The British journal of dermatology最新文献

{"title":"Digital ethnography in dermatology: studying patient experience where it now unfolds.","authors":"Monisha Madhumita, Anjali Ancy, Dominique duCrest","doi":"10.1093/bjd/ljag310","DOIUrl":"10.1093/bjd/ljag310","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"852-853"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biett sign: a diagnostic clue to secondary syphilis.","authors":"Ramamoorthy Logamoorthy, Natarajan Kannan Aswin, Kaliaperumal Karthikeyan","doi":"10.1093/bjd/ljag276","DOIUrl":"10.1093/bjd/ljag276","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"889"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.","authors":"Pascal Joly, Dedee F Murrell, Yumi Aoyama, Frédéric Caux, Dipankar De, Marilena Flouri, Matthias Goebeler, Chao Ji, Dimitra Kiritsi, Meng Pan, Aikaterini Patsatsi, Enno Schmidt, Snejina Vassileva, Lana Vandersarren, Ivaylo Stoykov, Peter Verheesen, Victoria P Werth, Russell P Hall","doi":"10.1093/bjd/ljag199","DOIUrl":"10.1093/bjd/ljag199","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are rare, chronic, potentially life-threatening, immunoglobulin (Ig)G-mediated, autoimmune skin and/or mucosal blistering diseases. Efgartigimod, a human IgG1 antibody Fc fragment, blocks the neonatal Fc receptor, decreasing IgG recycling and reducing both healthy and pathogenic IgG autoantibody levels.</p><p><strong>Objectives: </strong>To investigate the efficacy, safety and impact of subcutaneous efgartigimod PH20 (co-formulated with recombinant human hyaluronidase PH20) in conjunction with prednisone in the treatment of pemphigus.</p><p><strong>Methods: </strong>Adult participants with newly diagnosed or relapsing moderate-to-severe pemphigus were recruited in this phase III, prospective, multicentre, randomised, double-blinded, placebo-controlled study (NCT04598451). Participants were randomised (2 : 1) to weekly subcutaneous efgartigimod PH20 or placebo. Subcutaneous efgartigimod PH20 2000 mg was administered on days 1 and 8, followed by 1000 mg weekly until complete remission on minimal prednisone therapy (CRmin) (≤ 10 mg daily). All participants received concomitant prednisone starting at 0.5 mg kg-1 daily. The primary outcome was the proportion of participants with PV who achieved CRmin by week 30, while receiving minimal prednisone, for ≥ 8 weeks. Pharmacodynamics and safety were also assessed.</p><p><strong>Results: </strong>Overall, 222 participants (PV: n = 190; PF: n = 32) were randomised (subcutaneous efgartigimod PH20: n = 147; placebo: n = 75). The proportions of participants with PV achieving CRmin within 30 weeks were comparable between the subcutaneous efgartigimod PH20 and placebo groups, with no statistically significant difference observed [44/124 (35.5%) vs. 20/66 (30.3%); P = 0.60; odds ratio 1.19 (95% confidence interval 0.60-2.41)]. Total prednisone consumption over time was comparable between groups. Subcutaneous efgartigimod PH20 resulted in rapid reductions from baseline in total IgG and anti--desmoglein-1 and anti-desmoglein-3 autoantibody levels, but these did not translate to improvements in Pemphigus Disease Area Index scores. The rates of adverse events (AEs) in the subcutaneous efgartigimod PH20 and placebo groups were 89.1% (n = 131/147) and 76.0% (n = 57/75), respectively; most were mild to moderate [serious AEs: 12.2% (n = 18/147) and 13.3% (n = 10/75), respectively]. No deaths occurred.</p><p><strong>Conclusions: </strong>Subcutaneous efgartigimod PH20 in combination with systemic corticosteroids did not demonstrate clinical benefit over systemic corticosteroids alone in patients with moderate-to-severe pemphigus at 30 weeks, but it was well tolerated in this patient population.</p>","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"750-762"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does loss of chromosome Y in blood contribute to the sex disparity of dermatitis and eczema at older ages?","authors":"Josefin Bjurling, Lars A Forsberg","doi":"10.1093/bjd/ljag270","DOIUrl":"10.1093/bjd/ljag270","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"719-720"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Views and experiences of young people and their parents of managing acne: qualitative interview study.","authors":"Stephanie Easton, Rosie Essery, Mary Steele, Sebastien Pollet, Charlotte Cairns, Sophie Dove, Kate Henaghan-Sykes, Matthew J Ridd, Nick Francis, Andrew R Thompson, Alison M Layton, Kim S Thomas, Irene Soulsby, Miriam Santer, Ingrid Muller","doi":"10.1093/bjd/ljag284","DOIUrl":"10.1093/bjd/ljag284","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a common chronic skin disease among young people. Effective, early management improves outcomes and reduces risk of long-term impacts such as scarring. However, little is known about how young people seek information, treatment and product advice, or the role of parents in acne management.</p><p><strong>Objectives: </strong>To explore the views and experiences of young people and parent and child dyads in relation to their perceptions of living with and managing acne, particularly with regard to treatment, advice and information seeking.</p><p><strong>Methods: </strong>Qualitative semistructured interviews with young people aged 13-25 years with acne and their parents sought their views and experiences of acne management. Participants were recruited via social media. Purposeful sampling sought diverse participant characteristics. Transcripts were analysed using inductive thematic analysis. Interviews were conducted between July and September 2022 with young people and their parents from across England.</p><p><strong>Results: </strong>We carried out interviews with 21 young people with acne, 5 parents and 3 pairs of parents and young people. Participants discussed seeking trustworthy information and advice about acne (e.g. National Health Service website). However, other online information, particularly via social media, was commonly used to identify products, despite recognition this can be untrustworthy. Learning about experiences of others with acne was highly valued and relied upon for selecting products, as was perceived familiarity of products. The parents' role in acne management varied. Some helped with costs of products or as gatekeepers for seeking professional advice, especially during early stages of acne. Both parents and young people lacked awareness of effective treatments for acne, which seemed a barrier to effective self-management.</p><p><strong>Conclusions: </strong>Online information, from varying sources, is very important to young people with acne and, although they are aware of potential misinformation, they still value its accessibility. Parents appear to have a strong role in supporting young people through formal healthcare seeking but are less involved in making sense of online information which young people tend to use independently. Reliable information resources for acne management should be targeted at both young people and parents. Clinicians need to be aware of patients' reliance on online information and signpost towards evidence-based resources.</p>","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"782-792"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mees' lines.","authors":"Yi-Shan Teng, Huei-Jing Wang","doi":"10.1093/bjd/ljag257","DOIUrl":"10.1093/bjd/ljag257","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"887"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'It's not just skin': emotional impact of eczema in Inuit communities of Northern Quebec.","authors":"Angie Moshutz, Meghan Kanou, Said Dababneh, Agustina Hasbani, Alexandra S V Kelly, Arusa Shah, Phedra Fadel, Chenrui Xie, William Chow, Sammy Pootoo, Parsa Kitishimik, Annie Kumarluk, Ivan V Litvinov, Sandra Peláez","doi":"10.1093/bjd/ljag298","DOIUrl":"10.1093/bjd/ljag298","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"867-869"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and healthcare professionals' perspectives on pain management in hidradenitis suppurativa: a quantitative and qualitative study.","authors":"Hannah E Wainman, Roxanne M Parslow, Michael Lawton, Barry M McGrath, Angelika Razzaque, Graham Dunthorne, Roger Knaggs, Lauren A V Orenstein, Anthony Bewley, Kave Shams, John R Ingram","doi":"10.1093/bjd/ljag300","DOIUrl":"10.1093/bjd/ljag300","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"859-861"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site-specific relapse in pemphigus is associated with localized tissue-resident memory T-cell enrichment.","authors":"Xueting Peng, Jialu Zhao, Shiran Kang, Yumin Xia, Yale Liu","doi":"10.1093/bjd/ljag311","DOIUrl":"10.1093/bjd/ljag311","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"856-858"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shadow Report on Atopic Dermatitis: a Patient-Led Assessment of Multidimensional Burden From 15 Years of French Real-world Evidence.","authors":"Stéphanie Merhand, Bruno Halioua, Charles Taieb","doi":"10.1093/bjd/ljag459","DOIUrl":"https://doi.org/10.1093/bjd/ljag459","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}