Oral and maxillofacial surgery最新文献

{"title":"Can acupuncture be a viable method for pain control after lower third molar removal? A systematic review with meta-analysis.","authors":"Kayo Costa Alves, Pedro Henrique da Hora Sales, Paulo Goberlânio de Barros Silva, Kristiana Cerqueira Mousinho","doi":"10.1007/s10006-025-01415-6","DOIUrl":"https://doi.org/10.1007/s10006-025-01415-6","url":null,"abstract":"<p><strong>Introduction: </strong>Surgery to remove lower third molars is usually associated with events such as pain, swelling and trismus, thus increasing postoperative morbidity. The control of these signs and symptoms is essential for a quick recovery of the patient.</p><p><strong>Purpose: </strong>The objective of this study was to determine whether acupuncture is effective in controlling pain in lower third molar surgeries.</p><p><strong>Methods: </strong>A systematic review was carried out by two independent researchers and the selection of studies took place according to the inclusion and exclusion criteria previously established. The main outcome measure was the analysis of pain in the postoperative period. Data analysis included risk of bias assessment (RoB 2 Cochrane) and meta-analysis with heterogeneity based on random effects I² and 95% confidence.</p><p><strong>Results: </strong>In the initial results, 717 articles were found, and 6 studies were selected for analysis in this review. The results of the meta-analysis showed that there was a significant reduction in pain scores after 2 h (p < 0.001), 18 h (p = 0.008), 24 h (p < 0.001), 48 h (< 0.001) and 72 h (p < 0.001) in favor of the acupuncture group.</p><p><strong>Conclusions: </strong>According to the results of this study, acupuncture has shown an effective result in reducing pain, however due to the heterogeneity of studies and the low level of evidence, it is not possible to determine whether acupuncture is a viable method for pain control after lower third molar surgery. New standardized and controlled studies are needed to confirm the efficacy of this therapy.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"119"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free chimeric LD + SA flap for tongue and suprahyoid muscles reconstruction after total glossectomy.","authors":"Alexander V Mordovskiy, Andrey P Polyakov, Andrey D Kaprin, Mikhail V Ratushnyy, Irina V Novikova","doi":"10.1007/s10006-025-01418-3","DOIUrl":"https://doi.org/10.1007/s10006-025-01418-3","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to report the functional outcomes of patients who underwent total or near total glossectomy for oral SCC reconstructed with a chimeric latissimus dorsi and serratus anterior (LD + SA) flap.</p><p><strong>Methods: </strong>Thirty-two patients with tongue cancer, with a mean age of 48.8 years, were included in the study. All patients underwent total or near total glossectomy and subsequent reconstruction with chimeric LD + SA flap. Swallowing and speech functions were measured and prospectively recorded pre- and 3,6 and 12 months postoperatively. Patient-reported outcomes were measured using the Speech Handicap Index (SHI), M.D. Anderson Dysphagia Inventory (MDADI), and EORTC-QLQ-H&N 35 score at 12 months. Additionally, volume reduction in the flaps was measured.</p><p><strong>Results: </strong>The mean follow-up period was 21 months (range, 2-67 months). The flaps were successfully placed in 30 cases. The total success rate was 93.8% (30/32). In 25 cases (83,3%), a positive functional outcome was recorded, defined as the achievement of an adequate swallowing and speech ability. The swallowing evaluation study revealed that 83% (25/30) of patients experienced bolus transit. Speech function was assessed 3, 6, and 12 months prospectively by speech therapist, with patient-reported SHI outcomes at 12 months. Speech intelligibility was good in 16,7% of cases (5/30, mean SHI 29.18, SD 16.36) acceptable in 56,7% (17/30, mean SHI 51.14, SD 19.8) and poor intelligibility in 26,7% (8/30, mean SHI 65.62 SD 9.8) at 12 months. Mean MDADI score was 84.5 (SD 12.15), indicating good swallowing function. Decannulation was possible in 25 of the 30 patients (83,3%).</p><p><strong>Conclusion: </strong>The chimeric LD + SA free flap represents a feasible option for tongue reconstruction after salvage glossectomy, with promising functional outcomes and low donor-side morbidity. This approach significantly improved the patients' oral functions and quality of life.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of nano-hydroxyapatite/silica gel bone graft and/or hemodialysate paste on the regeneration and nano-mechanical properties of calvarial bone in gammairradiated albino rats.","authors":"Noha S Zein, Sara El Moshy, Mohammed Khashaba, Eman M F El-Maghraby, Engy R Rashed, Dalia M Abdel-Hamid","doi":"10.1007/s10006-025-01413-8","DOIUrl":"10.1007/s10006-025-01413-8","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluating the effect of synthetic nano-hydroxyapatite/silica gel bone substitute and/or hemodialysate on gamma irradiated bone regeneration and bone nano-mechanical properties in rat model.</p><p><strong>Methods: </strong>Seventy adult male Wistar albino rats (total of 70 defects, 1 defect/rat) were randomly divided into five groups (14 rats/group); 4 irradiated groups; control (Ir-C) without any treatment, NanoBone^®-treated (Ir-N), Solcoseryl^®-treated (Ir-S), NanoBone^® + Solcoseryl^®-treated (Ir-NS) groups, and one non-irradiated NanoBone^® + Solcoseryl^®-treated (Nr-NS) group. Each rat's calvarium was subjected to a single dose of gamma radiation (12 Gy) followed by a single critical-sized defect creation. Defects were then filled with the assigned treatments except the Ir-C group. Rats were euthanized after 4 weeks. Hematoxylin and Eosin, Masson's Trichrome staining and nano-indentation were performed for histologic and nano-mechanical properties assessment of specimens.</p><p><strong>Results: </strong>Scattered thin new bone trabeculae with randomly arranged fine collagen fibrils and extravasated blood were evident in Ir-C group, while thicker new bone trabeculae, well-organized collagen fibers and new blood vessels were observed in all treated groups. Ir-C group showed the lowest significant bone area percent, nano-hardness and indentation modulus values, while Nr-NS group possessed the highest significant percent and values. Ir-C group showed the highest significant indentation modulus to nano-hardness ratio followed by Ir-S group, while the lowest ratios were obtained by the rest of the groups with no significance.</p><p><strong>Conclusions: </strong>The combination of synthetic nano-hydroxyapatite/silica gel bone substitute and hemodialysate enhanced the quality and quantity of regenerated gamma-irradiated rats' bones.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"116"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of recovery in maxillofacial surgical patients undergoing intravenous conscious sedation using PSI monitoring.","authors":"Ramita Sood, Balubhai Ram, Mustafa Kurani, Anupama Chauhan, Nisarg Trivedi","doi":"10.1007/s10006-025-01408-5","DOIUrl":"https://doi.org/10.1007/s10006-025-01408-5","url":null,"abstract":"","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"117"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of ice saline and kangfuxin mouthwash on improving oral infection following buccal mucosa resection.","authors":"Yu Zhang, Chuanrui Yang, Lu Tang, Dandan Xie, Yulong Yi, Lei Lei, Li Xue","doi":"10.1007/s10006-025-01402-x","DOIUrl":"10.1007/s10006-025-01402-x","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the efficacy of ice saline and Kangfuxin mouthwash in reducing oral infection incidence following buccal mucosa resection in patients.</p><p><strong>Methods: </strong>A retrospective analysis was performed on patients who underwent buccal mucosa resection at a tertiary hospital's Urology Department from January 2020 to December 2024. Post-surgery, patients used ice saline and Kangfuxin mouthwash for six mouthwashes before and after meals, with 10 ml per use, gargling for 3 min each time. The incidence of oral infection was compared between the two groups using t-tests, chi-square tests, and non-parametric tests.</p><p><strong>Results: </strong>A total of 228 patients were included, with an overall oral infection incidence of 9.6%. After balancing the baseline characteristics and nutritional indicators between the groups, a statistically significant difference was observed in infection incidence and pain scores on the third postoperative day (p < 0.05).</p><p><strong>Conclusion: </strong>Addressing oral infection in patients following buccal mucosa resection is crucial; postoperative use of Kangfuxin mouthwash shows potential in reducing oral infection incidence.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of maxillofacial fractures on patients' quality-of-life measures: a systematic review.","authors":"Olga Beatriz Lopes Martins, Ighor Andrade Fernandes, Glaciele Maria de Souza, Patricia Furtado Gonçalves, Saulo Gabriel Moreira Falci, Endi Lanza Galvão","doi":"10.1007/s10006-025-01407-6","DOIUrl":"https://doi.org/10.1007/s10006-025-01407-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the impact of maxillofacial fractures (MFFs) on health-related quality of life (HRQoL) and oral health-related quality of life (OHRQoL).</p><p><strong>Methodology: </strong>A systematic literature review was carried out following the MOOSE and PRISMA guidelines. The search was conducted in LILACS, Embase, and PubMed databases alongside manual reference checks, with no date restrictions, including observational studies that assessed HRQoL or OHRQoL in patients with MFFs using validated instruments. Methodological quality was assessed using the JBI checklist.</p><p><strong>Results: </strong>Twelve studies were included in the analysis, most with a cohort design and male predominance. The results indicated a negative impact of MFFs on HRQoL, especially in the immediate post-traumatic period/immediately after MFF diagnosis, with impairment in domains such as pain, physical function, mental health, and social aspects. OHRQoL was also affected, mainly regarding pain, chewing difficulty, and dietary changes. Although most studies indicated improved quality of life after treatment and recovery, long-term sequelae, such as infraorbital nerve paresthesia, may persist. The review showed heterogeneity among studies regarding geographical origin, methodological design, follow-up periods, and quality of life assessment instruments. Small sample sizes, lack of detailed analysis of socioeconomic and health factors, inadequate control of variables, and the predominance of male patients in some studies limit the generalizability of the findings.</p><p><strong>Conclusion: </strong>MFFs seem to affect patients' HRQoL and OHRQoL, but further longitudinal studies with larger samples and standardized assessments are needed to deepen the understanding of the long-term impact.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"114"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of GPT-4 in oral and maxillofacial surgery board exams: challenges in specialized questions.","authors":"Felix Benjamin Warwas, Nils Heim","doi":"10.1007/s10006-025-01412-9","DOIUrl":"https://doi.org/10.1007/s10006-025-01412-9","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the performance of GPT-4 in answering oral and maxillofacial surgery (OMFS) board exam questions, given its success in other medical specializations.</p><p><strong>Methods: </strong>A total of 250 multiple-choice questions were randomly selected from an established OMFS question bank, covering a broad range of topics such as craniofacial trauma, oncological procedures, orthognathic surgery, and general surgical principles. GPT-4's responses were assessed for accuracy, and statistical analysis was performed to compare its performance across different topics.</p><p><strong>Results: </strong>GPT-4 achieved an overall accuracy of 62% in answering the OMFS board exam questions. The highest accuracies were observed in Pharmacology (92.8%), Anatomy (73.3%), and Mucosal Lesions (70.8%). Conversely, the lowest accuracies were noted in Dental Implants (37.5%), Orthognathic Surgery (38.5%), and Reconstructive Surgery (42.9%). Statistical analysis indicated significant variability in performance across different topics, with GPT-4 performing better in general topics compared to specialized ones.</p><p><strong>Conclusion: </strong>GPT-4 demonstrates a promising ability to answer OMFS board exam questions, particularly in general medical topics. However, its performance in highly specialized areas reveals significant limitations. These findings suggest that while GPT-4 can be a useful tool in medical education, further enhancements are needed for its application in specialized medical fields.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"113"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of lag screws and miniplates in the fixation of anterior mandibular fractures- a prospective study.","authors":"Sonal Jawa, G Prathibha, Kavitha Prasad, K Ranganath, Parimala Sagar, Surabhi Chandra","doi":"10.1007/s10006-025-01406-7","DOIUrl":"https://doi.org/10.1007/s10006-025-01406-7","url":null,"abstract":"<p><strong>Introduction: </strong>Mandibular fractures are among the commonest fractures of maxillofacial region with anterior-mandibular fractures accounting for 8-15%. Mini-plates with or without arch bar is the most commonly used fixation method to achieve ORIF. However, the mandible symphysis is uniquely shaped for the application of lag-screws.</p><p><strong>Aim: </strong>This study aims at evaluating the effectiveness of lag-screws in comparison with mini-plates in fixation of anterior mandibular fractures.</p><p><strong>Methodology: </strong>20 patients diagnosed with anterior mandibular fractures were divided into 2 equal groups. Group-A was treated using lag-screws and Group-B was treated using mini-plates. Radiographs were taken for evaluation of fracture site. The results were assessed for mobility of fracture segments, stability of occlusion, paresthesia, and pre-operative, intra-operative and post-operative distances between fracture segments.</p><p><strong>Results: </strong>There was a significant reduction in clinical distance between the reduced fracture fragments in the lag-screw group. A substantial reduction of radiographic distance between fracture segments was observed post-operatively in the lag-screw group, unlike the mini-plate group. A lesser interfragmentary distance was observed in patients treated with the lag-screw technique.</p><p><strong>Conclusion: </strong>While lag screws and miniplate techniques are both stable forms of fixation, there is more interfragmentary bony contact with lag-screws, thus ideal for fixation of anterior mandibular fractures.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented villonodular synovitis of the temporomandibular joint. evaluation of 12 patients from 2017 to 2023.","authors":"Machoň Vladimír, Vlachopulos Vasilis, Beňo Michal, Foltán René, Michl Petr","doi":"10.1007/s10006-025-01360-4","DOIUrl":"https://doi.org/10.1007/s10006-025-01360-4","url":null,"abstract":"<p><strong>Purpose: </strong>The authors evaluated a cohort of 12 patients with histologically verified pigmented villonodular synovitis of the TMJ between 2018 and 2023.</p><p><strong>Methods: </strong>The authors evaluated 12 patients (12 women). Only unilateral involvement was present in all patients. The mean age of the patients was 49.5 years. The authors focused on the evaluation of clinical symptoms, imaging findings, and arthroscopic findings. They also evaluated the effect of therapy, including the incidence of recurrence. The evaluation of therapy was performed at a minimum of 12 months after therapy and a maximum of 4.5 years after therapy.</p><p><strong>Results: </strong>Pain was the predominant clinical symptom (12 patients, 100%). Therapy consisted of arthroscopy and open surgery. Radiographs were taken in all patients. In 5 patients (42%) the joint structures were without obvious pathological changes, in 7 patients (58%) there was a finding of irregularities on the joint head. Magnetic resonance imaging was performed in all patients, and in 10 cases (83%) there was a finding of joint space enlargement, effusion. Therapy consisted of TMJ arthroscopy with removal of pathological tissue. If the joint was completely filled with pathological tissue, after histological verification, open surgery with complete removal of joint structures and subsequent reconstruction of the TMJ was indicated. Recurrence of PVNS was not reported in the cohort.</p><p><strong>Conclusion: </strong>PVNS is an uncommon benign lesion affecting the TMJ. In the authors' study, pain was the predominant symptom and effusion was the predominant finding on magnetic resonance imaging. Long-term follow-up is appropriate in patients with proven PVNS. This is due to the risk of recurrence, which is also associated with the difficulty of complete repair of the lesion in the anatomically limited space of the TMJ. The authors recommend 1,3,6 months after surgery, and annually for the first 5 years after surgery. One, two, and five years after surgery, they recommend a follow-up MRI. The results of the study support the view that MRI should always be indicated in patients with pain of arthrogenic origin lasting more than 3 months, and if effusion is found, arthroscopy should always be the next step. This procedure will ensure early detection of PVNS.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of postoperative delirium among patients who underwent head & neck surgery.","authors":"Rezarta Taga Senirli, Deniz Gediz, Yeşim Yüksel, Muhammet Yildiz, Nuray Ensari, N Didem Sonbay Yilmaz, Özer Erdem GüR","doi":"10.1007/s10006-025-01410-x","DOIUrl":"https://doi.org/10.1007/s10006-025-01410-x","url":null,"abstract":"<p><strong>Objective: </strong>Postoperative delirium is a state of confusion and cognitive impairment that can be observed after extensive surgery. This serious complication can lead to longer hospital stays and higher costs. As the global population ages, postoperative delirium has also become a concern for patients undergoing head and neck surgery. In this study, we investigated whether the preoperative recognition of cognitive impairment could help with the prediction of postoperative delirium among patients undergoing head and neck surgery.</p><p><strong>Methods: </strong>We conducted a three-year prospective study in our clinic to analyze 46 patients who underwent surgeries lasting 6 h or longer. Mini-Mental State Examination scores, demographic data, medical history, surgical details and delirium assessments were examined to identify risk factors for postoperative delirium.</p><p><strong>Results: </strong>Our study revealed that 8.7% of the patients developed postoperative delirium. Longer surgery durations, lower serum sodium levels and lower Mini-Mental State Examination scores were risk factors for postoperative delirium.</p><p><strong>Conclusion: </strong>Recognizing cognitive impairment and other potential risk factors during the preoperative period appears to play a critical role in reducing the incidence of postoperative delirium and its associated complications.</p>","PeriodicalId":520733,"journal":{"name":"Oral and maxillofacial surgery","volume":"29 1","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}