Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie最新文献

{"title":"Hip osteoarthritis - histopathological aspects.","authors":"Anton Tiberiu Paraliov, Răzvan Marius Vicaş, Rodica Dîrnu, Natalia Guţă, Lucreţiu Radu, Laurenţiu Mogoantă, Laura Corina Nicolescu","doi":"10.47162/RJME.66.1.20","DOIUrl":"10.47162/RJME.66.1.20","url":null,"abstract":"<p><p>Osteoarthritis is a complex, degenerative disease that can affect all the anatomical structures of the synovial joints. Most frequently, the joints of the hand, hip, and knee are affected, especially in the elderly patients. In our study, we evaluated 27 femoral heads, examining the histopathological changes that occurred in the articular cartilage, subchondral bone, and perisynovial soft tissues. At the level of the articular cartilage, there were observed a reduction in thickness, deformation of the articular surface, degradation of the cartilaginous matrix, the occurrence of fissures or fractures in the cartilaginous piece, a reduction in the number of chondrocytes, and changes in their morphology. In the subchondral bone, a rarefaction of the bone trabeculae and a reduction in their thickness were observed, along with an increase in the size of the alveolar cavities. These changes were accompanied by the formation of cystic cavities, non-homogeneous hypertrophy of the subchondral bone plate as a response to the reduction in thickness and change of the articular cartilage structure, or the reduction in the thickness of the subchondral bone plate. The trabecular bone exhibited an atrophic endosteum, absence of bone remodeling processes, cracks or even fractures in the trabecular bone. Likewise, we observed rare ectopic osteogenesis processes, either endochondral or desmal ones, forming osteophytes. The synovium and perisynovial connective tissue contained immune cells, vascular endothelial cells, fibroblasts, adipocytes, and other mesenchymal-derived stromal cells. The immunohistochemical study highlighted the presence of T-lymphocytes, B-lymphocytes, and macrophages, cells capable of synthesizing and releasing matrix metalloproteinases that are involved in the degradation of the articular cartilage. Exploration of cell proliferative capacity using the proliferating cell nuclear antigen (PCNA) showed that, in the articular cartilage, there are few cells (chondrocytes) capable of proliferation, while in the synovium there are numerous young fibroblasts capable of mitotic division.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"217-227"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 - multisystem disease.","authors":"Roberta Andreea Cercel, Florin Ionuţ Buibaş, Mircea Sebastian Şerbănescu, Adina Andreea Mirea, Florentina Dumitrescu, Ionica Pirici, Oana Badea-Voiculescu, Laurenţiu Mogoantă, Mihai Marius Botezat","doi":"10.47162/RJME.66.1.05","DOIUrl":"10.47162/RJME.66.1.05","url":null,"abstract":"<p><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), caused a global public health crisis, with a significant impact on multiple body systems. This virus, a member of the Coronaviridae family, shows ~80% genomic similarity to SARS-CoV and ~50% genomic similarity to Middle East respiratory syndrome coronavirus (MERS-CoV). The spike (S) protein plays an essential role in the pathogenesis of the virus, as it facilitates its entry into host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. In addition to the respiratory system damage, SARS-CoV-2 infection causes a variety of gastrointestinal (GI), neurological, cardiovascular (CV), ocular, renal, etc. clinical manifestations. Neurological complications, such as anosmia, ague, headache, encephalitis and cerebrovascular events, were frequently observed, being attributed to both direct viral invasion and a very strong systemic inflammatory response. GI symptoms such as diarrhea, nausea and vomiting are common and may occur independently of respiratory symptoms, and the presence of viral ribonucleic acid (RNA) detected in fecal samples suggests possible fecal-oral transmission. The CV system is affected by myocardial damage, inflammation and coagulation disorders, with an increased risk of thromboembolic events. At the ocular level, the virus was identified in ocular secretions, and conjunctivitis, uveitis and episcleritis were observed in about 11% of patients. Renal involvement, manifested by acute kidney injury, was detected in 0.5-7% of cases. In conclusion, SARS-CoV-2 infection is not limited to respiratory tract involvement but also has significant systemic implications.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathology assessment of inflammatory bowel disease - prospective study from two referral centers.","authors":"Christopher Jesse Vlad Pavel, Gabriel Constantinescu, Valentin Enache, Gabriel Becheanu, Mădălina Stan-Ilie, Vasile Şandru, Oana Mihaela Plotogea, Alexandru Constantinescu, Dan Ionuţ Gheonea, Bogdan Silviu Ungureanu, Horia Dan Lişcu, Mihai Mircea Diculescu, Alex Emilian Stepan","doi":"10.47162/RJME.66.1.19","DOIUrl":"10.47162/RJME.66.1.19","url":null,"abstract":"<p><p>We aimed to perform a comprehensive prospective histological analysis in a cohort of 40 inflammatory bowel disease (IBD) patients, both prior to and during biological therapy. The main objective was to establish the impact of histological activity in assessing treatment response and therapy guidance. Biopsy samples were assessed in two different stages of the disease course - before introduction of biological therapy and during follow-up (6-12 months later). Clinical, biochemical and endoscopic parameters were simultaneously gathered. By univariate analysis, presence of lymphoid aggregates, mucin depletion and ulcerations had a strong association with treatment response. IBD diagnosis >5 years and previous biological therapy were the most susceptible to treatment non-response. Nancy Index (NI) >1 is highly accurate, sensitive and specific in defining treatment responders. In addition to NI, high histological burden (mucin depletion, lymphoid aggregates and ulcerations) seems to predict treatment response in biological therapy-treated patients. Instead of a stringent \"histological remission\" goal, histological improvement of individual parameters might be a more reasonable goal, avoiding the risk of overtreatment. Further research is needed to assess histological burden in patients with endoscopic remission in order to stratify low- vs. high-risk \"relapsers\" and to avoid under- or over-treatment.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"205-215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cardiac lymphoma: autopsy case report and literature review.","authors":"Vladimír Tancoš, Peter Bohuš, Lucia Fröhlichová, Alžbeta Blichárová, Dorota Sopková","doi":"10.47162/RJME.66.1.23","DOIUrl":"10.47162/RJME.66.1.23","url":null,"abstract":"<p><p>Primary cardiac lymphoma (PCL), defined as extranodal non-Hodgkin's lymphoma involving exclusively the heart and∕or pericardium, is a neoplasm with an extremely low incidence, a high degree of malignancy, and a poor prognosis. It comprises 0.5% of all extranodal lymphomas and 1-2% of all primary cardiac tumors, while the most commonly reported subtype is diffuse large B-cell lymphoma (DLBCL). The tumor is more common in immunocompromised patients compared with those who are immunocompetent. Modern imaging methods now allow for earlier detection of these tumors, despite their variable clinical manifestation, which is often a cause of misdiagnosis. We present an autopsy case of undiagnosed PCL in an immunocompetent 72-year-old man, where postmortem examination revealed massive tumor infiltration of the right-sided heart chambers extending to the left ventricle. Histological analysis showed microscopic tumor infiltration within the left atrium as well. A diagnosis of DLBCL of non-germinal subtype was made based on immunohistochemistry.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":"66 1","pages":"245-250"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal obesity and placental pathology in correlation with adverse pregnancy outcome.","authors":"Maria Carmen Tabacu,&nbsp;Anca Maria Istrate-Ofiţeru,&nbsp;Maria Magdalena Manolea,&nbsp;Anda Lorena Dijmărescu,&nbsp;Luciana Teodora Rotaru,&nbsp;Mihail Virgil Boldeanu,&nbsp;Mircea Sebastian Şerbănescu,&nbsp;Adriana Tudor,&nbsp;Marius Bogdan Novac","doi":"10.47162/RJME.63.1.09","DOIUrl":"https://doi.org/10.47162/RJME.63.1.09","url":null,"abstract":"<p><p>Maternal obesity is associated with increased maternal and fetal morbidity and mortality, with an increased risk of gestational diabetes mellitus (GDM) and preeclampsia (PE). This prospective study histopathologically analyzes the placentas obtained from 34 pregnant obese women studied between October 2016 and May 2020. The 10 cases of term placentas from obese pregnancies with GDM and the 12 cases with PE were examined by the Hematoxylin-Eosin (HE), Masson's trichrome (MT) and Periodic Acid-Schiff-Hematoxylin (PAS-H) classical stainings, and by the immunohistochemical evaluation and compared to placentae from uncomplicated term obese pregnancies (12 cases). We did not meet placental histopathological (HP) abnormalities that we could classify as characteristic only for the state of obese pregnancy, but we did find placental changes associated with PE and GDM, in the context of obese pregnancy. In the case of association with PE, there were common lesions, manifested by intra- and perivillous fibrinoid deposition, calcification, and placental infarction area, to which were added numerous syncytial knots. In the case of obese pregnancy associated with GDM, we found, in addition to common placental lesions of obesity, intravillositary vascular edema and in the terminal villi appearing chorangiosis. This study revealed a number of HP changes that occur in maternal obesity, even in uncomplicated obese pregnancies. A characteristic of obese pregnancies associated with PE was the presence of numerous syncytial knots, and in obese pregnancies associated with GDM, the most common HP lesion was placental chorangiosis. Certainly, we cannot conclude that these HP lesions are specific to a particular pathology, but they belong primarily to the status of maternal obesity.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"99-104"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/54/RJME-63-1-99.PMC9593134.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated hypoplastic right ventricle - a challenge in medical practice.","authors":"Eliza Elena Cinteză,&nbsp;Alin Marcel Nicolescu,&nbsp;Mihaela Adela Iancu,&nbsp;Gabriela Ganea,&nbsp;Matei Dumitru,&nbsp;Gheorghe Gindrovel Dumitra","doi":"10.47162/RJME.63.1.04","DOIUrl":"https://doi.org/10.47162/RJME.63.1.04","url":null,"abstract":"Isolated right ventricle hypoplasia (IRVH) is a disease characterized by an underdeveloped right ventricle. It is a congenital heart disease than can associate heterogeneous structural defects and nonspecific clinical features, which can often present a challenging therapeutic management. In this article, there are presented diagnostic methods and treatment options for right ventricle hypoplasia (RVH) according to clinical features, patients age and associated structural heart defects. RVH has a different prognosis in accordance with the severity of the heart defects and the patient’s age at which the diagnosis is established. Thus, isolated forms of RVH generally present mild structural and functional defects that can be associated with the onset of symptoms in adolescence or even in adulthood. In these cases, atrial septal defect closure with or without superior cavo-pulmonary anastomosis can be the only procedures needed to correct the hemodynamic abnormalities and relief the symptomatology. Patients with severe form of RVH associated with complex cardiac malformations and onset of the symptoms in the neonatal period require prompt intervention and necessitate palliative procedures. In the long term, these patients could need multiple reinterventions. The family physician should be aware of the cardiac origin of isolated symptoms or clinical signs, such as exertional dyspnea or clubbing fingers, and send the patient for pediatric cardiological evaluation.","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"49-53"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/04/8c/RJME-63-1-49.PMC9593115.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33452182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current approach of juvenile nasopharyngeal angiofibroma: a case series.","authors":"Andreea Nicoleta Vlăescu,&nbsp;Elena Ioniţă,&nbsp;Mircea Sorin Ciolofan,&nbsp;Carmen Aurelia Mogoantă,&nbsp;Cătălina Voiosu,&nbsp;Andreea Rusescu,&nbsp;Răzvan Hainăroşie","doi":"10.47162/RJME.63.1.10","DOIUrl":"https://doi.org/10.47162/RJME.63.1.10","url":null,"abstract":"Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor that affects predominantly males and is known by its highly vascular character. We have performed a 3-year retrospective study of patients with JNA surgically treated within the third ENT Department of Prof. Dr. Dorin Hociotă Institute of Phonoaudiology and Functional ENT Surgery, Bucharest, Romania. In all the cases, the patients were investigated both clinically and through medical imaging before surgery and all tumors were embolized. Our study comprised of eight cases, of which seven were solved by endoscopic endonasal approach and one case was treated through a combined endonasal–external approach. JNA should always be managed through a multidisciplinary team (MDT) approach in centers with adequate experience, to gain favorable results.","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"105-111"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/be/RJME-63-1-105.PMC9593122.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The analysis of hormonal status and vascular and cell proliferation in endometrioid endometrial adenocarcinomas.","authors":"Ileana Drocaş,&nbsp;Ştefania Crăiţoiu,&nbsp;Alex Emilian Stepan,&nbsp;Dominic Gabriel Iliescu,&nbsp;Ioan Andrei Drocaş,&nbsp;Mioara Desdemona Stepan","doi":"10.47162/RJME.63.1.11","DOIUrl":"https://doi.org/10.47162/RJME.63.1.11","url":null,"abstract":"<p><p>Endometrioid endometrial carcinomas (EECs) are the most common malignancies of the uterus. Hormonal dependence of EEC, in relation to biomolecular mechanisms involved in tumor progression, such as angiogenesis and cell proliferation, are aspects that can contribute to improving the prognosis of patients. We analyzed the immunoexpression of markers addressed to steroid hormone receptors [estrogen receptor (ER), progesterone receptor (PR)], angiogenesis [cluster of differentiation (CD)105∕endoglin] and cell proliferation (Ki-67) in 50 EECs related to the histopathological prognostic criteria of the lesions. In this study, the ER and PR scores were higher in low grade and early stages EEC, the statistical aspects being variable. The CD105 microvessel density and the Ki-67 proliferation index were superior in high grade and advanced stages EEC, the statistical aspects being significant or at the limit of significance. The ER∕PR and CD105∕Ki-67 immunomarker groups indicated a positive linear intragroup relation and a negative linear intergroup relation, suggesting the presence of synergistic and antagonistic molecular mechanisms of tumor endometrial control that can be used to stratify patients for targeted therapy.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"113-120"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/ca/RJME-63-1-113.PMC9593126.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal, apoptotic, proliferative and inflammatory markers' expression in Desogestrel-treated women with ovarian endometriosis.","authors":"Daniela Roxana Matasariu,&nbsp;Ludmila Lozneanu,&nbsp;Irina Dumitraşcu,&nbsp;Mihaela Grigore,&nbsp;Alexandra Elena Cristofor,&nbsp;Cristina Elena Mandici,&nbsp;Iuliana Elena Bujor,&nbsp;Alexandra Ursache,&nbsp;Anca Daniela Brăila,&nbsp;Alexandra Bauşic,&nbsp;Romeo Micu","doi":"10.47162/RJME.63.1.14","DOIUrl":"https://doi.org/10.47162/RJME.63.1.14","url":null,"abstract":"<p><p>Endometriosis is a relatively frequent pathology in gynecological practice. We performed an analysis to demonstrate the molecular changes that occur in endometriosis synthetic progestin-treated patients, hoping to sketch a possible pathophysiological pathway that will help us to better understand and treat this debilitating disease. We conducted a prospective study that included a group of 40 women, evaluated in our hospital between 2020-2021. We evaluated immunohistochemical tissue expression of estrogen receptor (ER), progesterone receptor (PR), B-cell lymphoma 2 (Bcl-2) protein, Ki-67, and serum levels of osteopontin (OPN) and vascular endothelial growth factor (VEGF) in patients with ovarian endometrioma with and without progestin treatment. Our study revealed that Desogestrel treatment increases OPN serum levels, PR and Bcl-2 tissue expression and reduces VEGF serum levels and Ki-67 tissue expression. The results we have obtained are very interesting because the serum levels of OPN seem to be more influenced by progestin treatment, than by endometriosis itself. The study we have conducted gives a molecular complex view of what endometriosis represents and on how Desogestrel treatment works.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"137-144"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/a7/RJME-63-1-137.PMC9593118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of genetic and immunohistochemical markers in understanding abnormalities in aging retina.","authors":"Delia Maria Ormenişan,&nbsp;Angela Borda","doi":"10.47162/RJME.63.1.12","DOIUrl":"https://doi.org/10.47162/RJME.63.1.12","url":null,"abstract":"<p><p>The aim of the study was to better understand the interplay between genetic factors and the aging process in the human retina through mapping complement factor H (CFH) and related proteins. Two human eyes, from 92- and 64-year-old donors, were genotyped for the expression of CFH-related 1 (CFHR1) and CFH-related 3 (CFHR3) genes. Deoxyribonucleic acid (DNA) was extracted and analyzed for concentration and purity with a spectrophotometer, at 260 nm. The results showed a DNA concentration of 469.17 ng∕μL in the aged retina and of 399.20 ng∕μL in the younger one. Through polymerase chain reaction (PCR) genotyping, the DNA CFHR1 and CFHR3 were visible as bands of 175 bp and 181 bp. Immunohistochemistry by immunofluorescence method was used with a panel of specific antibodies for CFH, CFHR1, CFHR3 and GFAP, a marker for Müller cells. All the samples were examined, and images captured using confocal microscopy. In the younger retina, CFH was localized in the inner plexiform layer and below the outer nuclear layer, while in the aged retina, it was found in the photoreceptors. CFH was also detected in the choriocapillaris and within the end-feet of the Müller cells. Our controls showed autofluorescence of the retinal pigment epithelium shedding light on a false positive CFH immunostaining of this layer. GFAP immunoreactivity highlighted an increased gliosis within the aged retina. CFHR3 signal was found in the microglia, while CFHR1 was detected in the choriocapillaris. In summary, underpinning the expression of these components can show the potential involvement of these modulators in implementing new treatment strategies.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"121-127"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/0a/RJME-63-1-121.PMC9593114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}