Mariana Costache, Tiberiu Augustin Georgescu, Ana Maria Oproiu, Diana Costache, Alexandru Naie, Mariana Sajin, Adriana Elena Nica
{"title":"Emerging concepts and latest advances regarding the etiopathogenesis, morphology and immunophenotype of basal cell carcinoma.","authors":"Mariana Costache, Tiberiu Augustin Georgescu, Ana Maria Oproiu, Diana Costache, Alexandru Naie, Mariana Sajin, Adriana Elena Nica","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) represents the most common skin malignancy, which has been linked over time to multifactorial causes. It usually occurs on sun-exposed areas in people with fair skin and with predilection for men. BCC usually affects elderly patients and has an extremely wide range of histological subtypes, which can present clinically under different variants, some with really challenging differentials. Although BCC may occur in familial settings, such as nevoid BCC syndrome, Rombo or Bazex-Dupré-Christol syndromes, nonsyndromic multiple BCCs have also been described in the scientific literature. In this review, we discuss in detail the latest scientific concepts regarding BCC, its etiology, pathogenesis, genetic bases of disease, morphology and immunophenotype, as well as the currently known genetic syndromes, which may lead to development of multiple BCCs, especially in young adults.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"427-433"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36450464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgeta Ligia Stănescu, Radu Stănescu, Mihail Relu Stănescu, Elena Cătălina Bică, Gigi Călin, Radu Diaconu, Mihaela Niculescu, Garofiţa Olivia Mateescu, Mihaela Gheonea, Elena Carmen Niculescu, Mirela Anişoara Siminel
{"title":"Status thymicolymphaticus: real or fake?","authors":"Georgeta Ligia Stănescu, Radu Stănescu, Mihail Relu Stănescu, Elena Cătălina Bică, Gigi Călin, Radu Diaconu, Mihaela Niculescu, Garofiţa Olivia Mateescu, Mihaela Gheonea, Elena Carmen Niculescu, Mirela Anişoara Siminel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sudden infant death syndrome (SIDS) is the sudden, unexpected death of an infant less than one year of age that remains unexplained after a full investigation. SIDS is the most frequent cause of death of infants between two weeks and one year of age, explaining 35% to 55% of all deaths in this age group. We report a newborn male who died soon after birth. The newborn was cyanotic, bradycardic at first, and then asystolic; without any vesicular murmur, apneic, low amplitude thorax movements, even under conditions of positive pressure ventilation on the endotracheal tube. The microscopic aspect thymus highlighted a corticomedullary ratio quite high in favor of the cortical, rich in lymphocyte population, with the dilated subcapsular sinuses. In this report, we considered that cardiorespiratory failure, which was the immediate cause of death, could have been caused by the thymus hypertrophy. This hypertrophy can be a complication of an intrapartum preexistent condition, most probably of hepatic nature.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"607-611"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36452304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Smaranda Ioana Mitran, Emilia Burada, Cornelia Andreea Tănasie, Nicolae Cătălin Manea, Mihai Călin Ciorbagiu, Cecil Sorin Mirea, Tudor Adrian Bălşeanu
{"title":"Microglial morphology determined with confocal and two-photon laser scanning microscopy.","authors":"Smaranda Ioana Mitran, Emilia Burada, Cornelia Andreea Tănasie, Nicolae Cătălin Manea, Mihai Călin Ciorbagiu, Cecil Sorin Mirea, Tudor Adrian Bălşeanu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Microglia are the first and main form of active immune defense in the nervous system. The immune status of microglia is directly correlated to their morphology. Therefore, microglia morphology is used to distinguish between active and surveilling microglia. For the actual paper, we used confocal laser scanning microscopy (cLSM) and two-photon laser scanning microscopy (2P-LSM), to investigate microglia morphology of 14-16 weeks old male, transgenic mice (n=6). After obtaining, in vivo and fixed tissue, single cells images, we manually tracked individually branch segments of normal microglia. The total number of branches and their overall length were analyzed. Additionally, the number and mean length of each branch order were measured. The overall microglia branching morphology was not different between the two acquisition methods. However, a higher number of fifth branches was observed using cLSM and 2P-LSM, in both fixed and in vivo tissue. Although results from the two methods are mainly comparable, small differences between them should be taken in consideration when formulating an activating∕surveilling conclusion that is purely based on pure microscopic findings. Furthermore, in our opinion, due to their highly dynamic nature, microglia should be carefully labeled as resting or active, taking also into consideration the imaging method used to obtain the data.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"485-490"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36454325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Otilia Damian, Simona Manole, Cristina Ana Maria Pamfil, Liliana Rogojan, Simona Rednic, Alma Aurelia Maniu, Mărioara Poenaru
{"title":"Tracheal enlargement or Mounier-Kuhn syndrome in giant cell arteritis: a possible causal association with therapeutic implications.","authors":"Laura Otilia Damian, Simona Manole, Cristina Ana Maria Pamfil, Liliana Rogojan, Simona Rednic, Alma Aurelia Maniu, Mărioara Poenaru","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Giant cell arteritis (GCA) is a large-vessel vasculitis with rarely described respiratory initial manifestations. We report such a case presenting with hoarseness, stridor, cough and dyspnea, in which a tracheomegaly with tracheomalacia was found. No signs of relapsing polychondritis were present. The respiratory symptoms rapidly improved after glucocorticoids and Azathioprine. Tracheomegaly or Mounier-Kuhn syndrome is characterized by marked dilatation of trachea and central bronchi. The differential diagnosis and the possible relationship between tracheomegaly and GCA involving metalloproteinase-induced elastolysis are discussed. This is the first case, to our knowledge, of Mounier-Kuhn syndrome in vasculitis. The association of tracheomegaly with GCA may be underestimated, as the diagnosis is not always obvious on conventional radiographs. A tracheal enlargement finding in GCA requires monitoring to ensure early detection and prevention of spontaneous tracheal rupture. Adding a metalloproteinase inhibitor like Doxycycline to GCA therapy would be rational for the prophylaxis of complications.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"595-599"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36452302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anca Parmena Olimid, Liliana Marcela Rogozea, Daniel Alin Olimid
{"title":"Ethical approach to the genetic, biometric and health data protection and processing in the new EU General Data Protection Regulation (2018).","authors":"Anca Parmena Olimid, Liliana Marcela Rogozea, Daniel Alin Olimid","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>The main purpose of the present paper is to analyze the rules for processing of special categories of personal data (genetic data, including biological samples, biometric and health data) in the light of the new General Data Protection Regulation (GDPR), thus contributing to overview the health status and the biomedical state of the data subject.</p><p><strong>Background: </strong>Over the last two decades, debating the European Union's (EU) major legislation with regard to personal data and patients' rights became relevant for the scientific research. The paper assesses the basic legal provisions with regard to the genetic, biometric and data concerning health considered as \"sensitive data\", while safeguarding the ethical standards of the scientific research. The present article investigates the ethical and legal approaches to processing personal data in the understanding of the new regulatory guidelines regarding the data protection, here including the health status and the rights of a data subject.</p><p><strong>Conclusions: </strong>The protection of natural persons with regard to the processing of genetic, biometric and health data and the free movement of such data are reinforced in the new GDPR entered into force in May 2016 and applied from 25 May 2018. The new legal context elucidates: the special categories of personal data (\"sensitive data\"), the \"consent\" and the research exemption by explicitly recognizing the \"pseudonymised\" data. Although the new guidelines revisit the EU data protection reform, it also grants the EU Member States the right to maintain or introduce further limitations to the processing of such data.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"631-636"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36452308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Laurenţiu Pop, Roxana Folescu, Bogdan Nicolae Deleanu, Mihaela Iacob, Dinu Vermeşan, Radu Prejbeanu, Daniel Claudiu Maliţa, Horia George Hărăguş, Bogdan Cătălin Ciupe, Carmen Lăcrămioara Zamfir, Gheorghe Nodiţi
{"title":"The role of immunohistochemistry in the diagnosis and management of synovial sarcoma.","authors":"Daniel Laurenţiu Pop, Roxana Folescu, Bogdan Nicolae Deleanu, Mihaela Iacob, Dinu Vermeşan, Radu Prejbeanu, Daniel Claudiu Maliţa, Horia George Hărăguş, Bogdan Cătălin Ciupe, Carmen Lăcrămioara Zamfir, Gheorghe Nodiţi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Synovial sarcoma (SS) is a malignant soft tissue tumor representing 5-10% of all soft tissue sarcomas. Most synovial sarcomas are found at the extremities, especially in the lower limbs. A 28-year-old female presented at the Department of Plastic and Reconstructive Surgery, \"Dr. Pius Brînzeu\" Clinical Hospital, Timişoara, Romania, for evaluation of a mass located in the anterior region of the elbow. Imagistic, histological and immunohistochemically evaluations established the diagnosis of monophasic spindle cell SS G2. Block excision of the tumor with oncological safety margins was performed followed by total elbow arthroplasty. The patient then received radio- and chemotherapy. The case was followed-up at regular intervals for local recurrence and metastases and was free of symptoms at two years. Early diagnosis of SS, multimodal therapies and performing an arthroplasty of the elbow allowed the patient to resume daily activities. The unpredictable evolution requires regular follow-up for a long period of time.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"569-572"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36454283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniela Marinescu, Elena Cătălina Bică, Mirela Corina Ghiluşi, Marius Bică, Ana Maria Pătraşcu, Ştefan Pătraşcu, Stelian Pantea, Victor Dan Eugen Strâmbu, Valeriu Şurlin, Nicolae Dragoş Mărgăritescu, Konstantinos Sapalidis, Ionela Rotaru
{"title":"Indication of total parathyroidectomy for an Epstein syndrome patient with end-stage renal disease.","authors":"Daniela Marinescu, Elena Cătălina Bică, Mirela Corina Ghiluşi, Marius Bică, Ana Maria Pătraşcu, Ştefan Pătraşcu, Stelian Pantea, Victor Dan Eugen Strâmbu, Valeriu Şurlin, Nicolae Dragoş Mărgăritescu, Konstantinos Sapalidis, Ionela Rotaru","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Epstein syndrome is an extremely rare genetic disorder characterized by the association of nephritis, deafness and megathrombocytopenia. We present the case of a 21-year-old patient diagnosed with Epstein syndrome and hyperparathyroidism secondary to chronic kidney disease. The main particularity of this case resides in the association between megathrombocytopenia and secondary hyperparathyroidism requiring surgery, which could lead to a series of concerns regarding the intra- and postoperative hemorrhagic risk of the procedure. Nevertheless, both the surgical procedure and the postoperative recovery were uneventful, suggesting that the lower threshold for preoperative thrombocyte count in megathrombocytopenia should be specifically considered on an individual case analysis.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"573-576"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36454284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delia Hînganu, Cristinel Ionel Stan, Corina Ciupilan, Marius Valeriu Hînganu
{"title":"Anatomical considerations on the masseteric fascia and superficial muscular aponeurotic system.","authors":"Delia Hînganu, Cristinel Ionel Stan, Corina Ciupilan, Marius Valeriu Hînganu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The masseteric region is considered by the most researchers as a subdivision of the parotideomasseteric region. Because of its surgical significance, we emphasize it has distinctive morphofunctional features. The aim of this manuscript is to highlight particular characteristics of the masseteric region and practical applications of this concept. The material used was represented by 12 embalmed cephalic extremities dissected in \"Ion Iancu\" Institute of Anatomy, \"Grigore T. Popa\" University of Medicine and Pharmacy, Iaşi, 10 operating specimens from the Clinics of Maxillofacial Surgery and Plastic Surgery of the \"St. Spiridon\" University Hospital, Iaşi, Romania, and computed tomography (CT) and magnetic resonance (MR) images from the same patients. Our results underline the importance and individual arrangement of the superficial muscular aponeurotic system (SMAS) of the face, at the level of masseteric region. The superficial fascia facilitates adhesion to the dermis of the mimic muscles of the region. This reveals that the masseteric superficial fascia will follow the masticatory movements of the mandible and masseter, but also those of the minor and major zygomaticus muscles. These muscles are the infra-SMAS layer and thus take part in the formation of a unitary complex together with the superficial fascia. The particularities of the SMAS in the masseteric region are especially important in plastic and reconstructive surgery.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"513-516"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36454329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dragoş Cătălin Jianu, Claudia Bârsan, Traian Flavius Dan, Silviana Nina Jianu, Andrei Gheorghe Marius Motoc, Octavian Marius Creţu
{"title":"Left internal carotid artery agenesis associated with communicating arteries anomalies. A case report.","authors":"Dragoş Cătălin Jianu, Claudia Bârsan, Traian Flavius Dan, Silviana Nina Jianu, Andrei Gheorghe Marius Motoc, Octavian Marius Creţu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Agenesis, aplasia and hypoplasia of the internal carotid artery are rare congenital malformations. They are usually asymptomatic and incidentally discovered through ultrasound or imagistic tests. The aim of this study is to improve their management in our Departments. We report here the case of a 39-year-old woman addressed to our ambulatory in 2013 for benign symptoms like dizziness and headache. Imagistic findings (magnetic resonance imaging of the brain, and cervical spine, and magnetic resonance angiography of the head and neck) indicated a very rare condition: left internal carotid artery agenesis accompanied by the absence of the pre-communicant part of the left anterior cerebral artery and of the right posterior communicating artery. Internal carotid artery agenesis is an uncommon congenital anomaly and it could be misdiagnosed as stenosis/occlusion of this artery. This condition is important to be recognized due to the associated hemodynamic changes and in order to discover and evaluate other accompanying vascular malformations (aneurysms, collateral channels) and their life threatening potential risks (subarachnoid hemorrhage or ischemia). Also, it has a special importance in case of planning carotid or trans-sphenoidal hypophyseal surgery.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"601-605"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36452303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical and morphological correlations in early diagnosis of endometrial cancer.","authors":"Adrian Neacşu, Mădălina Lucia Marcu, Cătălina Diana Stănică, Anca Daniela Brăila, Irina Pacu, Raluca Gabriela Ioan, Cicerone Cătălin Grigorescu, Crîngu Antoniu Ionescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prevalence of endometrial cancer among asymptomatic women is rather reduced also due to the absence of a cost-efficient test, as there are no ideal screening examinations for endometrial cancer. Several methods were proposed in medical practice to discover endometrial neoplasia at an early stage, among which: endometrial biopsy, endovaginal ultrasound, targeted biopsy hysteroscopy. This study was made on a group of 38 patients monitored for metrorrhagia in the interval between July 1, 2014-July 1, 2016. All patients were monitored clinically and by ultrasound, endometrium samples were taken by biopsied uterine curettage, and a histopathological examination was performed, completed by immunomarking, whenever necessary. The clinical and paraclinical methods allowed for the creation of a protocol by which patients were monitored. This protocol allowed for the modulation and effectiveness of the treatment, establishing the best therapeutic conduct and the remote supervision.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"527-531"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36454331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}