusions: </strong>This model identifies mutated genes that are associated with the most aggressive ATCs and thus may aid in preoperative risk assessment when evaluating patients for surgery for curative intent.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Plasma Exchange and Changes in Calcium, Phosphate, Parathyroid Hormone, and Fibroblast Growth Factor-23.","authors":"Sami SeungMi Jin, Anushree Dugar, Andrew N Hoofnagle, Amber P Sanchez, David M Ward, Joachim H Ix, Charles Ginsberg","doi":"10.1210/clinem/dgaf400","DOIUrl":"https://doi.org/10.1210/clinem/dgaf400","url":null,"abstract":"<p><strong>Context: </strong>Therapeutic plasma exchange (TPE) removes plasma proteins and other unwanted substances, causing non-specific alterations of plasma components. A previous study showed ∼70% reduction in vitamin D metabolites following a single TPE treatment, prompting further investigation into TPE's effects on vitamin D regulators and metabolites: calcium, phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF-23).</p><p><strong>Objective: </strong>This study examined changes in plasma and effluent levels of total calcium, phosphate, PTH, and FGF-23 in persons undergoing TPE.</p><p><strong>Methods: </strong>Measurements were taken immediately before, immediately after, and at follow-up. Paired t-tests compared the percent changes in metabolites from pre- to post-TPE.</p><p><strong>Results: </strong>Study participants (N=42) had a mean age of 55 ± 16 years, 28 (67%) were female and 32 (76%) were white. TPE led to acute changes in calcium [-9%, (95% CI -11%, -8%)], phosphate [-14%, (-18%, -11%)], and FGF-23 [-12%, (-18%, -6%)] concentrations. In contrast, PTH levels increased [91% (63%, 119%)] from baseline to post-TPE. While most metabolites returned to baseline by the follow-up visit (median 4 [IQR 3,7] days), nearly 25% of patients experienced persistent asymptomatic hypocalcemia. This persistent calcium deficit was not fully corrected by continuous IV calcium gluconate infusions administered during the study, nor by the endogenously increased PTH levels.</p><p><strong>Conclusions: </strong>These findings underscore the need for improved care protocols and vigilant monitoring of mineral metabolism TPE patients, especially those receiving long-term treatment. Further research is warranted to understand the enduring effects of TPE on mineral metabolism and develop strategies to prevent complications.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}