Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society最新文献_第8页

Vitelline Vessel Remnant-Derived Funisitis Is a Sensitive and Specific Predictor of Histological Evidence of Amniotic Fluid Infection. 卵黄血管残余物源性输卵管炎是羊水感染组织学证据的敏感和特异性预测因子。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 Epub Date: 2021-07-21 DOI: 10.1177/10935266211033271

John Kemuel De Guzman, Weiming Yu, Lawrence de Koning, Christopher Horn, James R Wright

{"title":"Vitelline Vessel Remnant-Derived Funisitis Is a Sensitive and Specific Predictor of Histological Evidence of Amniotic Fluid Infection.","authors":"John Kemuel De Guzman, Weiming Yu, Lawrence de Koning, Christopher Horn, James R Wright","doi":"10.1177/10935266211033271","DOIUrl":"https://doi.org/10.1177/10935266211033271","url":null,"abstract":"Background: 4-11% of umbilical cords contain vitelline vessel remnants (VVRs). A recent study has described neutrophilic inflammation arising from VVRs and suggested an association with amniotic fluid infection (AFI).Methods: During routine placental pathology sign-out over a six month period, we identified 70 cords with VVRs. HE-stained sections were re-examined for \"VVR-derived funisitis,\" which was classified as low or high grade/stage based upon whether neutrophils were present only in Wharton's jelly near the VVRs or whether neutrophils were also present near the cord's amniotic surface. The same placentas were also examined for histologic evidence of AFI (maternal response = acute chorionitis or chorioamnionitis vs. fetal response = chorionic vasculitis, umbilical vasculitis, or funisitis vs. both).Results: Neutrophilic inflammation arising from VVRs was present in 54.3% (38/70); 15 and 23 lesions were low and high grade/stage, respectively. \"VVR-derived funisitis\" was strongly associated with histological evidence of AFI elsewhere in the placenta. Its overall sensitivity and specificity were 0.94 and 0.88; when VVR-derived funisitis was high grade/stage or diagnosed in the third trimester, specificity rose to 1.0.Conclusion: \"VVR-derived funisitis\" has a strong association with histological evidence of AFI.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"551-553"},"PeriodicalIF":1.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10935266211033271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39202634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Vertical Transmission of Trypanosoma Cruzi in a Non-Endemic Country: Histology of the Infected Placenta. 克氏锥虫在非流行国家的垂直传播:感染胎盘的组织学。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 Epub Date: 2021-08-08 DOI: 10.1177/10935266211012192

Anna Keogh, Wendy Ferguson, Debbie Nolder, Emma Doyle, Noel McEntagart

引用次数: 1

Undifferentiated Embryonal Sarcoma of the Liver With Rhabdoid Morphology Mimicking Carcinoma: Expanding the Morphologic Spectrum or a Distinct Variant? 未分化胚胎性肝肉瘤伴横纹肌样形态模拟癌:扩大形态谱还是不同变体?

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 Epub Date: 2021-06-14 DOI: 10.1177/10935266211018930

David J Papke, Adam S Fisch, Sarangarajan Ranganathan, Allison O'Neill, Micheál Breen, Alanna J Church, Antonio R Perez-Atayde, Alyaa Al-Ibraheemi

{"title":"Undifferentiated Embryonal Sarcoma of the Liver With Rhabdoid Morphology Mimicking Carcinoma: Expanding the Morphologic Spectrum or a Distinct Variant?","authors":"David J Papke, Adam S Fisch, Sarangarajan Ranganathan, Allison O'Neill, Micheál Breen, Alanna J Church, Antonio R Perez-Atayde, Alyaa Al-Ibraheemi","doi":"10.1177/10935266211018930","DOIUrl":"https://doi.org/10.1177/10935266211018930","url":null,"abstract":"Undifferentiated embryonal sarcoma of the liver (UESL) is a rare aggressive neoplasm that occurs predominantly in children. Like mesenchymal hamartoma of the liver (MHL), UESL harbors recurrent rearrangements involving 19q13.3 and 19q13.4, a region of the genome that contains a primate-specific cluster of micro-RNAs. Here, we present a case of a high-grade neoplasm that arose in the left hepatic lobe of a 5-year-old male and gave rise to widespread lymph node, visceral, and soft tissue metastases. The tumor was composed of sheets, tubules, and papillae of epithelioid cells with rhabdoid morphology. INI1 and BRG1 expression were retained. Tumor cells diffusely expressed epithelial markers, including multiple keratins. While the morphologic and immunophenotypic features were suggestive of poorly differentiated carcinoma with rhabdoid features, the tumor was found to harbor the t(11;19)(q13;q13.3) translocation characteristic of UESL, as well as a TP53 mutation. Given the clinical presentation, imaging, clinical course, the tumor was classified as UESL with unusual, carcinoma-like histopathologic features. In the context of an unclassified high-grade hepatic tumor in a young child, molecular or cytogenetic testing for chromosome 19q13 alterations should be considered.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"564-569"},"PeriodicalIF":1.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10935266211018930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39088871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients. 2例青少年男性恶性间皮瘤伴EWSR1-ATF1融合。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 Epub Date: 2021-06-12 DOI: 10.1177/10935266211021222

Hezhen Ren, S Rod Rassekh, Atilano Lacson, Cheng-Han Lee, Brendan C Dickson, Catherine T Chung, Anna F Lee

{"title":"Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients.","authors":"Hezhen Ren, S Rod Rassekh, Atilano Lacson, Cheng-Han Lee, Brendan C Dickson, Catherine T Chung, Anna F Lee","doi":"10.1177/10935266211021222","DOIUrl":"https://doi.org/10.1177/10935266211021222","url":null,"abstract":"Malignant mesothelioma is a neoplasm of serosal surfaces, most commonly affecting the pleura. The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium respectively. Both cases lacked a known exposure history. Microscopy in both cases showed predominantly epithelioid morphology with ample eosinophilic cytoplasm, and immunohistochemistry was positive for pan-keratin, calretinin, and WT1. Both cases showed EWSR1-ATF1 gene rearrangement by RNA sequencing, which was instrumental in confirming the diagnosis of malignant mesothelioma and to exclude more common pediatric sarcomas, especially in the context of limited sampling.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"570-574"},"PeriodicalIF":1.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10935266211021222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39009201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Autopsy Study of Calretinin Immunohistochemistry in the Anorectal Canal in Young Infants and Potential Implications for Rectal Biopsy Approach in the Neonatal Period. 婴儿肛肠管Calretinin免疫组织化学的解剖研究及其对新生儿期直肠活检方法的潜在意义。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 Epub Date: 2021-07-15 DOI: 10.1177/10935266211030172

Heather Rytting, Zachary J Dureau, Jose Velazquez Vega, Beverly B Rogers, Hong Yin

{"title":"Autopsy Study of Calretinin Immunohistochemistry in the Anorectal Canal in Young Infants and Potential Implications for Rectal Biopsy Approach in the Neonatal Period.","authors":"Heather Rytting, Zachary J Dureau, Jose Velazquez Vega, Beverly B Rogers, Hong Yin","doi":"10.1177/10935266211030172","DOIUrl":"https://doi.org/10.1177/10935266211030172","url":null,"abstract":"Background: Absent submucosal ganglion cells in biopsies 1-3 cm above the pectinate line establishes the pathologic diagnosis of Hirschsprung Disease (HD). Calretinin stains both ganglion cells and their mucosal neurites and has gained importance in HD diagnosis. Absent calretinin positive mucosal neurites in biopsies at the appropriate level above the pectinate line is highly specific for HD. Whether this applies to lower biopsies is uncertain. To address this, we studied anorectal canal autopsy specimens from infants.Methods: We performed an autopsy study of infant anorectal canal specimens to describe calretinin staining in this region. Calretinin staining was correlated with histologic and gross landmarks.Results: In all 15 non-HD specimens, calretinin positive mucosal neurites were present in glandular mucosa up to the anorectal line where neurites rapidly diminished. Age range was preterm 26 weeks to 3 months.Conclusions: Calretinin positive mucosal neurites are present in glandular mucosa up to the anorectal line in young infants. This is potentially important regarding neonatal HD biopsy level and diagnosis. Positive calretinin staining at the anorectal line favors normal innervation making HD unlikely. Absent calretinin positive neurites in glandular mucosa is worrisome for HD in young infants, regardless of location.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"542-550"},"PeriodicalIF":1.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10935266211030172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Editor in Chief's Message. 总编辑的话。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 DOI: 10.1177/10935266211062358

Pierre Russo

引用次数: 0

Programmed Death Ligand 1 Expression and Related Markers in Pleuropulmonary Blastoma. 程序性死亡配体1在胸膜肺母细胞瘤中的表达及相关标志物

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2021-11-01 Epub Date: 2021-07-15 DOI: 10.1177/10935266211027417

Zahra Alipour, Kris Ann P Schultz, Ling Chen, Anne K Harris, Ivan A Gonzalez, John Pfeifer, D Ashley Hill, Mai He, Louis P Dehner

{"title":"Programmed Death Ligand 1 Expression and Related Markers in Pleuropulmonary Blastoma.","authors":"Zahra Alipour, Kris Ann P Schultz, Ling Chen, Anne K Harris, Ivan A Gonzalez, John Pfeifer, D Ashley Hill, Mai He, Louis P Dehner","doi":"10.1177/10935266211027417","DOIUrl":"https://doi.org/10.1177/10935266211027417","url":null,"abstract":"Introduction: Pleuropulmonary blastoma (PPB), a rare childhood neoplasm of the lung, is linked to pathogenic DICER1 variants. We investigated checkpoint inhibitor markers including Programmed Death Ligand 1 (PD-L1), PD1, CD8 and tumor mutational burden (TMB) in PPB.Material and methods: Cases were collected from departmental archives and the International PPB/DICER1 Registry. Immunohistochemistry (IHC) for PD-L1, PD-1, CD8 and DNA mismatch repair (MMR) genes were performed. In addition, normal-tumor paired whole exome sequencing (WES) was performed in two cases.Results: Twenty-five PPB cases were studied, consisting of Type I (n = 8, including 2 Ir), Type II (n = 8) and Type III (n = 9). PD-L1 combined positive score (CPS) of 1, 4 and 80 was seen in three (3/25, 12.0%) cases of Type II PPB with negative staining in the remaining cases. PD-1 and CD8 stains demonstrated positive correlation (P < .05). The density of PD1 and CD8 in the interface area was higher than within tumor (P < .05). The MMR proteins were retained. TMB was 0.65 mutations/Mb in type II PPB with high expression of PD-L1, and 0.94 mutations/Mb in one negative PD-L1 case with metastatic tumor.Conclusion: A small subpopulation of PPB patient might benefit from checkpoint immunotherapy due to positive PD-L1 staining.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"523-530"},"PeriodicalIF":1.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10935266211027417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation. 一个10个月大的婴儿在没有激素升高的情况下出现继发于卵巢硬化间质瘤的性早熟症状。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2019-07-01 Epub Date: 2018-12-21 DOI: 10.1177/1093526618819605

Anthony I Squillaro, Shengmei Zhou, Stefanie M Thomas, Eugene S Kim

引用次数: 4

Noonan Syndrome Case Report: PTPN11 and Other Potential Genetic Factors Contributing to Lethal Hypertrophic Right Ventricular Cardiomyopathy. 努南综合征病例报告:PTPN11和其他潜在遗传因素导致致死性肥厚性右室心肌病。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2019-07-01 Epub Date: 2019-01-21 DOI: 10.1177/1093526618825411

Elena Daoud, David Zwick

引用次数: 0

Atypical Hepatic Mesenchymal Hamartoma: Histologic Appearance, Immunophenotype, and Molecular Findings. 非典型肝间充质错构瘤:组织学表现、免疫表型和分子表现。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2019-07-01 Epub Date: 2018-11-29 DOI: 10.1177/1093526618806750

Dina El Demellawy, James Yj Lee, Laura McDonell, David A Dyment, A S Knisely, Jean McGowan-Jordan, Bo Ngan, Milton Finegold, Raj P Kapur, Ahmed Nasr

引用次数: 4