The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease最新文献_第7页

Computer-aided detection of chest X-ray as a surrogate marker for disease severity in pulmonary TB. 计算机辅助胸部x线检测作为肺结核疾病严重程度的替代标志物。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-03-27 DOI: 10.5588/ijtld.25.0348

D Augustinsson, Ayu Sakao, M Sandstedt, A Getachew, J Idh, E Abate, S-G Fransson, K Niward, T Schön

引用次数: 0

How incarceration can amplify TB: a preventable public health failure in Ecuador. 监禁如何放大结核病：厄瓜多尔可预防的公共卫生失败。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-03-27 DOI: 10.5588/ijtld.26.0032

C Bastidas-Caldes, L Martinez, A D Harries

引用次数: 0

Risk factors associated with prolonged survival in patients with Mycobacterium abscessus pulmonary disease. 与脓肿分枝杆菌肺病患者延长生存期相关的危险因素

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-03-27 DOI: 10.5588/ijtld.25.0458

X Yu, M Wang, S Chen, J Wu, Y Ji, H Huang, H Duan

引用次数: 0

The impact of rifampin drug interactions on tuberculosis preventive treatment completion and safety. 利福平药物相互作用对结核病预防治疗完成度和安全性的影响。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-03-27 DOI: 10.5588/ijtld.25.0345

F Fregonese, J White, R K Lim, N Bedingfield, V J Cook, F Gafar, D Gibson, D Menzies, D Fisher

{"title":"The impact of rifampin drug interactions on tuberculosis preventive treatment completion and safety.","authors":"F Fregonese, J White, R K Lim, N Bedingfield, V J Cook, F Gafar, D Gibson, D Menzies, D Fisher","doi":"10.5588/ijtld.25.0345","DOIUrl":"10.5588/ijtld.25.0345","url":null,"abstract":"<sec><title>BACKGROUND</title>Rifamycin TB preventive treatment (TPT) is critical to TB elimination. However, clinicians may be reluctant to recommend it over concerns related to drug-drug interactions (DDI). In this secondary analysis of data from the 2R² randomised clinical trial (comparing standard dose rifampin to high-dose rifampin for TPT), we investigate if participants taking medications with potential rifampin DDI had similar TPT completion, safety, and follow-up visits compared to those without.</sec><sec><title>METHODS</title>Data on concomitant medications, adverse events, treatment completion, and follow-up visits were compared between participants with and without potential rifampin DDI. Analyses were conducted with R, reporting risk difference (RD) using g-computation with logistic regression.</sec><sec><title>RESULTS</title>282 of 1,368 participants (21%) were taking essential medications with potential rifampin DDI. There was no RD in TPT completion (RD 0.04 [95% confidence interval (CI): -0.02; 0.09]) or adverse events (RD 0.02 [95% CI: -0.01; 0.06]) between participants with and without these medications. Individuals talking medications with potential DDI had a higher percentage of two or more unscheduled visits (12%) compared to those not taking them (5%) (P = 0.0001).</sec><sec><title>CONCLUSION</title>In participants taking medications with potential rifampin DDI, rifampin TPT can be used safely without impacting completion rates. However, additional follow-up visits should be anticipated.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 4","pages":"167-173"},"PeriodicalIF":3.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High prevalence of TB in children less than 5 years old hospitalised with severe acute malnutrition. 因严重急性营养不良住院的5岁以下儿童中结核病发病率高。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-03-27 DOI: 10.5588/ijtld.25.0492

B J Vonasek, M Nyirongo, K Chetcuti, M Chiunda, T Kamvaunamwali, J Kaphatika, A Kondwani, M Kumwenda, E D McCollum, D Ng'oma, A-G Tepeka, A J Garcia-Prats, T Mvalo

引用次数: 0

Prognostic value of sputum HMGB1 in smear-negative and smear-positive pulmonary TB. 痰HMGB1在痰阴性和痰阳性肺结核中的预后价值。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0186

S Kamolratanakul, T Bhunyakarnjanarat, W Ariyanon, P Wilairatana, A Leelahavanichkul, W Chancharoenthana

{"title":"Prognostic value of sputum HMGB1 in smear-negative and smear-positive pulmonary TB.","authors":"S Kamolratanakul, T Bhunyakarnjanarat, W Ariyanon, P Wilairatana, A Leelahavanichkul, W Chancharoenthana","doi":"10.5588/ijtld.25.0186","DOIUrl":"10.5588/ijtld.25.0186","url":null,"abstract":"<sec><title>BACKGROUND</title>Diagnosing pulmonary TB (PTB) in patients with negative sputum acid-fast bacillus (AFB) staining is challenging and impedes transmission control. This study assessed the prognostic utility of sputum high-mobility group box protein 1 (HMGB1) in PTB, focusing on treatment outcomes.</sec><sec><title>METHODS</title>In a prospective cohort study, we enrolled 66 PTB patients: 37 smear-positive (MTB-MC) and 29 smear-negative but clinically suspected (MTB-SN), confirmed by bacteriology or treatment response. All underwent GeneXpert MTB/RIF testing. Sputum HMGB1 levels were measured at baseline, 2 months, and 6 months post-treatment.</sec><sec><title>RESULTS</title>Of the 66 participants, 37 had bacteriologically confirmed PTB (MTB-MC) with AFB grades ranging from scanty (n = 6) to 3+ (n = 12), and 29 had smear-negative PTB (MTB-SN). Sputum HMGB1 levels declined significantly during treatment (P < 0.001). Baseline HMGB1 strongly correlated with bacillary load (r2 = 0.4645, P < 0.0001). Notably, 2-month HMGB1 levels predicted culture conversion, with an area under the curve of 0.885 for treatment failure in the MTB-MC group.</sec><sec><title>CONCLUSION</title>Sputum HMGB1 is a promising marker for monitoring treatment response and predicting failure in PTB, especially in smear-negative cases. Despite limited diagnostic specificity due to elevation in inflammatory conditions, its role in assessing 2-month culture conversion warrants further study. Larger studies are needed to validate clinical thresholds.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 3","pages":"100-106"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Providing comprehensive TB care among conflict-affected populations. 为受冲突影响的人群提供全面的结核病治疗。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0279

M K Wakjira, D Jerene, D H Dano, D G Datiko, M A Adugna, T A Abagaro, Z G Dememew, Y M Alemayehu, H W Memberu, J S Mohammed, O A Ahmed, A G Woldegiorgis, G F Oli, D N Binagde, A A Kassa

{"title":"Providing comprehensive TB care among conflict-affected populations.","authors":"M K Wakjira, D Jerene, D H Dano, D G Datiko, M A Adugna, T A Abagaro, Z G Dememew, Y M Alemayehu, H W Memberu, J S Mohammed, O A Ahmed, A G Woldegiorgis, G F Oli, D N Binagde, A A Kassa","doi":"10.5588/ijtld.25.0279","DOIUrl":"10.5588/ijtld.25.0279","url":null,"abstract":"<sec><title>BACKGROUND</title>Ethiopia is facing significant internal displacement challenge. As of February 2022, the total number of internally displaced people was 4.56 million, out of which 3.85 million (84%) were displaced by conflicts. This has hindered access to facility-based care for TB, and the expanding pool of individuals with untreated TB among the displaced is an opportunity for continued TB transmission among the wider community. Strategies for addressing TB among conflict-affected community are not well defined.</sec><sec><title>METHODS</title>This study aimed at assessing if outreach-based active TB case finding at purposely selected transitional sites and institutions found within conflict-affected areas can offset the impact of conflict on access to facility-based care for TB.</sec><sec><title>RESULTS</title>From a total of 199,398 conflict-affected population groups screened for TB, 10,585 (5%) presumptive and 353 (2%) bacteriologically confirmed pulmonary TB cases were detected and treated. The yield of TB among the conflict-affected population groups (1,126) and prison inmates (1,111) was nine times higher than the national TB incidence estimate of 126 per 100,000 for the year.</sec><sec><title>CONCLUSION</title>The highest yield of TB among conflict-affected population highlights the need for targeting such groups.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 3","pages":"114-119"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiated service delivery for TB treatment. 提供差异化的结核病治疗服务。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0164

H B Mulenga, B K Moore, C Lyembele, E Kalunkumya, T Sinkala, L Mwiinga, P Lungu, J B Harris, S Bosomprah, C Banda, C Nkwemu, M W Mwanza, T Savory, C B Moore, A Mubanga, K Chiyenu, N Bweupe, M Chiyala, D Zachary

{"title":"Differentiated service delivery for TB treatment.","authors":"H B Mulenga, B K Moore, C Lyembele, E Kalunkumya, T Sinkala, L Mwiinga, P Lungu, J B Harris, S Bosomprah, C Banda, C Nkwemu, M W Mwanza, T Savory, C B Moore, A Mubanga, K Chiyenu, N Bweupe, M Chiyala, D Zachary","doi":"10.5588/ijtld.25.0164","DOIUrl":"10.5588/ijtld.25.0164","url":null,"abstract":"<sec><title>BACKGROUND</title>Differentiated service delivery (DSD) includes service decentralisation, multi-month medication dispensing, and treatment support. We describe demographic and clinical characteristics, treatment support, and outcomes among clients treated under a TB treatment DSD model in five facilities in Lusaka and Livingstone, Zambia, from February 2022 to March 2023.</sec><sec><title>METHODS</title>Medicines were dispensed for 2 months in intensive and 4 months in the continuation phases of TB treatment. Treatment support was provided through text message, phone, and home visits to monitor symptoms, adherence, and adverse events. Association between demographic, clinical, and treatment support variables and likelihood of successful treatment was examined using Pearson's χ² or Fisher's exact tests.</sec><sec><title>RESULTS</title>Among 970 clients treated under DSD, most were HIV-negative (72%) and had pulmonary TB (94%). Only 6% of the clients ever-responded to text-based surveys, while 85% were reached by phone or home visit. Overall, 83% of the clients were successfully treated for TB. Significant differences in treatment success were observed by facility (74%-91%, P < 0.001), form of TB (extra-pulmonary 72%, pulmonary 84%, P = 0.020), and received any treatment support (no, 76%, yes, 85%, P = 0.006).</sec><sec><title>CONCLUSION</title>DSD models including treatment support may give clients more control over how, when, and where they receive care while achieving treatment success.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 3","pages":"107-113"},"PeriodicalIF":3.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of community awareness, screening, testing, and treatment campaigns on TB prevention. 社区意识、筛查、检测和治疗运动对结核病预防的影响。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0530

R Mulebeke, J Izudi, S Agaba, J E O Bwalatum, D Jaganath

引用次数: 0

Preferences for tongue swab versus sputum collection for TB testing: a multi-country survey. 采用舌拭子采集与痰液采集进行结核病检测：一项多国调查。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-02-27 DOI: 10.5588/ijtld.25.0457

K M Kumar, A Borkman, A Kim, R Crowder, B Ajide, K Alí-Francia, M Chirwa, L Kamulegeya, H Le, V N Trung, R Venter, J Bimba, D J Christopher, V Dalay, N Van Hung, M Muyoyeta, L Nakiyingi, G Theron, C Yu, C Zamudio-Fuertes, J Atim, A D Kerkhoff, M Del Mar Castro, P Nahid, C M Denkinger, A Cattamanchi, S E Dorman, N West

引用次数: 0