Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie最新文献

{"title":"The quality of colorectal polypectomy. Is it enough to have just a visual assessment of the site?","authors":"Mihaela Caliţa,&nbsp;Dan Nicolae Florescu,&nbsp;Costin Teodor Streba,&nbsp;Andreea Doriana Stănculescu,&nbsp;Mirela Marinela Florescu,&nbsp;Petrică Popa,&nbsp;Dan Ionuţ Gheonea,&nbsp;Carmen Nicoleta Oancea,&nbsp;Adrian Săftoiu","doi":"10.47162/RJME.61.4.31","DOIUrl":"https://doi.org/10.47162/RJME.61.4.31","url":null,"abstract":"<p><strong>Introduction: </strong>Performing a colonoscopy allows the examination of the entire colon and the assessment of polyps.</p><p><strong>Patients, materials and methods: </strong>We performed a retrospective analysis of prospectively collected data from January 2018 until February 2020 (two years), in which we enrolled a number of 210 patients performing colonoscopy in the Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania. We performed 326 polypectomies.</p><p><strong>Results: </strong>We classified the polyps into diminutive (n=169), small (n=103) and large polyps (n=54). Regarding the polypectomy technique, our results indicated that 40 out of 48 (83.3%) polypectomies with the biopsy forceps were complete, as well as 27 out of 31 (87.1%) cold snare polypectomies and 12 out of 14 (85.7%) hot snare polypectomies. The differences were not statistically significant (p=0.116). Regarding the number of incomplete polypectomies, our data suggests that the high expertise endoscopist had two incomplete resections (5.1% of total), the medium expertise endoscopist 1 had also two incomplete resections (11.1% of total), the medium expertise endoscopist 2 had three incomplete resections (15% of total), the limited expertise endoscopist 1 had three incomplete resections (27.27% of total) and the limited expertise endoscopist 2 had four incomplete resections (30.76% of total). Analyzing the data, the differences were statistically significant (p=0.006).</p><p><strong>Conclusions: </strong>Our study is able to suggest that high-definition white-light endoscopy (HD-WLE) macroscopic visualization of the polyp resection site is not enough to assess complete polyp resection and follow-up colonoscopy should be performed for cases with incomplete margins of resection.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1301-1307"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/ed/RJME-61-4-1301.PMC8343597.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39127242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics of congenital solid tumors.","authors":"Maria Claudia Jurcă,&nbsp;Marius Evelin Ivaşcu,&nbsp;Aurora Alexandra Jurcă,&nbsp;Kinga Kozma,&nbsp;Ioan Magyar,&nbsp;Mircea Ioan Şandor,&nbsp;Alexandru Daniel Jurcă,&nbsp;Dana Carmen Zaha,&nbsp;Cristina Crenguţa Albu,&nbsp;Carmen Pantiş,&nbsp;Marius Bembea,&nbsp;Codruţa Diana Petcheşi","doi":"10.47162/RJME.61.4.06","DOIUrl":"https://doi.org/10.47162/RJME.61.4.06","url":null,"abstract":"<p><p>When we discuss the genetics of tumors, we cannot fail to remember that in the second decade of the twentieth century, more precisely in 1914, Theodore Boveri defined for the first time the chromosomal bases of cancer. In the last 30 years, progresses in genetics have only confirmed Boveri's remarkable predictions made more than 80 years ago. Before the cloning of the retinoblastoma 1 (RB1) gene, the existence of a genetic component in most, if not all, solid childhood tumors were well known. The existence of familial tumor aggregations has been found much more frequently than researchers expected to find at random. Sometimes, the demonstration of this family predisposition was very difficult, because the survival of children diagnosed as having a certain tumor, up to an age at which reproduction and procreation is possible, was very rare. In recent years, advances in the diagnosis and treatment of these diseases have made it possible for these children to survive until the age when they were able to start their own families, including the ability to procreate. Four distinct groups of so-called cancer genes have been identified: oncogenes, which promote tumor cell proliferation; tumor suppressor genes, which inhibit this growth/proliferation; anti-mutational genes, with a role in deoxyribonucleic acid (DNA) stability; and micro-ribonucleic acid (miRNA) genes, with a role in the posttranscriptional process.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1039-1049"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/8a/RJME-61-4-1039.PMC8343493.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39105553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk stratification of papillary thyroid microcarcinomas via an easy-to-use system based on tumor size and location: clinical and pathological correlations.","authors":"Emőke Andrea Szász,&nbsp;Adela Corina Nechifor-Boilă,&nbsp;Ancuţa Elena Zahan,&nbsp;Toader Septimiu Voidăzan,&nbsp;Angela Borda","doi":"10.47162/RJME.61.4.17","DOIUrl":"https://doi.org/10.47162/RJME.61.4.17","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to determine whether two clinically accessible parameters, tumor size and location within the thyroid, correlate with clinicopathological features that are predictors of high risk in papillary thyroid microcarcinomas (PTMCs).</p><p><strong>Materials and methods: </strong>PTMC cases were obtained from the database of the Department of Pathology, Emergency County Hospital, Târgu Mureş, Romania. Four tumor groups were created based on tumor size and location: Group I (≥5 mm, subcapsular), Group II (≥5 mm, nonsubcapsular), Group III (<5 mm, subcapsular), and Group IV (<5 mm, nonsubcapsular) PTMCs. Clinicopathological features and follow-up data were compared by univariate and multivariate analysis.</p><p><strong>Results: </strong>Our study included 164 PTMCs (n=70/20/19/55 in Groups I∕II∕III∕IV, respectively). High-grade morphological features, such as plump pink cells (p=0.010), tumor desmoplasia (p=0.022) and sclerosis (p=0.001), infiltrative tumor borders (p=0.005), positive resection margins (p=0.005), invasion into the perithyroid adipose tissue (p=0.001), irregular nuclear membranes (p=0.004), and pseudoinclusions (p=0.001) were significantly more prevalent among Group I PTMCs. Group IV PTMCs were characterized by a paucity of the above-mentioned morphological features, while Group II and III PTMCs displayed intermediate morphological profiles.</p><p><strong>Conclusions: </strong>Group I PTMCs proved to be associated with more aggressive morphological features and might need a more careful clinical approach.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1153-1162"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/dd/RJME-61-4-1153.PMC8343526.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39106501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodistribution of essential oil-conjugated silver nanoparticles.","authors":"Oana Gherasim,&nbsp;Alexandru Mihai Grumezescu,&nbsp;George Dan Mogoşanu,&nbsp;Bogdan Ştefan Vasile,&nbsp;Cornelia Bejenaru,&nbsp;Ludovic Everard Bejenaru,&nbsp;Ecaterina Andronescu,&nbsp;Laurenţiu Mogoantă","doi":"10.47162/RJME.61.4.12","DOIUrl":"https://doi.org/10.47162/RJME.61.4.12","url":null,"abstract":"<p><p>The beneficial synergy between antimicrobial silver nanoparticles (AgNPs) and essential oils (EOs), with therapeutic effects that have been acknowledged and explored for a long time, opens the way towards developing new and promising alternatives for anti-infective therapies. With the aim to improve the cytocompatibility and stability of AgNPs and to overcome the volatilization of EOs, AgNPs conjugated with sage (Salvia officinalis) and cinnamon (Cinnamomum aromaticum) EOs were obtained in our study. The synthesis process was realized either by classical or ultrasound-assisted chemical reduction. Compositional and microstructural characterization of the as-obtained Ag@EO NPs was performed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The biodistribution of Ag@EO NPs was evaluated on a mouse animal model.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1099-1109"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/aa/RJME-61-4-1099.PMC8343476.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39106497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium fructoborate coating of titanium-hydroxyapatite implants by chemisorption deposition improves implant osseointegration in the femur of New Zealand White rabbit experimental model.","authors":"Renata Maria Văruţ,&nbsp;Petru Răzvan Melinte,&nbsp;Andreea Silvia Pîrvu,&nbsp;Oana Gîngu,&nbsp;Gabriela Sima,&nbsp;Carmen Nicoleta Oancea,&nbsp;Alina Cristina Teişanu,&nbsp;Gheorghe Drăgoi,&nbsp;Andrei Biţă,&nbsp;Horia Octavian Manolea,&nbsp;Ioana Mitruţ,&nbsp;Otilia Constantina Rogoveanu,&nbsp;Ion Scorei Romulus,&nbsp;Johny Neamţu","doi":"10.47162/RJME.61.4.25","DOIUrl":"https://doi.org/10.47162/RJME.61.4.25","url":null,"abstract":"<p><strong>Background: </strong>The identification of biocomposites that improve cell adhesion and reduce bone integration time is a great challenge for implantology and bone reconstruction.</p><p><strong>Aim: </strong>Our aim was to evaluate a new method of chemisorption deposition (CD) for improving the biointegration of hydroxyapatite-coated titanium (HApTi) implants. CD method was used to prepare a calcium fructoborate (CaFb) coating on a HApTi (HApTiCaFb) implant followed by evaluation of histological features related to bone healing at the interface of a bioceramic material in an animal model.</p><p><strong>Methods: </strong>The coating composition was investigated by high-performance thin-layer chromatography/mass spectrometry. The surface morphology of the coating was studied by scanning electron microscopy (SEM), before and after the in vitro study. We implanted two types of bioceramic cylinders, HApTi and HApTiCaFb, in the femur of 10 New Zealand White (NZW) rabbits.</p><p><strong>Results: </strong>The release of CaFb from HApTiCaFb occurred rapidly within the first three days after phosphate-buffered saline immersion; there was then a linear release for up to 14 days. SEM analysis showed similar morphology and particle size diameter for both implants. Around the porous HApTiCaFb implant, fibrosis and inflammation were not highlighted.</p><p><strong>Conclusions: </strong>Easily applied using CD method, CaFb coatings promote HApTi implant osseointegration in the femur of NZW rabbits.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1235-1247"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/94/RJME-61-4-1235.PMC8343473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39107869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipocytes, mast cells and angiogenesis.","authors":"Domenico Ribatti,&nbsp;Tiziana Annese,&nbsp;Roberto Tamma","doi":"10.47162/RJME.61.4.07","DOIUrl":"https://doi.org/10.47162/RJME.61.4.07","url":null,"abstract":"<p><p>Healthy adipose tissue contains a wide variety of innate and adaptive immune cells, including macrophages, dendritic cells, mast cells, eosinophils, neutrophils, and lymphocytes. Numerous signaling molecules in the adipose microenvironment can positively or negatively modulate angiogenic processes, regulate the interaction between the vascular system and adipocytes, and participate in tumor progression. Mast cells are involved in the new formation or metabolism of fat, are present in abundant quantities in fatty tissue, among fat cells, and a number of mediators released from mast cells play a role in adipogenesis. Moreover, mast cells produce several pro-angiogenic factors and are involved in tumor angiogenesis. In this context, the angiogenic effect might be amplified when the adipocytes and mast cells act in concert, and treatment of adipose tissue- and mast cell-associated cancers with anti-angiogenic drugs may represent an alternative or adjuvant strategy for the treatment of these tumors.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1051-1056"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/15/RJME-61-4-1051.PMC8343648.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39105554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue microarrays - brief history, techniques and clinical future.","authors":"Alina Elena Ştefan,&nbsp;Daniela Gologan,&nbsp;Matthew O Leavitt,&nbsp;Sorin Muşat,&nbsp;Iancu Emil Pleşea,&nbsp;Liane Gloria Raluca Stan,&nbsp;Răzvan Mihail Pleşea,&nbsp;Manuella Militaru","doi":"10.47162/RJME.61.4.10","DOIUrl":"https://doi.org/10.47162/RJME.61.4.10","url":null,"abstract":"<p><strong>Introduction and aim: </strong>There is a growing need for better, cheaper and faster histopathological diagnostic. The authors reviewed the main steps of the efforts towards the improvement of the pre-analytical phase of tissue processing for histological examination.</p><p><strong>Results: </strong>Since their introduction decades ago tissue microarrays (TMAs) proved their value by increasing efficiency, standardization and accuracy of many histological techniques, such as histochemistry, histoenzymology, immunohistochemistry, in situ hybridization, etc. By allowing the simultaneous analysis and comparison of multiple different tissues on a single histology slide (up to 1000 individual samples), TMAs are also having a significant economic advantage (consumables and labor). From its first description until recent years, the TMA techniques have evolved steadily but slowly despite many attempts to adapt it for clinical diagnostics. In this paper, we are reviewing the main techniques of obtaining TMA blocks from the beginning to the present day, as well as recent developments that are expanding their scope into high accuracy/efficiency clinical diagnostics.</p><p><strong>Conclusions: </strong>Considering recent developments, we believe that the prospect of high-throughput histology might be achievable in the not-so-distant future.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1077-1083"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/25/RJME-61-4-1077.PMC8343478.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39105557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fortuitous discovery of melanomas in the ENT Department - a histopathological and immunohistochemical study.","authors":"Cornelia Marina Trandafir,&nbsp;Alina Andreea Tischer,&nbsp;Ioana Delia Horhat,&nbsp;Nicolae Constantin Balica,&nbsp;Adrian Mihail Sitaru,&nbsp;Kristine Guran,&nbsp;Raluca Morar,&nbsp;Flavia Baderca,&nbsp;Emilia Manuela Jifcu,&nbsp;Ion Cristian Moţ,&nbsp;Ovidiu Nicolae Burlacu,&nbsp;Mărioara Poenaru,&nbsp;Cristian Andrei Sarău","doi":"10.47162/RJME.61.4.18","DOIUrl":"https://doi.org/10.47162/RJME.61.4.18","url":null,"abstract":"<p><p>The melanoma, having its origin in the melanocyte cells, is one of the most aggressive forms of skin cancer in the world with one of the highest rates of brain metastasis. The incidence of cutaneous melanoma in the Mediterranean countries varies from three to five cases∕100 000 people∕year. Its prognosis is based on an early diagnosis. Sinonasal mucosal melanoma (SNMM) is an extremely rare tumor, accounting for 0.3-2% of all melanomas. The non-specific symptomatology is often delaying the presentation of the patient at the hospital and therefore the diagnosis. The SNMM is a highly aggressive tumor, and the presence of metastasis at the diagnosis usually implies a poor prognosis. The management of the melanomas requires a precise pre-therapeutic assessment and a multidisciplinary approach for the diagnosis, with surgical treatment or radiotherapy required in order to ensure a better a quality of life. In this paper, we retrospectively analyzed two cases of mucosal melanoma and one case of cutaneous melanoma of the nose.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"1163-1171"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/0c/RJME-61-4-1163.PMC8343656.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39106499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis.","authors":"Carmen Stanca Melincovici,&nbsp;Adina Bianca Boşca,&nbsp;Sergiu Şuşman,&nbsp;Mariana Mărginean,&nbsp;Carina Mihu,&nbsp;Mihnea Istrate,&nbsp;Ioana Maria Moldovan,&nbsp;Alexandra Livia Roman,&nbsp;Carmen Mihaela Mihu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vascular endothelial growth factor (VEGF) represents a growth factor with important pro-angiogenic activity, having a mitogenic and an anti-apoptotic effect on endothelial cells, increasing the vascular permeability, promoting cell migration, etc. Due to these effects, it actively contributes in regulating the normal and pathological angiogenic processes. In humans, the VEGF family is composed of several members: VEGF-A (which has different isoforms), VEGF-B, VEGF-C, VEGF-D, VEGF-E (viral VEGF), VEGF-F (snake venom VEGF), placenta growth factor (PlGF), and, recently, to this family has been added endocrine gland-derived vascular endothelial growth factor (EG-VEGF). VEGF binds to tyrosine kinase cell receptors (VEGFRs): VEGFR-1 [Fms-like tyrosine kinase 1 (Flt-1)], VEGFR-2 [kinase insert domain receptor (KDR) in human; fetal liver kinase 1 (Flk-1) in mouse] and VEGFR-3 [Fms-like tyrosine kinase 4 (Flt-4)]. While VEGFR-1 and VEGFR-2 are expressed predominantly on vascular endothelial cells, VEGFR-3 is expressed especially on lymphatic endothelial cells. VEGFR-2 has the strongest pro-angiogenic activity and a higher tyrosine kinase activity than VEGFR-1. Endothelial cells also express co-receptors, such as neuropilin-1 (NP-1) and neuropilin-2 (NP-2), which modulate tyrosine kinase receptor activity. Both VEGF and VEGFRs are expressed not only on endothelial cells, but also on non-endothelial cells. This article aims to highlight the most recent data referring to the VEGF family and its receptors, as well as its implications in the angiogenesis process. At present, blocking angiogenesis in cancer or in other pathological processes, using anti-VEGF and anti-VEGFRs therapies, is considered to be extremely important.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"455-467"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36450465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remember: Ambroise Paré (1510-1590) - message for young surgeons.","authors":"Cristian Constantin Popa,&nbsp;Andrei Alexandru Marinescu,&nbsp;Aurel George Mohan,&nbsp;Mircea Vicenţiu Săceleanu,&nbsp;Alexandru Vlad Ciurea","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ambroise Paré was a renowned French barber-surgeon, considered by many to be \"the father of surgery\". Originating from a family of barber-surgeons, he unraveled the secrets surgery at an early age, and he masters it by participating in the many military actions of the French Army of those times. As recognition of his merits, the kings of France proclaimed him their chief barber-surgeon and even president of the Royal College of French Surgeons. He was a doctor endowed with many qualities and contributed to the development of many medical specialties. Ambroise Paré has brought many contributions and innovations to the development of medicine. Worldwide, his name is closely related to the use of surgical hemostasis. As a true Professor, he offered his entire medical experience through the publication of 25 manuscripts that address various medical specialties. Perseverant and perfectionist by nature, Ambroise Paré represents a true role model for generations of surgeons to come.</p>","PeriodicalId":520773,"journal":{"name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","volume":" ","pages":"637-640"},"PeriodicalIF":1.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36455119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}