The British journal of dermatology最新文献

{"title":"Long-term particulate matter exposure and risk of alopecia areata: a nationwide epidemiological study with preliminary in vitro evidence.","authors":"Minsu Kim, Jihee Nam, Jin Lee, Suna Kang, Jihye Heo, Hwamin Woo, Sung-Won Kang, Jee Yoon Park, Chang-Hun Huh, Juhee Cho, Danbee Kang, Jung-Won Shin","doi":"10.1093/bjd/ljag254","DOIUrl":"10.1093/bjd/ljag254","url":null,"abstract":"<p><strong>Background: </strong>Although particulate matter (PM) has been implicated in various systemic and cutaneous diseases, large-scale evidence on whether PM exposure affects the risk of alopecia areata (AA) remains limited.</p><p><strong>Objectives: </strong>To assess the epidemiological association between long-term PM exposure and incident AA risk with exploration of potential biological mechanisms.</p><p><strong>Methods: </strong>In the epidemiological study, annual average concentrations of fine (PM2.5) and coarse (PM10) PM were linked to individuals who underwent national health screening between 2006 and 2022, and the risk of incident AA, defined as ≥ 3 outpatient claims with relevant diagnostic codes within a 1-year period, was evaluated. In the preliminary in vitro experiment, human hair outer root sheath (ORS) cells were exposed to varying concentrations of PM10-like fine dust for 24 h. The expression of inflammatory cytokines was evaluated using quantitative real-time polymerase chain reaction, Western blotting and immunofluorescence analyses.</p><p><strong>Results: </strong>Higher long-term PM2.5 and PM10 exposures were associated with increased risk of incident AA [per 10 μg m-3 increase: adjusted hazard ratio (aHR) 1.45, 95% confidence interval (CI) 1.39-1.52 for PM2.5 and aHR 1.32, 95% CI 1.28-1.36 for PM10] with the strongest association for alopecia universalis (per 10 μg m-3 increase: aHR 2.23, 95% CI 1.83-2.63 for PM2.5 and adjusted HR 1.82, 95% CI 1.58-2.07 for PM10). PM10 exposure increased reactive oxygen species generation, the expression of interleukin (IL)-1β, IL-6, IL-8 and IL-15RA, and phosphorylation of p38 and signal transducer and activator of transcription 3 in ORS cells.</p><p><strong>Conclusions: </strong>This study suggests that ambient PM may be a modifiable environmental risk factor for AA through the activation of selective inflammatory pathways, underscoring the need for public health efforts to reduce PM exposure and potentially mitigate AA risk.</p>","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"763-771"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eczema in inborn errors of immunity with atopy: frequency, timing and phenotypic clustering.","authors":"Hélène Aubert, Nizar Mahlaoui, Sébastien Barbarot, Mickaël Alligon, Isabelle Pellier, Coralie Mallebranche, Jacinta Bustamante, Jérémie Rosain, Capucine Picard, Antoine Néel, Marie Bodinier, Carole Brosseau, Laura Polivka, Christine Bodemer, Caroline Thomas","doi":"10.1093/bjd/ljag308","DOIUrl":"10.1093/bjd/ljag308","url":null,"abstract":"<p><strong>Background: </strong>Inborn errors of immunity (IEI) with atopy (IEI-A) are a subgroup of IEIs with eczema as a prominent clinical feature that can mimic atopic dermatitis (AD). However, IEI-A-associated eczema can differ from that of classic AD, and its frequency, genotype-specific clinical patterns and temporal relationships with other manifestations of IEI-A (infections, allergic manifestations, autoimmunity) remain poorly defined.</p><p><strong>Objectives: </strong>To characterize the frequency of eczema, timing and phenotypes in patients with IEI-A, and to explore the relationship of eczema with other clinical manifestations of IEI-A.</p><p><strong>Methods: </strong>This retrospective study used data from the French National Referral Center for Primary Immunodeficiency Diseases (CEREDIH), focusing on patients with genetically defined IEI-A followed in three large CEREDIH-participating centres and available clinical data. Eczema frequency and onset in relationship to other clinical events, particularly severe-or-unusual infections, was assessed, as were eczema phenotypes, concomitant allergic manifestations, treatments and autoimmunity. Clustering analyses were computed to identify distinct IEI-A eczema-associated clinical phenotypes.</p><p><strong>Results: </strong>Among 373 patients with IEI-A, varying widely by genotype, 50.9% (n = 190) had eczema. All patients deficient in DOCK8 (dedicator of cytokinesis-8) were affected, followed by those deficient in FOXP3 (n = 22/30; 73%) and those with STAT3 loss of function (n = 44/59; 75%). Onset was usually early (median 4 months). Eczema frequency and clinical presentation varied markedly across IEI-A genotypes; four phenotypic clusters were identified, with particular localizations and severe pruritus being strongly associated with pathogenic STAT3 or DOCK8 variants. For children with isolated eczema at 24 months, the risk of developing IEI-related severe or unusual infections was lower than that of persistent isolated eczema until the age of 6.8 years.</p><p><strong>Conclusions: </strong>Eczema is a common, early feature of IEI-A, often preceding infections by years. While 38.4% (n = 73/190) of patients with IEI-A with eczema fulfilled the UK Working Party diagnostic criteria for AD, some clinical pictures may differ from that of classic AD. At a time when systemic AD treatments are rapidly advancing in paediatrics, recognizing these patterns to identify patients with IEI-A could refine diagnostic strategies, improve IEI detection among children with eczema, shorten the time to IEI-A diagnosis, guide tailored management and ensure patients receive the optimal care.</p>","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":"840-851"},"PeriodicalIF":9.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When response lasts: ORR4 as an On-Treatment Prognostic Marker in Mogamulizumab-Treated Mycosis Fungoides and Sézary Syndrome.","authors":"Rudolf Stadler","doi":"10.1093/bjd/ljag466","DOIUrl":"https://doi.org/10.1093/bjd/ljag466","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Blister.","authors":"Farah Bocus","doi":"10.1093/bjd/ljag465","DOIUrl":"https://doi.org/10.1093/bjd/ljag465","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond TEWL: Toward a Multidimensional Assessment of Barrier Dysfunction in Atopic Dermatitis.","authors":"Anna De Benedetto, Jag S Lally","doi":"10.1093/bjd/ljag461","DOIUrl":"https://doi.org/10.1093/bjd/ljag461","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Profiling Differentiates Erythrodermic Atopic Dermatitis from Erythrodermic Psoriasis: A Novel insight of CD99 molecule.","authors":"Xueting Zeng, Fuchen Huang, Jiawen Chen, Zequn Tong, Zhixun Xiao, Li Zhu, Jing Mao, Rongying Chen, Ying Zou, Zhenlan Wu, Huayu Chen, Yihua Zhang, Renwei Luo, Bo Cheng, Ting Gong, Chao Ji","doi":"10.1093/bjd/ljag451","DOIUrl":"https://doi.org/10.1093/bjd/ljag451","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Microbiome Metabolism in Cutaneous Microenvironments: Implications for Skin Health and Disease.","authors":"Yue Li, Yu Wang, Xinyu Huang, Lan Yang, Rourou Wu, Evan Sweren, Zhen Lin, Yuyang Gan, Changzhou Li, Martin P Alphonse, Amy van Ee, Luis Garza, Gaofeng Wang","doi":"10.1093/bjd/ljag463","DOIUrl":"https://doi.org/10.1093/bjd/ljag463","url":null,"abstract":"<p><p>The human skin surface harbors a complex ecosystem in which epidermal cells, resident microbiota, and surface metabolites cooperate to maintain a stable barrier against external stressors. Disruption of host or microbial metabolism at this interface is closely associated with impaired epidermal barrier integrity and the development of localized skin diseases. Such conditions can drive microbial dysbiosis and metabolic imbalance, leading to altered skin physiology and pathological manifestations. These changes arise from abnormal host secretions, including those from sebaceous glands, sweat glands, and keratinocytes, and are further shaped by shifts in microbial communities and their metabolites. This review focuses on microbial metabolic activity at the skin surface, examines disease-associated changes in the cutaneous metabolic microenvironment, and critically evaluates the physiological and translational relevance of microbiota-derived metabolites. By systematically elucidating the interactions among the skin barrier, skin microbiota, and surface metabolites, we further assess the translational potential and current limitations of microbiome-derived metabolites and microbiome-based interventions.</p>","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summer Initiation of Ruxolitinib in Vitiligo: Natural Phototherapy Confounds the Seasonal Signal.","authors":"Xiangyun Li, Gang Nie","doi":"10.1093/bjd/ljag460","DOIUrl":"https://doi.org/10.1093/bjd/ljag460","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy with Mogamulizumab and Pegylated Liposomal Doxorubicin in Tumoral Advanced-Stage Mycosis Fungoides/Sézary Syndrome: A Two-Case Report.","authors":"Javier Gil-Lianes, Andrea Combalia, Teresa Estrach, Magí Brufau, Inés Monge, Irene López-Oreja, Pablo Mozas","doi":"10.1093/bjd/ljag457","DOIUrl":"https://doi.org/10.1093/bjd/ljag457","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Health-related Quality of Life in Patients With Basal Cell Naevus Syndrome and High-frequency Basal Cell Carcinoma: a Questionnaire Study'.","authors":"Nasywa Zahida Rochmah, Muhammad Ifham Hanif, Mentari Maratus Sholihah","doi":"10.1093/bjd/ljag455","DOIUrl":"https://doi.org/10.1093/bjd/ljag455","url":null,"abstract":"","PeriodicalId":520789,"journal":{"name":"The British journal of dermatology","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}