Effectiveness of peer support for people with severe mental health conditions in high-, middle- and low-income countries: multicentre randomised controlled trial.

IF 7.6
Bernd Puschner, Juliet Nakku, Ramona Hiltensperger, Philip Wolf, Inbar Adler Ben-Dor, Faith Bugeiga, Ashleigh Charles, Lion Gai Meir, Paula Garber-Epstein, Yael Goldfarb, Alina Grayzman, Shimri Hadas-Grundman, Maria Haun, Imke Heuer, Bahati Iboma, Jasmine Kalha, Lydia Kamwaga, Palak Korde, Yasuhiro Kotera, Silvia Krumm, Arti Kulkarni, Eric Kwebiiha, Jennifer Kyara, Max Lachman, Candelaria Mahlke, Benjamin Mayer, Galia Moran, Richard Mpango, Rachel Mtei, Annabel Müller-Stierlin, Roseline Nanyonga, Fileuka Ngakongwa, Jackline Niwemuhwezi, Rebecca Nixdorf, Lena Nugent, Soumitra Pathare, Mary Ramesh, Grace Ryan, Gwen Schulz, Maria Wagner, Tamara Waldmann, Lisa Wenzel, Donat Shamba, Mike Slade
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Abstract

Background: Some trials have evaluated peer support for people with mental ill health in high-income, mainly English-speaking countries, but the quality of the evidence is weak.

Aims: To investigate the effectiveness of UPSIDES peer support in high-, middle- and low-income countries.

Method: This pragmatic multicentre parallel-group wait-list randomised controlled trial (registration: ISRCTN26008944) with three measurement points (baseline and 4 and 8 months) took place at six study sites: two in Germany, and one each in Uganda, Tanzania, Israel and India. Participants were adults with long-standing severe mental health conditions. Outcomes were improvements in social inclusion (primary) and empowerment, hope, recovery, health and social functioning (secondary). Participants allocated to the intervention group were offered UPSIDES peer support.

Results: Of the 615 participants (305 intervention group), 337 (54.8%) identified as women. The average age was 38.3 (s.d. = 11.2) years, and the mean illness duration was 14.9 (s.d. = 38.4) years. Those allocated to the intervention group received 6.9 (s.d. = 4.2) peer support sessions on average. Intention-to-treat analysis showed effects on two of the three subscales of the Social Inclusion Scale, Empowerment Scale and HOPE Scale. Per-protocol analysis with participants who had received three or more intervention sessions also showed an effect on the Social Inclusion Scale total score (β = 0.18, P = 0.031, 95% CI: 0.02-0.34).

Conclusions: Peer support has beneficial impacts on social inclusion, empowerment and hope among people with severe mental health conditions across diverse settings. As social isolation is a key driver of mental ill health, and empowerment and hope are both crucial for recovery, peer support can be recommended as an effective component of mental healthcare. Peer support has the potential to move global mental health closer towards a recovery- and rights-based orientation.

高、中、低收入国家严重精神卫生疾患患者同伴支持的有效性:多中心随机对照试验
背景:一些试验评估了高收入国家(主要是英语国家)精神疾病患者的同伴支持,但证据质量较弱。目的:研究UPSIDES同伴支持在高、中、低收入国家的有效性。方法:这项实用的多中心平行组等待名单随机对照试验(注册号:ISRCTN26008944)有三个测点(基线和4个月和8个月),在六个研究地点进行:两个在德国,一个在乌干达,坦桑尼亚,以色列和印度。参与者是长期患有严重精神健康问题的成年人。结果是社会包容(主要)和赋权、希望、康复、健康和社会功能(次要)的改善。被分配到干预组的参与者得到了同伴支持。结果:615名参与者(305名干预组)中,337名(54.8%)为女性。患者平均年龄38.3岁(s.d = 11.2),平均病程14.9年(s.d = 38.4)。被分配到干预组的参与者平均接受6.9次同伴支持(sd = 4.2)次。意向治疗分析显示对社会包容量表、赋权量表和希望量表三个子量表中的两个有影响。对接受过三次或三次以上干预的参与者的方案分析也显示了对社会包容量表总分的影响(β = 0.18, P = 0.031, 95% CI: 0.02-0.34)。结论:同伴支持在不同环境下对严重精神疾病患者的社会包容、赋权和希望产生有益影响。由于社会孤立是精神疾病的主要驱动因素,而增强权能和希望对于康复都至关重要,因此可以建议将同伴支持作为精神保健的有效组成部分。同伴支持有可能使全球精神卫生更接近以康复和权利为基础的方向。
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