Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie最新文献

{"title":"The effect of physical exercises on TNF-α, IL-6, and IL-8 cytokines expression and NK cells in cancer.","authors":"Ligia Rusu, Tatiana Andreea Mihai, Ramona Adriana Schenker, Mihnea Ion Marin, Michael Schenker, Costin Teodor Streba, Dan Ionuţ Gheonea, Denisa Piele","doi":"10.47162/RJME.66.1.08","DOIUrl":"10.47162/RJME.66.1.08","url":null,"abstract":"<p><p>The main process in developing cancer is carcinogenesis, which means that proliferation of the cells is developed and is based on interplay between intrinsic and extrinsic processes. Many researchers consider that cytokines produced during muscle contractions (i.e., myokines) could influence cancer cells. Myokines, produced by muscles during physical activity, may have anti-inflammatory and antitumor effects by directly influencing the tumor microenvironment and the immune system. These signaling molecules have the potential to modulate tumor cell growth and viability, suggesting that exercise may contribute to cancer prevention and control through complex biochemical mechanisms. The aim of this review was to analyze the effects of physical exercise on cytokines and implicitly its influence on the cancer cells, by performing in-depth documentation leading to a synthesis, for analysis of the possible contribution of physical exercises as therapeutic potential. The search for articles was also extended to databases. Multiple studies have shown that exercise can inhibit the development of tumor cells and so apoptosis may be induced for various malignant cells and much more short-term and long-term training interventions suggest that training volume may influence the inhibition of cancer cells. Still, the specific impact of training modalities, volumes, as well as intensities on serum collected from individuals undergoing exercise programs - and its subsequent effects on cancer cells - remains unclear.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"89-98"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep endometriosis. Clinical, histopathological and confocal microscopy correlations in intestinal sites.","authors":"Elena Iuliana Anamaria Berbecaru, George Lucian Zorilă, Anca Maria Istrate-Ofiţeru, Daniel Pirici, Andreas Donoiu, Oana Iulia Creţu, Gabriela Camelia Roşu, Elvira Brătilă, Dumitra Miron, Valentin Octavian Mateescu, Cristina Elena Negroiu, Suzana Dănoiu, Dominic Gabriel Iliescu, Robertina Iulia Tudoraşcu","doi":"10.47162/RJME.66.1.13","DOIUrl":"10.47162/RJME.66.1.13","url":null,"abstract":"<p><p>Intestinal endometriosis (IE), a chronic condition affecting a notable percentage of women with endometriosis (estimates varying from roughly 4% to 37%) and can impact any part of the intestine, but it most frequently involves the rectum and sigmoid colon. This is a retrospective study that included 178 women diagnosed with this condition that were investigated taking into consideration the symptoms, diagnostic approaches, surgical treatments, and detailed features of the intestinal wall, including the behavior and quantity of interstitial cells of Cajal (ICC) correlated with the symptomatology experienced. We were able to highlight the most common symptoms such as pelvic pain and bowel disorders. The rectum was identified as the most commonly affected intestinal segment. Transvaginal ultrasound can be valuable in assessing IE, improving preoperative diagnosis and treatment strategies. Laparoscopic surgery remains the definitive diagnostic method, allowing direct visualization and excision of lesions. Surgical technique selections are complex and require careful consideration tailored to each patient. A reduction in ICC numbers may disrupt gut motility, emphasizing their importance in maintaining normal intestinal function, a factor particularly relevant in endometriosis where disruption of ICC networks can contribute to gastrointestinal dysfunction.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"137-151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional retinal vulnerability in multiple sclerosis: integrating OCT, MRI, and clinical data for enhanced diagnosis and automated monitoring.","authors":"Sorina Elena Abdul-Salam, Ruxandra Mădălina Florescu, Alin Ştefan Ştefănescu-Dima, Andrei Theodor Bălăşoiu, Valeria Carmen Albu, Ioana Andreea Gheonea, Veronica Sfredel, Dragoş Ovidiu Alexandru, Mircea Sebastian Şerbănescu","doi":"10.47162/RJME.66.1.11","DOIUrl":"10.47162/RJME.66.1.11","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, often affecting the visual pathways. Optical coherence tomography (OCT) has emerged as a valuable, non-invasive imaging tool for assessing neuroaxonal damage in MS. This study investigates retinal neurodegeneration in MS patients, focusing on ganglion cell layer and inner plexiform layer (GCL+IPL) thinning, macular volume (MV), and retinal nerve fiber layer (RNFL) alterations, and their correlation with clinical and magnetic resonance imaging (MRI) parameters. A total of 43 MS patients and 38 healthy controls underwent three OCT investigations over three years, measuring GCL+IPL thickness, MV, and RNFL parameters. Clinical disability was assessed using the Expanded Disability Status Scale (EDSS), and MRI data were available, with parameters such as lesion volume, whole brain volume, and white matter percentage analyzed. Statistical comparisons included t-tests, analysis of variance (ANOVA), and Pearson's correlation to evaluate OCT changes and their associations with clinical and MRI findings. MS patients exhibited significant GCL+IPL thinning, with quadrant analysis revealing regional disparities. Macular thickness showed no significant global differences; however, outer quadrant thinning was observed. RNFL analysis confirmed significant temporal quadrant thinning, further supporting its selective vulnerability in MS. Over three years, no significant longitudinal changes were detected in any OCT parameters (p>0.05). MRI lesion volume correlated strongly with EDSS (Pearson, r=0.61) and moderately with GCL+IPL thickness (Pearson, r=0.42), while a weaker correlation was found with temporal RNFL thickness. These findings reinforce OCT as an essential biomarker for MS-related neurodegeneration, particularly through GCL+IPL and temporal RNFL thinning. While macular changes were minimal, the observed selective temporal quadrant vulnerability aligns with previous research linking retinal alterations to trans-synaptic degeneration and optic radiation damage. The lack of significant longitudinal OCT progression over three years suggests that retinal atrophy may require longer monitoring periods to detect meaningful disease progression or to enable automated diagnosis. OCT is a reliable tool for detecting subclinical neurodegeneration in MS, particularly through temporal RNFL and GCL+IPL thinning. The moderate correlation between MRI lesion volume and retinal changes supports the integration of OCT with MRI for multimodal disease monitoring. The application of artificial intelligence (AI)-driven OCT analysis holds promise for enhanced MS diagnosis and automated progression monitoring. Future research should focus on long-term longitudinal studies, AI-assisted OCT diagnostics, and multimodal imaging approaches to optimize personalized MS management.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"119-130"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of diffuse large B-cell lymphoma of the frontal sinus and rapid review of literature.","authors":"Raluca Morar, Norberth Istvan Varga, Ioana Delia Horhat, Ion Cristian Moţ, Flavia Zară, Raluca Maria Cloşca, Cristian Andrei Sarău, Oana Silvana Sarău, Dan Costăchescu, Nicolae Constantin Balica","doi":"10.47162/RJME.66.1.22","DOIUrl":"10.47162/RJME.66.1.22","url":null,"abstract":"<p><strong>Introduction: </strong>Primary lymphoma of the paranasal sinuses, especially involving the frontal sinus, is exceedingly rare. Extranodal non-Hodgkin lymphoma (NHL) located in the head and neck frequently poses diagnostic challenges because its nonspecific symptoms can be mistaken for benign issues such as rhinosinusitis.</p><p><strong>Aim: </strong>This case report seeks to emphasize the challenges in diagnosis, the aggressive characteristics, and the effective treatment of an uncommon manifestation of diffuse large B-cell lymphoma (DLBCL) primarily affecting the frontal and ethmoid sinuses.</p><p><strong>Case presentation: </strong>We present a case of a 62-year-old male who initially presented with symptoms suggestive of acute rhinosinusitis complicated by periorbital cellulitis. Diagnostic workup included physical examination, laboratory investigations, computed tomography (CT) imaging, magnetic resonance imaging (MRI), histopathological (HP) analysis of biopsy specimens, immunohistochemical staining, and positron emission tomography (PET)-CT. The patient presented with right frontal headache, periorbital edema, palpebral ptosis, and posterior rhinorrhea. Initial CT revealed mucosal thickening, lytic changes, and a mass partially invading the right orbit. Following surgical excision, histopathology confirmed DLBCL with positivity for cluster of differentiation (CD)20, CD79a, B-cell lymphoma (Bcl)-6, and Bcl-2, and a Ki-67 proliferation index of 90%. Subsequent MRI revealed a hypointense mass extending into surrounding structures. Staging CT confirmed stage IVB disease. The patient received six cycles of Rituximab-Cyclophosphamide, Hydroxydaunorubicin (Doxorubicin), Oncovin (Vincristine), Prednisolone (R-CHOP) chemotherapy and radiotherapy for the frontal sinus. At the 6-month and 12-month follow-up CT scans, there was no evidence of metabolically active disease on PET-CT (Deauville score 1). During the 2-year follow-up, the patient remained in complete remission.</p><p><strong>Conclusions: </strong>This case underscores the importance of considering malignancy in cases of atypical sinusitis and the crucial role of HP examination of biopsy specimens. This case also highlights the importance of considering malignancy in cases of atypical sinusitis.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"239-244"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of CDX2, MUC5AC, and p53 in the evaluation of the progression of serrated lesions toward colorectal carcinoma.","authors":"Sergiu Marian Cazacu, Sevastiţa Iordache, Vlad Florin Iovănescu, Liliana Streba, Carmen Daniela Neagoe, Cristina Jana Busuioc, Dan Cârţu, Mirela Marinela Florescu","doi":"10.47162/RJME.66.1.09","DOIUrl":"10.47162/RJME.66.1.09","url":null,"abstract":"<p><strong>Background: </strong>Serrated colorectal lesions represent a potential precursor of 15-30% of colorectal carcinoma, although the exact mechanisms are not fully understood. The serrated pathway of colorectal carcinogenesis may be correlated with gastric-type metaplasia of the colon and modified expression of caudal type homeobox 2 (CDX2) and local mucins (MUCs).</p><p><strong>Patients, materials and methods: </strong>We performed a retrospective study of patients with resected polyps during 2014-2021. The prevalence of serrated lesions, risk factors associated with malignant polyps, and the role of gastric-type metaplasia associated with serrated pathway of carcinogenesis (CDX2, MUC5AC) and of p53 immunostaining in serrated lesions with dysplasia and carcinoma were assessed.</p><p><strong>Results: </strong>Five hundred twenty two (522) patients had 1199 polyps removed. We noted a 12.8% prevalence of sessile serrated adenoma∕polyps (SSA∕P) and traditional serrated adenomas (TSA); 17.4% had hyperplastic polyps. The malignancy rate of resected polyps was higher in tubulovillous adenoma (TVA) and villous adenoma (12.3-20%) than in SSA∕P (8.3%) and TSA (4.8%). In TSA, no significant associations between malignancy and age, gender, size, location, or endoscopic appearance were noted. In SSA∕P, malignant polyps were much larger, especially for the right side lesions, but the macroscopic type was not correlated with malignancy risk. Immunohistochemistry (IHC) was performed in 26 polyps with dysplasia or carcinoma; all cases had CDX2 immunostaining in the tumor cell's nucleus, with an average percentage of 96.5%. MUC5AC immunostaining was identified in the tumor cells' cytoplasm, with an average percentage of 31.81%; the intensity reaction was variable (average score 4.5). The percentage, intensity, and score for CDX2 IHC were similar for TSA and TVA and were lower for SSA∕P with low-grade dysplasia (LGD), while for SSA∕P with high-grade dysplasia (HGD) or carcinoma in situ (CIS), the percentage, intensity, and score were similar to TSA and TVA. p53 immunostaining was also positive in all cases, with an average percentage of 50.95% in the tumor cells' nucleus. p53 and MUC5AC had increased percentage, intensity, and scores from LGD to HGD in SSA∕P and decreased mean percentage, intensity, and scores in TSA and TVA.</p><p><strong>Conclusions: </strong>The risk of malignancy in serrated lesions seems lower than in conventional adenomas, however, sessile serrated lesions can be involved in the appearance of interval cancers because of flat and pale macroscopic aspects. Gastric-type intestinal metaplasia may be associated with the serrated pathway, but more studies are needed to clarify mechanisms associated with serrated carcinogenesis.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"99-109"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex vivo use of probe-based confocal laser endomicroscopy in lung cancer visualization: an ex vivo pilot study.","authors":"Andreea Georgiana Gheorghe, Liliana Streba, Alin Dragoş Demetrian, Mircea Sebastian Şerbănescu, Daniel Pirici, Costin Teodor Streba","doi":"10.47162/RJME.66.1.15","DOIUrl":"10.47162/RJME.66.1.15","url":null,"abstract":"<p><p>Lung neoplasia is the main cause of cancer death worldwide, with increasing incidence and an apparent stagnation in the decrease of morbidity. Early lung cancer (LC) diagnosis requires precise pathology and precise surgical intervention at the appropriate time. Current guidelines provide an outline for cancer management, involving multiple imaging methods as well as tissue-collection techniques; however, probe-based confocal laser endomicroscopy (pCLE), although being introduced several years ago, remains an experimental diagnostic method. Based on direct tissue observation that can occur during normal bronchoscopy, with the possibility of combining multiple imaging techniques in a single-step intervention, it however holds great promise. We included 18 consecutive patients diagnosed with LC over a period of six months who underwent curative surgery. After obtaining written consent and ethical approval, we used pCLE on ex vivo tissue samples that were later sent to pathology for confirmation. We then compared pCLE findings with the final pathology diagnosis. We included 12 males, median age in the study group being 64 years. We found 10 adenocarcinomas, four small cell lung carcinomas and four squamous cell carcinomas. The pCLE investigation provided key differentiating aspects between normal lung parenchyma, the structure of elastin fiber distribution and the shape and cellular content of alveoli, as opposed to the anarchic organization of the tumoral tissue. In conclusion, we presented here some of the first descriptive findings of lung tissue in pCLE imaging, thus contributing to the standardization of the technique for diagnostic purposes.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"163-171"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoprofile of some surface and cytoplasmic peripheral cell adhesion molecules in oral squamous cell carcinoma.","authors":"Ionuţ Octavian Ilie, Adrian Camen, Daniela Dumitrescu, Maria Cristina Munteanu, Marius Matei, Mircea Sebastian Şerbănescu, Claudiu Mărgăritescu","doi":"10.47162/RJME.66.1.17","DOIUrl":"10.47162/RJME.66.1.17","url":null,"abstract":"<p><p>Despite the recent advances in diagnosis and treatment, oral squamous cell carcinoma (OSCC) continues to have a low overall survival rate (around 50%), being a tumor with high locoregional aggressiveness and high risk of lymph node (LN) dissemination. Such behavior can also be explained by the alteration of the expression of adhesion molecules, allowing tumor cells to invade surrounding tissues and make them capable of metastasizing. In this regard, we initiated a study on the immunohistochemical expression of Integrin alphavbeta6 (Integrin αvβ6), CD44 and Ezrin in OSCCs. A number of 39 such tumors with various locations in the oral cavity were investigated by enzymatic immunohistochemistry together with several samples of oral mucosa and oral dysplastic lesions. Using integrated optical density (IOD) as a method to quantify, we observed that the reactivity of these three markers decreased in the progression of dysplastic lesions and in the transition from well to moderately and poorly differentiated tumors. Also, in both conditions we noticed a shift of pattern reactivity from the continuous membrane to discontinuous membrane and cytoplasmic one, even to a nuclear pattern. In addition, the reactivity of the three markers was more evident in the invasion front and especially in these tumors with discohesive growth patterns. All this suggests the involvement of these adhesion molecules in the processes of transformation and malignant progression of OSCCs. It also explains their possible involvement in locoregional aggressiveness and LN dissemination.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"179-197"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic neuroendocrine tumors - going beyond surgery. Literature review and experience of a tertiary center.","authors":"Rucsandra Ilinca Diculescu, Mădălina Stan-Ilie, Christopher Jesse Vlad Pavel, Oana Mihaela Plotogea, Gabriel Constantinescu, Vasile Şandru, Doina Istrătescu, Valeriu Bogdan Popa, Valentin Enache, Săndica Nicoleta Bucurică, Cătălina Poiană","doi":"10.47162/RJME.66.1.02","DOIUrl":"10.47162/RJME.66.1.02","url":null,"abstract":"<p><strong>Background: </strong>Surgery is the standard therapy for pancreatic neuroendocrine tumors (pNETs), but since post-resection fistulae and other surgery related complications are common, new minimal invasive approaches are emerging. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a promising tool for pNETs, with a good safety profile and favorable results.</p><p><strong>Patients, materials and methods: </strong>This is a single-center, retrospective case series including all patients with functional (F) and non-functional (NF) pNETs treated with EUS-RFA in the Department of Gastroenterology, Emergency Clinical Hospital of Bucharest, Romania, between March 2023 and March 2024 and followed for a mean period of 11.6 months. Technical success, clinical, sonographic and radiological response, adverse events (AEs) rate and severity were assessed.</p><p><strong>Case series: </strong>A total of five out of nine EUS-RFA were performed for pNETs, with a majority of NF-pNETs. In this pNET group, the mean size of the lesions was 13 mm. Technical success was achieved in 100% of patients and persistent clinical remission of hypoglycemia in the insulinoma case was attained. In the NF-pNET subgroup, two patients were successfully radiologically treated with complete disappearance of the lesions, one lesion showed cystic transformation, and one had modest size reduction at follow-up imagery. One procedure-related early AE occurred: mild abdominal pain with quick resolution. No major complications, nor death were reported.</p><p><strong>Conclusions: </strong>Reports from this literature review and small case series suggest that EUS-RFA can be effective in both F- and NF-pNETs, offering the best combination of real-time imaging guidance and minimal invasiveness with no severe AEs and short hospital stay.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of inflammation in age-related macular degeneration: new insights and implications for future therapies.","authors":"Paul Gabriel Borodi, Mark Slevin","doi":"10.47162/RJME.66.1.04","DOIUrl":"10.47162/RJME.66.1.04","url":null,"abstract":"<p><p>The retina consists of one of the body's most delicate organs, being sensitive to various metabolic disturbances, vascular abnormalities and inflammatory processes. Age-related macular degeneration (AMD) impacts millions of people worldwide and represents a notable cause of blindness. Chronic inflammation, implicated in several degenerative diseases including Parkinson's and Alzheimer's diseases, as well as atherosclerosis, has been linked to AMD. Both histopathological and genetic investigations have underscored the immune system's role in AMD progression. The objective of this literature review was to summarize the actual knowledge, identify research gaps and to serve as a basis for future studies regarding the correlations between inflammation and AMD. We conducted a thorough search of the primary databases (Web of Science, Cochrane Library, PubMed/MEDLINE), using keywords such as 'age-related macular degeneration', 'inflammation', 'neurodegeneration', and 'C-reactive protein'. We included systematic reviews and meta-analyses that offer the most relevant results in this research area. We also included the results from recent studies that have not yet been widely approached. Our strategy also consisted of looking for relevant articles in the reference list.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"51-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematomyelia after epidural anesthesia: a rare complication with putative multifactorial and occult etiology.","authors":"Gabriela Camelia Roşu, Ionica Pirici, Andrei Osman, Larisa Iovan, Ilona Mihaela Liliac, Cristina Jana Busuioc, Valentin Octavian Mateescu, Roberta Andreea Cercel, Florina Carmen Popescu, Mihai Marius Botezat","doi":"10.47162/RJME.66.1.07","DOIUrl":"10.47162/RJME.66.1.07","url":null,"abstract":"<p><p>Subarachnoid hemorrhage (SAH) and spinal hematomas are considered serious but rare complications of spinal pathology. They occur after spinal anesthesia, especially in patients with risk factors such as autoimmune diseases, blood coagulation pathology, anticoagulant treatment, vascular malformations, intramedullary or spinal cord tumors, or can be multifactorial. Usually, anticoagulant therapy represents an additional factor regarding spinal SAH (SSAH) or spinal hematomas. None of the direct oral anticoagulants has a higher chance of producing a spinal hemorrhage. The diagnosis can be established based on the clinical picture of SSAH or myelopathy syndrome, completed with magnetic resonance imaging (MRI). In this study, we present the latest data from the literature regarding SSAH and hematomas and compare them with the data of a 77-year-old man with a history of atrial fibrillation, on oral anticoagulant treatment, who developed a SSAH and spinal hematoma after elective surgery for an inguinal hernia.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"81-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}