Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie最新文献

{"title":"Contralateral breast cancer in patients carrying mutations in the BRCA1∕2 gene.","authors":"Sorana Caterina Anton, Setalia Popa, Carmen Rodica Anton, Emil Anton, Delia Nicolaiciuc, Ovidiu Sebastian Nicolaiciuc, Mihai Danciu, Şadiye Ioana Scripcariu, Dragoş Valentin Crauciuc, Mihaela Grigore","doi":"10.47162/RJME.66.1.10","DOIUrl":"10.47162/RJME.66.1.10","url":null,"abstract":"<p><strong>Aim: </strong>This study aim was to offer a better view of breast cancer (BC) in Romanian patients and to identify the most frequent BRCA1∕2 germline mutations in a cohort of Romanian patients with contralateral BC (CBC). This is one of the first comprehensive studies to determine the contribution of BRCA1∕2 germline mutations to CBC development in the Romanian population.</p><p><strong>Patients, materials and methods: </strong>This is a prospective study and included 281 patients with BC. We established the histological type and immunohistochemical profile for these breast tumors. We identified mutations in the BRCA1∕2 oncogenes in those patients diagnosed with CBC. We investigated correlations between the BRCA1∕BRCA2 genes mutation and the increased risk of collateral BC.</p><p><strong>Results: </strong>The most common histological type observed was ductal carcinoma. Our study group of tumors was classified into the following BC subtypes: 84.69% triple-negative BC, 9.60% Luminal A, 3.55% human epidermal growth factor receptor 2 (HER2)-positive and 2.13% Luminal B. Forty-one cases were diagnosed with collateral BC. For these 41 cases, genetic testing was performed for the BRCA1 and BRCA2 genes and we obtained seven cases with negative results and 34 cases with positive results for mutations in the BRCA1 gene, describing the following types of mutations: c.3067.C>T (24 cases - 70.6%), c.5266dupC (four cases - 11.8%), c.4035delA (six cases - 17.6%).</p><p><strong>Conclusions: </strong>This study offered a better view of BC in Romanian patients and identified the most frequent BRCA1∕2 germline mutations in a cohort of Romanian patients with CBC. Also, these results demonstrate that BRCA1 gene mutations increase the risk for CBC development.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"111-118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcomes of partial nephrectomy - considerations that contribute to positive surgical margins.","authors":"Alexandru Iordache, Nicoleta Alina Mareş, Niculae Iordache, Mihaela Gabriela Berdan, Mara Mardare, Alina Ioana Puşcaşu, Bogdan Florin Geavlete, Dragoş Adrian Georgescu, Răzvan Cosmin Petca, Viorel Jinga, Octav Ginghină, Alexandru Blidaru","doi":"10.47162/RJME.66.1.16","DOIUrl":"10.47162/RJME.66.1.16","url":null,"abstract":"<p><p>The diagnosis in the early stages of renal tumors, as well as the oncological outcomes equivalent to extensive nephrectomies, have increased interest in partial nephrectomy (PN), which is the preferred method for treating renal cell carcinoma less than 7 cm. The literature confirms that PN offers oncological outcomes equivalent to radical nephrectomy, especially in early stages. This is a prospective study, conducted in a single university center over a period of three years, aimed to evaluate the surgical and oncological outcomes regarding positive safety margins after PN performed using laparoscopic and open approaches. Following the analysis of the causes and consequences of incomplete tumor resection, the obtained results align with data from the literature. We found that specimens from laparoscopic surgery were approximately twice as likely to have positive surgical margins compared to tumors resected using the open approach, meaning that these patients require more intense follow-up both clinically and imaging. According to current published studies, positive safety margins are not predictors for disease recurrence rate, progression-free survival, or overall survival.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"173-177"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in schizophrenia - past, present and future.","authors":"Violeta Mancaş, Dana Galieta Mincă, Simona Corina Trifu","doi":"10.47162/RJME.66.1.06","DOIUrl":"10.47162/RJME.66.1.06","url":null,"abstract":"<p><p>Schizophrenia is a complex and debilitating neuropsychiatric syndrome. Although research into the etiology of this pathology has advanced considerably, consistent results are still awaited. The discovery of biomarkers that could underlie diagnosis and treatment could revolutionize the management of this pathology, and approaching biomarkers from an evolutionary perspective, along with the multitude of existing and future studies, can provide important information. The complexity of this multifactorial pathology requires its approach from an integrated and multidisciplinary perspective, which considers research on neurodevelopment, genetics, imaging and, last but not least, neurobiological research. The present material aims to bring to light a series of recent research, as well as the approach to this pathology from an evolutionary perspective of neurodevelopment, in the hope that it will constitute an attractive point of view that could imagine new ways of approaching this pathology.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"69-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor microenvironment in squamous cell lung cancer - histological and immunohistochemical study.","authors":"Ovidiu Lucian Cîmpeanu, Andrei Osman, Alina Maria Georgescu, Elena Cristina Andrei, Bogdan Oprea, Valentin Octavian Mateescu, Larisa Pătru, Carmen Aurelia Mogoantă, Ionuţ Tănase, Adriana Mihaela Ciocâlteu, Dan Iovănescu, Ilona Mihaela Liliac, Mihai Olteanu, Costin Teodor Streba","doi":"10.47162/RJME.66.1.14","DOIUrl":"10.47162/RJME.66.1.14","url":null,"abstract":"<p><p>Globally, lung cancer is the primary cause of cancer-related mortality. Squamous cell carcinoma (SCC) of the lung, a subtype of non-small cell lung cancer (NSCLC), accounts for a significant portion of new cases and is primarily associated with smoking and environmental pollutants. This study investigates the histopathological and immunohistochemical (IHC) characteristics of the tumor microenvironment (TME) in SCC using tissue samples from 19 patients who underwent surgery for lung cancer. IHC markers, including cluster of differentiation (CD)68, CD3 and CD34 were used to assess various components of the TME, including immune cell infiltration, and angiogenesis. The results revealed significant presence of macrophages, T-lymphocytes, and myofibroblasts, as well as increased vascularization in the tumor stroma. These findings highlight the complex interaction between tumor cells and the surrounding stroma, contributing to tumor progression. Understanding these mechanisms is crucial for improving early diagnosis and therapeutic strategies for SCC.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"153-161"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes of death in the Emergency Department: a retrospective monocentric study.","authors":"Adrian Iosif Moldoveanu, Radu Gheorghe Dan, Emil Florin Huţ, Dan Iliescu, Laurenţiu Vasile Sima, Bianca Moldoveanu, Cătălina Oana Băzăvan, Ovidiu Alexandru Mederle, Flavia Zară","doi":"10.47162/RJME.66.1.18","DOIUrl":"10.47162/RJME.66.1.18","url":null,"abstract":"<p><p>The Emergency Department (ED) serves as a critical entry point for patients with life-threatening conditions, yet mortality within this setting remains a significant clinical and epidemiological concern. This retrospective monocentric study investigates the primary causes of death in the ED of Emergency Municipal Hospital, Timişoara, Romania, over a five-year period (2019-2023). A total of 63 cases were analyzed, integrating clinical data at the time of presentation with post-mortem pathological findings to ensure diagnostic accuracy. Results indicate that irreversible cardiac arrest (ICA) constituted the predominant cause of mortality, with non-shockable rhythms accounting for 88.88% of cases - asystole (80.35%) and pulseless electrical activity (19.65%) - while shockable rhythms (ventricular fibrillation and pulseless ventricular tachycardia) were observed in only 11.12% of cases. Among non-cardiac etiologies, septic shock (31.74%) and respiratory failure (17.46%) were the most prevalent contributors. These findings highlight the need for improved diagnostic methodologies, optimized resuscitation strategies, and enhanced resource allocation within emergency settings. This study underscores the necessity for systematic mortality documentation, evidence-based intervention protocols, and targeted management strategies to mitigate preventable deaths in the ED. The integration of clinical and autopsy-based data offers valuable insights into pathophysiological mechanisms contributing to ED mortality and provides a foundation for future research aimed at improving emergency medical outcomes.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrioid adenofibroma of ovary - a literature review.","authors":"Laurenţiu Augustus Barbu, Liviu Vasile, Tiberiu Ştefăniţă Ţenea-Cojan, Gabriel Florin Răzvan Mogoş, Valeriu Şurlin, Ionică Daniel Vîlcea, Liliana Cercelaru, Stelian Ştefăniţă Mogoantă, Nicolae Dragoş Mărgăritescu","doi":"10.47162/RJME.66.1.03","DOIUrl":"10.47162/RJME.66.1.03","url":null,"abstract":"<p><strong>Background/objectives: </strong>Ovarian neoplasms are the third most common gynecological cancer and carry a poorer prognosis than breast cancer. Endometrioid borderline ovarian tumors (EBOTs) are intermediate epithelial lesions, histologically showing glandular patterns with mild to moderate atypia and no stromal invasion. Study selection for review: A comprehensive electronic search was conducted on PubMed to identify risk factors and etiological determinants associated with ovarian endometrioid adenofibroma (EA).</p><p><strong>Case presentation: </strong>A 27-year-old woman with a left ovarian cyst underwent a laparoscopic procedure to remove the adnexa after imaging showed a 6 cm mass. Surgery was successful, and she was discharged without complications.</p><p><strong>Conclusions: </strong>This study highlights the diagnostic challenges of EBOTs, the essential role of immunohistochemistry, and the need for careful surgical and fertility-preserving strategies. It also draws attention to possible risks linked to fertility treatments. Fertility preservation is crucial in young patients, favoring uterine and ovarian conservation. In early-stage, small, non-invasive tumors, laparoscopy is the preferred approach. EAs are uncommon benign ovarian tumors, accounting for approximately 1% of epithelial neoplasms, and are predominantly unilateral.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"39-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroepithelial lesions: assessing the risk of malignant phyllodes tumors in the breast.","authors":"Alexandru Cărăuleanu, Cristina David, Simona Juliette Mogoş, Gabriel Costăchescu, Iustina Petra Solomon-Condriuc, Andrei Ionuţ Cucu, Gabriel Valentin Tănase, Claudia Florida Costea, Demetra Gabriela Socolov, Dragoş Viorel Scripcariu, Florin Dumitru Petrariu, Adina Elena Tănase, Daniela Maria Tănase","doi":"10.47162/RJME.66.1.12","DOIUrl":"10.47162/RJME.66.1.12","url":null,"abstract":"<p><strong>Purpose: </strong>Phyllodes tumors (PTs) of the breast are rare fibroepithelial tumors (FETs), accounting for approximately 0.5% of all breast tumors. The diagnostic interpretation of borderline fibroepithelial lesions often requires further investigations.</p><p><strong>Patients, materials and methods: </strong>We used statistical analysis to evaluate the different surgical approaches, risk factors and prognosis during a five-year period, from January 2019 to December 2024, of women who underwent conservative surgeries for benign, borderline tumors and malignant breast tumors.</p><p><strong>Results: </strong>We examined a total of 481 breast tumors, with benign, borderline and reserved final diagnosis to paraffin, and discovered 35 FETs, corresponding to phyllodes-type tumors. Studies of enlarged PTs, which are often malignant on final paraffin results, are controversial regarding further postoperative treatment, because they require chemotherapy that is as aggressive as for soft tissue sarcomas, and also hormone therapy that has not shown long-term survival benefit yet. In order to improve the quality of life, survival rate, and disease management, the surgical team needs to be up to date with the latest protocols of management of the disease.</p><p><strong>Discussions: </strong>Management of breast tumors includes ultrasound examination, digital or three-dimensional (3D) mammography and magnetic resonance imaging (MRI) evaluation, while surgical management is consistent with core needle biopsy procedures and surgical excision known as tumorectomy, followed in certain cases by an enlarged sectorectomy.</p><p><strong>Conclusions: </strong>Aggressive surgery is sometimes necessary to achieve oncological safety margins and prevent subsequent disease recurrence.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational trophoblastic diseases - literature review and atypical case reports.","authors":"Anca Maria Istrate-Ofiţeru, Sidonia Cătălina Vrabie, George Lucian Zorilă, Marian Valentin Zorilă, Răzvan Grigoraş Căpitănescu, Elena Iuliana Anamaria Berbecaru, Ilona Mihaela Liliac, Larisa Iovan, Bianca Cătălina Andreiana, Valentin Octavian Mateescu, Cristina Jana Busuioc, Dominic Gabriel Iliescu, Marius Cristian Marinaş","doi":"10.47162/RJME.66.1.01","DOIUrl":"10.47162/RJME.66.1.01","url":null,"abstract":"<p><p>Gestational trophoblastic disease (GTD) arises from the abnormal development of trophoblastic tissue and encompasses a wide range of benign and malignant conditions. There is evidence that malignant transformation can occur in atypical areas of the placenta. A complete diagnosis of GTD involves assessing the signs and symptoms, with the most common being vaginal bleeding and pelvic-abdominal pain, alongside laboratory data and variations in human chorionic gonadotropin (hCG) levels. Imaging exploration, both local and distant, is critical for assessing tumor areas, utilizing various techniques such as ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)-CT. Furthermore, a detailed histopathological analysis is essential, which includes classical examination with Hematoxylin-Eosin (HE) staining to highlight the presence of abnormal villi or transformed trophoblasts. Immunohistochemical staining with antibodies like anti-cytokeratin 7 (CK7) marks tumor cells with trophoblastic origin, while anti-p57 is present in incomplete hydatidiform moles (HMs) and absent in complete HMs (CHMs). The tumor proliferation index, obtained by calculating the density of tumor cells undergoing division and immunolabeled with the anti-Ki67 antibody, along with the invasion into the myometrial structure among myocytes immunolabeled with anti-alpha-smooth muscle actin (α-SMA) antibody, helps establish a definitive diagnosis and classify GTD. Diagnosis remains a challenge even among expert gynecologists and pathologists. This study has gathered data from literature and analyzed the evolution of a series of atypical cases and the management strategies related to the diagnosis and therapeutic opportunities of GTD.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"7-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Walthard cell nests in the intestine. Report of two cases and review of the literature.","authors":"José Fernando Val-Bernal, Marta María Mayorga, Horacio Requena-Cabello, Ramiro Raphael Gutierrez-Vasquez, Sofía Del Carmen, Juan García-Cardo","doi":"10.47162/RJME.66.1.24","DOIUrl":"10.47162/RJME.66.1.24","url":null,"abstract":"<p><p>Walthard cell nest (WCN) is a rare incidental finding in the intestine including the vermiform appendix and the mesocolon. This article describes a case of WNCs in the vermiform appendix and the mesocolon. The location in the mesocolon is reported for the first time. A review of the seven published intestinal cases including our report is presented. The lesion is seen in children, adults, and both sexes. The number of present cell nests varied between one and three per case. The diagnosis rests on histopathological examination. A potential source for histopathological diagnostic error includes a NET. The coexistence of WCNs with an appendicular neuroendocrine tumor (NET) may complicate the diagnosis. WCNs show the immunohistochemical profile of urothelial differentiation. To establish a diagnosis of WCN the absence of significant atypia, significant mitotic activity, atypical mitoses, necrosis, desmoplastic stroma, and tissue invasion must be confirmed. The lesion is a benign proliferation and once the appendectomy or colectomy has been performed, no further treatment is required.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"251-255"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the patient's demographic profile and tumor characteristics on reconstructive techniques in lip cancers.","authors":"Ana Cătălina Ţânţu, Marius Eugen Ciurea, Vasilica Mihaela Dumitrache, Alina Păunescu, Marilena Monica Ţânţu, Constantin Ciucurel, Elena Ioana Iconaru, Daniel Corneliu Diaconescu, Georgeta Ionescu, George Mihail Man, Sorina Octavia Honţaru, Consuela Dicu, George Popescu","doi":"10.47162/RJME.66.1.21","DOIUrl":"10.47162/RJME.66.1.21","url":null,"abstract":"<p><p>With an incidence of approximately 30% of all oral cavity neoplasms, lip cancer significantly impacts the patient quality of life (QoL). The frequent localization is in the lower lip, predominantly affecting men aged between 60-70 years old. The surgical treatment aims at aesthetic and functional reconstruction of the lip. The present study aims at defining a demographic profile of patients with lip cancer and at establishing correlations between tumor characteristics and reconstruction methods. The analysis of the group of 26 patients showed that the lip cancer patient was predominantly female, urban, with a mean age of 73.27±11.17 years old, with squamous cell carcinoma of the lower lip, mean diameter of 1.52 cm and mean depth of 0.72 cm. The tumor characteristics revealed a guide of the decision on the method of lip reconstruction, considering the correlations between a variety of factors, including the size of the affected area, etiology and location of the formation, integration of the flap into the relaxed skin tension lines, the patient general condition, and the degree of cooperation. Regardless of the reconstructive method chosen, the aim is to preserve the functions of the lip in mastication, speech and definition of facial expression. Complex cases require extensive reconstructive interventions involving combinations of various types of flaps. Multidisciplinary management of these patients leads to improved QoL and prevention of recurrences.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"229-238"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}