The British journal of psychiatry : the journal of mental science最新文献

{"title":"The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults: CORRIGENDUM.","authors":"Graham Reid, Philip Vassilev, Jessica Irving, Triin Ojakäär, Liron Jacobson, Erin G Lawrence, Jenny Barnett, Malika Tapparel, Ivan Koychev","doi":"10.1192/bjp.2025.10369","DOIUrl":"https://doi.org/10.1192/bjp.2025.10369","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study: commentary, Hasnain et al.","authors":"Syeda Fatima Hasnain, Mahnoor Tariq Sulehria, Furqan Ahmad Sethi","doi":"10.1192/bjp.2025.10325","DOIUrl":"https://doi.org/10.1192/bjp.2025.10325","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders.","authors":"Annabelle Trew, Joanne Rodda, Sukhi S Shergill","doi":"10.1192/bjp.2025.33","DOIUrl":"https://doi.org/10.1192/bjp.2025.33","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study: commentary, Ophir.","authors":"Yaakov Ophir","doi":"10.1192/bjp.2025.122","DOIUrl":"https://doi.org/10.1192/bjp.2025.122","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meritocracy in psychiatry training: abandoning the common good: commentary, Howarth et al.","authors":"Harrison Howarth, Dominic Kennedy, Mark Berelowitz","doi":"10.1192/bjp.2024.284","DOIUrl":"https://doi.org/10.1192/bjp.2024.284","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term segregation and seclusion for people with an intellectual disability and/or autism in hospitals: a critique of the current state of affairs: commentary, Tromans et al.","authors":"Samuel J Tromans, Indermeet Sawhney, Mahesh Odiyoor, Jana de Villiers, Jane McCarthy, Harm Boer, Regi Alexander, Stuart Wallace, Satheesh Gangadharan, Ashok Roy, Amy Blake, Kiran Purandare, Anupama Iyer, Richard Laugharne, Vivien Weisner, Rohit Shankar","doi":"10.1192/bjp.2025.10315","DOIUrl":"https://doi.org/10.1192/bjp.2025.10315","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-based study of long-term mortality risk associated with clozapine use among patients with schizophrenia.","authors":"Huiquan Zhou, Hao Luo, Jennifer Yee-Man Tang, William G Honer, Tarun Bastiampillai, Jiayi Zhou, Heidi Taipale, Wing Chung Chang, Simon Sai Yu Lui, Edwin Ho Ming Lee, Sherry Kit Wa Chan","doi":"10.1192/bjp.2025.10312","DOIUrl":"https://doi.org/10.1192/bjp.2025.10312","url":null,"abstract":"<p><strong>Background: </strong>Patients with schizophrenia have a significantly elevated risk of mortality. Clozapine is effective for treatment-resistant schizophrenia, but its use is limited by side-effects. Understanding its association with mortality risk is crucial.</p><p><strong>Aims: </strong>To investigate the associations of clozapine with all-cause and cause-specific mortality risk in schizophrenia patients.</p><p><strong>Method: </strong>In this 18-year population-based cohort study, we retrieved electronic health records of schizophrenia patients from all public hospitals in Hong Kong. Clozapine users (ClozUs) comprised schizophrenia patients who initiated clozapine treatment between 2003 and 2012, with the index date set at clozapine initiation. Comparators were non-clozapine antipsychotic users (Non-ClozUs) with the same diagnosis who had never received a clozapine prescription. They were 1:2 propensity score matched with demographic characteristics and physical and psychiatric comorbidities. ClozUs were further defined according to continuation of clozapine use and co-prescription of other antipsychotics (polypharmacy). Accelerated failure time (AFT) models were used to estimate the risk of all-cause and cause-specific mortality (i.e. suicide, cardiovascular disease, infection and cancer).</p><p><strong>Results: </strong>This study included 9,456 individuals (mean (s.d.) age at the index date: 39.13 (12.92) years; 50.73% females; median (interquartile range) follow-up time: 12.37 (9.78-15.22) years), with 2020 continuous ClozUs, 1132 discontinuous ClozUs, 4326 continuous non-ClozUs and 1978 discontinuous Non-ClozUs. Results from adjusted AFT models showed that continuous ClozUs had a lower risk of suicide mortality (acceleration factor 3.01; 99% CI: 1.41-6.44) compared with continuous Non-ClozUs. Continuous ClozUs with co-prescription of other antipsychotics exhibited lower risks of suicide mortality (acceleration factor 3.67; 1.41-9.60) and all-cause mortality (acceleration factor 1.42; 1.07-1.88) compared with continuous Non-ClozUs. No associations were found between clozapine and other cause-specific mortalities.</p><p><strong>Conclusions: </strong>These results add to the existing evidence on the effectiveness of clozapine, particularly its anti-suicide effects, and emphasise the need for continuous clozapine use for suitable patients and the possible benefit of clozapine polypharmacy.</p>","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of psychological therapies for depression or anxiety in adults with intellectual disabilities: retrospective, matched, observational cohort study of primary care electronic healthcare records in England.","authors":"Céline El Baou, Rob Saunders, Joshua E J Buckman, Dave Dagnan, William Mandy, Elizabeth O'Nions, Katrina Scior, Richard Pender, Sarah Hoare, Marcus Richards, Henry Clements, Stephen Pilling, Amber John, Joshua Stott","doi":"10.1192/bjp.2025.127","DOIUrl":"https://doi.org/10.1192/bjp.2025.127","url":null,"abstract":"<p><strong>Background: </strong>Treatment guidelines recommend evidence-based psychological therapies for adults with intellectual disabilities with co-occurring anxiety or depression. No previous research has explored the effectiveness of these therapies in mainstream psychological therapy settings or outside specialist settings.</p><p><strong>Aims: </strong>To evaluate the effectiveness of psychological therapies delivered in routine primary care settings for people with intellectual disability who are experiencing co-occurring depression or anxiety.</p><p><strong>Method: </strong>This study used linked electronic healthcare records of 2 048 542 adults who received a course of NHS Talking Therapies for anxiety and depression in England between 2012 and 2019 to build a retrospective, observational cohort of individuals with intellectual disability, matched 1:2 with individuals without intellectual disability. Logistic regressions were used to compare metrics of symptom improvement and deterioration used in the national programme, on the basis of depression and anxiety measures collected before and at the last attended therapy session.</p><p><strong>Results: </strong>The study included 6870 adults with intellectual disability and 2 041 672 adults without intellectual disability. In unadjusted analyses, symptoms improved on average for people with intellectual disability after a course of therapy, but these individuals experienced poorer outcomes compared with those without intellectual disability (reliable improvement 60.2% for people with intellectual disability <i>v</i>. 69.2% for people without intellectual disability, odds ratio 0.66, 95% CI 0.63-0.70; reliable deterioration 10.3% for people with intellectual disability <i>v</i>. 5.7% for those without intellectual disability, odds ratio 1.89, 95% CI 1.75-2.04). After propensity score matching, some differences were attenuated (reliable improvement, adjusted odds ratio 0.97, 95% CI 1.91-1.04), but some outcomes remained poorer for people with intellectual disability (reliable deterioration, adjusted odds ratio 1.28, 95% CI 1.16-1.42).</p><p><strong>Conclusions: </strong>Evidence-based psychological therapies may be effective for adults with intellectual disability, but their outcomes may be similar to (for improvement and recovery) or poorer than (for deterioration) those for adults without intellectual disability. Future work should investigate the impact of adaptations of therapies for those with intellectual disability to make such interventions more effective and accessible for this population.</p>","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis: commentary, Green et al.","authors":"Jessica Emily Green, Anna Wrobel, Emma Todd, Wolfgang Marx, Michael Berk, Mojtaba Lotfalian, David Castle, John F Cryan, Eugene Athan, Christopher Hair, Andrew A Nierenberg, Felice N Jacka, Samantha Dawson","doi":"10.1192/bjp.2025.115","DOIUrl":"https://doi.org/10.1192/bjp.2025.115","url":null,"abstract":"","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":"227 1","pages":"511-512"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of peer support for people with severe mental health conditions in high-, middle- and low-income countries: multicentre randomised controlled trial.","authors":"Bernd Puschner, Juliet Nakku, Ramona Hiltensperger, Philip Wolf, Inbar Adler Ben-Dor, Faith Bugeiga, Ashleigh Charles, Lion Gai Meir, Paula Garber-Epstein, Yael Goldfarb, Alina Grayzman, Shimri Hadas-Grundman, Maria Haun, Imke Heuer, Bahati Iboma, Jasmine Kalha, Lydia Kamwaga, Palak Korde, Yasuhiro Kotera, Silvia Krumm, Arti Kulkarni, Eric Kwebiiha, Jennifer Kyara, Max Lachman, Candelaria Mahlke, Benjamin Mayer, Galia Moran, Richard Mpango, Rachel Mtei, Annabel Müller-Stierlin, Roseline Nanyonga, Fileuka Ngakongwa, Jackline Niwemuhwezi, Rebecca Nixdorf, Lena Nugent, Soumitra Pathare, Mary Ramesh, Grace Ryan, Gwen Schulz, Maria Wagner, Tamara Waldmann, Lisa Wenzel, Donat Shamba, Mike Slade","doi":"10.1192/bjp.2025.10299","DOIUrl":"https://doi.org/10.1192/bjp.2025.10299","url":null,"abstract":"<p><strong>Background: </strong>Some trials have evaluated peer support for people with mental ill health in high-income, mainly English-speaking countries, but the quality of the evidence is weak.</p><p><strong>Aims: </strong>To investigate the effectiveness of UPSIDES peer support in high-, middle- and low-income countries.</p><p><strong>Method: </strong>This pragmatic multicentre parallel-group wait-list randomised controlled trial (registration: ISRCTN26008944) with three measurement points (baseline and 4 and 8 months) took place at six study sites: two in Germany, and one each in Uganda, Tanzania, Israel and India. Participants were adults with long-standing severe mental health conditions. Outcomes were improvements in social inclusion (primary) and empowerment, hope, recovery, health and social functioning (secondary). Participants allocated to the intervention group were offered UPSIDES peer support.</p><p><strong>Results: </strong>Of the 615 participants (305 intervention group), 337 (54.8%) identified as women. The average age was 38.3 (s.d. = 11.2) years, and the mean illness duration was 14.9 (s.d. = 38.4) years. Those allocated to the intervention group received 6.9 (s.d. = 4.2) peer support sessions on average. Intention-to-treat analysis showed effects on two of the three subscales of the Social Inclusion Scale, Empowerment Scale and HOPE Scale. Per-protocol analysis with participants who had received three or more intervention sessions also showed an effect on the Social Inclusion Scale total score (<i>β</i> = 0.18, <i>P</i> = 0.031, 95% CI: 0.02-0.34).</p><p><strong>Conclusions: </strong>Peer support has beneficial impacts on social inclusion, empowerment and hope among people with severe mental health conditions across diverse settings. As social isolation is a key driver of mental ill health, and empowerment and hope are both crucial for recovery, peer support can be recommended as an effective component of mental healthcare. Peer support has the potential to move global mental health closer towards a recovery- and rights-based orientation.</p>","PeriodicalId":520791,"journal":{"name":"The British journal of psychiatry : the journal of mental science","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}